K_ATP-mediated Vasodilation is Impaired in Obese Zucker Rats

REFERENCES

• Bailey J K, Kindig C A, Behnke B J, Musch T I, Schmid-Schöenbein G W, Poole D C. Spinotrapezius muscle microcirculatory function: effects of surgical exteriorization. Am J Physiol Heart Circ Physiol 2000; 279: H3131–H3137
   PubMed Web of Science ®Google Scholar
• Bouchard J-F, Dumont E C, Lamontagne D. Modification of vasodilator response in streptozotocin-induced diabetic rat. Can J Physiol Pharmacol 1999; 77: 980–985
   Google Scholar
• Bowles D K, Hu Q, Laughlin M H, Sturek M. Heterogeneity of L-type calcium current density in coronary smooth muscle. Am J Physiol Heart Circ Physiol 1997; 273: H2083–H2089
   Google Scholar
• Bray G A. Risks of obesity. Endocrinol Metab Clin North Am 2003; 32: 787–804
   PubMed Web of Science ®Google Scholar
• Brayden J E. Functional roles of KATP channels in vascular smooth muscle. Clin Exp Pharmacol Physiol 2002; 29: 312–316
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey. 2006, Available at: http://www.cdc.gov/nchs/about/major/nhanes/datalink.htm. Accessed 1 November 2007
   Google Scholar
• Clapp L H, Gurney A M. ATP-sensitive K+ channels regulate resting potential of pulmonary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 1992; 262: H916–H920
   PubMed Web of Science ®Google Scholar
• Clifford P S, Hellsten Y. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 2004; 97: 393–403
   PubMed Web of Science ®Google Scholar
• Frisbee J C. Enhanced arteriolar α -adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. J Appl Physiol 2004; 97: 764–772
   PubMedGoogle Scholar
• Frisbee J C. Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome. Microcirculation 2005; 12: 383–392
   PubMed Web of Science ®Google Scholar
• Frisbee J C. Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol 2001; 281: H1568–H1574
   Google Scholar
• Frisbee J C. Impaired skeletal muscle perfusion in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 2003; 285: R1124–R1134
   Google Scholar
• Frisbee J C. Remodeling of the skeletal muscle microcirculation increases resistance to perfusion in obese Zucker rats. Am J Physiol Heart Circ Physiol 2003; 285: H104–H111
   Google Scholar
• Frisbee J C, Maier K G, Stepp D W. Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats. Am J Physiol Heart Circ Physiol 2002; 283: H2160–H2168
   Google Scholar
• Gonzalez-Alonso J, Olsen D B, Saltin B. Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP. Circ Res 2002; 91: 1046–1055
   PubMed Web of Science ®Google Scholar
• Griffith T M. Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?. Br J Pharmacol. 2004; 141: 881–903
   PubMed Web of Science ®Google Scholar
• Hammer L W, Ligon A L, Hester R L. Differential inhibition of functional dilation of small arterioles by indomethacin and glibenclamide. Hypertension 2001; 37: 599–603
   Google Scholar
• Ikenaga H, Bast J P, Fallet R W, Carmines P K. Exaggerated impact of ATP-sensitive K+ channels on afferent arteriolar diameter in diabetes mellitus. J Am Soc. Nephrol 2000; 11: 1199–1207
   Google Scholar
• Jackson W F. Arteriolar tone is determined by activity of ATP-sensitive potassium channels. Am J Physiol Heart Circ Physiol 1993; 265: H1797–H1803
   PubMed Web of Science ®Google Scholar
• Jackson W F. Potassium channels in the peripheral microcirculation. Microcirculation 2005; 12: 113–127
   PubMed Web of Science ®Google Scholar
• Jackson W F, Konig A, Dambacher T, Busse R. Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels. Am J Physiol Heart Circ Physiol 1993; 264: H238–H243
   Google Scholar
• Juel C, Pilegaard H, Nielsen J J, Bangsbo J. Interstitial K+ in human skeletal muscle during and after dynamic graded exercise determined by microdialysis. Am J Physiol Regul Integr Comp Physiol 2000; 278: R400–R406
   Web of Science ®Google Scholar
• Kamata K, Miyata N, Kasuya Y. Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes. Eur J Pharmacol 1989; 166: 319–323
   PubMed Web of Science ®Google Scholar
• Kilbom A, Wennmalm A. Endogenous prostaglandins as regulators of blood flow in man: effect of indomethacin on reactive and functional hyperaemia. J Physiol (Lond) 1976; 257: 109–121
   Google Scholar
• Lash J M, Bohlen H G. Perivascular and tissue PO2 in contracting rat spinotrapezius muscle. Am J Physiol Heart Circ Physiol 1987; 252: H1192–H1202
   PubMedGoogle Scholar
• Lott M EJ, Hogeman C S, Vickery L, Kunselman A R, Sinoway L I, MacLean D A. Effects of dynamic exercise on mean blood velocity and muscle interstitial metabolite responses in humans. Am J Physiol Heart Circ Physiol 2001; 281: H1734–H1741
   Google Scholar
• Mayhan W G. Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels. Brain Res 1994; 636: 35–39
   PubMed Web of Science ®Google Scholar
• Mayhan W G, Faraci F M. Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels. Am J Physiol Heart Circ Physiol 1993; 265: H152–H157
