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Review

Muscle changes after stroke and their impact on recovery: time for a paradigm shift? Review and commentary

ORCID Icon, , ORCID Icon, , , , , ORCID Icon, , , ORCID Icon & show all
Pages 104-111 | Received 27 Feb 2020, Accepted 15 May 2020, Published online: 26 Jun 2020

References

  • Boyd LA , Hayward KS , Ward NS , et al. Biomarkers of stroke recovery: consensus-based core recommendations from the stroke recovery and rehabilitation roundtable. Neurorehabil Neural Repair . 2017;31(10–11):864–876. doi:10.1177/1545968317732680.
  • Bernhardt J , Borschmann K , Boyd L , et al. Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research. Neurorehabil Neural Repair . 2017;31(8):694–698. doi:10.1177/1545968317724290.
  • Craig LE , Wu O , Bernhardt J , et al. Predictors of poststroke mobility: systematic review. Int J Stroke . 2011;6(4):321–327. doi:10.1111/j.1747-4949.2011.00621.x.
  • Kollen B , Kwakkel G , Lindeman E. Longitudinal robustness of variables predicting independent gait following severe middle cerebral artery stroke: a prospective cohort study. Clin Rehabil . 2006;20(3):262–268. doi:10.1191/0269215506cr910oa.
  • Kollen B , van de Port I , Lindeman E , et al. Predicting improvement in gait after stroke: a longitudinal prospective study. Stroke . 2005;36(12):2676–2680. doi:10.1161/01.STR.0000190839.29234.50.
  • Veerbeek JM , Van Wegen EEH , Harmeling–van der Wel BC , et al. Is accurate prediction of gait in nonambulatory stroke patients possible within 72 hours poststroke? The EPOS study. Neurorehabil Neural Repair . 2011;25(3):268–274. doi:10.1177/1545968310384271.
  • Morone G , S. Masiero, P. Coiro, D. De Angelis, V. Venturiero, S. Paolucci, and M. Iosa. Clinical features of patients who might benefit more from walking robotic training. Rest Neurol Neurosci . 2018;36(2):293–299.
  • Stinear CM. Prediction of motor recovery after stroke: advances in biomarkers. Lancet Neurol . 2017;16(10):826–836. doi:10.1016/S1474-4422(17)30283-1.
  • Scherbakov N , Sandek A , Doehner W . Stroke-related sarcopenia: specific characteristics. J Am Med Dir Assoc . 2015;16(4):272–276. doi:10.1016/j.jamda.2014.12.007.
  • Ryan AS , Ivey FM , Serra MC , et al. Sarcopenia and physical function in middle-aged and older stroke survivors. Arch Phys Med Rehabil . 2017;98(3):495–499. doi:10.1016/j.apmr.2016.07.015.
  • Hunnicutt JL , Gregory CM . Skeletal muscle changes following stroke: a systematic review and comparison to healthy individuals. Top Stroke Rehabil . 2017;24(6):463–471. doi:10.1080/10749357.2017.1292720.
  • Cruz-Jentoft AJ , G. Bahat, J. Bauer, Y. Boirie, O. Bruyere, T. Cederholm, C. Cooper, F. Landi, Y. Rolland, A.A. Sayer, S.M. Schneider, C.C. Sieber, E. Topinkova, M. Sarcopenia: Revised European Consensus on Definition and Diagnosis . Age Ageing; 2019. 48(1): 16-31.
  • Petersen AM , Pedersen BK . The anti-inflammatory effect of exercise. J Appl Physiol . 2005;98(4):1154–1162. doi:10.1152/japplphysiol.00164.2004.
  • Rosenberg IH . Sarcopenia: origins and clinical relevance. J Nutr . 1997;127(5 Suppl):990s–991s. doi:10.1093/jn/127.5.990S.
  • Anker SD , Morley JE , von Haehling S . Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle . 2016;7(5):512–514. doi:10.1002/jcsm.12147.
  • Cruz-Jentoft AJ , et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing . 2018. afy169-afy169
  • Dent E , et al., International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management . 2018.
  • Lauretani F , Bautmans I , De Vita F , et al. Identification and treatment of older persons with sarcopenia. Aging Male . 2014;17(4):199–204. doi:10.3109/13685538.2014.958457.
