Peritubular Capillary Loss Is Ameliorated by Ramipril or Valsartan Treatment

REFERENCES

• Wolf G, Butzmann U, Wenzel U O. The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology. Nephron Physiol 2003; 93: p3–p13
   PubMedGoogle Scholar
• Jafar T H, Stark P C, Schmid C H, Landa M, Maschio G, de Jong P E, de Zeeuw D, Shahinfar S, Toto R, Levey A S, AIPRD Study Group. Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysis. Ann Intern Med 2003; 139: 244–252
   PubMed Web of Science ®Google Scholar
• Atkins R C, Briganti E M, Lewis J B, Hunsicker L G, Braden G, Champion de Crespigny P J, DeFerrari G, Drury P, Locatelli F, Wiegmann T B, Lewis E J. Proteinuria reduction and progression to renal failure in patients with type 2 diabetes mellitus and overt nephropathy. Am J Kidney Dis 2005; 45: 281–287
   PubMed Web of Science ®Google Scholar
• Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006; 17: 17–25
   PubMed Web of Science ®Google Scholar
• Manotham K, Tanaka T, Matsumoto M, Ohse T, Miyata T, Inagi R, Kurokawa K, Fujita T, Nangaku M. Evidence of tubular hypoxia in the early phase in the remnant kidney model. J Am Soc Nephrol 2004; 15: 1277–1288
   PubMed Web of Science ®Google Scholar
• Norman J T, Stidwill R, Singer M, Fine L G. Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron Physiol 2003; 94: p39–p46
   Google Scholar
• Lombardi D, Gordon K L, Polinsky P, Suga S, Schwartz S M, Johnson R J. Salt-sensitive hypertension develops after short-term exposure to Angiotensin II. Hypertension 1999; 33: 1013–1019
   PubMed Web of Science ®Google Scholar
• Shao J, Nangaku M, Miyata T, Inagi R, Yamada K, Kurokawa K, Fujita T. Imbalance of T-cell subsets in angiotensin II-infused hypertensive rats with kidney injury. Hypertension 2003; 42: 31–38
   PubMed Web of Science ®Google Scholar
• Ibrahim H N, Hostetter T. The renin-aldosterone axis in two models of reduced renal mass in the rat. J Am Soc Nephrol 1998; 9: 72–76
   Google Scholar
• Shimizu A, Kitamura H, Masuda Y, Ishizaki M, Sugisaki Y, Yamanaka N. Rare glomerular capillary regeneration and subsequent capillary regression with endothelial cell apoptosis in progressive glomerulonephritis. Am J Pathol 1997; 151: 1231–1239
   PubMed Web of Science ®Google Scholar
• Ohashi R, Kitamura H, Yamanaka N. Peritubular capillary injury during the progression of experimental glomerulonephritis in rats. J Am Soc Nephrol 2000; 11: 47–56
   PubMed Web of Science ®Google Scholar
• Kim Y G, Suga S, Kang D H, Jefferson J A, Mazzali M, Gordon K L, Matsui K, Breiteneder-Geleff S, Shankland S J, Hughes J, Kerjaschki D, Schreiner G F, Johnson R J. Vascular endothelial growth factor stimulates vascular remodeling and tissue repair in a model of thrombotic microangiopathy. Kidney Int 2000; 58: 2390–2399
   PubMed Web of Science ®Google Scholar
• Kang D H, Joly A H, Oh S W, Hugo C, Kerjaschki D, Gordon K L, Mazzali M, Jefferson J A, Hughes J, Madsen K M, Schreiner G F, Johnson R J. Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 2001; 12: 1434–1447
   PubMed Web of Science ®Google Scholar
• Bohle A, von Gise H, Mackensen-Haen S, Stark-Jakob B. The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Functional interpretation of morphologic findings. Klin Wochenschr 1981; 59: 1043–1051
   PubMedGoogle Scholar
• Choi Y J, Chakraborty S, Nguyen V, Nguyen C, Kim B K, Shim S I, Suki W N, Truong L D. Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: Altered expression of vascular endothelial growth factor. Hum Pathol 2000; 31: 1491–149
   PubMed Web of Science ®Google Scholar
• YuanH-T, LiX-Z, Pitera J E, Long D A, Woolf A S. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1alpha. Am J Pathol 2003; 163: 2289–230
   PubMed Web of Science ®Google Scholar
• Kairaitis L K, Wang Y, Gassmann M, Tay Y C, Harris D C. HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis. Am J Physiol Renal Physiol 2005; 288: F198–F20
   Google Scholar
