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Research Article

Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)

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Pages 268-273 | Received 23 Aug 2008, Accepted 17 Sep 2008, Published online: 01 Jul 2009

References

  • Biessen, E.A., Bakkeren, H.F., Beuting, D.M., Kuiper, J., Van Berkel, T.J. (1994). Ligand size is a major determinant of high-affinity binding of fucose- and galactose-exposing (lipo)proteins by the hepatic fucose receptor. Biochem J. 299, 291–6.
  • Bijsterbosch, M.K., Van Berkel, T.J. (1990). Uptake of lactosylated low-density lipoprotein by galactose-specific receptors in rat liver. Biochem J. 270, 233–9.
  • Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H., Stanley, K.K. (1988). Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. Embo J. 7, 4119–27.
  • Herz, J., Kowal, R.C., Ho, Y.K., Brown, M.S., Goldstein, J.L. (1990). Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. J Biol Chem. 265, 21355–62.
  • Herz, J., Strickland, D.K. (2001). LRP: a multifunctional scavenger and signaling receptor. J Clin Invest. 108, 779–84.
  • Huettinger, M., Retzek, H., Eder, M., Goldenberg, H. (1988). Characteristics of chylomicron remnant uptake into rat liver. Clin Biochem. 21, 87–92.
  • Huettinger, M., Retzek, H., Hermann, M., Goldenberg, H. (1992). Lactoferrin specifically inhibits endocytosis of chylomicron remnants but not alpha-macroglobulin. J Biol Chem. 267, 18551–7.
  • Kalyuzhniy, O., Di Paolo N.C., Silvestry, M., Hofherr, S.E., Barry, M.A., Stewart, P.L., Shayakhmetov, D.M. (2008). Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo. Proc Natl Acad Sci USA. 105, 5483–8.
  • Kita, T., Brown, M.S., Bilheimer, D.W., Goldstein, J.L. (1982). Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits. Proc Natl Acad Sci USA. 79, 5693–7.
  • Kita, T., Goldstein, J.L., Brown, M.S., Watanabe, Y., Hornick, C.A., Havel, R.J. (1982). Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor. Proc Natl Acad Sci USA. 79, 3623–7.
  • Kuiper, J., Bakkeren, H.F., Biessen, E.A., Van Berkel, T.J. (1994). Characterization of the interaction of galactose-exposing particles with rat Kupffer cells. Biochem J. 299, 285–90.
  • Lehrman, M.A., Hill, R.L. (1986). The binding of fucose-containing glycoproteins by hepatic lectins. Purification of a fucose-binding lectin from rat liver. J Biol Chem. 261, 7419–25.
  • Lehrman, M.A., Haltiwanger, R.S., Hill, R.L. (1986). The binding of fucose-containing glycoproteins by hepatic lectins. The binding specificity of the rat liver fucose lectin. J Biol Chem. 261, 7426–32.
  • Lehrman, M.A., Pizzo, S.V., Imber, M.J., Hill, R.L. (1986). The binding of fucose-containing glycoproteins by hepatic lectins. Re-examination of the clearance from blood and the binding to membrane receptors and pure lectins. J Biol Chem. 261, 7412–8.
  • Ludtke, J.J., Sololoff, A.V., Wong, S.C., Zhang, G., Wolff, J.A. (2007). In vivo selection and validation of liver-specific ligands using a new T7 phage peptide display system. Drug Deliv. 14, 357–69.
  • Lupu, F., Heim, D., Bachmann, F., Kruithof, E.K. (1994). Expression of LDL receptor-related protein/alpha 2-macroglobulin receptor in human normal and atherosclerotic arteries. Arterioscler Thromb. 14, 1438–44.
  • Moestrup, S.K., Gliemann, J., Pallesen, G. (1992). Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res. 269, 375–82.
  • Novagen. (2000). T7Select System Manual. Madison, WI: Novagen.
  • Park, J.H., Kim, K.L., Cho, E.W. (2006). Detection of surface asialoglycoprotein receptor expression in hepatic and extra-hepatic cells using a novel monoclonal antibody. Biotechnol Lett. 28, 1061–9.
  • Rensen, P.C., Sliedregt, L.A., Ferns, M., Kieviet, E., van Rossenberg, S.M., van Leeuwen, S.H., van Berkel T.J., Biessen, E.A. (2001). Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo. J Biol Chem. 276, 37577–84.
  • Rohlmann, A., Gotthardt, M., Willnow, T.E., Hammer, R.E., Herz, J. (1996). Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nat Biotechnol. 14, 1562–5.
  • Rohlmann, A., Gotthardt, M., Hammer, R.E., Herz, J. (1998). Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest. 101, 689–95.
  • Russell, R.G., Xia, Z., Dunford, J.E., Oppermann, U., Kwaasi, A., Hulley, P.A., Kavanagh, K.L., Triffitt, J.T., Lundy, M.W., Phipps, R.J., Barnett, B.L., Coxon, F.P., Rogers, M.J., Watts, N.B., Ebetino, F.H. (2007). Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann NY Acad Sci. 1117, 209–57.
  • Shayakhmetov, D.M., Gaggar, A., Ni, S., Li, Z.Y., Lieber, A. (2005). Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity. J Virol 79, 7478–91.
  • Sliedregt, L.A., Rensen, P.C., Rump, E.T., van Santbrink, P.J., Bijsterbosch, M.K., Valentijn, A.R., van der Marel, G.A., van Boom, J.H., van Berkel, T.J., Biessen, E.A. (1999). Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor. J Med Chem. 42, 609–18.
  • Sokoloff, A.V., Bock, I., Zhang, G., Sebestyen, M.G., Wolff, J.A. (2000). The interactions of peptides with the innate immune system studied with use of T7 phage peptide display [comment]. Mol Ther. 2, 131–9.
  • Sokoloff, A.V., Wong, S.C., Ludtke, J.J., Sebestyen, M.G., Subbotin, V.M., Zhang, G., Budker, T., Bachhuber, M., Sumita, Y., Wolff, J.A. (2003). A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo. Mol Ther. 8, 867–72.
  • Springer, T.A. (1998). An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. J Mol Biol. 283, 837–62.
  • Waddington, S.N., McVey, J.H., Bhella, D., Parker, A.L., Barker, K., Atoda, H., Pink, R., Buckley, S.M., Greig, J.A., Denby, L., Custers, J., Morita, T., Francischetti, I.M., Monteiro, R.Q., Barouch, D.H., van Rooijen, N., Napoli, C., Havenga, M.J., Nicklin, S.A., Baker, A.H. (2008). Adenovirus serotype 5 hexon mediates liver gene transfer. Cell. 132, 397–409.
  • Willnow, T.E., Herz, J. (1994). Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands. J Cell Sci. 107, 719–26.
  • Wong, S.C., Wakefield, D., Klein, J., Monahan, S.D., Rosema, D.B., Lewis, D.L., Higgs, L., Ludtke, J.J., Sokoloff, A.V., Wolff, J.A. (2006). Hepatocyte targeting of nucleic acid complexes and liposomes by a T7 phage p17 peptide. Mol Pharm. 3, 386–97.

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