Relationship between hemodynamic alteration and sympathetic nerve activation following a single oral dose of cinnamtannin A2

References

• Hammerstone JF, Lazarus SA, Mitchell AE, et al. Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem. 1999;47(2):490–496.
   PubMed Web of Science ®Google Scholar
• Carando S, Teissedre PL, Pascual-Martinez L, et al. Levels of flavan-3-ols in French wines. J Agric Food Chem. 1999;47(10):4161–4166.
   PubMed Web of Science ®Google Scholar
• Knaze V, Zamora-Ros R, Lujan-Barroso L, et al. Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Br J Nutr. 2012;108(6):1095–1108.
   PubMed Web of Science ®Google Scholar
• Buitrago-Lopez A, Sanderson J, Johnson L, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ (Clinical Research ed.). 2011;343:d4488–d4488.
   PubMed Web of Science ®Google Scholar
• Petrone AB, Gaziano JM, Djousse L. Chocolate consumption and risk of heart failure in the Physicians’ Health Study. Eur J Heart Fail. 2014;16(12):1372–1376.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Virtamo J, Wolk A. Chocolate consumption and risk of stroke: a prospective cohort of men and meta-analysis. Neurology. 2012;79(12):1223–1229.
   PubMed Web of Science ®Google Scholar
• Ried K, Sullivan T, Fakler P, et al. Does chocolate reduce blood pressure? A meta-analysis. BMC Med. 2010;8(1):39.
   PubMedGoogle Scholar
• Shrime MG, Bauer SR, McDonald AC, et al. Flavonoid-rich cocoa consumption affects multiple cardiovascular risk factors in a meta-analysis of short-term studies. J Nutr. 2011;141(11):1982–1988.
   PubMed Web of Science ®Google Scholar
• Tokede OA, Gaziano JM, Djousse L. Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis. Eur J Clin Nutr. 2011;65(8):879–886.
   PubMed Web of Science ®Google Scholar
• Engler MB, Engler MM, Chen CY, et al. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr. 2004;23(3):197–204.
   PubMed Web of Science ®Google Scholar
• Farouque HM, Leung M, Hope SA, et al. Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study. Clin Sci (Lond). 2006;111(1):71–80.
   PubMed Web of Science ®Google Scholar
• Baba S, Osakabe N, Natsume M, et al. Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats. Free Rad Biol Med. 2002;33(1):142–148.
   PubMed Web of Science ®Google Scholar
• Serra A, Macia A, Romero MP, et al. Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. Br J Nutr. 2010;103(7):944–952.
   PubMed Web of Science ®Google Scholar
• Saito A, Inagawa K, Ebe R, et al. Onset of a hypotensive effect following ingestion of flavan 3-ols involved in the activation of adrenergic receptors. Free Rad Biol Med. 2016;99:584–592.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick DF, Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol. 1993;265(2):H774–8.
   PubMedGoogle Scholar
• Desch S, Schmidt J, Kobler D, et al. Effect of cocoa products on blood pressure: systematic review and meta-analysis. Am J Hypertens. 2010;23(1):97–103.
   PubMed Web of Science ®Google Scholar
• Grassi D, Desideri G, Ferri C. Blood pressure and cardiovascular risk: what about cocoa and chocolate? Arch Biochem Biophys. 2010;501(1):112–115.
   PubMed Web of Science ®Google Scholar
• Dower JI, Geleijnse JM, Kroon PA, et al. Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomised, crossover study. Mol Nutr Food Res. 2016:2379–2386.
   PubMed Web of Science ®Google Scholar
• Schroeter H, Heiss C, Balzer J, et al. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS. 2006;103(4):1024–1029.
   PubMed Web of Science ®Google Scholar
• Mancia G, Grassi G, Ferrari A, et al. Reflex cardiovascular regulation in humans. J Cardiovasc Pharmacol. 1985;7(Suppl 3):S152–S9.
   PubMedGoogle Scholar
• Mladěnka P, Zatloukalová L, Filipský T, et al. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radical Biol Med. 2010;49(6):963–975.
   PubMed Web of Science ®Google Scholar
• Baba S, Osakabe N, Yasuda A, et al. Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radical Res. 2000;33(5):635–641.
