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Articles

Acute Leakage Patterns of Fluorescent Plasma Flow Markers after Transient Focal Cerebral Ischemia Suggest Large Openings in Blood-Brain Barrier

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Pages 1-14 | Received 26 Sep 2006, Accepted 20 Feb 2007, Published online: 10 Jul 2009

REFERENCES

  • Aronowski J, Strong R, Grotta J. Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab 1997; 17: 1048–1056
  • Belayev L, Busto R, Ikeda M, Rubin L L, Kajiwara A, Morgan L, Ginsberg M D. Protection against blood-brain barrier disruption in focal cerebral ischemia by the type IV phosphodiesterase inhibitor BBB02: a quantitative study. Brain Res 1998; 787: 277–285
  • Brown S L, Ewing J R, Nagaraja T N, Cao Y, Swerdlow P S, Fenstermacher J D, Kim J H. Sickle red blood cells accumulate in tumor. Magn Reson Med 2003; 50: 1209–1214
  • del Zoppo G J. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 1994; 6: 47–96
  • del Zoppo G J, Hallenbeck J M. Advances in the vascular pathophysiology of ischemic stroke. Thrombosis Res 2000; 98: 73–81
  • Ewing J R, Wei L, Knight R A, Pawa S, Nagaraja T N, Brusca T, Divine G W, Fenstermacher J D. Direct comparison of local cerebral blood flow rates measured by MRI arterial spin tagging and quantitative autoradiography in a rat model of experimental cerebral ischemia. J Cereb Blood Flow Metab 2003a; 23: 198–209
  • Ewing J R, Knight R A, Nagaraja T N, Yee J S, Nagesh V, Whitton P A, Li L, Fenstermacher J D. Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003b; 50: 283–292
  • Fagan S C, Nagaraja T N, Fenstermacher J D, Zheng J, Johnson M, Knight R A. Hemorrhagic transformation is dependent on the duration of occlusion and treatment with recombinant tissue plasminogen activator in a non-embolic stroke model. Neurol Res 2003; 25: 377–382
  • Gesztelyi G, Finnegan W, De Maro J A, Wang J Y, Chen J L, Fenstermacher J. Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats. Brain Res 1993; 611: 349–257
  • Gotoh O, Asano T, Koide T, Takakura K. Ischemic brain edema following occlusion of the middle cerebral artery in the rat. I: the time courses of the brain water, sodium and potassium contents and blood-brain barrier permeability to 125I-albumin. Stroke 1985; 16: 101–109
  • Hamann G F, Liebetrau M, Martens H, Burggraf D, Kloss C UA, Bultemeier G, Wunderlich N, Jager G, Pfefferkorn T. Microvascular basal lamina injury after experimental focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab 2002; 22: 526–533
  • Huang Z G, Xue D, Preston E, Karbalai H, Buchan A M. Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia. Can J Neurol Sci 1999; 26: 298–304
  • Huber J D, Egleton R D, Davis T P. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci 2001; 24: 719–725
  • Jiang Q, Zhang R L, Zhang Z G, Knight R A, Ewing J R, Ding D L, Arniego P, Zhang L, Hu J, Li Q, Chopp M. Magnetic resonance imaging characterization of hemorrhagic transformation of embolic stroke in the rat. J Cereb Blood Flow Metab 2002; 22: 559–568
  • Kaur J, Zhao J, Klein G M, Lo E H, Buchan A M. The neurotoxicity of tissue plasminogen activator?. J Cereb Blood Flow Metab 2004; 24: 945–963
  • Knight R A, Barker P B, Fagan S C, Li Y, Jacobs M A, Welch K MA. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998; 29: 144–151
  • Knight R A, Nagaraja T N, Ewing J R, Nagesh V, Whitton P A, Bershad E, Fagan S C, Fenstermacher J D. Quantitation and localization of blood-to-brain influx by MRI and quantitative autoradiography in a model of focal transient ischemia. Magn Reson Med 2005a; 54: 813–821
