Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy

References

• Albanese A, Tang P, Chan W. (2012). The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 14:1–16.
   PubMed Web of Science ®Google Scholar
• Cha B, Jeong J, Kim J. (2018). Extra-large pore mesoporous silica nanoparticles enabling co-delivery of high amounts of protein antigen and toll-like receptor 9 agonist for enhanced cancer vaccine efficacy. ACS Cent Sci 4:484–92.
   PubMed Web of Science ®Google Scholar
• Chang CC, Dinh TK, Lee YA, et al. (2020). Nanoparticle delivery of MnO2 and antiangiogenic therapy to overcome hypoxia-driven tumor escape and suppress hepatocellular carcinoma. ACS Appl Mater Interfaces 12:44407–19.
   PubMed Web of Science ®Google Scholar
• Chao Y, Chen G, Liang C, et al. (2019). Iron nanoparticles for low-power local magnetic hyperthermia in combination with immune checkpoint blockade for systemic antitumor therapy. Nano Lett 19:4287–96.
   PubMed Web of Science ®Google Scholar
• Chen S, Weitemier AZ, Zeng X, et al. (2018). Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science 359:679–84.
   PubMed Web of Science ®Google Scholar
• Chen Y, Xu L, Tang T, et al. (2020). STING activator c-di-GMP-loaded mesoporous silica nanoparticles enhance immunotherapy against breast cancer. ACS Appl Mater Interfaces 12:56741–52.
   PubMed Web of Science ®Google Scholar
• Cheng W, Nie J, Gao N, et al. (2017). A multifunctional nanoplatform against multidrug resistant cancer: merging the best of targeted chemo/gene/photothermal therapy. Adv Funct Mater 27:1704135.
   Web of Science ®Google Scholar
• Cheung AS, Zhang DKY, Koshy ST, Mooney DJ. (2018). Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells. Nat Biotechnol 36:160–9.
   PubMed Web of Science ®Google Scholar
• Chou N, Cheng C, Wu H, et al. (2012). Chlorella sorokiniana-induced activation and maturation of human monocyte-derived dendritic cells through NF-κB and PI3K/MAPK pathways. Evid Based Complement Alternat Med 2012:735396.
   PubMed Web of Science ®Google Scholar
• Dai B, Wang J, Xiong Z, et al. (2016). Programmable artificial phototactic microswimmer. Nat Nanotechnol 11:1087–92.
   PubMed Web of Science ®Google Scholar
• Ding B, Shao S, Yu C, et al. (2018). Large-pore mesoporous-silica-coated upconversion nanoparticles as multifunctional immunoadjuvants with ultrahigh photosensitizer and antigen loading efficiency for improved cancer photodynamic immunotherapy. Adv Mater 30:e1802479.
   PubMed Web of Science ®Google Scholar
• Dong Y, Gao J, Pei M, et al. (2020). Antigen-conjugated silica solid sphere as nanovaccine for cancer immunotherapy. Int J Nanomed 15:2685–97.
   PubMed Web of Science ®Google Scholar
• Dou Z, Ghosh K, Vizioli MG, et al. (2017). Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550:402–6.
   PubMed Web of Science ®Google Scholar
• Fan Y, Moon JJ. (2015). Nanoparticle drug delivery systems designed to improve cancer vaccines and immunotherapy. Vaccines (Basel) 3:662–85.
   PubMed Web of Science ®Google Scholar
• Gaidzik N, Westerlind U, Kunz H. (2013). The development of synthetic antitumour vaccines from mucin glycopeptide antigens. Chem Soc Rev 42:4421–42.
   PubMed Web of Science ®Google Scholar
• Ge R, Liu C, Zhang X, et al. (2018). Photothermal-activatable Fe3O4 superparticle nanodrug carriers with PD-L1 immune checkpoint blockade for anti-metastatic cancer immunotherapy. ACS Appl Mater Interfaces 10:20342–55.