   Google Scholar
• McKay M K, Gardner A L, Boyd D, Hester R L. Influence of venular prostaglandin release on arteriolar diameter during functional hyperemia. Hypertension 1998; 31: 213–217
   Google Scholar
• Murrant C L, Sarelius I H. Coupling of muscle metabolism and muscle blood flow in capillary units during contraction. Acta Physiologica Scandinavica 2000; 168: 531–541
   Google Scholar
• Naik J S, Xiang L, Hester R L. Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 2006; 290: R154–R161
   PubMed Web of Science ®Google Scholar
• Negrao C E, Trombetta I C, Batalha L T, Ribeiro M M, Rondon M UPB, Tinucci T, Forjaz C LM, Barretto A CP, Halpern A, Villares S MF. Muscle metaboreflex control is diminished in normotensive obese women. Am J Physiol Heart Circ Physiol. 2001; 281: H469–H475
   Google Scholar
• Nuttle L C, Ligon A L, Farrell K R, Hester R L. Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle. Am J Physiol Heart Circ Physiol 1999; 276: H1289–H1294
   Google Scholar
• Ogden C L, Carroll M D, Curtin L R, McDowell M A, Tabak C J, Flegal K M. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006; 295: 1549–1555
   PubMed Web of Science ®Google Scholar
• Phillips S A, Sylvester F A, Frisbee J C. Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 2005; 288: R522–R530
   Google Scholar
• Ribeiro M M, Silva A G, Santos N S, Guazzelle I, Matos L NJ, Trombetta I C, Halpern A, Negrao C E, Villares S MF. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 2005; 111: 1915–1923
   PubMed Web of Science ®Google Scholar
• Ribeiro M M, Trombetta I C, Batalha L T, Rondon M UPB, Forjaz C LM, Barretto A CP, Villares S MF, Negrao C E. Muscle sympathetic nerve activity and hemodynamic alterations in middle-aged obese women. Braz J Med Biol Res 2001; 34: 475–478
   Google Scholar
• Ritter J M, Barrow S E, Blair I A, Dollery C T. Release of prostacyclin in vivo and its role in man. Lancet 1983; 1: 317–319
   PubMed Web of Science ®Google Scholar
• Saito Y, McKay M, Eraslan A, Hester R L. Functional hyperemia in striated muscle is reduced following blockade of ATP-sensitive potassium channels. Am J. Physiol Heart Circ Physiol 1996; 270: H1649–H1654
   Web of Science ®Google Scholar
• Schubert R, Serebryakov V N, Mewes H, Hopp H H. Iloprost dilates rat small arteries: role of KATP- and KCa-channel activation by cAMP-dependent protein kinase. Am J Physiol Heart Circ Physiol 1997; 272: H1147–H1156
   PubMed Web of Science ®Google Scholar
• Siegel G, Carl A, Adler A, Stock G. Effect of the prostacyclin analogue iloprost on K+ permeability in the smooth muscle cells of the canine carotid artery. Eicosanoids 1989; 2: 213–222
   Google Scholar
• Siegel G, Emden J, Wenzel K, Mironneau J, Stock G. Potassium channel activation in vascular smooth muscle. Adv Exp Med Biol 1992; 311: 53–72
   Google Scholar
• Smirnov S V, Beck R, Tammaro P, Ishii T, Aaronson P I. Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries. J Physiol 2002; 538: 867–878
   PubMed Web of Science ®Google Scholar
• Smith W L. Prostaglandin biosynthesis and its compartmentation in vascular smooth muscle and endothelial cells. Ann Rev Physiol 1986; 48: 251–262
   PubMed Web of Science ®Google Scholar
• Smith W L. Prostanoid biosynthesis and mechanisms of action. Am J Physiol Renal Physiol 1992; 263: F181–F191
   PubMed Web of Science ®Google Scholar
• Smith W L, Marnett L J, DeWitt D L. Prostaglandin and thromboxane biosynthesis. Pharmacol Ther 1991; 49: 153–179
   PubMedGoogle Scholar
• Sobey C G. Potassium channel function in vascular disease. Arterioscler Thromb Vasc Biol 2001; 21: 28–38
   PubMed Web of Science ®Google Scholar
• Steinberg H O, Chaker H, Leaming R, Johnson A, Brechtel G, Baron A D. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996; 97: 2601–2610
   PubMed Web of Science ®Google Scholar
• Vesterqvist O, Green K. Development of a GC-MS method for quantitation of 2,3-dinor-6-keto-PGF1α and determination of the urinary excretion rates in healthy humans under normal conditions and following drugs. Prostaglandins 1984; 28: 139–154
   PubMedGoogle Scholar
• Wennmalm A, FitzGerald G A. Excretion of prostacyclin and thromboxane A2 metabolites during leg exercise in humans. Am J Physiol Heart Circ Physiol 1988; 255: H15–H18
   Google Scholar
• Wilson J R, Kapoor S C. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol Heart Circ Physiol 1993; 265: H171–H175
   PubMed Web of Science ®Google Scholar
• Xiang L, Naik J, Hester R L. Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 2005; 288: R987–R991
   Web of Science ®Google Scholar
• Xiang L, Naik J S, Hodnett B L, Hester R L. Altered arachidonic acid metabolism impairs functional vasodilation in metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 2006; 290: R134–R138
   PubMed Web of Science ®Google Scholar