  • Knight R A, Nagesh V, Nagaraja T N, Ewing J R, Whitton P A, Bershad E, Fagan S C, Fenstermacher J D. Acute BBB opening in experimentally induced focal cerebral ischemia is preferentially identified by quantitative magnetization transfer imaging. Magn Reson Med 2005b; 54: 822–832
  • Kuroiwa T, Cahn R, Juhler M, Goping G, Campbell G, Klatzo I. Role of extracellular proteins in the dynamics of vasogenic brain edema. Acta Neuropathol 1985; 66: 3–11
  • Kuroiwa T, Ting P, Marinez H, Klatzo I. The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta. Neuropathol 1985; 68: 122–129
  • Lin B, Ginsberg M. Quantitative assessment of the normal cerebral microvasculature by endothelial barrier antigen (EBA) immunohistochemistry: application to focal cerebral ischemia. Brain Res 2000; 865: 237–244
  • Lo E H, Singhal A B, Torchilin V P, Abbott N J. Drug delivery to damaged brain. Brain Res—Brain Res Rev 2001; 38: 140–148
  • Longa E Z, Weinstein P R, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20: 84–91
  • Mayhan W G. Regulation of blood-brain barrier permeability. Microcirculation 2001; 8: 89–104
  • Mayhan W G, Heistad D D. Permeability of blood-brain barrier to various sized molecules. Am J Physiol Heart Circ Physiol 1985; 248: H712–H718
  • Murakami K, Kawase M, Kondo T, Chan P. Cellular accumulation of extravasated serum protein and DNA fragmentation following vasogenic edema. J Neurotrauma 1998; 15: 825–835
  • Nadal A, Fuentes E, Pastor J, McNaughton P A. Plasma albumin is a potent trigger of calcium signals and DNA synthesis in astrocytes. Proc Natl Acad Sci USA 1985; 92: 1426–1430
  • Nagaraja T N, Keenan K A, Brown S L, Fenstermacher J D, Knight R A. Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia. Neurol Res 2007; 29: 78–80
  • Preston E, Foster D O. Evidence for pore-like opening of the blood brain barrier following forebrain ischemia in rats. Brain Res 1997; 761: 4–10
  • Preston E, Webster J. Differential passage of [14C]sucrose and [3H]inulin across rat blood-brain barrier after cerebral ischemia. Acta Neuropathol 2002; 103: 237–242
  • Remmers M, Schmidt-Kastner R, Belayev L, Lin B, Busto R, Ginsberg M D. Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats. Brain Res 1999; 827: 237–242
  • Rosenberg G S. Ischemic brain edema. Prog Cardovasc Dis 1999; 42: 209–216
  • Rosenberg G S, Estrada E Y, Dencoff J E. Matrix mettalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brains. Stroke 1998; 29: 2189–2195
  • Sage J I, Van Uitert R L, Duffy T E. Early changes in blood brain barrier permeability to small molecules after transient cerebral ischemia. Stroke 1984; 15: 46–50
  • Takahashi M, Macdonald R. Vascular aspects of neuroprotection. Neurol Res 2004; 26: 862–869
  • Taylor A E, Neil Granger D. Exchange of macromolecules across the microcirculation. Handbook of Physiology, Volume IV, Microcirculation Part 1, E M Renkin, C C Michel. American Physiological Society, Bethesda 1984; 467–520
  • Yang G-Y, Betz A L. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 1994; 25: 1658–1665
  • Zhang Z G, Davies K, Prostak J, Fenstermacher J, Chopp M. Quantitation of microvascular plasma perfusion and neuronal microtubule-associated protein in ischemic mouse brain by laser confocal microscopy. J Cereb Blood Flow Metab 1999; 19: 68–78
  • Ziylan Y A, Robinson P J, Rapoport S I. Differential blood-brain barrier permeabilities to [14C]sucrose and [3H]inulin after osmotic opening in the rat. Exp Neurol 1983; 79: 845–857

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