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Research Articles

Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments

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Pages 2428-2441 | Received 20 Jun 2022, Accepted 11 Jul 2022, Published online: 26 Jul 2022

References

  • Abdelbari MA, El-Mancy SS, Elshafeey AH, Abdelbary AA. (2021). Implementing Spanlastics for Improving the Ocular Delivery of Clotrimazole: In vitro characterization, ex vivo permeability, microbiological assessment and in vivo safety study. Int J Nanomedicine 16:6249–61.
  • Abdelbary AA, Abd-Elsalam WH, Al-Mahallawi AM. (2016). Fabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: In vitro characterization, ex vivo permeation and in vivo safety assessment. Int J Pharm 513:688–96.
  • Abdelbary AA, AbouGhaly MH. (2015). Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box-Behnken design, in-vitro evaluation and in-vivo skin deposition study. Int J Pharm 485:235–43.
  • Abdelbary G, Fahmy RH. (2009). Diazepam-loaded solid lipid nanoparticles: design and characterization. AAPS PharmSciTech 10:211–9.
  • Abdelbary GA, Aburahma MH. (2015). Oro-dental mucoadhesive proniosomal gel formulation loaded with lornoxicam for management of dental pain. J Liposome Res 25:107–21.
  • Abdelbary GA, Amin MM, Abdelmoteleb M. (2016). Novel mixed hydrotropic solubilization of Zaleplon: Formulation of oral tablets and in-vivo neuropharmacological characterization by monitoring plasma GABA level. J Drug Delivery Sci Technol 33:98–113.
  • Abdelbary GA, Amin MM, Zakaria MY. (2017). Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies. Drug Deliv 24:309–19.
  • Abd-Elsalam WH, ElKasabgy NA. (2019). Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension. Int J Pharm 560:235–45.
  • Abd-Elsalam WH, Ibrahim RR. (2021). Span 80/TPGS modified lipid-coated chitosan nanocomplexes of acyclovir as a topical delivery system for viral skin infections. Int J Pharm 609:121214.
  • Ahmad I, Pandit J, Sultana Y, et al. (2019). Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: Characterization, pharmacokinetic and deposition study. Mater Sci Eng C Mater Biol Appl 100:959–70.
  • Ahmed S, Kassem MA, Sayed S. (2020). Bilosomes as promising nanovesicular carriers for improved transdermal delivery: Construction, in vitro optimization, ex vivo permeation and in vivo evaluation. Int J Nanomedicine 15:9783–98.
  • Ahmed S, Kassem MA, Sayed S. (2021). Co-polymer mixed micelles enhanced transdermal transport of Lornoxicam: in vitro characterization, and in vivo assessment of anti-inflammatory effect and antinociceptive activity. J Drug Delivery Sci Technol 62:102365.
  • Albash R, Al-Mahallawi AM, Hassan M, Alaa-Eldin AA. (2021). Development and optimization of terpene-enriched vesicles (terpesomes) for effective ocular delivery of fenticonazole nitrate: In vitro characterization and in vivo assessment. Int J Nanomedicine 16:609–21.
  • Albash R, Elmahboub Y, Baraka K, et al. (2020). Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative ex vivo and in vivo studies. Drug Deliv 27:1514–23.
  • Albash R, El-Nabarawi MA, Refai H, Abdelbary AA. (2019). Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment. Int J Nanomedicine 14:6555–74.
  • Albash R, Yousry C, Al-Mahallawi AM, Alaa-Eldin AA. (2021). Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment. Drug Deliv 28:1–9.
  • Al-Mahallawi AM, Khowessah OM, Shoukri RA. (2014). Nano-transfersomal ciprofloxacin loaded vesicles for non-invasive trans-tympanic ototopical delivery: in-vitro optimization, ex-vivo permeation studies, and in-vivo assessment. Int J Pharm 472:304–14.
  • Al-Mahallawi AM, Khowessah OM, Shoukri RA. (2017). Enhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: Fabrication, in-vitro characterization, and comparative ex-vivo permeation studies. Int J Pharm 522:157–64.
  • Basha M, Abd El-Alim SH, Shamma RN, Awad GE. (2013). Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole. J Liposome Res 23:203–10.
  • Campos R, Bittencourt SF, Rojas-Moscoso JA, et al. (2018). The rabbit vagina as an in vivo model for vaginal fenticonazole permeability and toxicity. J Pharmacol Toxicol Methods 94:14–8.
