Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment

References

• Abd-Elrahman AA, El Nabarawi MA, Hassan DH, Taha AA. (2016). Ketoprofen mesoporous silica nanoparticles SBA-15 hard gelatin capsules: preparation and in vitro/in vivo characterization. Drug Deliv 23: 1582–98.
   Web of Science ®Google Scholar
• Albash R, El-Nabarawi MA, Refai H, Abdelbary AA. (2019). Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment. Int J Nanomedicine 14:6555–74.
   PubMed Web of Science ®Google Scholar
• Albash R, Elmahboub Y, Baraka K, et al. (2020). Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies. Drug Deliv 27: 1514–23.
   PubMed Web of Science ®Google Scholar
• Bharti C, Nagaich U, Kumar Pal A, Gulati N. (2015). Mesoporous silica nanoparticles in target drug delivery system: a review. Int J Pharm Investig 5:124–33. https://doi.org/10.4103/2230-973X.160844.
   PubMed Web of Science ®Google Scholar
• Budiman A. (2019). Characterization of drugs encapsulated into mesoporous silica. Int J App Pharm 11: 7–11.
   Google Scholar
• Chand YY, Pattnaik S, Swain K. (2019). Curcumin loaded mesoporous silica nanoparticles: assessment of bioavailability and cardioprotective effect. Drug Dev Ind Pharm 45: 1889–95.
   PubMed Web of Science ®Google Scholar
• Chaudhari SP, Gupte A. (2017). Mesoporous silica as a carrier for amorphous solid dispersion. BJPR 16: 1–19.
   Web of Science ®Google Scholar
• El-Nabarawi MA, Khalil IA, Saad RM. (2016). Impact of hydrophilic polymer solubilization on bioavailability enhancement of repaglinide by solid dispersion. Inventi Rapid: Pharm Tech 2016: 1–12.
   Google Scholar
• El-Sisi AE, El-Sayad ME, Abdelsalam NM. (2017). Protective effects of mirtazapine and chrysin on experimentally induced testicular damage in rats. Biomed Pharmacother 95: 1059–66.
   PubMed Web of Science ®Google Scholar
• Ezealisiji KE, Mbah CJ, Osadebe PO. (2015). Aqueous solubility enhancement of mirtazapine: effect of cosolvent and surfactant. Pharmacol Pharmacy 06: 471–6.
   Google Scholar
• Ezealisiji KM, Mbah CJ, Osadebe P, Krause R. (2017). Pharmacokinetics studies of mirtazapine loaded nanoemulsion and its evaluation as transdermal delivery system. J Chem Pharmaceutical Res 9: 74–84.
   Google Scholar
• Fiani E, Vierling M, Molie M. (2015). Comptes rendus chimie synthesis of CuO/SBA-15 adsorbents for SO x removal applications, using different impregnation methods ` Se d ’ Adsorbants CuO/SBA-15 Par Diffe ’. Rentes Me. 18:1013–29.
   Google Scholar
• Gonçalves MC. (2018). Sol-gel silica nanoparticles in medicine: a natural choice. design, synthesis and products. Molecules 23: 2021–6.
   PubMed Web of Science ®Google Scholar
• Hamed HE, Hussein AA. (2020). Preparation, in vitro and ex-vivo evaluation of mirtazapine nanosuspension and nanoparticles incorporated in orodispersible tablets. IJPS 29: 62–75.
   Google Scholar
• Huang X, Young NP, Townley HE. (2014). Characterization and comparison of mesoporous silica particles for optimized drug delivery. Nanomater Nanotechnol 4: 2–15.
   Web of Science ®Google Scholar
• Huang Y, Zhao X, Zu Y, et al. (2019). Enhanced solubility and bioavailability of apigenin via preparation of solid dispersions of mesoporous silica nanoparticles. Iran J Pharm Res 18: 168–82. https://doi.org/10.22037/ijpr.2019.2347.
   PubMed Web of Science ®Google Scholar
• Ibrahim TM, Eissa RG, El-Megrab NA, El-Nahas HM. (2021). Morphological characterization of optimized risperidone-loaded in-situ gel forming implants with pharmacokinetic and behavioral assessments in rats. J Drug Delivery Sci Technol 61:102195.
