References
- Bernacki J, Dobrowolska A, Nierwinska K, Malecki A. (2008). Physiology and pharmacological role of the blood-brain barrier. Pharmacol Rep 60:600–22.
- Chen Q, Gong T, Liu J, et al. (2009). Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery. J Drug Target 17:318–28.
- Fan W, Wu Y, Li XK, et al. (2011). Design, synthesis and biological evaluation of brain-specific glucosyl thiamine disulfide prodrugs of naproxen. Eur J Med Chem 46:3651–61.
- Jakki SL, Ramesh YV, Gowthamarajan K, et al. (2016). Novel anionic polymer as a carrier for CNS delivery of anti-Alzheimer drug. Drug Deliv 23:3471–9.
- Liu X, Sui BY, Sun J. (2017). Blood-brain barrier dysfunction induced by silica NPs in vitro and in vivo: involvement of oxidative stress and Rho-kinase/JNK signaling pathways. Biomaterials 121:64–82.
- Pavan B, Dalpiaz A, Ciliberti N, et al. (2008). Progress in drug delivery to the central nervous system by the prodrug approach. Molecules 13:1035–65.
- Qiu SB, Zhao Y, Liu S, et al. (2017). Design, synthesis and evaluation of dual-targeting prodrug co-modified by organic amine and L-ascorbic acid for CNS delivery. Lett Drug Des Discov 14:1065–72.
- Qu BY, Li XC, Guan M, et al. (2014). Design, synthesis and biological evaluation of multivalent glucosides with high affinity as ligands for brain targeting liposomes. Eur J Med Chem 72:110–8.
- Saraiva C, Praca C, Ferreira R, et al. (2016). Nanoparticle-mediated brain drug delivery: overcoming blood-brain barrier to treat neurodegenerative diseases. J Control Release 235:34–47.
- Teema AM, Zaitone SA, Moustafa YM. (2016). Ibuprofen or piroxicam protects nigral neurons and delays the development of L-dopa induced dyskinesia in rats with experimental Parkinsonism: influence on angiogenesis. Neuropharmacology 107:432–50.
- Tian T, Zhang HX, He CP, et al. (2017). Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy. Biomaterials 150:137–49.
- Wang XY, Qi BW, Su HF, et al. (2017). Pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter for brain-specific drug delivery. J Control Release 254:34–43.
- Wu XY, Li XC, Mi J, et al. (2013). Design, synthesis and preliminary biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen. Chin Chem Lett 24:117–9.
- Zhang Y, Zhai MF, Chen ZJ, et al. (2017). Dual-modified liposome codelivery of doxorubicin and vincristine improve targeting and therapeutic efficacy of glioma. Drug Deliv 24:1045–55.
- Zhao Y, Qu BY, Wu XY, et al. (2014). Design, synthesis and biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen with “lock-in function”. Eur J Med Chem 82:314–23.
- Zhao Y, Zhang L, Peng Y, et al. (2017). GLUT1-mediated venlafaxine-thiamine disulfide system-glucose conjugates with “lock-in” function for central nervous system delivery. Chem Biol Drug Des doi: 10.1111/cbdd.13128 [Epub ahead of print].
- Zheng D, Shuai X, Li YP, et al. (2016). Novel flurbiprofen derivatives with improved brain delivery: synthesis, in vitro and in vivo evaluations. Drug Deliv 23:2183–92.