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Research Article

Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

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Pages 503-514 | Received 24 Jan 2008, Accepted 30 Mar 2008, Published online: 06 Nov 2008

REFERENCES

  • M. Abdulrazik, S. Tamilvanan, K. Khoury, and S. Benita. (2001). Oculer delivery of cyclosporin A. II. Effect of submicron emulsion's surface charge on ocular distribution of topical cyclosporin A. STP Pharm. Sci. 11:427–432.
  • M. J. Barnes, and B. Boothroyd. (1961). The metabolism of griseofulvin in mammals. Biochem. J. 78:41–43.
  • T. R. Bates, and P. J. Carrigan. (1975). Apparent absorption kinetics of micronized griseofulvin after its oral administration on single- and multiple-dose regimens to rats as a corn oil-in-water emulsion and aqueous suspension. J. Pharm. Sci. 64:1475–1481.
  • T. R. Bates, H. J. Pieniaszek, J. L. Sequeira, and J. E. Rassmussen. (1977). Gastrointestinal absorption of griseofulvin from corn oil-in-water emulsions. Arch. Dermatol. 113:302–306.
  • T. R. Bates, and J. A. Sequeira. (1975). Bioavailability of micronized griseofulvin from corn oil-in-water emulsion, aqueous suspension, and commercial tablet dosage forms in humans. J. Pharm. Sci. 64:793–797.
  • P. Becher. Technique of emulsificationEmulsions: Theory and Practice, 2nd ed. Reinhold, New York, (1965) 267–325.
  • S. Benita. (1999). Prevention of topical and ocular oxidative stress by positively charged submicron emulsion. Biomed. Pharmacother. 53:193–206.
  • S. Benita, and M. Y. Levy. (1993). Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization. J. Pharm. Sci. 82:1069–1079.
  • P. J. Carrigan, and T. R. Bates. (1973). Biopharmaceutics of drugs administered in lipid-containing dosage forms. I: GI absorption of griseofulvin from an oil-in-water emulsion in the rat. J. Pharm. Sci. 62:1476–1479.
  • W. L. Chiou, and S. Riegelman. (1971). Absorption characteristics of solid dispersed and micronized griseofulvin in man. J. Pharm. Sci. 60:1376–1380.
  • S. C. De Araujo, A. C. De Mattos, H. F. Teixeira, P. M. Coelho, D. L. Nelson, and M. C. De Oliveira. (2007). Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions. Int. J. Pharm. 337:307–315.
  • E. Elbaz, A. Zeevi, S. Klang, and S. Benita. (1993). Positively charged submicron emulsions—a new type of colloidal drug carrier. Int. J. Pharm. 96:R1–R6.
  • M. H. El-shabouri. (2002). Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int. J. Pharm. 249:101–108.
  • R. Ezra, S. Benita, I. Ginsburg, and R. Kohen. (1996). Prevention of oxidative damage in fibroblast cell cultures and rat skin by positively changed submicron emulsion of α-tocopherol. Eur. J. Pharm. Biopharm. 42:294–298.
  • J. Y. Fang, Y. L. Leu, C. C. Chang, C. H. Lin, and Y. H. Tsai. (2004). Lipid nano/submicron emulsions as vehicles for topical flurbiproien delivery. Drug deliv. 11:97–105.
  • T. Gershanik, and S. Benita. (1996). Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone. Pharm. Dev. Technol. 1:147–157.
  • T. Gershanik, S. Benzeno, and S. Benita. (1998). Interaction of self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge. Pharm. Res. 15:863–869.
  • T. Gershanik, E. Haltner, C. M. Lehr, and S. Benita. (2000). Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity. Int. J. Pharm. 211:29–36.
  • R. J. Haskell. (1998). Characterisation of submicron systems via optical methods. J. Pharm. Sci. 87:125–129.
  • H. Hedeman, M. Lück, T. Blunk, S. Frkjaer, and R. H. Müller. (1996). Fat emulsions based on structured lipids (1-3-specific triglycerides) an investigation of the in vitro interaction with plasma proteins. Clin. Nutr. 15:175–178.
  • S. Kadir, T. Murakami, Y. Higashi, and N. Yata. (1986). Gastrointestinal absorption of griseofulvin from liquid organic acids and esters in rats. Int. J. Pharm. 33:235–242.
  • K. Kakemi, H. Sezaki, S. Muranishi, H. Ogata, and K. Giga. (1972a). Mechanism of intestinal absorption of drugs from oil in water emulsions. II. Absorption from oily solution. Chem. Pharm. Bull. 20:715–720.
  • K. Kakemi, H. Sezaki, S. Muranishi, H. Ogata, and S. Isemura. (1972b). Mechanism of intestinal absorption of drugs from oil in water emulsions. I. Chem. Pharm. Bull. 20:708–714.
  • T. T. Kararli, T. E. Needham, M. Griffin, G. Schoenhard, L. J. Ferro, and L. Alcorn. (1992). Oral delivery of a renin inhibitor compound using emulsion formulations. Pharm. Res. 9:888–893.
