Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles

References

• Abou-Taleb HA, Khallaf RA, Abdel-Aleem JA. (2018). Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation. Drug Des Devel Ther 12:3501–16.
   PubMed Web of Science ®Google Scholar
• Ahmed OAA, Kurakula M, Banjar ZM, et al. (2015). Quality by design coupled with near infrared in formulation of transdermal glimepiride liposomal films. J Pharm Sci 104:2062–75.
   PubMed Web of Science ®Google Scholar
• Alghaith AF, Alshehri S, Alhakamy NA, Hosny KM. (2021). Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea. Drug Deliv 28:343–56.
   PubMed Web of Science ®Google Scholar
• Alhakamy NA, Badr-Eldin SM, A Fahmy U, et al. (2020). Thymoquinone-Loaded Soy-phospholipid-based phytosomes exhibit anticancer potential against human lung cancer cells. Pharmaceutics 12:761.
   PubMed Web of Science ®Google Scholar
• Alkhalidi HM, Naguib GH, Kurakula M, et al. (2018). In vitro and preclinical assessment of factorial design based nanoethosomal transdermal film formulation of mefenamic acid to overcome barriers to its use in relieving pain and inflammation. J Drug Deliv Sci Technol 48:450–6.
   Web of Science ®Google Scholar
• Anwar M, Muhammad F, Akhtar B, et al. (2020). Nephroprotective effects of curcumin loaded chitosan nanoparticles in cypermethrin induced renal toxicity in rabbits. Environ Sci Pollut Res Int 27:14771–9.
   PubMed Web of Science ®Google Scholar
• Baldisserotto B, Parodi TV, Stevens ED. (2018). Lack of postexposure analgesic efficacy of low concentrations of eugenol in zebrafish. Vet Anaesth Analg 45:48–56.
   PubMed Web of Science ®Google Scholar
• Bellmann R, Smuszkiewicz P. (2017). Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients. Infection 45:737–79.
   PubMed Web of Science ®Google Scholar
• Buss N, Snell P, Bock J, et al. (2001). Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. Br J Clin Pharmacol 52:255–64.
   PubMed Web of Science ®Google Scholar
• Cao SL, Ren XW, Zhang QZ, et al. (2009). In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate. Int J Pharm 365:109–15.
   PubMed Web of Science ®Google Scholar
• Cevc G, Blume G. (2003). Biological activity, and characteristics of triamcinolone-acetonide formulated with the self-regulating drug carriers, Transfersomes. Biochim Biophys Acta 1614:156–64. 7
   PubMed Web of Science ®Google Scholar
• Chakrabarti A, Das A, Panda NK. (2009). Controversies surrounding the categorization of fungal sinusitis. Med Mycol 47:S299–S308.
   PubMed Web of Science ®Google Scholar
• Chris Rathbun R, Hoffman HL. (2002). Review of the safety and efficacy of voriconazole. Expert Opin Investig Drugs 11:409–29.
   PubMed Web of Science ®Google Scholar
• Darvishi E, Omidi M, Bushehri AAS, et al. (2013). The antifungal eugenol perturbs dual aromatic and branched-chain amino acid permeases in the cytoplasmic membrane of yeast. PLoS One 8:e76028.
   PubMed Web of Science ®Google Scholar
• Dervis E, Yurt Kilcar A, Medine EI, et al. (2017). In vitro incorporation of radioiodinated eugenol on adenocarcinoma cell lines (Caco2, MCF7, and PC3). Cancer Biother Radiopharm 32:75–81.,
   PubMed Web of Science ®Google Scholar
• El Maghraby GM, Williams AC, Barry BW. (2000). Oestradiol skin delivery from ultradeformable liposomes: refinement of surfactant concentration. Int J Pharm 196:63–74. 25
   PubMed Web of Science ®Google Scholar
• El-Emam GA, Girgis GNS, El-Sokkary MMA, et al. (2020). Ocular inserts of voriconazole-loaded proniosomal gels: formulation, evaluation and microbiological studies. Int J Nanomedicine 15:7825–40.