   PubMed Web of Science ®Google Scholar
• Robbins RJ, Leonczak J, Johnson JC, et al. Method performance and multi-laboratory assessment of a normal phase high pressure liquid chromatography-fluorescence detection method for the quantitation of flavanols and procyanidins in cocoa and chocolate containing samples. J Chromatogr A. 2009;1216(24):4831–4840.
   PubMed Web of Science ®Google Scholar
• Tanaka N, Sekiya N, Hattori M, et al. Measurement of plasma procyanidin B-2 and procyanidin B-3 levels after oral administration in rat. Phytomedicine. 2003;10(2-3):122–126.
   PubMed Web of Science ®Google Scholar
• Lee MJ, Wang ZY, Li H, et al. Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev. 1995;4(4):393–399.
   PubMed Web of Science ®Google Scholar
• Sanae F, Miyaichi Y, Kizu H, et al. Effects of catechins on vascular tone in rat thoracic aorta with endothelium. Life Sci. 2002;71(21):2553–2562.
   PubMed Web of Science ®Google Scholar
• Holt RR, Lazarus SA, Sullards MC, et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr. 2002;76(4):798–804.
   PubMed Web of Science ®Google Scholar
• Karim M, McCormick K, Kappagoda CT. Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr. 2000;130(8):2105S–2108S.
   PubMed Web of Science ®Google Scholar
• Charkoudian N, Rabbitts JA. Sympathetic neural mechanisms in human cardiovascular health and disease. Mayo Clinic Proc. 2009;84(9):822–830.
   PubMed Web of Science ®Google Scholar
• Nakagawa Y, Ishimura K, Oya S, et al. Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice. PloS One. 2018;13(7):e0201203.
   PubMed Web of Science ®Google Scholar
• Leonetti G, Egan CG. Use of carvedilol in hypertension: an update. Vasc Health Risk Manag. 2012;8:307–322.
   PubMedGoogle Scholar
• Brixius K, Bundkirchen A, Bolck B, et al. Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. Br J Pharmacol. 2001;133(8):1330–1338.
   PubMed Web of Science ®Google Scholar
• Flordellis C, Manolis A, Scheinin M, et al. Clinical and pharmacological significance of alpha2-adrenoceptor polymorphisms in cardiovascular diseases. Int J Cardiol. 2004;97(3):367–372.
   PubMed Web of Science ®Google Scholar
• Millan MJ, Newman-Tancredi A, Audinot V, et al. Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states. Synapse (New York, N.Y.). 2000;35(2):79–95.
   PubMed Web of Science ®Google Scholar
• Heusch G. The paradox of alpha-adrenergic coronary vasoconstriction revisited. J Mol Cell Cardiol. 2011;51(1):16–23.
   PubMed Web of Science ®Google Scholar
• Rodriguez I, Gonzalez M. Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation. Front Pharmacol. 2014;5:209.
   PubMed Web of Science ®Google Scholar
• Hudlicka O, Brown MD. Adaptation of skeletal muscle microvasculature to increased or decreased blood flow: role of shear stress, nitric oxide and vascular endothelial growth factor. J Vasc Res. 2009;46(5):504–512.
   PubMed Web of Science ®Google Scholar
• Miao H, Yuan S, Wang Y, et al. Role of Cbl in shear-activation of PI 3-kinase and JNK in endothelial cells. Biochem Biophys Res Commun. 2002;292(4):892–899.
   PubMed Web of Science ®Google Scholar
• Tzima E, Irani-Tehrani M, Kiosses WB, et al. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 2005;437(7057):426–431.
   PubMed Web of Science ®Google Scholar
• Ahern GP. Transient receptor potential channels and energy homeostasis. Trends Endocrinol Metabol. 2013;24(11):554–560.
   PubMed Web of Science ®Google Scholar
• Roper SD. TRPs in taste and chemesthesis. Handb Exp Pharmacol. 2014;223:827–871.
   PubMedGoogle Scholar
• Kurogi M, Kawai Y, Nagatomo K, et al. Auto-oxidation products of epigallocatechin gallate activate TRPA1 and TRPV1 in sensory neurons. Chem Senses. 2015;40(1):27–46.
   PubMed Web of Science ®Google Scholar