  • Beckwee D , Delaere A , Aelbrecht S , et al. Exercise interventions for the prevention and treatment of sarcopenia. a systematic umbrella review. J Nutr Health Aging . 2019;23(6):494–502. doi:10.1007/s12603-019-1196-8.
  • Buch A , Kis O , Carmeli E , et al. Circuit resistance training is an effective means to enhance muscle strength in older and middle aged adults A systematic review and meta-analysis. Ageing Res Rev . 2017;37:16–27. doi:10.1016/j.arr.2017.04.003.
  • Csapo R , Alegre LM . Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta-analysis. Scan J Med Sci Sports . 2016;26(9):995–1006. doi:10.1111/sms.12536.
  • Peterson MD , Sen A , Gordon PM . Influence of resistance exercise on lean body mass in aging adults: a meta-analysis. Med Sci Sports Exerc . 2011;43(2):249–258. doi:10.1249/MSS.0b013e3181eb6265.
  • Theodorakopoulos C , Jones J , Bannerman E , et al. Effectiveness of nutritional and exercise interventions to improve body composition and muscle strength or function in sarcopenic obese older adults: A systematic review. Nutr Res . 2017;43:3–15. doi:10.1016/j.nutres.2017.05.002.
  • Yoshimura Y , H. Wakabayashi, M. Yamada, H. Kim, A. Harada, and H. Arai. Interventions for treating sarcopenia: a systematic review and meta-analysis of randomized controlled studies. JAMDA . 2017;18(6): p. 553 e1-553 e16.
  • Borst SE . Interventions for sarcopenia and muscle weakness in older people. Age Ageing . 2004;33(6):548–555. doi:10.1093/ageing/afh201.
  • Martins WR , de Oliveira RJ , Carvalho RS , et al. Elastic resistance training to increase muscle strength in elderly: A systematic review with meta-analysis. Arch Gerontol Geriatr . 2013;57(1):8–15. doi:10.1016/j.archger.2013.03.002.
  • Peterson MD , Rhea MR , Sen A , et al. Resistance exercise for muscular strength in older adults: a meta-analysis. Ageing Res Rev . 2010;9(3):226–237. doi:10.1016/j.arr.2010.03.004.
  • Papa EV , Dong X , Hassan M . Resistance training for activity limitations in older adults with skeletal muscle function deficits: a systematic review. Clin Interven Aging . 2017;12:955–961. doi:10.2147/CIA.S104674.
  • Ryan AS , Dobrovolny CL , Smith GV , et al. Hemiparetic muscle atrophy and increased intramuscular fat in stroke patients. Arch Phys Med Rehabil . 2002;83(12):1703–1707. doi:10.1053/apmr.2002.36399.
  • Scherbakov N , Doehner W . Sarcopenia in stroke-facts and numbers on muscle loss accounting for disability after stroke. J Cach Sarc Muscle . 2011;2(1):5–8. doi:10.1007/s13539-011-0024-8.
  • Arasaki K , Igarashi O , Ichikawa Y , et al. Reduction in the motor unit number estimate (MUNE) after cerebral infarction. J Neurol Sci . 2006;250(1–2):27–32. doi:10.1016/j.jns.2006.06.024.
  • Arasaki K , O. Igarashi, Y. Ichikawa, T. Machida, I. Shirozu, A. Hyodo, and R. Ushijima. Reduction in the motor unit number estimate (MUNE) after cerebral infarction. J Neurol Sci, 2006. 250(1-2): p. 27-32.
  • Yi Y , Shim JS , Oh B-M , et al. Grip strength on the unaffected side as an independent predictor of functional improvement after stroke. Am J Phys Med Rehabil . 2017;96(9):616–620. doi:10.1097/PHM.0000000000000694.
  • Canning CG , Ada L , Adams R , et al. Loss of strength contributes more to physical disability after stroke than loss of dexterity. Clin Rehabil . 2004;18(3):300–308. doi:10.1191/0269215504cr715oa.
  • Park S , Ham JO , Lee BK . A positive association between stroke risk and sarcopenia in men aged >/= 50 years, but not women: results from the Korean National Health and Nutrition Examination Survey 2008–2010. J Nutr Health Aging . 2014;18(9):806–812. doi:10.1007/s12603-014-0553-x.
  • Patterson SL , L.W. Forrester, M.M. Rodgers, A.S. Ryan, F.M. Ivey, J.D. Sorkin, and R.F. Macko. Determinants of walking function after stroke: differences by deficit severity. Arch Phys Med Rehabil . 2007;88(1):115–119. doi:10.1016/j.apmr.2006.10.025.
