Development of Controlled Release Sildenafil Formulations for Vaginal Administration

REFERENCES

• Acartürk F., Değim T., Tuğcu-Demiröz F., İbasmı S. Vaginal controlled release sildenafil tablets, First EUFEPS conference on Optimising drug delivery and formulation: New challenges in drug delivery. APGI, ParisFrance 2003
   Google Scholar
• Ahuja A., Khar R. K., Ali J. Mucoadhesive drug delivery systems,. Drug Dev. Ind. Pharm. 1997; 23: 489–515
   Web of Science ®Google Scholar
• Andersson K. E., Stief C. Penile erection and cardiac risk: Pathophysiologic and pharmacologic mechanisms. Am. J. Cardiol. 2000; 86(Suppl)23F–26F
   PubMedGoogle Scholar
• Artursson P., Lindmark T., Davis S. S., lllum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (CAC O-2). Pharm. Res. 1994; 11: 1358–1361
   PubMed Web of Science ®Google Scholar
• Ballard S. A., Gingell C. J., Tang K., Turner L. A., Price M. E., Naylor A. M. Effects of Sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes. J. Urol. 1998; 159: 2164–2171
   PubMed Web of Science ®Google Scholar
• Bernkop-Schnurch A., Hornof M., Zoidl T. Thiolated polymers—Thiomers: Modification of chitosan with 2-iminothiolane. Int. J. Pharm. 2003; 260: 229–237
   PubMed Web of Science ®Google Scholar
• Boskey E. R., Cone R A, Whaley K. J., Moench D. R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 2001; 16: 1809–1813
   PubMed Web of Science ®Google Scholar
• Boyce E. G., Umland E. M. Sildenafil citrate: A therapeutic update. Clini. Therapeutics. 2001; 23: 2–23
   PubMed Web of Science ®Google Scholar
• Brannon-Peppas L. Novel vaginal drug release applications. Adv. Drug Deliv. Rev. 1993; 11: 169–177
   Web of Science ®Google Scholar
• Carson D. D., Bagchi I., Dey S. K., Enders A. C., Fazleabas A. T., Lessey B. A., Bruce A., Yoshinaga L., Yoshinaga K. Embryo implantation. Dev. Biol. 2000; 223: 217–237
   PubMed Web of Science ®Google Scholar
• Ceschel G. C., Maffei P., Lombardi B. S., Ronchi C., Rossi S. Development of a mucoadhesive dosage form for vaginal administration. Drug Dev. Ind. Pharm. 2001; 27: 541–554
   PubMed Web of Science ®Google Scholar
• Degim Z., Degim T., Acarturk F., Erdogan D., Ozogul C., Koksal M. Rectal and vaginal administration of insulin-chitosan formulations: an experimental study in rabbits. J. Drug Target. 2005; 3: 563–572
   Google Scholar
• Dodane V., Vilivalam V. D. Pharmaceutical applications of chitosan. Pharm. Sci. Technol. Today 1998; 1: 246–253
   Google Scholar
• Duchene D., Ponchel G. Principle and investigation of the bioadhesion mechanism of solid dosage forms. Biomaterials 1992; 13: 709–714
   PubMed Web of Science ®Google Scholar
• Edi-Osagie E. C. O., Seif M. W., Aplin J. D., Jones C. J. P., Wilson G., Path M. R. C., Lieberman B. A. Characterizing the endometrium in unexplained and tubal factor infertility: a multiparametric investigation. Fertil. Steril. 2004; 82: 1379–1389
   PubMed Web of Science ®Google Scholar
• El-Kamel A. H., Sokar M. S., Naggar V. F., Al-Gamal S. Chitosan and sodium alginate-based bioadhesive vaginal tablets. AAPS Pharm Sci. 2004; 4: E44
   Google Scholar
• Felt O., Buri P., Gurny R. T. Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm. 1998; 24: 979–1003
   PubMed Web of Science ®Google Scholar
• Ferrer J. Vaginal candidosis: epidemiological and etiological factors. Int. J. Gynaecol. Obstet. 2000; 71: S21–S27
   PubMed Web of Science ®Google Scholar
• Fiorilli A., Molteni B., Milani M. Successful treatment of bacterial vaginosis with a polycarbophil-carbopol acidic vaginal gel: results from a randomised double-blind, placebo-controlled trial. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005; 120: 202–205
   PubMed Web of Science ®Google Scholar
• Genc L., Oguzlar C., Guler E. Studies on vaginal bioadhesive tablets of acyclovir. Pharmazie 2000; 55: 297–299
   PubMed Web of Science ®Google Scholar
• Graham R. A., Seif M. W., Aplin J. D., Li T. C., Cooke I. D., Rogers A. W. An endometrial factor in unexplained infertility,. BMJ 1990; 300: 1428–1431
   PubMed Web of Science ®Google Scholar
• Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 1998; 15: 1326–1331
   PubMed Web of Science ®Google Scholar
• Issa M. M., Koping-Hoggard M., Artursson P. Chitosan and the mucosal delivery of biotechnology drugs”. Drug Discov. Today 2005; 2: 1–6
   Google Scholar
• Kim K. W., Thomas R. L., Lee C., Park H. J. Antimicrobial activity of native chitosan, degraded chitosan, and Ocarboxymethylated chitosan. J. Food Prot. 2003; 66: 1495–1498
   PubMed Web of Science ®Google Scholar