   PubMed Web of Science ®Google Scholar
• Godfrey D, Kronenberg M. (2004). Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 114:1379–88.
   PubMed Web of Science ®Google Scholar
• Gong N, Sheppard N, Billingsley M, et al. (2021). Nanomaterials for T-cell cancer immunotherapy. Nat Nanotechnol 16:25–36.
   PubMed Web of Science ®Google Scholar
• Gupta AK, Gupta M. (2005). Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–4021.
   PubMed Web of Science ®Google Scholar
• Han R, Liu Q, Lu Y, et al. (2022). Tumor microenvironment-responsive Ag2S-PAsp(DOX)-cRGD nanoparticles-mediated photochemotherapy enhances the immune response to tumor therapy. Biomaterials 281:121328.
   PubMed Web of Science ®Google Scholar
• Hao Y, Zheng C, Wang L, et al. (2017). Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging. Acta Biomater 62:293–305.
   PubMed Web of Science ®Google Scholar
• Hashemi V, Farhadi S, Ghasemi Chaleshtari M, et al. (2020). Nanomedicine for improvement of dendritic cell-based cancer immunotherapy. Int Immunopharmacol 83:106446.
   PubMed Web of Science ®Google Scholar
• Heath W, Carbone F. (2001). Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 19:47–64.
   PubMed Web of Science ®Google Scholar
• Heße C, Kollenda S, Rotan O, et al. (2019). A tumor-peptide-based nanoparticle vaccine elicits efficient tumor growth control in antitumor immunotherapy. Mol Cancer Ther 18:1069–80.
   PubMed Web of Science ®Google Scholar
• Hobernik D, Bros M. (2018). DNA vaccines-how far from clinical use? IJMS 19:3605.
   Web of Science ®Google Scholar
• Hong X, Zhong X, Du G, et al. (2020). The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency. Sci Adv 6:eaaz4462.
   PubMed Web of Science ®Google Scholar
• Hou L, Tian C, Yan Y, et al. (2020). Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity. ACS Nano 14:3927–40.
   PubMed Web of Science ®Google Scholar
• Hu Y, Lin L, Chen J, et al. (2020). Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger. Biomaterials 252:120114.
   PubMed Web of Science ®Google Scholar
• Huang C, Zhang L, Guo Q, et al. (2021). Robust nanovaccine based on polydopamine-coated mesoporous silica nanoparticles for effective photothermal-immunotherapy against melanoma. Adv Funct Mater 31:2010637. doi:.
   Web of Science ®Google Scholar
• Huang F, Zhao J, Wei Y, et al. (2020). Anti-tumor efficacy of an adjuvant built-in nanovaccine based on ubiquitinated proteins from tumor cells. Int J Nanomedicine 15:1021–35.
   PubMed Web of Science ®Google Scholar
• Im S, Lee J, Park D, et al. (2019). Hypoxia-triggered transforming immunomodulator for cancer immunotherapy via photodynamically enhanced antigen presentation of dendritic cell. ACS Nano 13:476–88.
   PubMed Web of Science ®Google Scholar
• Kalbasi A, Ribas A. (2020). Tumour-intrinsic resistance to immune checkpoint blockade. Nat Rev Immunol 20:25–39.
   PubMed Web of Science ®Google Scholar
• Kong M, Tang J, Qiao Q, et al. (2017). Biodegradable hollow mesoporous silica nanoparticles for regulating tumor microenvironment and enhancing antitumor efficiency. Theranostics 7:3276–92.
   PubMed Web of Science ®Google Scholar
• Kuboyabu T, Yabata I, Aoki M, et al. editors. Fundamentals and advances in magnetic hyperthermia. In: International Workshop on Magnetic Particle Imaging; 2016.
   Google Scholar
• Kuntz K, Wells R, Hu J, et al. (2017). Control of surface and edge oxidation on phosphorene. ACS Appl Mater Interfaces 9:9126–35.
