Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis

References

• Batrakova EV, Kim MS. (2015). Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release 219:396–405.
   PubMed Web of Science ®Google Scholar
• Cao G, Meng X, Han X, Li J. (2020). Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-α-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. Biosci Rep 40:BSR20193436.
   PubMed Web of Science ®Google Scholar
• Carnero A, Blanco-Aparicio C, Renner O, et al. (2008). The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8:187–98.
   PubMed Web of Science ®Google Scholar
• Chen W, Quan Y, Fan S, et al. (2020). Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression. Cancer Lett 475:119–28.
   PubMed Web of Science ®Google Scholar
• Chen Y, Yuan B, Wu Z, et al. (2017). Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Gene 629:35–42.
   PubMed Web of Science ®Google Scholar
• Cooks T, Pateras IS, Jenkins LM, et al. (2018). Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. Nat Commun 9:771.
   PubMed Web of Science ®Google Scholar
• Duan X, Wang Y, He J, et al. (2017). [Progress of the application of stem cell therapy for end-stage liver disease]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 42:457–62.
   PubMedGoogle Scholar
• Gonzalez-Begne M, Lu B, Han X, et al. (2009). Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res 8:1304–14.
   PubMed Web of Science ®Google Scholar
• Hao LS, Zhang XL, An JY, et al. (2009). PTEN expression is down-regulated in liver tissues of rats with hepatic fibrosis induced by biliary stenosis. APMIS 117:681–91.
   PubMed Web of Science ®Google Scholar
• He L, Gubbins J, Peng Z, et al. (2016). Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair 9:8.
   PubMedGoogle Scholar
• Higashi T, Friedman SL, Hoshida Y. (2017). Hepatic stellate cells as key target in liver fibrosis. Adv Drug Deliv Rev 121:27–42.
   PubMed Web of Science ®Google Scholar
• Horwitz EM, Le Blanc K, Dominici M, et al. (2005). Clarification of the nomenclature for MSC: The International Society for Cellular Therapy Position Statement. Cytotherapy 7:393–5.
   PubMed Web of Science ®Google Scholar
• Hua X, Sun Y, Chen J, et al. (2019). Circular RNAs in drug resistant tumors. Biomed Pharmacother 118:109233.
   PubMed Web of Science ®Google Scholar
• Ji D, Chen GF, Wang JC, et al. (2020). Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3. Aging 12:1643–55.
   PubMedGoogle Scholar
• Kalani A, Tyagi A, Tyagi N. (2014). Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol 49:590–600.
   PubMed Web of Science ®Google Scholar
• Kalluri R, LeBleu VS. (2020). The biology, function, and biomedical applications of exosomes. Science 367:eaau6977.
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, et al. (2019). The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 20:675–91.
   PubMed Web of Science ®Google Scholar
• Li S, Song F, Lei X, et al. (2020). hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. Aging 12:11517–29.
   PubMedGoogle Scholar
• Liang H, Wang X, Si C, et al. (2020). Downregulation of miR‑141 deactivates hepatic stellate cells by targeting the PTEN/AKT/mTOR pathway. Int J Mol Med 46:406–14.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yang Y, Wang Z, et al. (2020). Insights into the regulatory role of circRNA in angiogenesis and clinical implications. Atherosclerosis 298:14–26.
   PubMed Web of Science ®Google Scholar
• Lodder J, Denaës T, Chobert MN, et al. (2015). Macrophage autophagy protects against liver fibrosis in mice. Autophagy 11:1280–92.
   PubMed Web of Science ®Google Scholar
• Lou G, Chen Z, Zheng M, Liu Y. (2017). Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases. Exp Mol Med 49:e346.
   PubMed Web of Science ®Google Scholar
• Ma PF, Gao CC, Yi J, et al. (2017). Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. J Hepatol 67:770–9.
   PubMed Web of Science ®Google Scholar
• Pedrosa M, Gomes J, Laranjeira P, et al. (2020). Immunomodulatory effect of human bone marrow-derived mesenchymal stromal/stem cells on peripheral blood T cells from rheumatoid arthritis patients. J Tissue Eng Regen Med 14:16–28.
   PubMed Web of Science ®Google Scholar
• Reif S, Lang A, Lindquist JN, et al. (2003). The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. J Biol Chem 278:8083–90.
   PubMed Web of Science ®Google Scholar
• Rong X, Liu J, Yao X, et al. (2019). Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem Cell Res Ther 10:98.
   PubMed Web of Science ®Google Scholar
• Samsonraj RM, Raghunath M, Nurcombe V, et al. (2017). Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine. Stem Cells Transl Med 6:2173–85.
   PubMed Web of Science ®Google Scholar
• Shi J, Zhao J, Zhang X, et al. (2017). Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients. Sci Rep 7:44544.
   PubMed Web of Science ®Google Scholar
• Teixeira FG, Carvalho MM, Sousa N, Salgado AJ. (2013). Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration? Cell Mol Life Sci 70:3871–82.
   PubMed Web of Science ®Google Scholar
• Tsuchida T, Friedman SL. (2017). Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol 14:397–411.
   PubMed Web of Science ®Google Scholar
• Vo JN, Cieslik M, Zhang Y, et al. (2019). The landscape of circular RNA in cancer. Cell 176:869–881.
   PubMed Web of Science ®Google Scholar
• Wang S, Zhan J, Lin X, et al. (2020). CircRNA-0077930 from hyperglycaemia-stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells. Cell Biochem Funct 38:1056–68.
   PubMed Web of Science ®Google Scholar
• Wang W, Dong R, Guo Y, et al. (2019). CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. J Cell Mol Med 23:5486–96.
   PubMed Web of Science ®Google Scholar
• Wu J, Qi X, Liu L, et al. (2019). Emerging epigenetic regulation of circular RNAs in human cancer. Mol Ther Nucleic Acids 16:589–96.
   PubMedGoogle Scholar
• Yang Y, Liu Y, Xue J, et al. (2017). MicroRNA-141 targets Sirt1 and inhibits autophagy to reduce HBV replication. Cell Physiol Biochem 41:310–22.
   PubMedGoogle Scholar
• Yang Y, Ye Y, Su X, et al. (2017). MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury. Front Cell Neurosci 11:55.
   PubMed Web of Science ®Google Scholar
• Yu J, Xu QG, Wang ZG, et al. (2018). Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol 68:1214–27.
   PubMed Web of Science ®Google Scholar
• Zhang CY, Yuan WG, He P, et al. (2016). Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets. World J Gastroenterol 22:10512–22.
   PubMed Web of Science ®Google Scholar
• Zhou R, Chen KK, Zhang J, et al. (2018). The decade of exosomal long RNA species: an emerging cancer antagonist. Mol Cancer 17:75.
   PubMed Web of Science ®Google Scholar