• Klentzeris L. D., Bulmer J. N., Li T. C., Morrison L., Warren A., Cooke I. D. Lectin binding of endometrium in women with unexplained infertility. Fertil. Steril. 1991; 56: 660–667
   PubMed Web of Science ®Google Scholar
• Khanvilkar K., Donovan M. D., Flanagan D. R. Drug transfer through mucus. Adv. Drug Deliv. Rev. 2001; 48: 173–193
   PubMed Web of Science ®Google Scholar
• Kloner R. A., Zusman R. M. Cardiovascular effects of sildenafil citrate and recommendations for Its use. Am. J. Cardiol. 1999; 84: 11N–17N
   PubMed Web of Science ®Google Scholar
• Lanchares J. L., Hernandez M. L. Recurrent vaginal candidiasis changes in etiopathogenical patterns. Int. J. Gynaecol. Obstet. 2000; 71: S29–S35
   PubMed Web of Science ®Google Scholar
• Lehr C. M., Bouwstra J. A., Schacht E. H., Junginger H. E. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 1992; 78: 43–48
   Web of Science ®Google Scholar
• Lessey B. A., Castlebaum A. J., Swain S. W., Sun J. Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertil. Steril. 1995; 63: 535–542
   PubMed Web of Science ®Google Scholar
• Liaw J., Chang T. W. Determination of transdermal sildenafil in nude mouse skin by reversed- phase high- performance liquid chromatography. J. Chromatog. B. 2001; 765: 161–166
   PubMed Web of Science ®Google Scholar
• Luessen H. L., Leeuw B. J., Langemeyer M. W., Boer A. B., Verhoef J. C., Junginger H. E. Mucoadhesive polymers in peroral peptide drug delivery: VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm. Res. 1996; 13: 1668–1672
   PubMed Web of Science ®Google Scholar
• Martina L., Wilsona C. G., Kooshab F., Uchegbua I. F. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. Eur. J. Pharm. Biopharm. 2003; 55: 35–45
   PubMed Web of Science ®Google Scholar
• Miyazaki S., Nakayama A., Oda M., Takad M. Chitosan and sodium alginate based bioadhesive tablets for intra oral drug delivery. Biol. Pharm. Bull. 1994; 17: 745–747
   PubMed Web of Science ®Google Scholar
• Nevado J. J. B., Flores J. R., Peńalvo G. C., Farińas N. G. Determination of sildenafil citrate and its main metabolite by sample stacking with polarity switching using micellar electrokinetic chromatography. J. Chromatog. A. 2002; 953: 279–286
   PubMed Web of Science ®Google Scholar
• Neves J., Bahia M. F. Gels as vaginal drug delivery systems. Int. J. Pharm. 2006; 318: 1–14
   PubMed Web of Science ®Google Scholar
• Nigalaye A. G., Adusumilli P., Bolton S. Investigation of prolonged drug release from matrix formulations of chitosan. Drug Dev. Ind. Pharm. 1990; 16: 449–467
   Web of Science ®Google Scholar
• Peppas N. A., Bury P. A. Surface interfacial and molecular aspects of polymer bioadhesion on soft tissues. J. Control. Release 1985; 2: 257–275
   Google Scholar
• Robinson J. R., Mlynek G. M. Bioadhesive and phase-change polymers for ocular drug delivery. Adv. Drug Deliv. Rev. 1995; 16: 45–50
   Web of Science ®Google Scholar
• Sawayanagi Y., Nambu N., Nagai T. Use of chitosan for sustained release preparations of water soluble drugs. Chem. Pharm. Bull. 1982; 31: 4213–4215
   Google Scholar
• Schwartz L. B., Chiu A. S., Courtney M., Krey L., Schmidt-Sarosi C. The embryo versus endometrium controversy revisited as it relates to predicting pregnancy outcome in in-vitro fertilization–embryo transfer cycles. Hum. Reprod. 1997; 12: 45–50
   PubMed Web of Science ®Google Scholar
• Sher G., Fisch J. D. Effect of vaginal sildenafil on the outcome of in vitro fertilization (IVF) after multiple IVF failures attributed to poor endometrial development. Fertil. Steril. 2002; 78: 1073–1076
   PubMed Web of Science ®Google Scholar
• Stewart-Tull D. E. S. Evidence that vaginal lactobacilli do not ferment glycogen. J. Obstet. Gynaecol. 1964; 88: 676–679
   Google Scholar
• Telfer J. F., Irvine G. A., Kohnen G., Cambell S., Cameron S., Cameron I. T. Expresion of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium. Mol. Hum. Reprod. 1997; 3: 69–75
   PubMed Web of Science ®Google Scholar
• Thacharodi D., Panduranga R. K. Collagen-chitosan composite membranes controlled transdermal delivery of nifedipine and propranolol hydrochloride. Int. J. Pharm. 1996; 134: 239–241
   Google Scholar
• Valenta C. The use of mucoadhesive polymers in vaginal delivery. Advanced Drug Delivery Reviews. 2005; 57: 1692–1712
   PubMed Web of Science ®Google Scholar
• Vermani K., Garg S. The scope and potential of vaginal drug delivery. Pharm. Sci. Technol. Today 2000; 3: 359–364
   PubMedGoogle Scholar
• Walsh P. Physicians' Desk Reference, 55th Edition. Medical Economics Company, Montvale 2001
   Google Scholar
• Wyshak G. Infertility in American college alumnae. Int. J. Gynecol. Obstet. 2001; 73: 237–242
   PubMed Web of Science ®Google Scholar