Pharmacological inhibition of SIRT-2 by AK-7 modulates redox status and apoptosis via regulating Nrf2 in an experimental model of chronic obstructive pulmonary disease: an invivo and insilico study

References

• Brightling C, Greening N. Airway inflammation in COPD: progress to precision medicine. Eur Respir J. 2019;54(2):1900651. doi: 10.1183/13993003.00651-2019.
   PubMed Web of Science ®Google Scholar
• Thomashow BM, Mannino DM, Tal-Singer R, et al. A rapidly changing understanding of COPD: world COPD day from the COPD foundation. Am J Physiol Lung Cell Mol Physiol. 2021;321(5):L983–L987. doi: 10.1152/ajplung.00400.2021.
   PubMed Web of Science ®Google Scholar
• Rodrigues S, Cunha C, Soares G, et al. Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease. Pharmaceuticals. 2021;14(10):979. doi: 10.3390/ph14100979.
   Web of Science ®Google Scholar
• De Rose V, Molloy K, Gohy S, et al. Airway epithelium dysfunction in cystic fibrosis and COPD. Mediators Inflamm. 2018;2018:1309746. Oct doi: 10.1155/2018/1309746.
   PubMed Web of Science ®Google Scholar
• López‐Campos JL, Tan W, Soriano JB. Global burden of COPD. Respirology. 2016;21(1):14–23. doi: 10.1111/resp.12660.
   PubMed Web of Science ®Google Scholar
• Kim SM, Hwang KA, Choi DW, et al. The cigarette smoke components induced the cell proliferation and epithelial to mesenchymal transition via production of reactive oxygen species in endometrial adenocarcinoma cells. Food Chem Toxicol. 2018;121:657–665. doi: 10.1016/j.fct.2018.09.023.
   PubMed Web of Science ®Google Scholar
• Hadzic S, Wu CY, Avdeev S, et al. Lung epithelium damage in COPD–an unstoppable pathological event? Cell Signal. 2020;68:109540. doi: 10.1016/j.cellsig.2020.109540.
   PubMed Web of Science ®Google Scholar
• Magallón M, Navarro-García MM, Dasí F. Oxidative stress in COPD. J Clin Med. 2019;8(11):1953. doi: 10.1016/j.cellsig.2020.109540.
   PubMed Web of Science ®Google Scholar
• Wang J, Lu Q, Cai J, et al. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1–Nrf2 feedback loop. Nat Commun. 2019;10(1):5043. doi: 10.1038/s41467-019-12925-9.
   PubMedGoogle Scholar
• Lee J, Jang J, Park SM, et al. An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches. Int J Mol Sci. 2021;22(16):8406. doi: 10.3390/ijms22168406.
   PubMed Web of Science ®Google Scholar
• Sakao S, Tatsumi K. The importance of epigenetics in the development of chronic obstructive pulmonary disease. Respirology. 2011; 16(7):1056–1063. doi: 10.1111/j.1440-1843.2011.02032.x.
   PubMed Web of Science ®Google Scholar
• Shanmugam MK, Sethi G. Role of epigenetics in inflammation-associated diseases. Epigenetics: development and Disease. 2012;61:627–657. doi: 10.1007/978-94-007-4525-4_27.
   Google Scholar
• Zhang L, Lu Q, Chang C. Epigenetics in health and disease. Adv Exp Med Biol. 2020;1253:3–55. 55. doi: 10.1007/978-981-15-3449-2_1.
   PubMed Web of Science ®Google Scholar
• Wang M, Lin H. Understanding the function of mammalian sirtuins and protein lysine acylation. Annu Rev Biochem. 2021;90(1):245–285. doi: 10.1146/annurev-biochem-082520-125411.
   PubMedGoogle Scholar
• Kaladhar DS, Kant S. In silico protein–protein interaction studies of Sirtuins as anti-inflammatory and anti-cancer agents. metabolism. 2017; Aug4:162–185.
