Passive targeting and lung tolerability of enoxaparin microspheres for a sustained antithrombotic activity in rats

References

• Bagre A, Jain K, Jain N. (2013). Alginate coated chitosan core shell nanoparticles for oral delivery of enoxaparin: in vitro and in vivo assessment. Int J Pharm 456:31–40
   PubMed Web of Science ®Google Scholar
• Bai S, Ahsan F. (2010). Inhalable liposomes of low molecular weight heparin for the treatment of venous thromboembolism. J Pharm Sci 99:4554–64
   PubMed Web of Science ®Google Scholar
• Baldwin A, Robinson K, Militar J, et al. (2012). In situ-crosslinkable heparin-containing poly (ethylene glycol) hydrogels for sustained anticoagulant release. J Biomed Mater Res A 100:2106–18
   PubMed Web of Science ®Google Scholar
• Bancroft J, Stevens A, Turner D. 1996. Theory and practice of histological techniques. 4th ed. New York, London, San Francisco, Tokyo: Churchill Livingstone
   Google Scholar
• Boonsongrit Y, Mitrevej A, Mueller B. (2006). Chitosan drug binding by ionic interaction. Eur J Pharm Biopharm 62:267–74
   PubMed Web of Science ®Google Scholar
• Chao P, Deshmukh M, Kutscher H, et al. (2010). Pulmonary targeting microparticulate camptothecin delivery system: anti-cancer evaluation in a rat orthotopic lung cancer model. Anti-Cancer Drugs 21:65–76
   PubMed Web of Science ®Google Scholar
• Das S, Khan W, Mohsin S, Kumar N. (2011). Miltefosine loaded albumin microparticles for treatment of visceral leishmaniasis: formulation development and in-vitro evaluation. Polym Adv Technol 22:172–9
   Web of Science ®Google Scholar
• Davies N, Takemoto J, Brocks D, Yáñez J. (2010). Multiple peaking phenomena in pharmacokinetic disposition. Clin Pharm 49:351–77
   Google Scholar
• Deshmukh M, Kutscher H, Gao D, et al. (2012). Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanogel aggregates. J Control Release 164:65–73
   PubMed Web of Science ®Google Scholar
• El-Mahdy M, Ibrahim E, Safwat S, et al. (1998). Effects of preparation conditions on the monodispersity of albumin microspheres. J Microencapsul 15:661–73
   PubMed Web of Science ®Google Scholar
• Francis L, Meng D, Knowles J, et al. (2011). Controlled delivery of gentamicin using poly (3-hydroxybutyrate) microspheres. Int J Mol Sci 12:4294–314
   PubMed Web of Science ®Google Scholar
• Gülsu A, Ayhan F, Ayhan H. (2012). Preparation and characterization of ketoprofen loaded albumin microspheres. Turk J Biochem 37:120–8
   Web of Science ®Google Scholar
• Gupta P, Hung C, Perrier D. (1986). Albumin microspheres. I. Release characteristics of adriamycin. Int J Pharm 33:137–46
   Web of Science ®Google Scholar
• Gupta P, Hung C. (1989). Albumin microspheres II: applications in drug delivery. J Microencapsul 6:463–72
   PubMed Web of Science ®Google Scholar
• Huo D, Deng S, Li L, Ji J. (2005). Studies on the poly(lactic-co-glycolic) acid microspheres of cisplatin for lung-targeting. Int J Pharm 289:63–7
   PubMed Web of Science ®Google Scholar
• Ibrahim S, Osman R, Awad G, et al. (2015). Low molecular weight heparins for current and future uses: approaches for micro- and nano-particulate delivery. Drug Deliv 16:1–7
   Web of Science ®Google Scholar
• Iemma F, Spizzirri U, Puoci F, et al. (2009). Synthesis and release profile analysis of thermo-sensitive albumin hydrogels. Colloid Polym Sci 287:779–87
   Web of Science ®Google Scholar
• Jana S, Maji N, Nayak A, et al. (2013). Development of chitosan-based nanoparticles through inter-polymeric complexation for oral drug delivery. Carbohydr Polym 98:870–6
   PubMed Web of Science ®Google Scholar
• Jana S, Manna S, Nayak A, et al. (2014). Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery. Colloids Surf B Biointerfaces 114:36–44
   PubMed Web of Science ®Google Scholar
• Jeffery H, Davis S, O'Hagan D. (1993). The preparation and characterization of poly (lactide-co-glycolide) MP. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique. Pharm Res 10:362–8
   PubMed Web of Science ®Google Scholar
• Jiao Y, Ubrich N, Marchand-Arvier M, et al. (2002). In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 105:230–5
   PubMed Web of Science ®Google Scholar
• Kadam R, Bourne D, Kompella U. (2012). Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance. Drug Metab Dispos 40:1380–8
   PubMed Web of Science ®Google Scholar
• Kutscher H, Chao P, Deshmukh M, et al. (2010). Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats. Control Release 143:31–7
   PubMed Web of Science ®Google Scholar
• Lanke S, Gayakwad S, Strom J, D'Souza M. (2009). Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system. J Microencapsul 26:493–500
   PubMed Web of Science ®Google Scholar
• Lee Y, Nam J, Shin H, Byun Y. (2001). Conjugation of low-molecular-weight heparin and deoxycholic acid for the development of a new oral anticoagulant agent. Circulation 104:3116–20