• Colman R W. Regulation of angiogenesis by the kallikrein-kinin system. Curr Pharm Des 2006; 12: 2599–260
   PubMed Web of Science ®Google Scholar
• Agodoa L Y, Appel L, Bakris G L, Beck G, Bourgoignie J, Briggs J P, Charleston J, Cheek D, Cleveland W, Douglas J G, Douglas M, Dowie D, Faulkner M, Gabriel A, Gassman J, Greene T, Hall Y, Hebert L, Hiremath L, Jamerson K, Johnson C J, Kopple J, Kusek J, Lash J, Lea J, Lewis J B, Lipkowitz M, Massry S, Middleton J, Miller E R, 3rd, Norris K, O'Connor D, Ojo A, Phillips R A, Pogue V, Rahman M, Randall O S, Rostand S, Schulman G, Smith W, Thornley-Brown D, Tisher C C, Toto R D, Wright J T, Jr, Xu S, African American Study of Kidney Disease and Hypertension (AASK) Study Group. Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA 2001; 285: 2719–2728
   PubMed Web of Science ®Google Scholar
• Wright J T, Jr., Bakris G, Greene T, Agodoa L Y, Appel L J, Charleston J, Cheek D, Douglas-Baltimore J G, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips R A, Toto R D, Middleton J P, Rostand S G, African Am Study of Kidney Disease and Hypertension Study Group. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 2002; 288: 2421–2431
   PubMed Web of Science ®Google Scholar
• Ruggenenti P, Perna A, Benini R, Remuzzi G, for the “gruppo italiano di studi epidemiologici in nefrologia” (GISEN). Effects of dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibition, and blood pressure control on chronic, nondiabetic nephropathies. J Am Soc Nephrol 1998; 9: 2096–2101
   PubMed Web of Science ®Google Scholar
• Brenner B M, Cooper M E, de Zeeuw D, Keane W F, Mitch W E, Parving H H, Remuzzi G, Snapinn S M, Zhang Z, Shahinfar S, RENAAL Study Investigators. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861–869
   PubMed Web of Science ®Google Scholar
• Safran M, Kaelin W G. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003; 111: 779–78
   PubMed Web of Science ®Google Scholar
• Rosenberger C, Mandriota S, Jurgensen J S, Wiesener M S, Horstrup J H, Frei U, Ratcliffe P J, Maxwell P H, Bachmann S, Eckardt K U. Expression of hypoxia-inducible factor-1alpha and-2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002; 13: 1721–1732
   PubMed Web of Science ®Google Scholar
• Griffin K A, Picken M M, Churchill M, Churchill P, Bidani A K. Functional and structural correlates of glomerulosclerosis after renal mass reduction in the rat. J Am Soc Nephrol 2000; 11: 497–506
   PubMed Web of Science ®Google Scholar
• Fine L G, Bandyopadhay D, Norman J T. Is there a common mechanism for the progression of different types of renal disease other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 2000; 57: S22–S26, [Suppl 75]
   Google Scholar
• Norman J T, Clark I M, Garcia P. Hypoxia promotes fibrogenesis in human renal fibroblast. Kidney Int 2000; 58: 2351–2366
   PubMed Web of Science ®Google Scholar
• Orphanides C, Fine L G, Norman J T. Hypoxia stimulates proximal tubular cell matrix production via TGF-β 1 independent mechanism. Kidney Int 1997; 52: 637–647
   Google Scholar
• Tanaka T, Hanafusa N, Ingelfinger J R, Ohse T, Fujita T, Nangaku M. Hypoxia induces apoptosis in SV40-immortalized rat proximal tubular cells through the mitochondrial pathways, devoid of HIF1-mediated upregulation of Bax. Biochem Biophys Res Commun 2003; 309: 222–231
   PubMed Web of Science ®Google Scholar
• Tanaka T, Miyata T, Inagi R, Kurokawa K, Adler S, Fujita T, Nangaku M. Hypoxia-induced apoptosis in cultured glomerular endothelial cells: Involvement of mitochondrial pathways. Kidney Int 2003; 64: 2020–2032
   Google Scholar
• Manotham K, Tanaka T, Matsumoto M, Ohse T, Inagi R, Miyata T, Kurokawa K, Fujita T, Ingelfinger J R, Nangaku M. Transdifferentiation of cultured tubular cell induced by hypoxia. Kidney Int 2004; 65: 871–880
   PubMed Web of Science ®Google Scholar
• Loutzenhiser R D, Epstein M, Fischetti F, Horton C. Effects of amlodipine on renal hemodynamics. Am J Cardiol 1989; 64: 122I–127I
   PubMed Web of Science ®Google Scholar