  • De Deyne PG ,  C.E. Hafer-Macko, F.M. Ivey, A.S. Ryan, and R.F. Macko. Muscle molecular phenotype after stroke is associated with gait speed. Muscle Nerve . 2004;30(2):209–215. doi:10.1002/mus.20085.
  • Beyer I , Mets T , Bautmans I . Chronic low-grade inflammation and age-related sarcopenia. Curr Opin Clin Nutr Metab Care . 2012;15(1):12–22. doi:10.1097/MCO.0b013e32834dd297.
  • Norheim KL , Bautmans I , Kjaer M . Handgrip strength shows no improvements in geriatric patients with persistent inflammation during hospitalization. Exp Gerontol . 2017;99:115–119. doi:10.1016/j.exger.2017.10.006.
  • Bautmans I , Njemini R , Lambert M , et al. Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients. J Gerontol A Biol Sci Med Sci . 2005;60(3):361–367. doi:10.1093/gerona/60.3.361.
  • Norheim KL , CULLUM CK , ANDERSEN JL , et al. Inflammation relates to resistance training–induced hypertrophy in elderly patients. Med Sci Sports Exerc . 2017;49(6):1079–1085. doi:10.1249/MSS.0000000000001221.
  • Emsley HC , C.J. Smith, C.M. Gavin, R.F. Georgiou, A. Vail, E.M. Barberan, J.M. Hallenbeck, G.J. del Zoppo, N.J. Rothwell, P.J. Tyrrell, and S.J. Hopkins. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol . 2003;139(1–2):93–101. doi:10.1016/S0165-5728(03)00134-6.
  • Anrather J , Iadecola C . Inflammation and Stroke: an Overview. Neurotherapeutics . 2016;13(4):661–670. doi:10.1007/s13311-016-0483-x.
  • Becker KJ . Inflammation and the Silent Sequelae of Stroke. Neurotherapeutics . 2016;13(4):801–810. doi:10.1007/s13311-016-0451-5.
  • Morley W , Jackson K , Mead GE . Post-stroke fatigue: an important yet neglected symptom. Age Ageing . 2005;34(3):313. doi:10.1093/ageing/afi082.
  • Bendz M . The first year of rehabilitation after a stroke - from two perspectives. Scand J Caring Sci . 2003;17(3):215–222. doi:10.1046/j.1471-6712.2003.00217.x.
  • Forti LN , Van Roie E , Njemini R , et al. Effects of resistance training at different loads on inflammatory markers in young adults. Eur J Appl Physiol . 2017;117(3):511–519. doi:10.1007/s00421-017-3548-6.
  • Liberman K , Forti LN , Beyer I , et al. The effects of exercise on muscle strength, body composition, physical functioning and the inflammatory profile of older adults: a systematic review. Curr Opin Clin Nutr Metab Care . 2017;20(1):30–53. doi:10.1097/MCO.0000000000000335.
  • Bautmans I , Njemini R , Vasseur S , et al. Biochemical changes in response to intensive resistance exercise training in the elderly. Gerontology . 2005;51(4):253–265. doi:10.1159/000085122.
  • Forti LN , Van Roie E , Njemini R , et al. Load-specific inflammation mediating effects of resistance training in older persons. J Am Med Dir Assoc . 2016;17(6):547–552. doi:10.1016/j.jamda.2016.02.010.
  • Pedersen BK , Febbraio MA . Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol . 2012;8(8):457–465. doi:10.1038/nrendo.2012.49.
  • Nieman DC , Henson DA , Smith LL , et al. Cytokine changes after a marathon race. J Appl Physiol . 2001;91(1):109–114. doi:10.1152/jappl.2001.91.1.109.
  • Pedersen BK , Febbraio MA . Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev . 2008;88(4):1379–1406. doi:10.1152/physrev.90100.2007.
  • Gleeson M , Bishop NC , Stensel DJ , et al. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol . 2011;11(9):607–615. doi:10.1038/nri3041.
  • Nieman DC . Clinical implications of exercise immunology. J Sport Health Sci . 2012;1(1):12–17. doi:10.1016/j.jshs.2012.04.004.
