971
Views
25
CrossRef citations to date
0
Altmetric
Research Article

Insulin-loaded poly(acrylic acid)-cysteine nanoparticles: Stability studies towards digestive enzymes of the intestine

, , &
Pages 254-260 | Received 02 Feb 2009, Accepted 26 Mar 2009, Published online: 30 Apr 2009

References

  • Akiyoshi, K., Kobayashi, S., Shichibe, S., Mix, D., Baudys, M., Kim, S.W., Sunamoto, J. (1998). Self-assembled hydrogel nanoparticles of cholesterol-bearing pullulan as a carrier of protein drugs: complexation and stabilization of insulin. J Contr Rel. 54, 313–20.
  • Bai, J.P., Chang, L.L., Guo, J.H. (1996). Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. J Pharm Pharmacol. 48, 17–21.
  • Bernkop-Schnürch, A., Fragner, R. (1996). Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration. Pharm Sci. 2, 361–3.
  • Bernkop-Schnürch, A., Walker, G. (2001). Multifunctional matrices for oral peptide delivery. Crit Rev Ther Drug Carrier Syst. 18, 459–501.
  • Bernkop-Schnürch, A., Schwarz, V., Steininger, S. (1999). Polymers with thiol groups: a new genereation of mucoadhesive polymers? Pharm Res. 16, 876–81.
  • Bernkop-Schnürch, A., Walker, G., Zarti, H. (2001). Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N J Pharm Sci. 90, 1907–14.
  • Bodmeier, R., Chen, H.G., Paeratakul, O. (1989). A novel approach to the oral delivery of micro- or nanoparticles. Pharm Res. 96, 413–7.
  • Coupe, A.J., Davis, S.S., Wilding, I.R. (1991). Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm Res. 8, 360–4.
  • Cui, F.D., Tao, A.J., Cun, D.M., Zhang, L.Q., Shi, K. (2007). Preparation of insulin loaded PLGA-Hp55 nanoparticles for oral delivery. J Pharm Sci. 96, 421–7.
  • Habeeb, A.F. (1973). A sensitive method for localization of disulfide containing peptides in column effluents. Anal Biochem. 56, 60–5.
  • James, D.E., Jenkins, A.B., Kaegen, E.W., Chisholm, D.J. (1981). Insulin precipitation in artificial infusion devices. Diabetologia. 21, 554–7.
  • Jintapattanakit, A., Junyaprasert, V.B., Mao, S., Sitterberg, J., Bakowsky, U., Kissel, T. (2007). Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles. Int J Pharm. 342, 240–249.
  • Kriwet, B., Walter, E., Kissel, T. (1998). Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates. J Contr Rel. 56, 149–58.
  • Lamprecht, A., Schafer, U., Lehr, C.M. (2001). Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res. 18, 788–93.
  • Marschütz, M.K., Bernkop-Schnürch, A. (2000). Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro. Biomaterials. 21, 1499–507.
  • Marschütz, M.K., Bernkop-Schnürch, A. (2002). Thiolated polymers: self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci. 15, 387–94.
  • Mollmann, S.H., Elofsson, U., Bukrinsky, J.T., Frokjaer, S. (2005). Displacement of adsorbed insulin by Tween 80 monitored using internal reflection fluorescence and ellipsometry. Pharm Res. 22, 1931–41.
  • Narayanan, A.S., Anwar, R.A. (1969). The specifity of purified porcine pancreatic elastase. Biochem J. 114, 11–17.
  • Nurkeeva, Z.S., Mun, G.A., Khutoryanskiy, V.V., Bitekenova, A.B., Dubolazov, A.V., Esirkegenova, S.Z. (2003). pH effects in the formation of interpolymer complexes between poly(N- vinylpyrrolidone) and poly(acrylic acid) in aqueous solutions. Eur Phys J E Soft Mater. 10, 65–8.
  • Palmberger, T.F., Albrecht, K., Loretz, B., Bernkop-Schnürch, A. (2007). Thiolated polymers: evaluation of the influence of the amount of covalently attached L-cysteine to poly(acrylic acid). Eur J Pharm Biopharm. 66, 405–412.
  • Ponchel, G., Irache, J. (1998). Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv Drug Deliv Rev. 34, 191–219.
  • Pusztai, A. (1989). Transport of proteins through the membranes of the adult gastro-intestinal tract—a potential for drug delivery? Adv Drug Deliv Rev. 3, 215–28.
  • Sakuma, S., Ishida, Y., Sudo, R., Suzuki, N., Kikuchi, H., Hiwatari, K., Kishida, A., Akashi, M., Hayashi, M. (1997). Stabilization of salmon calcitonin by polystyrene nanoparticles having surface hydrophobic polymeric chains, against enzymatic degradation. Int J Pharm. 159, 181–9.
  • Satake, K., Okuyama, T., Ohashi, M., Shinoda, T. (1960). The spectrophotometric determination of amines, amino acids and peptide with 2,4,6-trinitrobenzene-1-sulfonic acid. J Biochem. 47, 654.
  • Schilling, R.J., Mitra, A.K. (1991). Degradation of insulin by trypsin and alpha-chymotrypsin. Pharm Res. 8, 360–4.
  • Stark, B., Andreae, F., Mosgoeller, W., Edetsberger, M., Gaubitzer, E., Koehler, G., Prassl, R. (2008). Liposomal vasoactive intestinal peptide for lung application: protection from proteolytic degradation. Eur J Pharm Biopharm. 70, 153–64.
  • Werle, M., Samhaber, A., Bernkop-Schnürch, A. (2006). Degradation of teriparatide by gastro-intestinal proteolytic enzymes. J Drug Target. 14, 109–15.
  • Woodley, J.F. (1994). Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst. 11, 61–95.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.