Effectiveness of Botulinum Toxin for Lower Limbs Spasticity after Stroke: A Systematic Review and Meta-Analysis

References

• Sheean G, Lannin N, Turner-Stokes L, Rawicki B, Snow BJ. Botulinum toxin assessment, intervention and after-care for upper limb hypertonicity in adults: international consensus statement. Eur J Neurol. 2010;17(suppl 2):74–93.10.1111/ene.2010.17.issue-s2
   PubMed Web of Science ®Google Scholar
• Sommerfeld DK, Eek EU, Svensson AK, Holmqvist LW, von Arbin MH. Spasticity after stroke: its occurrence and association with motor impairments and activity limitations. Stroke. 2004;35(1):134–139.
   PubMed Web of Science ®Google Scholar
• Watkins CL, Leathley MJ, Gregson JM, Moore AP, Smith TL, et al. Prevalence of spasticity post stroke. Clin Rehabil. 2002;16(5):515–522.10.1191/0269215502cr512oa
   PubMed Web of Science ®Google Scholar
• Cioni M, Esquenazi A, Hirai B. Effects of botulinum toxin-A on gait velocity, step length, and base of support of patients with dynamic equinovarus foot. Am J Phys Med Rehabil. 2006;85(7):600–606.10.1097/01.phm.0000223216.50068.bc
   PubMed Web of Science ®Google Scholar
• Ferreira LA, Neto HP, Grecco LA. Effect of ankle-foot orthosis on gait velocity and cadence of stroke patients: a systematic review. J Phys Ther Sci. 2013;25(11):1503–1508.10.1589/jpts.25.1503
   PubMed Web of Science ®Google Scholar
• Simon O, Yelnik AP. Managing spasticity with drugs. Eur J Phys Rehabil Med. 2010;46(3):401–410.
   PubMed Web of Science ®Google Scholar
• Ward AB. Spasticity treatment with botulinum toxins. J Neural Transm. 2008;115(4):607–616.10.1007/s00702-007-0833-2
   PubMed Web of Science ®Google Scholar
• Reiter F, Danni M, Lagalla G, Ceravolo G, Provinciali L. Low-dose botulinum toxin with ankle taping for the treatment of spastic equinovarus foot after stroke. Arch Phys Med Rehabil. 1998;79(5):532–535.10.1016/S0003-9993(98)90068-5
   PubMed Web of Science ®Google Scholar
• Dunne J. Botulinum toxin type A (BOTOX) in the treatment of lower limb spasticity during stroke rehabilitation. Intern Med J. 2002;33(suppl):41–44.
   Google Scholar
• Rosales RL, Chua-Yap AS. Evidence-based systematic review on the efficacy and safety of botulinum toxin-A therapy in post-stroke spasticity. J Neural Transm. 2008;115(4):617–623.
   PubMed Web of Science ®Google Scholar
• Gracies JM, Singer BJ, Dunne JW. The role of botulinum toxin injections in the management of muscle overactivity of the lower limb. Disabil Rehabil. 2007;29(23):1789–1805.10.1080/09638280701568437
   PubMed Web of Science ®Google Scholar
• Higgins J, Green S. Cochrane handbook for systematic reviews of interventions version 510. The Cochrane Collaboration; 2011.
   Google Scholar
• Higgins J, Green S. Cochrane handbook for systematic reviews of interventions. In: Cochrane Book Series. Chichester, England: John Wiley & Sons; 2008. p. 187–241. http://www.cochrane-handbook.org
   Google Scholar
• Burbaud P, Wiart L, Dubos JL, Gaujard E, Debelleix X, et al. A randomised, double blind, placebo controlled trial of botulinum toxin in the treatment of spastic foot in hemiparetic patients. J Neurol Neurosurg Psychiatry. 1996;61(3):265–269.10.1136/jnnp.61.3.265
   PubMed Web of Science ®Google Scholar
• Kaji R, Osako Y, Suyama K, Maeda T, Uechi Y, Iwasaki M. Botulinum toxin type A in post-stroke lower limb spasticity: a multicenter, double-blind, placebo-controlled trial. J Neurol. 2010;257(8):1330–1337.10.1007/s00415-010-5526-3
   PubMed Web of Science ®Google Scholar
• Dunne JW, Gracies JM, Hayes M, Zeman B, Singer BJ. A prospective, multicentre, randomized, double-blind, placebo-controlled trial of onabotulinumtoxinA to treat plantarflexor/invertor overactivity after stroke. Clin Rehabil. 2012;26(9):787–797.10.1177/0269215511432016
   PubMed Web of Science ®Google Scholar
• Tao W, Yan D, Li JH, Shi ZH. Gait improvement by low-dose botulinum toxin A injection treatment of the lower limbs in subacute stroke patients. Phys Ther Sci. 2015;27(3):759–762.10.1589/jpts.27.759
   PubMed Web of Science ®Google Scholar
• Ding XD, Zhang GB, Chen HX, Wang W, Song JH, Fu DG. Color Doppler ultrasound-guided botulinum toxin type A injection combined with an ankle foot brace for treating lower limb spasticity after a stroke. Eur Rev Med Pharmacol Sci. 2015;19(3):406–411.
