Age-related effect of aerobic exercise training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats

References

• Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–E386.
   PubMed Web of Science ®Google Scholar
• Dolinsky VW, Rogan KJ, Sung MM, et al. Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. Am J Physiol Endocrinol Metab. 2013;00044(2):E243–E253.
   PubMed Web of Science ®Google Scholar
• Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013;65(2):157–170.
   PubMed Web of Science ®Google Scholar
• Dudka J, Gieroba R, Korga A, et al. Different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity. Evid Based Complement Alternat Med. 2012;2012:606183.
   PubMed Web of Science ®Google Scholar
• Singla S, Kumar NR, Kaur J. In vivo studies on the protective effect of propolis on doxorubicin-induced toxicity in liver of male rats. Toxicol Int. 2014;21(2):191–195.
   PubMedGoogle Scholar
• Zhang S, Liu X, Bawa-Khalfe T, et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med. 2012;18(11):1639–1642.
   PubMed Web of Science ®Google Scholar
• Tangpong J, Miriyala S, Noel T, et al. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana. Neuroscience. 2011;175:292–299.
   PubMed Web of Science ®Google Scholar
• Ascensão A, Oliveira PJ, Magalhães J. Exercise as a beneficial adjunct therapy during doxorubicin treatment – role of mitochondria in cardioprotection. Int J Cardiol. 2012;156(1):4–10.
   PubMed Web of Science ®Google Scholar
• Mete R, Oran M, Topcu B, et al. Protective effects of onion (Allium cepa) extract against doxorubicin-induced hepatotoxicity in rats. Toxicol Ind Health. 2016;32(3):551–557.
   PubMed Web of Science ®Google Scholar
• Mansouri E, Jangaran A, Ashtari A. Protective effect of pravastatin on doxorubicin-induced hepatotoxicity. Bratislavske Lek Listy. 2017;118(5):273–277.
   PubMed Web of Science ®Google Scholar
• Ascensão A, Magalhães J, Soares J, et al. Endurance exercise training attenuates morphological signs of cardiac muscle damage induced by doxorubicin in male mice. Basic Appl Myol. 2006;16(1):27–35.
   Google Scholar
• Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc. 1999;31(7):987–997.
   PubMed Web of Science ®Google Scholar
• Maughan RJ, Otani H, Watson P. Influence of relative humidity on prolonged exercise capacity in a warm environment. Eur J Appl Physiol. 2012;112(6):2313–2321.
   PubMed Web of Science ®Google Scholar
• Alves CRR, da Cunha TF, da Paixão NA, et al. Aerobic exercise training as therapy for cardiac and cancer cachexia. Life Sci. 2015;125:9–14.
   PubMed Web of Science ®Google Scholar
• Scott JM, Lakoski S, Mackey JR, et al. The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics. Oncologist. 2013;18(2):221–231.
   PubMed Web of Science ®Google Scholar
• Braidy N, Guillemin GJ, Mansour H, et al. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in Wistar rats. PLoS One. 2011;6(4):e19194.
   PubMed Web of Science ®Google Scholar
• Løhmann DJ, Abrahamsson J, Ha SY, et al. Effect of age and body weight on toxicity and survival in pediatric acute myeloid leukemia: results from NOPHO-AML 2004. Haematologica. 2016;101(11):146175.
   PubMed Web of Science ®Google Scholar
• Mustian KM, Sprod LK, Janelsins M, et al. Exercise recommendations for cancer-related fatigue, cognitive impairment, sleep problems, depression, pain, anxiety, and physical dysfunction: a review. Oncol Hematol Rev. 2012;8(2):81–88.
   PubMedGoogle Scholar
• Umanskaya A, Santulli G, Xie W, et al. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci USA. 2014;111(42):15250–15255.
   PubMed Web of Science ®Google Scholar
• Behnke BJ, Ramsey MW, Stabley JN, et al. Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology. J Appl Physiol (1985). 2012;113(11):1699–1708.
   PubMed Web of Science ®Google Scholar
• Roshan VD, Assali M, Moghaddam AH, et al. Exercise training and antioxidants: effects on rat heart tissue exposed to lead acetate. Int J Toxicol. 2011;30(2):190–196.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhang TP, Zhang Y, et al. Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein. Sci Rep. 2016;6:28399.
   Web of Science ®Google Scholar
• Tulubas F, Gurel A, Oran M, et al. The protective effects of ω-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats. Toxicol Ind Health. 2015;31(7):638–644.
   PubMed Web of Science ®Google Scholar
• Liu LL, Li QX, Xia L, et al. Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats. Toxicology. 2007;231(1):81–90.
   PubMed Web of Science ®Google Scholar
• Melo JUS, Santos JMV, Kimura Ode S, et al. Effects of fatty acids on liver regeneration in rats. *Rev Colégio Bras Cir. 2010;37(5):351–357.
   PubMedGoogle Scholar
• El-Moselhy MA, El-Sheikh AA. Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomed Pharmacother. 2014;68(1):101–110.