   Web of Science ®Google Scholar
• Ibrahim TM, El-Megrab NA, El-Nahas HM. (2020). Optimization of injectable PLGA in-situ forming implants of anti-psychotic risperidone via box-behnken design. J Drug Delivery Sci Technol 58:101803.
   Web of Science ®Google Scholar
• Jambhrunkar S, Qu Z, Popat A, et al. (2014). Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. J Colloid Interface Sci 434:218–25.
   PubMed Web of Science ®Google Scholar
• Kankala RK, Ya Hui Han J, Na Chia Hung Lee Z et al. (2020). Nanoarchitectured structure and surface biofunctionality of mesoporous silica nanoparticles. Adv Mater 32: 1907035–27.
   PubMed Web of Science ®Google Scholar
• Kankala RK, Zhang H, Liu CG, et al. (2019). Metal species–encapsulated mesoporous silica nanoparticles: current advancements and latest breakthroughs. Adv Funct Mater 29: 1902652–42.
   Web of Science ®Google Scholar
• Kim MK, Ki DH, Na YG, et al. (2021). Optimization of mesoporous silica nanoparticles through statistical design of experiment and the application for the anticancer drug. Pharmaceutics 13:184.
   PubMed Web of Science ®Google Scholar
• Kokunešoski M, Gulicovski J, Matović B, et al. (2010). Synthesis and surface characterization of ordered mesoporous silica SBA-15. Mater Chem Phys 124: 1248–52.
   Web of Science ®Google Scholar
• Lai J, Lin W, Scholes P, Li M. (2017). Investigating the effects of loading factors on the in vitro pharmaceutical performance of mesoporous materials as drug carriers for ibuprofen. Materials 10:150.
   PubMed Web of Science ®Google Scholar
• Le T-t, Khaliq A, Elyafi E, et al. 2019. Delivery of poorly soluble drugs via mesoporous silica: impact of drug overloading on release and thermal profiles. Pharmaceutics. 11:269.
   Google Scholar
• Lehto VP, and Riikonen J. (2014). “14 - Drug Loading and Characterization of Porous Silicon Materials”. In: Hélder A. Santos, editor. Porous Silicon for Biomedical Applications. Amsterdam: Woodhead Publishing, 337–355.
   Google Scholar
• Li T, Geng T, Md A, et al. (2019). Novel Scheme for Rapid Synthesis of Hollow Mesoporous Silica Nanoparticles (HMSNs) and their application as an efficient delivery carrier for oral bioavailability improvement of poorly water-soluble BCS Type II drugs. Colloids Surf B Biointerfaces 176:185–93.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang Y, Feng N. (2019). Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery. Expert Opin Drug Deliv 16: 219–37.
   PubMed Web of Science ®Google Scholar
• Madan JR, Patil S, Mathure D, et al. (2018). Improving dissolution profile of poorly water-soluble drug u s i n g non-ordered mesoporous silica. Marmara Pharmaceutical Journal 22: 249–58. https://doi.org/10.12991/mpj.2018.62.
   Google Scholar
• Maleki A, Kettiger H, Schoubben A, et al. (2017). Mesoporous silica materials: From physico-chemical properties to enhanced dissolution of poorly water-soluble drugs. J Control Release 262:329–47.
   PubMed Web of Science ®Google Scholar
• Mccarthy CA, RJ, Ahern R, Dontireddy KB, Ryan, et al. 2016. Mesoporous silica formulation strategies for drug dissolution enhancement: a review mesoporous silica formulation strategies for drug dissolution enhancement: a review. Expert Opin Drug Deliv 13: 93–108.
   PubMed Web of Science ®Google Scholar
• National Research Council. 2011. Guide laboratory animals for the care and use of laboratory animals. 8th ed. NW Washington (DC): The National Academies Press, 246.
   Google Scholar
• Palanikumar L, Choi ES, Cheon JY, et al. (2015). Noncovalent polymer-gatekeeper in mesoporous silica nanoparticles as a targeted drug delivery platform. Adv Funct Mater 25: 957–65.