   PubMed Web of Science ®Google Scholar
• Lee J, Kim M, Nguyen T, Kim J. (2020). Hollow mesoporous silica nanoparticles with extra-large mesopores for enhanced cancer vaccine. ACS Appl Mater Interfaces 12:34658–66.
   PubMed Web of Science ®Google Scholar
• Li Q, Shi Z, Zhang F, et al. (2022). Symphony of nanomaterials and immunotherapy based on the cancer-immunity cycle. Acta Pharm Sin B 12:107–34.
   PubMed Web of Science ®Google Scholar
• Li S, Jiang Q, Liu S, et al. (2018). A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nat Biotechnol 36:258–64.
   PubMed Web of Science ®Google Scholar
• Li Y, Kurlander RJ. (2010). Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation. J Transl Med 8:104.
   PubMed Web of Science ®Google Scholar
• Liang Q, Bie N, Yong T, et al. (2019). The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nat Biomed Eng 3:729–40.
   PubMed Web of Science ®Google Scholar
• Liang X, Ye X, Wang C, et al. (2019). Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation. J Control Release 296:150–61.
   PubMed Web of Science ®Google Scholar
• Liu X, Yan B, Li Y, et al. (2020). Graphene oxide-grafted magnetic nanorings mediated magnetothermodynamic therapy favoring reactive oxygen species-related immune response for enhanced antitumor efficacy. ACS Nano 14:1936–50.
   PubMed Web of Science ®Google Scholar
• Liu X, Zheng J, Sun W, et al. (2019). Ferrimagnetic vortex nanoring-mediated mild magnetic hyperthermia imparts potent immunological effect for treating cancer metastasis. ACS Nano 13:8811–25.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Z, Yu F, et al. (2021). The adjuvant of α-galactosylceramide presented by gold nanoparticles enhances antitumor immune responses of MUC1 antigen-based tumor vaccines. Int J Nanomed 16:403–20.
   PubMed Web of Science ®Google Scholar
• Löb S, Königsrainer A, Rammensee HG, et al. (2009). Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Nat Rev Cancer 9:445–52.
   PubMed Web of Science ®Google Scholar
• Lu J, Liu X, Liao Y, et al. (2017). Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun 8:1811.
   PubMed Web of Science ®Google Scholar
• Luo L, Zhu C, Yin H, et al. (2018). Laser immunotherapy in combination with perdurable PD-1 blocking for the treatment of metastatic tumors. ACS Nano 12:7647–62.
   PubMed Web of Science ®Google Scholar
• Méndez-Blanco C, Fondevila F, García-Palomo A, et al. (2018). Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors. Exp Mol Med 50:1–9.
   PubMed Web of Science ®Google Scholar
• Nguyen T, Cha B, Choi Y, et al. (2020). Injectable dual-scale mesoporous silica cancer vaccine enabling efficient delivery of antigen/adjuvant-loaded nanoparticles to dendritic cells recruited in local macroporous scaffold. Biomaterials 239:119859.
   PubMed Web of Science ®Google Scholar
• Nguyen T, Choi Y, Kim J. (2019). Mesoporous silica as a versatile platform for cancer immunotherapy. Adv Mater 31:e1803953.
   PubMed Web of Science ®Google Scholar
• Ojha T, Pathak V, Shi Y, et al. (2017). Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors. Adv Drug Deliv Rev 119:44–60.
   PubMed Web of Science ®Google Scholar
• Ou M, Lin C, Wang Y, et al. (2022). Heterojunction engineered bioactive chlorella for cascade promoted cancer therapy. J Control Release 345:755–69.
   PubMed Web of Science ®Google Scholar
• Pan J, Hu P, Guo Y, et al. (2020). Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments. ACS Nano 14:1033–44.