   Google Scholar
• Kosciuk T, Wang M, Hong JY, et al. Updates on the epigenetic roles of sirtuins. Curr Opin Chem Biol. 2019;51:18–29. doi: 10.1016/j.cbpa.2019.01.023.
   PubMed Web of Science ®Google Scholar
• Matucci A, Bormioli S, Nencini F, et al. Asthma and chronic rhinosinusitis: how similar are they in pathogenesis and treatment responses? Int J Mol Sci. 2021;22(7):3340. doi: 10.3390/ijms22073340.
   PubMed Web of Science ®Google Scholar
• Afzaal A, Rehman K, Kamal S, et al. Versatile role of sirtuins in metabolic disorders: from modulation of mitochondrial function to therapeutic interventions. J Biochem Mol Toxicol. 2022;36(7):e23047. doi: 10.1002/jbt.23047.
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang Y, Zhu K, et al. Emerging role of sirtuin 2 in parkinson’s disease. Front Aging Neurosci. 2019;11:372. doi: 10.3389/fnagi.2019.00372.
   PubMed Web of Science ®Google Scholar
• Lee YG, Reader BF, Herman D, et al. Sirtuin 2 enhances allergic asthmatic inflammation. JCI Insight. 2019;4(4):e124710. doi: 10.1172/jci.insight.e124710.
   Web of Science ®Google Scholar
• Zhang L, Kim S, Ren X. The clinical significance of SIRT2 in malignancies: a tumor suppressor or an oncogene? Front Oncol. 2020;10:1721. doi: 10.3389/fonc.2020.01721.
   PubMed Web of Science ®Google Scholar
• Zhu C, Dong X, Wang X, et al. Multiple roles of SIRT2 in regulating physiological and pathological signal transduction. Genet Res (Camb). 2022;2022:9282484–9282414. doi: 10.1155/2022/9282484.
   PubMed Web of Science ®Google Scholar
• Ferreira LL, Andricopulo AD. ADMET modeling approaches in drug discovery. Drug Discov Today. 2019;24(5):1157–1165. doi: 10.1016/j.drudis.2019.03.015.
   PubMed Web of Science ®Google Scholar
• Naqvi AA, Mohammad T, Hasan GM, et al. Advancements in docking and molecular dynamics simulations towards ligand-receptor interactions and structure-function relationships. Curr Top Med Chem. 2018;18(20):1755–1768. doi: 10.2174/1568026618666181025114157.
   PubMed Web of Science ®Google Scholar
• Guan L, Yang H, Cai Y, et al. ADMET-score–a comprehensive scoring function for evaluation of chemical drug-likeness. Medchemcomm. 2019;10(1):148–157. doi: 10.1039/C8MD00472B.
   PubMed Web of Science ®Google Scholar
• Agrawal S, Pathak E, Mishra R, et al. Computational exploration of the dual role of the phytochemical fortunellin: antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host. Comput Biol Med. 2022;149:106049. doi: 10.1016/j.compbiomed.2022.106049.
   PubMed Web of Science ®Google Scholar
• Khaerunnisa S, Kurniawan H, Awaluddin R, et al. Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints. 2020;2020:2020030226. doi: 10.20944/preprints202003.0226.v1.
   Google Scholar
• Beckett EL, Stevens RL, Jarnicki AG, et al. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol. 2013;131(3):752–762. doi: 10.1016/j.jaci.2012.11.053.
   PubMed Web of Science ®Google Scholar
• Ghorani V, Boskabady MH, Khazdair MR, et al. Experimental animal models for COPD: a methodological review. Tob Induc Dis. 2017;15(1):25. doi: 10.1186/s12971-017-0130-2.
   PubMedGoogle Scholar
• Wang X, Wang M, Yang L, et al. Inhibition of sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural Regen Res. 2014;9(21):1917–1922. doi: 10.4103/1673-5374.145361.
   PubMed Web of Science ®Google Scholar
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;8(12):1103–1111. doi: 10.1016/j.clinbiochem.2005.08.008.