   PubMed Web of Science ®Google Scholar
• Li X, Deng X, Yuan M, et al. (1999). Investigation on process parameters involved in preparation of poly-dl-lactide-poly (ethylene glycol) microspheres containing Leptospira Interrogans antigens. Int J Pharm 178:245–55
   PubMed Web of Science ®Google Scholar
• Lyons K, Nesbitt V, Menown I. (2011). Dose capping of enoxaparin results in sub-therapeutic anti-Xa level. Br J Cardiol 18:82–3
   Google Scholar
• Mathew S, Devi S, Sandhya K. (2007). Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration. AAPS PharmSciTech 8:E100–8
   PubMed Web of Science ®Google Scholar
• Mathew S, Gayathri Devi S, Prasanth V, Vinod B. (2009). Formulation and in vitro–in vivo evaluation of ketoprofen-loaded albumin microspheres for intramuscular administration. J Microencapsul 26:456–69
   PubMed Web of Science ®Google Scholar
• Merli G, Groce J. (2010). Pharmacological and clinical differences between low-molecular-weight heparins: implications for prescribing practice and therapeutic interchange. Pharm Ther 35:95–105
   Google Scholar
• Moon J, Song Y, Jee J, et al. (2006). Effect of subconjunctivally injected, liposome-bound, low-molecular-weight heparin on the absorption rate of subconjunctival hemorrhage in rabbits. Invest Ophthalmol Vis Sci 47:3968–74
   PubMed Web of Science ®Google Scholar
• Müller B, Leuenberger H, Kissel T. (1996). Albumin nanospheres as carriers for passive drug targeting: an optimized manufacturing technique. Pharm Res 13:32–7
   PubMed Web of Science ®Google Scholar
• Pande S, Vyas S, Dixit V. (1991). Localized rifampicin albumin microspheres. J Microencapsul 8:87–93
   PubMed Web of Science ®Google Scholar
• Priglinger U, DelleKarth G, Geppert A, et al. (2003). Prophylactic anticoagulation with enoxaparin: is the subcutaneous route appropriate in the critically ill? Crit Care Med 31:1405–9
   PubMed Web of Science ®Google Scholar
• Rawat A, Majumder QH, Ahsan F. (2008b). Inhalable large porous microspheres of low molecular weight heparin: in vitro and in vivo evaluation. J Control Release 128:224–32
   PubMed Web of Science ®Google Scholar
• Rawat A, Yang T, Hussain A, Ahsan F. (2008a). Complexation of a poly-l-arginine with low molecular weight heparin enhances pulmonary absorption of the drug. Pharm Res 25:936–48
   PubMed Web of Science ®Google Scholar
• Sahin S, Selek H, Ponchel G, et al. (2002). Preparation, characterization and in-vivo distribution of terbutaline sulfate loaded albumin microspheres. J Control Release 82:345–58
   PubMed Web of Science ®Google Scholar
• Shailesh T, Vipul P, Girishbhai J, Manish C. (2010). Preparation and in-vitro evaluation of ethylcellulose coated egg albumin microspheres of diltiazem hydrochloride. J Young Pharm 2:27–34
   PubMedGoogle Scholar
• Sjöström B, Bergenståhl B, Kronberg B. (1993). A method for the preparation of submicron particles of sparingly water-soluble drugs by precipitation in oil-in-water emulsions. II: Influence of the emulsifier, the solvent, and the drug substance. J Pharm Sci 82:584–9
   PubMed Web of Science ®Google Scholar
• Sun W, Mao S, Wang Y, et al. (2010). Bioadhesion and oral absorption of enoxaparin nanocomplexes. Int J Pharm 386:275–81
   PubMed Web of Science ®Google Scholar
• Tang D, Yu S, Ho Y, et al. (2010). Heparinized chitosan/poly (γ-glutamic acid) nanoparticles for multi-functional delivery of fibroblast growth factor and heparin. Biomaterials 31:9320–32
   PubMed Web of Science ®Google Scholar
• Thakkar H, Sharma R, Mishra A, et al. (2005). Albumin microspheres as carriers for the antiarthritic drug celecoxib. AAPS PharmSciTech 6:E65–73
   PubMed Web of Science ®Google Scholar
• Urs A, Kavitha K, Sockan GN. (2010). Albumin microspheres: an unique system as drug delivery carriers for non steroidal anti-inflammatory drugs (NASIDs). Int J Pharm Sci Rev Res 5:10–17
   Google Scholar
• Vural I, Kasl H, Hincal A, Cavé G. (1990). Cyclophosphamide loaded albumin microspheres. II. Release characteristics. J Microencapsul 7:511–16
   PubMed Web of Science ®Google Scholar
• Walter R, Moores L, Jiménez D. (2014). Pulmonary embolism: current and new treatment options. Curr Med Res Opin 30:1975–89
   PubMed Web of Science ®Google Scholar
• Wang Y, Wu Y, Lin J, et al. (2012). Rapid quantitative analysis of clarithromycin in rat plasma by UPLC–MS/MS after intravenous injection of the clarithromycin-loaded ultrafine PLGA nanoparticles. J Chromatogr B 895–896:178–81
   PubMed Web of Science ®Google Scholar
• Willmott N, Cummings J, Stuart J, Florence A. (1985). Adriamycin-loaded albumin microspheres: preparation, in vivo distribution and release in the rat. Biopharm Drug Dispos 6:91–104
   PubMed Web of Science ®Google Scholar
• Yang T, Hussain A, Bai S, et al. (2006). Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin. J Control Release 115:289–97
   PubMed Web of Science ®Google Scholar