  • Castro G, Roca M, Rodríguez I, et al. (2016). Identification and determination of chlorinated azoles in sludge using liquid chromatography quadrupole time-of-flight and triple quadrupole mass spectrometry platforms. J Chromatogr A 1476:69–76.
  • Chambers MA, Wright DC, Brisker J, et al. (2004). A single dose of killed Mycobacterium bovis BCG in a novel class of adjuvant (Novasome) protects guinea pigs from lethal tuberculosis. Vaccine 22:1063–71.
  • Dai Y, Zhou R, Liu L, et al. (2013). Liposomes containing bile salts as novel ocular delivery systems for tacrolimus (FK506): in vitro characterization and improved corneal permeation. Int J Nanomedicine 8:1921–33.
  • Diaz DA, Colgan ST, Langer CS, et al. (2016). Dissolution similarity requirements: How similar or dissimilar are the global regulatory expectations? AAPS J 18:15–22.
  • El-Laithy HM, Shoukry O, Mahran LG. (2011). Novel sugar esters proniosomes for transdermal delivery of vinpocetine: preclinical and clinical studies. Eur J Pharm Biopharm 77:43–55.
  • Elsayed I, Sayed S. (2017). Tailored nanostructured platforms for boosting transcorneal permeation: Box-Behnken statistical optimization, comprehensive in vitro, ex vivo and in vivo characterization. Int J Nanomedicine 12:7947–62.
  • Emad Eldeeb A, Salah S, Ghorab M. (2019). Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in-vivo pharmacodynamic study. J Drug Delivery Sci Technol 52:236–47.
  • Emad Eldeeb A, Salah S, Ghorab M. (2019). Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study. Drug Deliv 26:509–21.
  • Fahmy AM, Hassan M, El-Setouhy DA, et al. (2021). Voriconazole ternary micellar systems for the treatment of ocular mycosis: Statistical optimization and in vivo evaluation. J Pharm Sci 110:2130–8.
  • Gaudana R, Ananthula HK, Parenky A, Mitra AK. (2010). Ocular drug delivery. AAPS J 12:348–60.
  • Gregoriadis G. (1995). Engineering liposomes for drug delivery: progress and problems. Trends Biotechnol 13:527–37.
  • Gupta U, Singh V, Kumar V, Khajuria Y. (2014). Spectroscopic studies of cholesterol: Fourier transform infra-red and vibrational frequency analysis. Material Focus 3:1–7.
  • HariPrasad D T, Reddy RM, Maheswari CU, Reddy E. (2020). Effect of iron scrap additives in stearic acid as PCM for thermal energy storage system. J Therm Anal Calorim 141:2497–510.
  • Harisa GI, Badran MM. (2015). Simvastatin nanolipid carriers decreased hypercholesterolemia induced cholesterol inclusion and phosphatidylserine exposure on human erythrocytes. J Mol Liq 208:202–10.
  • Hathout RM, Mansour S, Mortada ND, Guinedi AS. (2007). Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies. AAPS PharmSciTech 8:1.
  • Huang J, Peng T, Li Y, et al. (2017). Ocular cubosome drug delivery system for timolol maleate: Preparation, characterization, cytotoxicity, ex vivo, and in vivo evaluation. AAPS PharmSciTech 18:2919–26.
  • Humphries RM, Ambler J, Mitchell SL, et al. (2018). CLSI methods development and standardization working group best practices for evaluation of antimicrobial susceptibility tests. J Clin Microbiol 56: e01934–17.
  • Imanian ME, Biglari FR. (2022). Modeling and prediction of surface roughness and dimensional accuracy in SLS 3D printing of PVA/CB composite using the central composite design. J Manuf Processes 75:154–69.
  • Ing LY, Zin NM, Sarwar A, Katas H. (2012). Antifungal activity of chitosan nanoparticles and correlation with their physical properties. Int J Biomater 2012:632698.
  • Jin Y, Wen J, Garg S, et al. (2013). Development of a novel niosomal system for oral delivery of Ginkgo biloba extract. IJN 8:421–30.
  • Kaur IP, Garg A, Singla AK, Aggarwal D. (2004). Vesicular systems in ocular drug delivery: an overview. Int J Pharm 269:1–14.
  • Kim Y-I, Kim S-I, Choi J-Y. Dissolution enhancement of fenticonazole nitrate from hydrophilic polymer solid dispersions. 1989;19:109–116.
  • Mohanty B, Mishra SK, Majumdar DK. (2013). Effect of formulation factors on in vitro transcorneal permeation of voriconazole from aqueous drops. J Adv Pharm Technol Res 4:210–6.