   Google Scholar
• Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37(2):112–119. doi: 10.1016/j.clinbiochem.2003.10.014.
   PubMed Web of Science ®Google Scholar
• Chauhan, Preeti S, Jaiswal, Anju, Singh, Rashmi, Subhashini,. Combination therapy with curcumin alone plus piperine ameliorates ovalbumin-induced chronic asthma in mice. Inflammation., 2018;41( 5):1922–1933. doi: 10.1007/s10753-018-0836-1.
   PubMed Web of Science ®Google Scholar
• Kumari A, Tyagi N, Dash D, et al. Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2015;38(3):1103–1112. Jun doi: 10.1007/s10753-014-0076-y.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193(1):265–275. doi: 10.1016/S0021-9258(19)52451-6.
   PubMed Web of Science ®Google Scholar
• Levine RL, Garland D, Oliver CN, et al. Determination of carbonyl content in oxidatively modified proteins. In: Packer L, Glazer AN, editors. Vol. 186. Methods in enzymology. Cambridge: Academic Press, Elsevier; 1990. p. 464–478. doi: 10.1016/0076-6879(90)86141-H.
   Google Scholar
• Miranda KM, Espey MG, Yamada K, et al. Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion. J Biol Chem. 2001;276(3):1720–1727. doi: 10.1074/jbc.M006174200.
   PubMed Web of Science ®Google Scholar
• Das K, Samanta L, Chainy GB. A modified spectrophotometric assay of superoxide dismutase using nitrite formation by superoxide radicals.2000 http://nopr.niscpr.res.in/handle/123456789/15379.
   Google Scholar
• Aebi H. Catalase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. Weinheim/NewYork, NY: Verlag Chemie/ Academic press Inc, Elsevier;1974. p. 673–684. doi: 10.1016/B978-0-12-091302-2.50032-3.
   Google Scholar
• Goyal A, Srivastava A, Sihota R, et al. Evaluation of oxidative stress markers in aqueous humor of primary open angle glaucoma and primary angle closure glaucoma patients. Curr Eye Res. 2014;39(8):823–829. doi: 10.3109/02713683.2011.556299.
   PubMed Web of Science ®Google Scholar
• Carlberg I, Mannervik B. Glutathione reductase. In Methods in enzymology. Cambridge: Academic press, Elsevier;1985 (Vol. 113, pp. 484–490. doi: 10.1016/S0076-6879(85)13062-4.
   Google Scholar
• Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferase AA from rat liver. Arch Biochem Biophys. 1976; Aug 1175(2):710–716. doi: 10.1016/0003-9861(76)90563-4.
   PubMed Web of Science ®Google Scholar
• Macdonald IO, Olusola OJ, Osaigbovo UA. Effects of chronic ethanol administration on body weight, reduced glutathione (GSH), malondialdehyde (MDA) levels and glutathione-s-transferase activity (GST) in rats. N.Y. Sci J. 2010;3(4):3947.
   Google Scholar
• Kumar G, Sharmila Banu G, Murugesan AG, et al. Effect of helicteresisora. Bark extracts on brain antioxidant status and lipid peroxidation in streptozotocin diabetic rats. Pharm Biol. 2007;45(10):753–759. doi: 10.1080/13880200701585782.
   Web of Science ®Google Scholar
• Salsabili S, Lithopoulos M, Sreeraman S, et al. Fully automated estimation of the mean linear intercept in histopathology images of mouse lung tissue. J Med Imaging. 2021;8(2):027501. doi: 10.1117/1.JMI.8.2.027501.
   Web of Science ®Google Scholar
• Gibson-Corley KN, Olivier AK, Meyerholz DK. Principles for valid histopathologic scoring in research. Vet Pathol. 2013;50(6):1007–1015. doi: 10.1177/0300985813485099.
   PubMed Web of Science ®Google Scholar
• Liang Y, Mak JC. Inhaled therapies for asthma and chronic obstructive pulmonary disease. Curr Pharm Des. 2021; Apr 127(12):1469–1481. doi: 10.2174/1389201021666201126144057.