   PubMed Web of Science ®Google Scholar
• Fietzek UM, Kossmehl P, Schelosky L, Ebersbach G, Wissel J. Early botulinum toxin treatment for spastic pes equinovarus – a randomized double-blind placebo-controlled study. Eur J Neurol. 2014;21(8):1089–1095.10.1111/ene.2014.21.issue-8
   PubMed Web of Science ®Google Scholar
• Pittock SJ, Moore AP, Hardiman O, Ehler E, Kovac M, Bojakowski J, et al. A double-blind randomised placebo-controlled evaluation of three doses of botulinum toxin type A (Dysport) in the treatment of spastic equinovarus deformity after stroke. Cerebrovasc Dis. 2003;15(4):289–300.10.1159/000069495
   PubMed Web of Science ®Google Scholar
• Richardson D, Greenwood R, Sheean G. Treatment of focal spasticity with botulinum toxin: effect on the ‘positive support reaction’. Physiother Res Int. 2000;5(1):62–70.10.1002/(ISSN)1471-2865
   PubMedGoogle Scholar
• Das TK, Park DM. Effect of treatment with botulinum toxin on spasticity. Postgrad Med J. 1989;65(762):208–210.10.1136/pgmj.65.762.208
   PubMed Web of Science ®Google Scholar
• Hesse S, Lucke D, Malezic M, Bertelt C, Friedrich H, Gregoric M, et al. Botulinum toxin treatment for lower limb extensor spasticity in chronic hemiparetic patients. J Neurol Neurosurg Psychiatry. 1994;57(11):1321–1324.10.1136/jnnp.57.11.1321
   PubMed Web of Science ®Google Scholar
• Comella CL, Jankovic J, Shannon KM, Tsui J, Swenson M, Leurgans S, et al. Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia. Neurology. 2005;65(9):1423–1429.10.1212/01.wnl.0000183055.81056.5c
   PubMed Web of Science ®Google Scholar
• Pathak MS, Nguyen HT, Graham HK, Moore AP. Management of spasticity in adults: practical application of botulinum toxin. Eur J Neurol. 2006;13(Suppl 1):42–50.10.1111/ene.2006.13.issue-s1
   PubMed Web of Science ®Google Scholar
• Santamato A, Micello MF, Panza F, Fortunato F, Pilotto A, Giustini A. Spasticity: a prospective open-label study. Eur J Phys Rehabil Med. 2013;49(4):483–489.
   PubMed Web of Science ®Google Scholar
• Yaşar E, Tok F, Safaz I, Balaban B, Yilmaz B, Alaca R. The efficacy of serial casting after botulinum toxin type A injection in improving equinovarus deformity in patients with chronic stroke. Brain Inj. 2010;24(5):736–739.
   PubMed Web of Science ®Google Scholar
• Verplancke D, Snape S, Salisbury CF, Jones PW, Ward AB. A randomized controlled trial of botulinum toxin on lower limb spasticity following acute acquired severe brain injury. Clin Rehabil. 2005;19(2):117–125.10.1191/0269215505cr827oa
   PubMed Web of Science ®Google Scholar
• Bayram S, Sivrioglu K, Karli N, Ozcan O. Low-dose botulinum toxin with short-term electrical stimulation in post stroke spastic drop foot: a preliminary study. Am J Phys Med Rehabil. 2006;85(1):75–81.10.1097/01.phm.0000193505.85874.61
   PubMed Web of Science ®Google Scholar
• Ozcakir S, Sivrioglu K. Botulinum toxin in poststroke spasticity. Clin Med Res. 2007;5(2):132–138.10.3121/cmr.2007.716
   PubMedGoogle Scholar
• Kaňovský P, Slawek J, Denes Z. Efficacy and safety of botulinum neurotoxin NT 201 in post-stroke upper limb spasticity. Clin Neuropharmacol. 2009;32(5):259–265.
   PubMed Web of Science ®Google Scholar
• De Paiva A, Meunier FA, Molgo J, Aoki KR, Dolly JO. Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals. Proc Natl Acad Sci USA. 1999;96(6):3200–3205.10.1073/pnas.96.6.3200
   PubMed Web of Science ®Google Scholar
• Hesse S, Reiter F, Konrad M. Botulinum toxin type A and short term electrical stimulation in the treatment of upper limb flexor spasticity after stroke: a randomised, double-blind, placebo-controlled trial. Clin Rehabil. 1998;12(5):381–388.10.1191/026921598668275996
   PubMed Web of Science ®Google Scholar