   PubMed Web of Science ®Google Scholar
• Rikans LE. Influence of aging on chemically induced hepatotoxicity: role of age-related changes in metabolism. Drug Metab Rev. 1989;20(1):87–110.
   PubMed Web of Science ®Google Scholar
• Rao PV, Gupta N, Jayaraj R, et al. Age-dependent effects on biochemical variables and toxicity induced by cyclic peptide toxin microcystin-LR in mice. Comp Biochem Physiol C Toxicol Pharmacol. 2005;140(1):11–19.
   PubMed Web of Science ®Google Scholar
• Yang W, Burkhardt B, Fischer L, et al. Age-dependent changes of the antioxidant system in rat livers are accompanied by altered MAPK activation and a decline in motor signaling. *Excli J. 2015;14:1273–1290.
   PubMedGoogle Scholar
• Migliore L, Coppedè F. Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat Res. 2009;674(1–2):73–84.
   PubMed Web of Science ®Google Scholar
• Giergiel M, Lopucki M, Stachowicz N, et al. The influence of age and gender on antioxidant enzyme activities in humans and laboratory animals. Aging Clin Exp Res. 2012;24(6):561–569.
   PubMed Web of Science ®Google Scholar
• Lee J, Koo N, Min DB. Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr Rev Food Sci Food Saf. 2004;3(1):21–33.
   PubMed Web of Science ®Google Scholar
• Scott JM, Khakoo A, Mackey JR, et al. Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation. 2011;124(5):642–650.
   PubMed Web of Science ®Google Scholar
• Chicco AJ, Hydock DS, Schneider CM, et al. Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity. J Appl Physiol (1985). 2006;100(2):519–527.
   PubMed Web of Science ®Google Scholar
• Vasili A, Sharifi G, Faramarzi M, et al. The effect of aerobic exercise on hepatotoxicity induced by intratracheal instillation of iron oxide nanoparticles in Wistar rats. Gen Physiol Biophys. 2016;35(1):35–43.
   PubMed Web of Science ®Google Scholar
• Alishahi A, Roshan VD, Hedayyati M. Pretreatment effects of regular aerobic training on the IGF system and hepatotoxicity induced by doxorubicin in rats. Asian Pac J Cancer Prev. 2013;14(12):7427–7431.
   PubMedGoogle Scholar
• Miyagi MYS, Seelaender M, Castoldi A, et al. Long-term aerobic exercise protects against cisplatin-induced nephrotoxicity by modulating the expression of IL-6 and HO-1. PLoS One. 2014;9(10):e108543.
   Web of Science ®Google Scholar
• Yu AF, Jones LW. Breast cancer treatment-associated cardiovascular toxicity and effects of exercise countermeasures. Cardio-Oncology. 2016;2(1).
   PubMedGoogle Scholar
• Ballard-Barbash R, Friedenreich CM, Courneya KS, et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(11):815–840.
   PubMed Web of Science ®Google Scholar
• Campia U, Barac A. Exercise and aerobic fitness to reduce cancer-related cardiovascular toxicity. Curr Treat Opt Cardiovasc Med. 2016;18(7):44.
   PubMedGoogle Scholar
• Campbell PT, Gross MD, Potter JD, et al. Effect of exercise on oxidative stress: a 12-month randomized, controlled trial. Med Sci Sports Exerc. 2010;42(8):1448–1453.
   PubMed Web of Science ®Google Scholar
• Gomes MJ, Martinez PF, Campos DHS, et al. Beneficial effects of physical exercise on functional capacity and skeletal muscle oxidative stress in rats with aortic stenosis-induced heart failure. Oxid Med Cell Longev. 2016;2016:8695716.
   Google Scholar
• Onur E, Kabaroğlu C, Günay O, et al. The beneficial effects of physical exercise on antioxidant status in asthmatic children. Allergol Immunopathol. 2011;39(2):90–95.
   PubMed Web of Science ®Google Scholar
• Moghaddasi M, Javanmard SH, Reisi P, et al. The effect of regular exercise on antioxidant enzyme activities and lipid peroxidation levels in both hippocampi after occluding one carotid in rat. J Physiol Sci. 2014;64(5):325–332.
   PubMed Web of Science ®Google Scholar
• Yagmurca M, Bas O, Mollaoglu H, et al. Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats. Arch Med Res. 2007;38(4):380–385.
   PubMed Web of Science ®Google Scholar
• Guo H, Liu Y, Wang L, et al. Alleviation of doxorubicin–induced hepatorenal toxicities with sesamin via the suppression of oxidative stress. Hum Exp Toxicol. 2016;35(11):1183–1193.
   PubMed Web of Science ®Google Scholar
• Omobowale TO, Oyagbemi AA, Ajufo UE, et al. Ameliorative effect of gallic acid in doxorubicin-induced hepatotoxicity in Wistar rats through antioxidant defense system. J Dietary Suppl. 2018;15(2):183–196.
   PubMedGoogle Scholar
• Sengupta P. The laboratory rat: relating its age with human’s. Int J Prev Med. 2013;4(6):624–630.
   PubMedGoogle Scholar