β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund’s adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway

References

• Arham S, Shahzad M, Ali A, Zia-Ur-Rehman M. (2016). Discovery of new benzothiazine derivative as modulator of pro- and anti-inflammatory cytokines in rheumatoid arthritis. Inflammation 39(6): 1918–29.
   PubMed Web of Science ®Google Scholar
• Ahmad A, Abuzinadah MF, Alkreathy HM, et al. (2018). Ursolic acid rich ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-α and IL-1: Pharmacological and docking studies. PLoS One 13:e0193451.
   PubMed Web of Science ®Google Scholar
• Aiyalu R, Govindarjan A, Ramasamy A. (2016). Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model. Brazilian J Pharm Sci 49:493–507.
   Web of Science ®Google Scholar
• Amresh G, Singh PN, Rao CV. (2007). Antinociceptive and antiarthritic activity of Cissampelos pareira roots. J Ethnopharmacol 111:531–6.
   PubMed Web of Science ®Google Scholar
• Andima M, Costabile G, Isert L, et al. (2018). Evaluation of β-sitosterol loaded PLGA and PEG-PLA nanoparticles for effective treatment of breast cancer: preparation, physicochemical characterization, and antitumor activity. Pharmaceutics 10:232.
   PubMed Web of Science ®Google Scholar
• Arora R, Kuhad A, Kaur IP, Chopra K. (2015). Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur J Pain 19:940–52.
   PubMed Web of Science ®Google Scholar
• Awad AB, Chinnam M, Fink CS, Bradford PG. (2007). beta-Sitosterol activates Fas signaling in human breast cancer cells . Phytomedicine 14:747–54.
   PubMed Web of Science ®Google Scholar
• Awad AB, Downie AC, Fink CS. (2000). Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. Int J Mol Med 5:541–5.
   PubMed Web of Science ®Google Scholar
• Awad AB, Williams H, Fink CS. (2001). Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutr Cancer 40:157–64.
   PubMed Web of Science ®Google Scholar
• Bainbridge J, Sivakumar B, Paleolog E. (2006). Angiogenesis as a therapeutic target in arthritis: lessons from oncology. Curr Pharm Des 12:2631–44.
   PubMed Web of Science ®Google Scholar
• Bilia AR, Piazzini V, Guccione C, et al. (2017). Improving on nature: the role of nanomedicine in the development of clinical natural drugs. Planta Med 83:366–81.
   PubMed Web of Science ®Google Scholar
• Brennan FM, McInnes IB. (2008). Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118:3537–45.
   PubMed Web of Science ®Google Scholar
• Farkas E, Schubert R, Zelkó R. (2006). Effect of beta-sitosterol concentration and high pressure homogenization on the chlorhexidine release from vesicular gels. Int J Pharm 307:51–5.
   PubMed Web of Science ®Google Scholar
• Funk JL, Oyarzo JN, Frye JB, et al. (2006). Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod 69:351–5.
   PubMed Web of Science ®Google Scholar
• Gao LN, Feng QS, Zhang XF, et al. (2016). Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation. J Orthop Res 34:1557–68.
   PubMed Web of Science ®Google Scholar
• Imanaka H, Koide H, Shimizu K, et al. (2008). Chemoprevention of tumor metastasis by liposomal β-sitosterol intake. Biol Pharm Bull 31:400–4.
   PubMed Web of Science ®Google Scholar
• Isomäki P. (2012). Cytokines in rheumatoid arthritis. In: Scientific basis of healthcare: arthritis. pp 49–68.
   Google Scholar
• Jalalpure SS, Mandavkar YD, Khalure PR, et al. (2011). Antiarthritic activity of various extracts of Mesua ferrea Linn. seed. J Ethnopharmacol 138:700–4.
   PubMed Web of Science ®Google Scholar
• Kamel KM, Gad AM, Mansour SM, et al. (2018). Novel anti-arthritic mechanisms of polydatin in complete Freund’s adjuvant-induced arthritis in rats: involvement of IL-6, STAT-3, IL-17, and NF-кB. Inflammation 41:1974–86.
   PubMed Web of Science ®Google Scholar
• Kim A-J, Park S. (2006). Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. J Med Food 9:431–5.
   PubMed Web of Science ®Google Scholar
• Kim KA, Lee IA, Gu W, et al. (2014). β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway. Mol Nutr Food Res 58:963–72.
   PubMed Web of Science ®Google Scholar
• Krause A, Scaletta N, Ji J-D, Ivashkiv LB. (2002). Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J Immunol 169:6610–6.