  • Mosallam S, Ragaie MH, Moftah NH, et al. (2021). Use of novasomes as a vesicular carrier for improving the topical delivery of terconazole: In vitro characterization, in vivo assessment and exploratory clinical experimentation. Int J Nanomedicine 16:119–32.
  • Moustafa MA, Elnaggar YSR, El-Refaie WM, Abdallah OY. (2017). Hyalugel-integrated liposomes as a novel ocular nanosized delivery system of fluconazole with promising prolonged effect. Int J Pharm 534:14–24.
  • Muller RH, Jacobs C, Kayser O. (2001). Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv Drug Deliv Rev 47:3–19.
  • Patil S, Sandberg A, Heckert E, et al. (2007). Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential. Biomaterials 28:4600–7.
  • Prausnitz MR, Noonan JS. (1998). Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J Pharm Sci 87:1479–88.
  • Rathod LV, Kapadia R, Sawant KK. (2017). A novel nanoparticles impregnated ocular insert for enhanced bioavailability to posterior segment of eye: In vitro, in vivo and stability studies. Mater Sci Engin C, Mater Biol Appl 71:529–40.
  • Ruckmani K, Sankar V. (2010). Formulation and optimization of Zidovudine niosomes. AAPS PharmSciTech 11:1119–27.
  • Said M, Aboelwafa AA, Elshafeey AH, Elsayed I. (2021). Central composite optimization of ocular mucoadhesive cubosomes for enhanced bioavailability and controlled delivery of voriconazole. J Drug Delivery Sci Technol 61:102075.
  • Sayed S, Abdelmoteleb M, Amin MM, Khowessah OM. (2020). Effect of formulation variables and gamma sterilization on transcorneal permeation and stability of proniosomal gels as ocular platforms for antiglaucomal drug. AAPS PharmSciTech 21:87.
  • Sayed S, Abdel-Moteleb M, Amin MM, Khowessah OM. (2021). Cubogel as potential platform for glaucoma management. Drug Deliv 28:293–305.
  • Sayed S, Elsayed I, Ismail MM. (2018). Optimization of beta-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug. Int J Pharm 549:249–60.
  • Sayed S, Habib BA, Elsayed GM. (2018). Tri-block co-polymer nanocarriers for enhancement of oral delivery of felodipine: preparation, in vitro characterization and ex vivo permeation. J Liposome Res 28:182–92.
  • Shamma RN, Sayed S, Sabry NA, El-Samanoudy SI. (2019). Enhanced skin targeting of retinoic acid spanlastics: in vitro characterization and clinical evaluation in acne patients. J Liposome Res 29:283–90.
  • Silva TAC. (2019). Josilene; Salgado, Hérida Regina Nunes. Development of stability-indicating LC method assisted by Design of Experiment for fenticonazole cream analysis in presence of degradation product. J Basic Appl Pharmaceut Sci 40:e622.
  • Singh A, Yadagiri G, Parvez S, et al. (2020). Formulation, characterization and in vitro anti-leishmanial evaluation of amphotericin B loaded solid lipid nanoparticles coated with vitamin B12-stearic acid conjugate. Mater Sci Engin C, Mater Biol Appl 117:111279.
  • Veraldi S, Milani R. (2008). Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs 68:2183–94.
  • Xu D, Li Y, Yang F, et al. (2022). Structure and transport mechanism of the human cholesterol transporter ABCG1. Cell Rep 38:110298.
  • Younes NF, Abdel-Halim SA, Elassasy AI. (2018). Corneal targeted Sertaconazole nitrate loaded cubosomes: Preparation, statistical optimization, in vitro characterization, ex vivo permeation and in vivo studies. Int J Pharm 553:386–97.
  • Younes NF, Abdel-Halim SA, Elassasy AI. (2018). Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization. Drug Deliv 25:1706–17.
  • Zhang Y, Wang X, Lin X, et al. (2010). High azithromycin loading powders for inhalation and their in vivo evaluation in rats. Int J Pharm 395:205–14.
  • Zhu J, Liu B, Li L, et al. (2016). Simple and green fabrication of super-hydrophobic surface by one-step immersion for continuous oil/water separation. J Phys Chem A 120:5617–23.
  • Zubairu Y, Negi LM, Iqbal Z, Talegaonkar S. (2015). Design and development of novel bioadhesive niosomal formulation for the transcorneal delivery of anti-infective agent: In-vitro and ex-vivo investigations. Asian J Pharm Sci 10:322–30.