   PubMed Web of Science ®Google Scholar
• Pan J, Xu Y, Wu Q, et al. (2021). Mild magnetic hyperthermia-activated innate immunity for liver cancer therapy. J Am Chem Soc 143:8116–28.
   PubMed Web of Science ®Google Scholar
• Peng S, Xiao F, Chen M, Gao H. (2022). Tumor-microenvironment-responsive nanomedicine for enhanced cancer immunotherapy. Adv Sci (Weinh) 9:e2103836.
   PubMedGoogle Scholar
• Portilla Y, Mellid S, Paradela A, et al. (2021). Iron oxide nanoparticle coatings dictate cell outcomes despite the influence of protein coronas. ACS Appl Mater Interfaces 13:7924–44.
   PubMed Web of Science ®Google Scholar
• Portilla Y, Mulens-Arias V, Paradela A, et al. (2022). The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type. Biomaterials 281:121365.
   PubMed Web of Science ®Google Scholar
• Qin L, Zhang H, Zhou Y, et al. (2021). Nanovaccine-based strategies to overcome challenges in the whole vaccination cascade for tumor immunotherapy. Small 17:e2006000.
   PubMed Web of Science ®Google Scholar
• Rabinovich G, Gabrilovich D, Sotomayor E. (2007). Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267–96.
   PubMed Web of Science ®Google Scholar
• Rosenberg S, Restifo N. (2015). Adoptive cell transfer as personalized immunotherapy for human cancer. Science 348:62–8.
   PubMed Web of Science ®Google Scholar
• Ruan S, Xie R, Qin L, et al. (2019). Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment. Nano Lett 19:8318–32.
   PubMed Web of Science ®Google Scholar
• Sangro B, Sarobe P, Hervás-Stubbs S, Melero I. (2021). Advances in immunotherapy for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 18:525–43.
   PubMed Web of Science ®Google Scholar
• Sanz-Ortega L, Portilla Y, Pérez-Yagüe S, Barber D. (2019). Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes . J Nanobiotechnology 17:87.
   PubMed Web of Science ®Google Scholar
• Saxena M, van der Burg S, Melief C, Bhardwaj N. (2021). Therapeutic cancer vaccines. Nat Rev Cancer 21:360–78.
   PubMed Web of Science ®Google Scholar
• Scott SA, Selvy PE, Buck JR, et al. (2009). Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5:108–17.
   PubMed Web of Science ®Google Scholar
• Shi Z, Zhou Y, Fan T, et al. (2020). Inorganic nano-carriers based smart drug delivery systems for tumor therapy. Smart Mater Med 1:32–47.
   Google Scholar
• Siegel R, Miller K, Jemal A. (2019). Cancer statistics, 2019. CA A Cancer J Clin 69:7–34.
   PubMed Web of Science ®Google Scholar
• Sullivan RJ, Hamid O, Gonzalez R, et al. (2019). Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients. Nat Med 25:929–7.
   PubMed Web of Science ®Google Scholar
• Sun Q, Zhou Z, Qiu N, Shen Y. (2017). Rational design of cancer nanomedicine: nanoproperty integration and synchronization. Adv Mater 29:1606628.
   Web of Science ®Google Scholar
• Tang H, Xu X, Chen Y, et al. (2021). Reprogramming the tumor microenvironment through second-near-infrared-window photothermal genome editing of PD-L1 mediated by supramolecular gold nanorods for enhanced cancer immunotherapy. Adv Mater 33:e2006003.
   PubMed Web of Science ®Google Scholar
• Tyznik A, Tupin E, Nagarajan N, et al. (2008). Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol 181:4452–6.
   PubMed Web of Science ®Google Scholar
• Vela D. (2018). Iron metabolism in prostate cancer; from basic science to new therapeutic strategies. Front Oncol 8:547.
   PubMed Web of Science ®Google Scholar
• Wang C, Guan Y, Lv M, et al. (2018). Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses. Immunity 48:675–87.e7.