   Web of Science ®Google Scholar
• Pande VV, Jadhav KS, Giri MA, et al. (2019). Design and development of paliperidone mesoporous silica template as a platform for surge dose drug delivery system. Mater Technol 34: 117–25.
   Web of Science ®Google Scholar
• Paper R, Huang X, Young NP, Townley HE. (2014). Characterization and comparison of mesoporous silica particles for optimized drug delivery regular paper. Nanomater Nanotechnol 4:2–15.
   Web of Science ®Google Scholar
• Patel J, Kevin G, Patel A, et al. (2011). Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery. Int J Pharm Investig 1: 112–8.
   PubMedGoogle Scholar
• Patel RB, Patel MR, Mehta JB. (2017). Validation of stability indicating high performance liquid chromatographic method for estimation of desloratadine in tablet formulation. Arabian J Chem 10:S644–S50.
   Web of Science ®Google Scholar
• Nemeroff CB, Schatzberg AF, Rasgon N, Strakowski SM. The American Psychiatric Association Publishing textbook of mood disorders. Washington, DC: American Psychiatric Association Publishing; 2022.
   Google Scholar
• Ren X, Cheng S, Liang Y, et al. (2020). Mesoporous silica nanospheres as nanocarriers for poorly soluble drug itraconazole with high loading capacity and enhanced bioavailability. MicroporousMesoporous Mater 305:110389–8.
   Web of Science ®Google Scholar
• Rouini MR, Lavasani H, Sheikholeslami B, et al. (2014). Pharmacokinetics of mirtazapine and its main metabolites after single intravenous and oral administrations in rats at two dose rates. Daru 22:13. https://doi.org/10.1186/2008-2231-22-13.
   PubMed Web of Science ®Google Scholar
• Salazar-Juárez A, Barbosa-Méndez S, Merino-Reyes P, et al. (2017). Chronic dosing with mirtazapine does not produce sedation in rats. Braz J Psychiatry 39: 228–36.
   PubMed Web of Science ®Google Scholar
• Seljak KB, Kocbek P, Gašperlin M. (2020). Mesoporous silica nanoparticles as delivery carriers: an overview of drug loading techniques. J Drug Delivery Sci Technol 59:101906.
   Web of Science ®Google Scholar
• Soares AP. (2013). Development of mesoporous silica nanoparticles of ritonavir with enhanced bioavailability potential: formulation optimization, in-vitro and in-vivo evaluation.. J Chem Inf Model 53: 1689–99.
   PubMed Web of Science ®Google Scholar
• Trzeciak K, A, Chotera-ouda II, Bak-sypien MJ. Potrzebowski   2021. Mesoporous silica particles as drug delivery systems — the state of the art in loading methods and the recent progress in analytical techniques for monitoring these processes. Pharmaceutics. 13:950.
   PubMed Web of Science ®Google Scholar
• Varshosaz J, Dayani L, Chegini SP, Minaiyan M. (2019). Production of a new platform based on fumed and mesoporous silica nanoparticles for enhanced solubility and oral bioavailability of raloxifene HCl. IET Nanobiotechnol 13: 392–9.
   PubMed Web of Science ®Google Scholar
• Venugopal V, Kumar KJ, Muralidharan S, et al. (2016). OpenNano optimization and in-vivo evaluation of isradipine nanoparticles using box-behnken design surface response methodology. OpenNano 1:1–15.
   Google Scholar
• Wang Z, Chen B, Quan G, et al. (2012). Increasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica. Inter J Nanomed 7:5807–18.
   PubMed Web of Science ®Google Scholar
• WHO. 2021. Depression. https://www.who.int/news-room/fact-sheets/detail/depression.
   Google Scholar
• Zhai QZ. (2020). Study on SBA-15 as an effective sorbent for dye butyl rhodamine B. J Sol-Gel Sci Technol 96: 34–46.
   Web of Science ®Google Scholar
• Zhang W, Zheng N, Chen L, et al. (2018). Effect of Shape on mesoporous silica nanoparticles for oral delivery of indomethacin. Pharmaceutics 11:4.
   PubMed Web of Science ®Google Scholar