Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis

References

• Arunkumar P, Indulekha S, Vijayalakshmi S, et al. (2016). Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis. Mat Sci Eng C Mater 61:534–44.
   PubMed Web of Science ®Google Scholar
• Bajpayee AG, Grodzinsky AJ. (2017). Cartilage-targeting drug delivery: can electrostatic interactions help? Nat Rev Rheumatol 13:183–93.
   PubMed Web of Science ®Google Scholar
• Bajpayee AG, Wong CR, Bawendi MG, et al. (2014). Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials 35:538–49.
   PubMed Web of Science ®Google Scholar
• Chambers AW, Lacy KW, Liow MHL, et al. (2017). Multiple hip intra-articular steroid injections increase risk of periprosthetic joint infection compared with single injections. J Arthroplasty 32:1980–3.
   PubMed Web of Science ®Google Scholar
• Cherng JY, Hou TY, Shih MF, et al. (2013). Polyurethane-based drug delivery systems. Int J Pharm 450:145–62.
   PubMed Web of Science ®Google Scholar
• Fan WS, Wang YM, Yuan L, et al. (2016). Enhancing synovial mesenchymal sem cell adhesion and selection via an Avidin-Biotin-CD105 binding system for cartilage tissue engineering. J Biomater Tissue Eng 6:27–34.
   Web of Science ®Google Scholar
• Fang J, Ye SH, Shankarraman V, et al. (2014). Biodegradable poly(ester urethane)urea elastomers with variable amino content for subsequent functionalization with phosphorylcholine. Acta Biomater 10:4639–49.
   PubMed Web of Science ®Google Scholar
• Hayami T, Pickarski M, Zhuo Y, et al. (2006). Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 38:234–43.
   PubMed Web of Science ®Google Scholar
• Johnson K, Zhu ST, Tremblay MS, et al. (2012). A stem cell-based approach to cartilage repair. Science 336:717–21.
   PubMed Web of Science ®Google Scholar
• Kang ML, Im GI. (2014). Drug delivery systems for intra-articular treatment of osteoarthritis. Expert Opin Drug Deliv 11:269–82.
   PubMed Web of Science ®Google Scholar
• Kang ML, Jeong SY, Im GI. (2017). Hyaluronic acid hydrogel functionalized with self-assembled micelles of amphiphilic PEGylated kartogenin for the treatment of osteoarthritis. Tissue Eng Part A 23:630–9.
   PubMed Web of Science ®Google Scholar
• Kang ML, Ko JY, Kim JE, et al. (2014). Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration. Biomaterials 35:9984–94.
   PubMed Web of Science ®Google Scholar
• Karsdal MA, Michaelis M, Ladel C, et al. (2016). Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future. Osteoarthr Cartilage 24:2013–21.
   PubMed Web of Science ®Google Scholar
• Kim SR, Ho MJ, Kim SH, et al. (2016). Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Des Devel Ther 10:3779–87.
   PubMed Web of Science ®Google Scholar
• Li X, Ding J, Zhang Z, et al. (2016). Kartogenin-incorporated thermogel supports stem cells for significant cartilage regeneration. Acs Appl Mater Interf 8:5148–59.
   PubMed Web of Science ®Google Scholar
• Li MH, Xiao R, Li JB, et al. (2017). Regenerative approaches for cartilage repair in the treatment of osteoarthritis. Osteoarthr Cartil 25:1577–87.
   PubMed Web of Science ®Google Scholar
• Liu C, Ma XQ, Li T, et al. (2015). Kartogenin, transforming growth factor-1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells. Cell Biol Int 39:1026–35.
   PubMed Web of Science ®Google Scholar
• Loeser RF, Collins JA, Diekman BO. (2016). Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12:412–20.
   PubMed Web of Science ®Google Scholar
• Mcalindon TE, Bannuru RR, Sullivan MC, et al. (2014). OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartilage 22:363–88.
   PubMed Web of Science ®Google Scholar
• Mcmasters J, Poh S, Lin JB, et al. (2017). Delivery of anti-inflammatory peptides from hollow PEGylated poly (NIPAM) nanoparticles reduces inflammation in an ex vivo osteoarthritis model. J Control Release 258:161–70.
   PubMed Web of Science ®Google Scholar
• Mohan G, Magnitsky S, Melkus G, et al. (2016). Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: a pilot study. J Orthop Res 34:1780–9.
   PubMed Web of Science ®Google Scholar
• Morgen M, Tung D, Boras B, et al. (2013). Nanoparticles for improved local retention after intra-articular injection into the knee joint. Pharm Res 30:257–68.
   PubMed Web of Science ®Google Scholar
• Ou CW, Su CH, Jeng US, et al. (2014). Characterization of biodegradable polyurethane nanoparticles and thermally induced self-assembly in water dispersion. ACS Appl Mater Interf 6:5685–94.
   PubMed Web of Science ®Google Scholar
• Owen SG, Francis HW, Roberts MS. (1994). Disappearance kinetics of solutes from synovial fluid after intra-articular injection. Brit J Clin Pharmaco 38:349–55.
   PubMed Web of Science ®Google Scholar
• Pacardo DB, Ligler FS, Gu Z. (2015). Programmable nanomedicine: synergistic and sequential drug delivery systems. Nanoscale 7:3381–91.
   PubMed Web of Science ®Google Scholar
• Pritzker KP, Gay S, Jimenez SA, et al. (2006). Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr Cartilage 14:13–29.
   Web of Science ®Google Scholar
• Qiu L, Hong CY, Pan CY. (2015). Doxorubicin-loaded aromatic imine-contained amphiphilic branched star polymer micelles: synthesis, self-assembly, and drug delivery. Int J Nanomed 10:3623–40.
   PubMed Web of Science ®Google Scholar
• Rothenfluh DA, Bermudez H, O'neil CP, et al. (2008). Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater 7:248–54.
   PubMed Web of Science ®Google Scholar
• Shi D, Xu X, Ye Y, et al. (2016). Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration. ACS Nano 10:1292–9.
   PubMed Web of Science ®Google Scholar
• Singh M, Kundu S, Reddy MA, et al. (2014). Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale 6:12849–55.
   PubMed Web of Science ®Google Scholar
• Stalder E, Zumbuehl A. (2017). Liposome-containing mechanoresponsive hydrogels. Macromol Mater Eng 302:1600549.
   Web of Science ®Google Scholar
• Vermeij EA, Koenders MI, Bennink MB, et al. (2015). The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis. PLoS One 10:e0126687.
   PubMed Web of Science ®Google Scholar
• Woolf AD, Pfleger B. (2003). Burden of major musculoskeletal conditions. B World Health Organ 81:646–56.
   PubMed Web of Science ®Google Scholar
• Xu X, Shi D, Shen Y, et al. (2015). Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin. Arthritis Res Ther 17:20.
   PubMed Web of Science ®Google Scholar
• Yu SP, Hunter DJ. (2016). Intra-articular therapies for osteoarthritis. Expert Opin Pharmacother 17:2057–71.
   PubMed Web of Science ®Google Scholar