  • Veerbeek JM ,  E. van Wegen, R. van Peppen, P.J. van der Wees, E. Hendriks, M. Rietberg, and G. Kwakkel. What is the evidence for physical therapy poststroke? A systematic review and meta-analysis. PLoS One . 2014;9(2):e87987.
  • Wist S , Clivaz J , Sattelmayer M . Muscle strengthening for hemiparesis after stroke: A meta-analysis. Ann Phys Rehabil Med . 2016;59(2):114–124. doi:10.1016/j.rehab.2016.02.001.
  • Veerbeek JM , et al. KNGF Clinical Practice Guideline for Physical Therapy in Patients with Stroke . 2017.
  • Winstein CJ , et al. Guidelines for adult stroke rehabilitation and recovery: a guideline for healthcare professionals from the American heart association/American stroke association. Stroke . 2016;47(6). e98-e169.
  • Åstrand A , Saxin C , Sjöholm A , et al. Poststroke physical activity levels no higher in rehabilitation than in the acute hospital. J Stroke Cerebrovasc Dis . 2016;25(4):938–945. doi:10.1016/j.jstrokecerebrovasdis.2015.12.046.
  • Esmonde T , McGinley J , Wittwer J , et al. Stroke rehabilitation: patient activity during non-therapy time. Aus J Physiother . 1997;43(1):43–51. doi:10.1016/S0004-9514(14)60401-3.
  • Kramer SF , Cumming T , Churilov L , et al. Measuring activity levels at an acute stroke ward: comparing observations to a device. Biomed Res Int . 2013;2013:460482. doi:10.1155/2013/460482.
  • Kunkel D , Fitton C , Burnett M , et al. Physical inactivity post-stroke: a 3-year longitudinal study. Disabil Rehabil . 2015;37(4):304–310. doi:10.3109/09638288.2014.918190.
  • West T , Bernhardt J . Physical activity in hospitalised stroke patients. Stroke Res Treat . 2012;2012:813765. doi:10.1155/2012/813765.
  • Sharp SA , Brouwer BJ . Isokinetic strength training of the hemiparetic knee: effects on function and spasticity. Arch Phys Med Rehabil . 1997;78(11):1231–1236. doi:10.1016/S0003-9993(97)90337-3.
  • Teixeira-Salmela LF , Olney SJ , Nadeau S , et al. Muscle strengthening and physical conditioning to reduce impairment and disability in chronic stroke survivors. Arch Phys Med Rehabil . 1999;80(10):1211–1218. doi:10.1016/S0003-9993(99)90018-7.
  • Moreland JD , Goldsmith CH , Huijbregts MP , et al. Progressive resistance strengthening exercises after stroke: a single-blind randomized controlled trial. Arch Phys Med Rehabil . 2003;84(10):1433–1440. doi:10.1016/S0003-9993(03)00360-5.
  • Flansbjer U-B , Miller M , Downham D , et al. Progressive resistance training after stroke: effects on muscle strength, muscle tone, gait performance and perceived participation. J Rehabil Med . 2008;40(1):42–48. doi:10.2340/16501977-0129.
  • Pak S , Patten C . Strengthening to promote functional recovery poststroke: an evidence-based review. Top Stroke Rehabil . 2008;15(3):177–199. doi:10.1310/tsr1503-177.
  • Dorsch S , Ada L , Alloggia D . Progressive resistance training increases strength after stroke but this may not carry over to activity: a systematic review. J Physiother . 2018;64(2):84–90. doi:10.1016/j.jphys.2018.02.012.
  • Lopes JSS , Machado AF , Micheletti JK , et al. Effects of training with elastic resistance versus conventional resistance on muscular strength: A systematic review and meta-analysis. SAGE Open Med . 2019;7:2050312119831116. doi:10.1177/2050312119831116.
  • Nascimento LR , Michaelsen SM , Ada L , et al. Cyclical electrical stimulation increases strength and improves activity after stroke: a systematic review. J Physiother . 2014;60(1):22–30. doi:10.1016/j.jphys.2013.12.002.
  • WHO . World Health Organization-World Report on Ageing and Health . Geneva, Switzerland: WHO Press; 2015:260.
  • Cortes JC , Goldsmith J , Harran MD , et al. A short and distinct time window for recovery of arm motor control early after stroke revealed with a global measure of trajectory kinematics. Neurorehabil Neural Repair . 2017;31(6):552–560. doi:10.1177/1545968317697034.

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