  • T. Kimura, K. Takeda, A. Kageyu, M. Toda, Y. Kurosaki, and T. Nakayama. (1989). Intestinal absorption of dolichol from emulsions and liposomes in rats. Chem. Pharm. Bull. 37:463–466.
  • S. H. Klang, M. Abdulrazik, and S. Benita. (2000). Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution. Pharm. Dev. Technol. 5:521–532.
  • S. H. Klang, J. Frucht-Pery, A. Hoffman, and S. Benita. (1994). Physicochemical characterization and acute toxicity evaluation of a positively charged submicron emulsion vehicle. J. Pharm. Pharmacol. 46:986–993.
  • A. L. Le Roy Boehm, and H. Fessi. (2000). Pharmaceutical applications of zeta potential - Interest for colloidal drug carriers characterization. J. Pharm. Belg. 55:40–48.
  • C. Lin, and S. Symchowicz. (1975). Absorption, distribution, metabolism, and excretion of griseofulvin in man and animals. Drug Metab. Rev. 4:75–95.
  • J. Moore. (1996). Mathematical comparison of dissolution profiles. Pharm. Technol. 20:64–74.
  • G. Mulak, and J. Cotty. (1975). Solubilite et constante dielectrique. Sci. Technol. Pharm. 4:281–288.
  • R. A. Myers, and V. J. Stella. (1992). Systemic bioavailability of penolomedine (NSC-338720) from oil-in-water emulsions administered intraduodenally to rats. Int. J. Pharm. 78:217–226.
  • G. Nicolaos, S. Crauste-Manciet, R. Farinotti, and D. Brossard. (2003). Improvement of cefpodoxime proxetil oral absorption in rats by an oil-in-water submicron emulsion. Int. J. Pharm. 263:165–171.
  • L. Rabinovich-Guilatt, P. Couvreur, G. Lambert, D. Goldstein, S. Benita, and C. Dubernet. (2004). Extensive surface studies help to analyse zeta potential data: the case of cationic emulsions. Chem. Phys. Lipids 131:1–13.
  • M. Rowland, S. Riegelman, and L. Epstein. (1968). Absorption kinetics of griseofulvin in man. J. Pharm. Sci. 57:984–989.
  • M. Schafer-Korting. (1993). Pharmacokinetic optimisation of oral antifungal therapy. Clin. Pharmacokinet. 25:329–341.
  • S. Symchowicz, and K. K. Wong. (1966). Metabolism of griseofulvin-14C; studies in vivo. Biochem. Pharmacol. 15:1595–1600.
  • S. Tamilvanan, S. Schmidt, R. H. Müller, and S. Benita. (2005). In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration. Eur. J. Pharm. Biopharm. 59:1–7.
  • B. D. Tarr, T. G. Sambandan, and S. H. Yalkowsky. (1987). A new parenteral emulsion for the administration of taxol. Pharm. Res. 4:162–165.
  • H. Teixeira, C. Dubernet, V. Rosilio, S. Benita, J. Lepault, I. Erk, and P. Couvreur. (2000). New bicompartmental structures are observed when stearylamine is mixed with triglyceride emulsions. Pharm. Res. 17:1329–1332.
  • S. B. Tiwari, and M. M. Amiji. (2006). Improved oral delivery of paclitaxel following administration in nanoemulsion formulations. J. Nanosci. Nanotechnol. 6:3215–3221.
  • H. Togushi, Y. Ogawa, and T. Shimamoto. (1990). Effects of the physicochemical properties of the emulsion formulation on the bioavailability of ethyl-2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate in rats. Chem. Pharm. Bull. 38:2797–2800.
  • K. M. Tur, H. S. Ch'ng, and S. Baie. (1997). Use of bioadhesive polymer to improve the bioavailability of griseofulvin. Int. J. Pharm. 148:63–71.
  • T. Uno, T. Kazui, Y. Suzuki, H. Hashimoto, K. Suzuki, and B. A. H. Muhammad. (1999). Pharmacokinetic advantages of a newly developped tacrolimus oil-in-water-type emulsion via the enteral route. Lipids 34:249–254.
  • G. Waeldele, and J. C. Stoclet. (1973). Permanent catheterization of the thoracic aorta. Direct measure of blood pressure, injection of substances, and blood sampling in the waking rat. J. Physiol. 66:357–366.
  • J. G. Wagner, E. S. Gerard, and D. G. Kaiser. (1966). The effect of the dosage form on serum levels of indoxole. Clin. Pharmacol. Ther. 7:610–619.
  • C. Washington. (1996). Stability of lipid emulsions for drug delivery. Adv. Drug Deliv. Rev. 20:131–145.
  • S. H. Yang, and S. Benita. (2000). Enhanced absorption and drug targeting by positively charged submicron emulsions. Drug Deliv. Res. 50:476–486.
  • M. P. Youenang Piemi, D. Korner, S. Benita, and J. P. Marty. (1999). Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. J. Control Release 58:177–187.
  • A. Zeevi, S. Klang, V. Alard, F. Brossard, and S. Benita. (1994). The design and characterization of a positively charged submicron emulsion containing a sunscreen agent. Int. J. Pharm. 108:57–68.
  • H. Zia, W. J. Proveaux, J. P. O'donnel, and J. K. Ma. (1980). Chromatographic analysis of griseofulvin and metabolites in biological fluids. J. Chromatograph. 181:77–84.

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