   PubMed Web of Science ®Google Scholar
• Kumar V, Ahmed D, Anwar F, et al. (2016a). Fostered antiarthritic upshot of moringa oleifera lam. stem bark extract in diversely induced arthritis in wistar rats with plausible mechanism. Int J Pharm Sci Res 22:3894–901.
   Google Scholar
• Kumar V, Al-Abbasi FA, Ahmed D, et al. (2015a). Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE2 and COX-2 expression via nuclear factor-κB. Food Funct 6:1652–66.
   PubMed Web of Science ®Google Scholar
• Kumar V, Al-Abbasi FA, Verma A, et al. (2015b). Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2. Toxicol Res (Camb) 4:1072–84.
   Web of Science ®Google Scholar
• Kumar V, Bhatt PC, Rahman M, et al. (2016b). Melastoma malabathricum Linn attenuates complete freund’s adjuvant-induced chronic inflammation in Wistar rats via inflammation response. BMC Complement Altern Med 16:510.
   PubMed Web of Science ®Google Scholar
• Lacatusu I, Badea N, Stan R, Meghea A. (2012). Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol. Nanotechnology 23:455702.
   PubMed Web of Science ®Google Scholar
• Mahdi HJ, Khan NAK, Asmawi MB, et al. (2018). In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund's adjuvant (CFA)-induced arthritis in rats. Integr Med Res 7:85–94.
   PubMed Web of Science ®Google Scholar
• Paleolog EM. (1996). Angiogenesis: a critical process in the pathogenesis of RA-a role for VEGF? Br J Rheumatol 35:917–9.
   PubMedGoogle Scholar
• Paleolog EM, Miotla JM. (1998). Angiogenesis in arthritis: Role in disease pathogenesis and as a potential therapeutic target. Angiogenesis 2:295–307.
   PubMedGoogle Scholar
• Patil CR, Rambhade AD, Jadhav RB, et al. (2011). Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions. Homeopathy 100:131–7.
   PubMed Web of Science ®Google Scholar
• Petchi R, Parasuraman S, Vijaya C, et al. (2015). Antiarthritic activity of a polyherbal formulation against Freund′s complete adjuvant induced arthritis in Female Wistar rats. J Basic Clin Pharm 6:77–83.
   PubMedGoogle Scholar
• Premaratna R, Halambarachchige LP, Nanayakkara DM, et al. (2011). Evidence of acute rickettsioses among patients presumed to have chikungunya fever during the chikungunya outbreak in Sri Lanka. Int J Infect Dis 15:e871–3.
   PubMed Web of Science ®Google Scholar
• Rahman M, Al-Ghamdi SA, Alharbi KS, et al. (2019). Ganoderic acid loaded nano-lipidic carriers improvise treatment of hepatocellular carcinoma. Drug Deliv 26:782–93.
   PubMed Web of Science ®Google Scholar
• Rahman M, Beg S, Sharma G, et al. (2015). Emergence of lipid-based vesicular carriers as nanoscale pharmacotherapy in rheumatoid arthritis. Recent Patents Nanomed 5:111–21.
   Google Scholar
• Rahman M, Beg S, Sharma G, et al. (2016). Lipid-based vesicular nanocargoes as nanotherapeutic targets for the effective management of rheumatoid arthritis. Recent Pat Antiinfect Drug Discov 11:3–15.
   PubMedGoogle Scholar
• Rahman M, Beg S, Verma A, et al. (2017). Phytoconstituents as pharmacotherapeutics in rheumatoid arthritis: challenges and scope of nano/submicromedicine in its effective delivery. J Pharm Pharmacol 69:1–14.
   PubMed Web of Science ®Google Scholar
• Rutherford A, Nikiphorou E, Galloway J. (2017) Rheumatoid arthritis. In: Comorbidity in rheumatic diseases.
   Google Scholar
• Sengupta K, Kolla JN, Krishnaraju AV, et al. (2011). Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: A novel Boswellia serrata extract. Mol Cell Biochem 354:189–97.
   PubMed Web of Science ®Google Scholar
• Sharmila R, Sindhu G. (2017). Modulation of angiogenesis, proliferative response and apoptosis by β-sitosterol in rat model of renal carcinogenesis. Ind J Clin Biochem 32:142–52.
   PubMed Web of Science ®Google Scholar
• Thakkar H, Sharma RK, Murthy RSR. (2007). Enhanced retention of celecoxib-loaded solid lipid nanoparticles after intra-articular administration. Drugs R D 8:275–85.
   PubMedGoogle Scholar
• Woodruff TM, Strachan AJ, Dryburgh N, et al. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis Rheum 46:2476–85.
   PubMed Web of Science ®Google Scholar
• Zhou L, Ivanov II, Spolski R, et al. (2007). IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8:967–74.
   PubMed Web of Science ®Google Scholar