   PubMed Web of Science ®Google Scholar
• Galgatte UC, Kumbhar AB, Chaudhari PD. (2014). Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation. Drug Deliv 21:62–73.
   PubMed Web of Science ®Google Scholar
• Guo J, Ping Q, Sun G, Jiao C. (2000). Lecithin vesicular carriers for transdermal delivery of cyclosporin A. Int J Pharm 194:201–7.
   PubMed Web of Science ®Google Scholar
• Gupta A, Aggarwal G, Singla S, Arora R. (2012). Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline, development, characterization, and performance evaluation. Sci Pharm 80:1061–80.
   PubMedGoogle Scholar
• Hamed SF, Sadek Z, Edris A. (2012). Antioxidant and antimicrobial activities of clove bud essential oil and eugenol nanoparticles in alcohol-free microemulsion. J Oleo Sci 61:641–8.
   PubMed Web of Science ®Google Scholar
• Herbrecht R. (2004). Voriconazole: therapeutic review of a new azole antifungal. Expert Rev anti Infect Ther 2:485–97.
   PubMedGoogle Scholar
• Hosny KM, Alhakamy NA, Sindi AM, Khallaf RA. (2020). Coconut oil nanoemulsion loaded with a statin hypolipidemic drug for management of burns, formulation and in vivo evaluation. Pharmaceutics 7:1061.
   Google Scholar
• Hosny KM, Alhakamy NA. (2020). Nasal gel loaded with amphotericin nanotransferosomes as antifungal treatment for fungal sinusitis. Pharmaceutics 13:35.
   PubMed Web of Science ®Google Scholar
• Hosny KM, Rizg WY, Khallaf RA. (2020). Preparation and optimization of in situ gel loaded with rosuvastatin-ellagic acid nanotransfersomes to enhance the anti-proliferative activity. Pharmaceutics 12:263.
   PubMed Web of Science ®Google Scholar
• Hosny KM, Sindi AM, Alkhalidi HM, et al. (2021). Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain. Drug Deliv 28:741–51.
   PubMed Web of Science ®Google Scholar
• Jeu L, Piacenti FJ, Lyakhovetskiy AG, Fung HB. (2003). Voriconazole. Clin Ther 25:1321–81.
   PubMed Web of Science ®Google Scholar
• Jogani V, Jinturkar K, Vyas T, Misra A. (2008). Recent patents review on intranasal administration for CNS drug delivery. Recent Pat Drug Deliv Formul 2:25–40.
   PubMedGoogle Scholar
• Khajeh M. (2009). Application of Box-Behnken design in the optimization of a magnetic nanoparticle procedure for zinc determination in analytical samples by inductively coupled plasma optical emission spectrometry. J Hazard Mater 172:385–9. 15
   PubMed Web of Science ®Google Scholar
• Khallaf RA, Aboud HM, Sayed OM. (2020). Surface modified niosomes of olanzapine for brain targeting via nasal route; preparation, optimization, and in vivo evaluation. J Liposome Res 30:163–73.
   PubMed Web of Science ®Google Scholar
• Kim SS, Oh OJ, Min HY, et al. (2003). Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264. 7 cells. Life Sci 73:337–48.
   PubMed Web of Science ®Google Scholar
• Laverdiere M, Bow EJ, Rotstein C, et al. (2014). Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective. Can J Infect Dis Med Microbiol 25:327–43.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Han JI, Lee SHG, et al. (2007). Antifungal effect of eugenol and nerolidol against microsporum gypseum in a guinea pig model. Biol Pharm Bull 30:184–8.
   PubMed Web of Science ®Google Scholar
• Maertens JA, Raad II, Marr KA, et al. (2016). Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial. Lancet 387:760–9. 20
   PubMed Web of Science ®Google Scholar
• Maheshwari RG, Tekade RK, Sharma PA, et al. (2012). Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: a comparative assessment. Saudi Pharm J 20:161–70.