   PubMed Web of Science ®Google Scholar
• Wang C, Piao J, Li Y, et al. (2020). Construction of liposomes mimicking cell membrane structure through frame-guided assembly. Angew Chem Int Ed Engl 59:15176–80.
   PubMed Web of Science ®Google Scholar
• Wang C, Wang J, Zhang X, et al. (2018). In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy. Sci Transl Med 10:eaan3682.
   PubMed Web of Science ®Google Scholar
• Wang J, Chen H, Hang T, et al. (2018). Physical activation of innate immunity by spiky particles. Nat Nanotechnol 13:1078–86.
   PubMed Web of Science ®Google Scholar
• Wang S, Sun Z, Hou Y. (2021). Engineering nanoparticles toward the modulation of emerging cancer immunotherapy. Adv Healthc Mater 10:e2000845.
   PubMed Web of Science ®Google Scholar
• Wang X, Ihara S, Li X, et al. (2019). Rod-scale design strategies for immune-targeted delivery system toward cancer immunotherapy. ACS Nano 13:7705–15.
   PubMed Web of Science ®Google Scholar
• Wang X, Li X, Ito A, et al. (2017). Biodegradable metal ion-doped mesoporous silica nanospheres stimulate anticancer Th1 immune response in vivo. ACS Appl Mater Interfaces 9:43538–44.
   PubMed Web of Science ®Google Scholar
• Wang X, Li X, Ito A, et al. (2018). Synergistic effects of stellated fibrous mesoporous silica and synthetic dsRNA analogues for cancer immunotherapy. Chem Commun (Camb) 54:1057–60.
   PubMed Web of Science ®Google Scholar
• Wang Y, Xie Y, Li J, et al. (2019). Correction to tumor-penetrating nanoparticles for enhanced anticancer activity of combined photodynamic and hypoxia-activated therapy. ACS Nano 13:4855.
   PubMed Web of Science ®Google Scholar
• Wölfl M, Greenberg PD. (2014). Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells. Nat Protoc 9:950–66.
   PubMed Web of Science ®Google Scholar
• Xu J, Yang P, Sun M, et al. (2017). Highly emissive dye-sensitized upconversion nanostructure for dual-photosensitizer photodynamic therapy and bioimaging. Acs Nano 11:4133–44.
   PubMed Web of Science ®Google Scholar
• Yang Q, Shi G, Chen X, et al. (2020). Nanomicelle protects the immune activation effects of paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy. Theranostics 10:8382–99.
   PubMed Web of Science ®Google Scholar
• Ye X, Liang X, Chen Q, et al. (2019). Surgical tumor-derived personalized photothermal vaccine formulation for cancer immunotherapy. ACS Nano 13:2956–68.
   PubMed Web of Science ®Google Scholar
• Yu W, He X, Yang Z, et al. (2019). Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis. Biomaterials 217:119309.
   PubMed Web of Science ®Google Scholar
• Zeng X, Luo M, Liu G, et al. (2018). Polydopamine-modified black phosphorous nanocapsule with enhanced stability and photothermal performance for tumor multimodal treatments. Adv Sci (Weinh) 5:1800510.
   PubMedGoogle Scholar
• Zhang F, Lu G, Wen X, et al. (2020). Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy. J Controlled Release 326:131–9.
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang F, Hu C, et al. (2020). The progress and perspective of nanoparticle-enabled tumor metastasis treatment. Acta Pharm Sin B 10:2037–53.
   PubMed Web of Science ®Google Scholar
• Zhao X, Guo K, Zhang K, et al. (2022). Orchestrated yolk-shell nanohybrids regulate macrophage polarization and dendritic cell maturation for oncotherapy with augmented antitumor immunity. Adv Mater 34:e2108263.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Wang H, Huang H, et al. (2016). Surface coordination of black phosphorus for robust air and water stability. Angew Chem Int Ed Engl 55:5003–7.
   PubMed Web of Science ®Google Scholar