Prostacyclin Analogs Stimulate Receptor-Mediated cAMP Synthesis and ATP Release from Rabbit and Human Erythrocytes

REFERENCES

• Aronoff D, Peres C, Serezani C, Ballinger M, Carstens J, Coleman N, Moore B, Peebles R, Faccioli L, Peters-Golden M. Synthetic prostacyclin analogues differentially regulate macrophage function via distinct analog-receptor binding specificities. J Immonol 2007; 178: 1628–1634
   PubMed Web of Science ®Google Scholar
• Barst R, Rubin L, McGoon M, Caldwell E, Long W, Levy P. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med 1994; 121: 409–415
   PubMed Web of Science ®Google Scholar
• Bergfeld G, Forrester T. Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnea. Cardiovasc Res 1992; 26: 40–47
   PubMedGoogle Scholar
• Brown I, Thompson C, Belloni F. Mechanisms of coronary vasodilation produced by ATP in guinea-pig isolated perfused heart. Br J Pharmacol 1992; 105: 211–215
   Google Scholar
• Collins D, McCullough W, Ellsworth M. Conducted vascular responses: communication across the capillary bed. Microvasc Res 1998; 56: 43–53
   PubMedGoogle Scholar
• Conte J, Gaine S, Orens J, Harris T, Rubin L. The influence of continuous prostacyclin therapy for primary pulmonary hypertension on the timing and outcome of transplantation. J Heart Lung Transpl 1998; 17: 679–685
   PubMed Web of Science ®Google Scholar
• Clapp L, Finney P, Turcato S, Tran S, Rubin L, Tinker A. Differential effects of stable prostacyclin analogues on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am J Respir Cell Mol Biol 2002; 26: 194–201
   PubMed Web of Science ®Google Scholar
• Clark R, Jahangir A, Severance D, Salazar R, Chang T, Chang D, Jett M, Smith S, Bley K. Discovery and SAR development of 2-(phenolamino) imidazolines as prostacyclin receptor antagonists. Bioorg Med Chem Lett 2004; 14: 1053–1056
   PubMedGoogle Scholar
• Dietrich H, Ellsworth M, Sprague R, Dacey R. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol 2000; 278: H1294–H1298
   PubMed Web of Science ®Google Scholar
• Dutta-Roy A, Hoque L, Paterson B. Prostaglandin-E1-binding sites in rabbit erythrocyte membranes. Eur J Biochem 1993; 213: 1167–1173
   PubMedGoogle Scholar
• Dutta-Roy A, Sinha A. Binding of prostaglandin E1 to human erythrocyte membranes. Biochim Biophys Acta 1985; 812: 671–678
   PubMedGoogle Scholar
• Ellsworth M, Forrester T, Ellis C, Dietrich H. The erythrocyte as a regulator of vascular tone. A J Physiol 1995; 269: H2155–H2161
   Google Scholar
• Ellsworth M. The red blood cell as an oxygen sensor: what is the evidence?. Acta Physiol Scand 2000; 168: 551–559
   Google Scholar
• Fetalvero K, Martin K, Hwa J. Cardioprotective prostacyclin signaling in vascular smooth muscle. Prostagland Lipid Mediat 2007; 82: 109–118
   PubMed Web of Science ®Google Scholar
• Forsberg E, Feuerstein G, Shohami E, Pollard H. Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci USA 1987; 84: 5630–5634
   PubMed Web of Science ®Google Scholar
• Higgenbottam T, Butt A, Dinh-Xuan A, Takao M, Cremona G, Akamine S. Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost. Heart 1998; 79: 175–179
   PubMed Web of Science ®Google Scholar
• Higgenbottam T, Butt Y, McMahon A, Westerbeck R, Sharples L. Long term intravenous prostaglandin (epoprostenol or iloprost) for treatment of severe pulmonary hypertension. Heart 1998; 80: 151–155
   Google Scholar
• Houston D, Burnstock G, Vanhoutte P. Different P2-purinergic receptor subtypes of endothelium and smooth muscle in canine blood vessels. J Pharmacol Exp Ther 2001; 241: 501–506
   Google Scholar
• Jagger J, Bateman R, Ellsworth M, Ellis C. Role of erythrocyte in regulating local O2 delivery mediated by hemoglobin oxygenation. Am J Physiol Heart Circ Physiol 2001; 280: H2833–H2839
   Google Scholar
• Kaestner L, Tabellion W, Lipp P, Bernhardt I. Prostaglandin E2 activates channel-mediated calcium entry into human erythrocytes: an indication for a blood clot formation supporting process. Thromb Haemost 2004; 92: 1269–1272
   Google Scholar
• Kaneko F, Arroliga A, Dweik R, Comhair S, Laskowski D, Oppedisano R, Thomassen M, Erzurum S. Biochemical reaction products of nitric oxide as quantitative markers of primary pulmonary hypertension. Am J Respir Crit Care Med 1998; 158: 917–923
   PubMed Web of Science ®Google Scholar
• Kennedy C, Delbro D, Burnstock G. P2-purinoceptors mediate both vasodilation (via the endothelium) and vasoconstriction of the isolated rat femoral artery. Eur J Pharmacol 1985; 1072: 161–168
   Google Scholar
• Korbut R, Adamek-Guzik T, Madej J, Korbut R. Endothelial secretagogues and deformability of erythrocytes. J Physiol Pharmacol 2002; 53: 655–665
   PubMed Web of Science ®Google Scholar
• Kovacs I, O'Grady J. Prostacyclin increases filterability of normal and rigidified human red blood cells in vitro. Agents Actions 1984; 14: 306–310
   PubMedGoogle Scholar
• Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 1997; 122: 217–224
   PubMed Web of Science ®Google Scholar
• Kukovetz W, Holtzmann S, Wurm A, Poch G. Prostacyclin increases cAMP in coronary arteries. J Cyclic Nucleotide Res 1979; 5: 469–476
   Google Scholar
• Kuniciki T, Newman P. The molecular immunology of human platelet proteins. Blood 1992; 80: 1386–1404
   Google Scholar
• Laliberte K, Arneson C, Jeffs R, Hunt T, Wade M. Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin®) administered by the intravenous and subcutaneous route to normal volunteers. J Cardiovasc Pharmacol 2004; 44: 209–214
   PubMed Web of Science ®Google Scholar
• Li Q, Jungmann V, Kiyatkin A, Low P. Prostaglandin E2 stimulates Ca2 +-dependent K+ channel in human erythrocytes and alters cell volume and filterability. J Biol Chem 1996; 271: 18651–18656
   PubMed Web of Science ®Google Scholar
• McLaughlin V, Gaine S, Barst R, Oudiz R, Bourge R, Frost A, Robbins I, Tapson V, McGoon M, Badesch D, Sigman J, Roscigno R, Blackburn S, Arneson C, Rubin L, Rich S, the Treprostinil Study Group. Efficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertension. J Cardiovasc Pharm 2003; 41: 293–299
   PubMed Web of Science ®Google Scholar
• Matsura T, Kanayama Y, Inoue T, Takeda T, Morishima I. cAMP-induced changes in intracellular free Mg2 + levels in human erythrocytes. Biochem Biophys Acta 1993; 1220: 31–36
   Google Scholar
• McCullough W, Collins D, Ellsworth M. Arteriolar responses to extracellular ATP in striated muscle. Am J Physiol 1997; 272: H1886–H1891
   Google Scholar
• Moroi M, Jung S. Integrin-mediated platelet adhesion. Front Bioscience 1998; 3: 719–728
   Google Scholar
• Motte S, Pirotton S, Boeynaems J. Heterogeneity of ATP receptors in aortic endothelial cells: involvement of P2y and P2u receptors in inositol phosphate response. Circ Res 1993; 72: 504–510
   PubMed Web of Science ®Google Scholar
• Nakagawa M, Willner J, Cerri C, Reydel P. The effect of membrane preparation and cellular maturation on human erythrocyte adenylate cyclase. Biochem Biophys Acta 1984; 770: 122–126
   Google Scholar
• Narumiya S, Sugimoto Y, Fumitaka U. Prostanoid receptors: structures, properties, and functions. Pharmacol Rev 1999; 70: 1193–1219
   Google Scholar
• Olearczyk J, Ellsworth M, Stephenson A, Lonigro A, Sprague R. Nitric oxide inhibits ATP release from erythrocytes. J Pharmacol Exp Ther 2004; 309: 1079–1084
   Google Scholar
• Olearczyk J, Stephenson A, Lonigro A, Sprague R. Receptor-mediated activation of the heterotrimeric G-protein Gs results in ATP release from erythrocytes. Med Sci Monit 2001; 7: 669–674
   Google Scholar
• Olearczyk J, Stephenson A, Lonigro A, Sprague R. Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes. Am J Physiol 2004; 286: H940–H945
   Google Scholar
• Ozkan M, Dweik R, Laskowski D, Arroliga A, Erzurum S. High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy. Lung 2002; 179: 233–243
   Google Scholar
• Sager G. Receptor binding sites for beta-adrenergic ligands on human erythrocytes. Biochem Pharmacol 1982; 31: 99–104
   Google Scholar
• Sprague R, Bowles E, Stumpf M, Ricketts G, Friedman A, Hou W-H, Stephenson A, Lonigro A. Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi. Pharmacol Rep 2005; 57: 222–228
   Google Scholar
• Sprague R, Ellsworth M, Stephenson A, Kleinhenz M, Lonigro A. Deformation-induced ATP release from red blood cells requires cystic fibrosis transmembrane conductance regulator activity. Am J Physiol 1998; 275: H1726–H1732
   Google Scholar
• Sprague R, Ellsworth M, Stephenson A, Lonigro A. ATP: the red blood cell link to NO and local control of the pulmonary circulation. Am J Physiol 1996; 271: H2717–H2722
   Google Scholar
• Sprague R, Ellsworth M, Stephenson A, Lonigro A. Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation of ATP release. Am J Physiol 2001; 281: C1158–C1164
   Google Scholar
• Sprague R, Olearczyk J, Spence D, Stephenson A, Sprung R, Lonigro A. Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol 2003; 285: H693–H700
   Google Scholar
• Sprague R, Stephenson A, Bowles E, Stumpf S, Lonigro A. Reduced expression of Gi in erythrocytes of humans with diabetes type 2 is associated with impairment of both cAMP generation and ATP release. Diabetes 2006; 55: 3588–3593
   Google Scholar
• Sprague R, Stephenson A, Ellsworth M, Keller C, Lonigro A. Impaired release of ATP from red blood cells of humans with primary pulmonary hypertension. Exp Biol Med 2001; 226: 434–439
   Google Scholar
• Tateson J, Moncada S, Vane J. Effects of prostacyclin (PGX) on cyclic AMP concentration in human platelets. Prostaglandins 1977; 13: 389–397
   PubMed Web of Science ®Google Scholar
• Willems C, Stel H, van Aken W, van Mourik J. Binding and inactivation of prostacyclin (PGI2) by human erythrocytes. Br J Haematol 1983; 54: 43–52
   Google Scholar