   PubMed Web of Science ®Google Scholar
• Bereda G. Chronic obstructive pulmonary disease: definition, risk factors, pathophysiology and management. J Biomed Biol Sci. 2022;2(1):1–2.
   Google Scholar
• Barnes PJ. Oxidative stress-based therapeutics in COPD. Redox Biol. 2020;33:101544. doi: 10.1016/j.redox.2020.101544.
   PubMed Web of Science ®Google Scholar
• Singh CK, Chhabra G, Ndiaye MA, et al. The role of sirtuins in antioxidant and redox signaling. Antioxid Redox Signal. 2018;28(8):643–661. doi: 10.1089/ars.2017.7290.
   PubMed Web of Science ®Google Scholar
• Lagorce D, Douguet D, Miteva MA, et al. Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors. Sci Rep. 2017;7(1):46277. doi: 10.1038/srep46277.
   PubMedGoogle Scholar
• Sahiner UM, Birben E, Erzurum S, et al. Oxidative stress in asthma. World Allergy Organ J. 2011;4(10):151–158. doi: 10.1097/WOX.0b013e318232389e.
   PubMedGoogle Scholar
• Erzurum SC. New insights in oxidant biology in asthma. Ann Am Thorac Soc. 2016;13(Suppl 1):S35–S9. doi: 10.1513/AnnalsATS.201506-385MG.
   PubMedGoogle Scholar
• Janssen‐Heininger YM, Nolin JD, Hoffman SM, et al. Emerging mechanisms of glutathione‐dependent chemistry in biology and disease. J Cell Biochem. 2013;114(9):1962–1968. doi: 10.1002/jcb.24551.
   PubMed Web of Science ®Google Scholar
• Ghosh N, Das A, Chaffee S, et al. Reactive oxygen species, oxidative damage and cell death. In: Chatterjee S, Jungraithmayr W, Bagchi D, editors. Immunity and inflammation in health and disease. Cambridge: Academic Press, Elsevier; 2018. p. 45–55. doi: 10.1016/B978-0-12-805417-8.00004-4.
   Google Scholar
• Song Q, Zhou ZJ, Cai S, et al. Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke. Int J Environ Health Res. 2022;32(8):1745–1755. doi: 10.1080/09603123.2021.1910211.
   PubMed Web of Science ®Google Scholar
• Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol. 2012;13(4):225–238. doi: 10.1038/nrm3293.
   PubMed Web of Science ®Google Scholar
• Shim KS, Song HK, Hwang YH, et al. Ethanol extract of Veronica persica ameliorates house dust mite-induced asthmatic inflammation by inhibiting STAT-3 and STAT-6 activation. Biomed Pharmacother. 2022;152:113264. doi: 10.1016/j.biopha.2022.113264.
   PubMed Web of Science ®Google Scholar
• Obling N, Backer V, Hurst JR, et al. Nasal and systemic inflammation in chronic obstructive pulmonary disease (COPD). Respir Med. 2022;195:106774. doi: 10.1016/j.rmed.2022.106774.
   PubMed Web of Science ®Google Scholar
• Fukutomi T, Takagi K, Mizushima T, et al. Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. Mol Cell Biol. 2014;34(5):832–846.* doi: 10.1128/MCB.01191-13.
   PubMed Web of Science ®Google Scholar
• Alam J, Cook JL. How many transcription factors does it take to turn on the heme oxygenase-1 gene? Am J Respir Cell Mol Biol. 2007; 36(2):166–174. doi: 10.1165/rcmb.2006-0340TR.
   PubMed Web of Science ®Google Scholar
• Yang X, Park SH, Chang HC, et al. Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest. 2017;127(4):1505–1516. doi: 10.1172/JCI88574.
   PubMed Web of Science ®Google Scholar
• Yang X, Chang HC, Tatekoshi Y, et al. SIRT2 inhibition protects against cardiac hypertrophy and heart failure. bioRxiv. 2023. doi: 10.1101/2023.01.25.525524.
   Google Scholar