Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2/Bax mediated apoptosis

References

• Leena C, Ehab HS, Prabhat CG. 2-(4-Chlorophenyl)benzo-1,4-quinone induced ROS-signaling inhibits proliferation in human non-malignant prostate epithelial cells. Environ Int 2010;36:924–930.
   PubMed Web of Science ®Google Scholar
• Wadley AJ, Chen YW, Bennett SJ, Lip GY, Turner JE, Fisher JP, et al. Monitoring changes in thioredoxin and over-oxidised peroxiredoxin in response to exercise in humans. Free Radic Res 2015;49:290–298.
   PubMed Web of Science ®Google Scholar
• Virginio VW, Nunes VS, Moura FA, Menezes FH, Andreoll NA, Rogerio F, et al. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. Free Radic Res 2015;49:199–203.
   PubMed Web of Science ®Google Scholar
• Yosra H, Hadhemi K, David V, Jérôme L, Amira Z, Mohamed H, et al. Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes. Peptides 2015;71:56–65.
   PubMed Web of Science ®Google Scholar
• Qipin Q, Zhenfeng C, Jiaolan Q, Xiaoju H, Yulan L, Yancheng L, et al. Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis. Eur J Med Chem 2015;92:302–313.
   PubMed Web of Science ®Google Scholar
• Melanie JG, Cifuentes ME, Stephen RH, Donald BD. A local paracrine and endocrine network involving TGFbeta, Cox-2, ROS, and estrogen receptor beta influences reactive stromal cell regulation of prostate cancer cell motility. Mol Endocrinol 2012;26:940–954.
   PubMed Web of Science ®Google Scholar
• Yoshihiro H, Kousuke M, Yujiro A, Hisamitsu I, Shohei N, Yukio O. Relationship between serum prostate specific antigen and histological prostatitis in patients with benign prostatic hyperplasia. Prostate 1994;25:91–96.
   PubMed Web of Science ®Google Scholar
• Hideyuki S, Tatsuya N, Ken-Ya S, Wataru M, Tokio F, Sadao K. Properties of a high-torularhodin-producing mutant of Rhodotorula glutinis cultivated under oxidative stress. J Biosci Bioeng 2000;89:203–205.
   PubMed Web of Science ®Google Scholar
• Hideyuki S, Hidesato N, Sadao K, Wataru M. Effect of active oxygen species on the productivity of torularhodin by Rhodotorula glutinis No. 21. J Biosci Bioeng 2002;93:338–340.
   PubMed Web of Science ®Google Scholar
• Chao D, Yingchao L, Yahui G, Mei H, Weiguo Z, He Q. Torularhodin, isolated from Sporidiobolus pararoseus, inhibits human prostate cancer LNCaP and PC-3 cell growth through Bcl-2/Bax mediated apoptosis and AR down-regulation. RSC Adv 2015;5:106387–106395.
   Web of Science ®Google Scholar
• Chao D, Yingchao L, Yahui G, Mei H, Weiguo Z, He Q. The suppression of torulene and torularhodin treatment on the growth of PC-3 xenograft prostate tumors. Biochem Biophys Res Commun 2016;469:1146–1152.
   PubMed Web of Science ®Google Scholar
• Qiuyu S, Heya W, Chao D, Weiguo Z, He Q. Tentative identification of torulene cis/trans geometrical isomers isolated from Sporidiobolus pararoseus by high-performance liquid chromatography-diode array detection-mass spectrometry and preparation by column chromatography. Anal Sci 2013;29:997–1002.
   PubMed Web of Science ®Google Scholar
• Xiaolong H, Qing T, Wenqing W, Wei X, Chunyang S, Jianguo F. Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways. Life Sci 2015;130:38–46.
   PubMed Web of Science ®Google Scholar
• Yan C, Qing Y, Heya W, Yingchao L, Weirong Y, He Q. Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol-induced hepatotoxicity in mice. J Sci Food Agric 2014;94:1764–1771.
   PubMed Web of Science ®Google Scholar
• Seunghee S, Gilsaeng J. Fisetin inhibits TNF-alpha-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression. Int Immunopharmacol 2015;29:246–253.
   PubMed Web of Science ®Google Scholar
• Haripaul S, Rajnee K, Natarajan B, Sanjay G. Plant flavone apigenin binds to nucleic acid bases and reduces oxidative DNA damage in prostate epithelial cells. PLoS One 2014;9:e91588.
   PubMed Web of Science ®Google Scholar
• Nuri A, Susana S, Guadalupe D, Carmen A, Brenda A. Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines. Prostate 2013;73:31–41.
   PubMed Web of Science ®Google Scholar
• Yongli W, Yousong X, Xu H, Yan Q, Lina X, Youwei X, et al. Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway. Food Chem Toxicol 2013;59:118–128.
   PubMed Web of Science ®Google Scholar
• Yanfei P, Jiandang S, Xiaoling D, Liang W, Helmut K, Linjian M, et al. Prostaglandin E2 induces stromal cell-derived factor-1 expression in prostate stromal cells by activating protein kinase A and transcription factor Sp1. Int J Biochem Cell Biol 2013;45:521–530.
   PubMed Web of Science ®Google Scholar
• W LP, C JQ, S AV. Prevalence of and risk factors for prostatitis in African American men: the Flint Men's Health Study. Prostate 2009;69:24–32.
   PubMed Web of Science ®Google Scholar
• Rassarin C, Steven JS, Jirawat Y. Antioxidant activities and antiproliferative activity of Thai purple rice cooked by various methods on human colon cancer cells. Food Chem 2015;188:99–105.
   PubMed Web of Science ®Google Scholar
• Simova ED, Frengova GI, Beshkova DM. Synthesis of carotenoids by Rhodotorula rubra GED8 co-cultured with yogurt starter cultures in whey ultrafiltrate. J Ind Microbiol Biotechnol 2004;31:115–121.
   PubMed Web of Science ®Google Scholar
• Siejka A, Schally AV, Barabutis N. The effect of LHRH antagonist cetrorelix in crossover conditioned media from epithelial (BPH-1) and stromal (WPMY-1) prostate cells. Horm Metab Res 2014;46:21–26.
   PubMed Web of Science ®Google Scholar
• Zahid N, Ejaz A, Melih A, Niyazi K, Ilker S, Ahmet C, et al. Protective effect of cholesterol-loaded cyclodextrin pretreatment against hydrogen peroxide induced oxidative damage in ram sperm. Cryobiology 2015;71:18–23.
   PubMed Web of Science ®Google Scholar
• Ranlu L, Jing L, Zhigang T, Zhihong Z, Yong X. Overexpressed MicroRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). PLoS One 2013;8:e68982.
   PubMed Web of Science ®Google Scholar
• Chao F, Liying Z, Ting Y, Gang X, Honglei T, Jinjie X, et al. A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. Int J Cancer 2012;131:1445–1454.
   PubMed Web of Science ®Google Scholar
• Hu Z, Chen Z, Chao Q, Tao T, Jie L, Gong C, et al. Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP. Biochem Biophys Res Commun 2013;432:320–325.
   PubMed Web of Science ®Google Scholar
• Da HL, Yoon JN, Min SL, Dong SS, Chung SL. Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. Eur J Pharmacol 2015;749:39–48.
   PubMed Web of Science ®Google Scholar
• Xiaolong Y, Xin Z, Changlin F, Qiang W, Tao N, Fan Z, et al. Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway. Oncol Rep 2015;34:1129–1136.
   PubMed Web of Science ®Google Scholar