   PubMed Web of Science ®Google Scholar
• Mahtab A, Anwar M, Mallick N, et al. (2016). Transungual delivery of ketoconazole nanoemulgel for the effective management of onychomycosis. AAPS PharmSciTech 17:1477–90.
   PubMed Web of Science ®Google Scholar
• Miranda-Cadena K, Marcos-Arias C, Mateo E, et al. (2018). Prevalence and antifungal susceptibility profiles of Candida glabrata, Candida parapsilosis and their close-related species in oral candidiasis. Arch Oral Biol 95:100–7.
   PubMed Web of Science ®Google Scholar
• Montone KT. (2014). Recent considerations in the classification and pathogenesis of fungal rhinosinusitis. In: pathobiology of human disease, a dynamic encyclopedia of disease mechanisms. Amsterdam, The Netherlands: Elsevier. pp. 1432–44.
   Google Scholar
• Montone KT. (2016). Pathology of fungal rhinosinusitis: a review. Head Neck Pathol 10:40–6.
   PubMed Web of Science ®Google Scholar
• Mutalik S, Udupa N. (2003). Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin. Pharmazie 58:891–4.
   PubMed Web of Science ®Google Scholar
• Patra JK, Das G, Fraceto LF, et al. (2018). Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology 16:71.
   PubMed Web of Science ®Google Scholar
• Qushawy M, Nasr A, Abd-Alhaseeb M, Swidan S. (2018). Design, optimization and characterization of a transfersomal gel using miconazole nitrate for the treatment of candida skin infections. Pharmaceutics 10:26.
   PubMed Web of Science ®Google Scholar
• Raju YP, Hyndavi N, Chowdary VH, et al. (2017). In vitro assessment of non-irritant microemulsified voriconazole hydrogel system. Artif Cells Nanomed Biotechnol 45:1539–47.
   PubMed Web of Science ®Google Scholar
• Rençber S, Karavana SY. (2018). Development and in vitro evaluation of voriconazole nanoparticle formulation for mucosal application. Turk J Pharm Sci 15:142–8.
   PubMed Web of Science ®Google Scholar
• Salem HF, El-Menshawe SF, Khallaf RA, Rabea YK. (2020). A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension, optimization using Box-Benkhen design, in vitro and in vivo characterization. Drug Deliv Transl Res 10:227–40.
   PubMed Web of Science ®Google Scholar
• Salem HF, Nafady MM, Ewees MGE, et al. (2021). Rosuvastatin calcium-based novel nanocubic vesicles capped with silver nanoparticles-loaded hydrogel for wound healing management: optimization employing Box-Behnken design, in vitro and in vivo assessment. J Liposome Res 11:1–17.
   Web of Science ®Google Scholar
• Scott LJ, Simpson D. (2007). Voriconazole : a review of its use in the management of invasive fungal infections. Drugs 67:269–98.
   PubMed Web of Science ®Google Scholar
• Singh NK, Lee DS. (2014). In situ gelling pH- and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery. J Control Release 193:214–27.
   PubMed Web of Science ®Google Scholar
• Singh RM, Kumar A, Pathak K. (2013). Thermally triggered mucoadhesive in situ gel of loratadine: β-cyclodextrin complex for nasal delivery. AAPS PharmSciTech 14:412–24.
   PubMed Web of Science ®Google Scholar
• Somani SM, Husain K, Whitworth C, et al. (2000). Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats, Antioxidant defense system. Pharmacol Toxicol 86:234–41.
   PubMedGoogle Scholar
• Srinivas P, Sreeja K. (2013). Formulation and evaluation of voriconazole loaded nanospongesfor oral and topical delivery. Int J Drug Dev Res 5:55–69.
   Google Scholar
• Zhang H, Chen X, He JJ. (2009). Pharmacological action of clove oil and its application in oral care products. Oral Care Industry 19:23–4.
   Google Scholar
• Zhu L, Ao J, Li P. (2015). A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation. Drug Des Devel Ther 29:3943–9.
   Google Scholar