5
Views
6
CrossRef citations to date
0
Altmetric
Donald Munro Lecture 2004

Gifts From The Molecular Revolution: Protection Andrepair Of The Injured Spinal Cord

, MD, PhD
Pages 304-310 | Published online: 02 Sep 2016

References

  • Stys PK, Waxman SG, Ransom BR. lonic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na+ -Ca2+ exchanger. Neurosci. 1992;2:430–439.
  • Kapoor R, Davies M, Blaker P, Hall SM, Smith KJ. Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration. Ann Neurol. 2003;53 :174–180.
  • Teng YD, Wrath all JR. Local blockade of sodium channels by tetrodotoxin ameliorates tis sue loss and long-term fundian al deficits resulting from experimental spinal cord injury. J Neurosci. 1997;17:4359–4366.
  • Rosenberg L). Teng YD, Wrathall JR. Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. Neuroseienee. 1999;19: 6122–6133.
  • Fern R, Ransom BR, Stys PK, Waxman SG. Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam. J Pharmacol Exp. Ther. 1993;266:1549–1555.
  • Hains BC, Saab CY, Lo AC, Waxman SG. Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI. Exp. Neurol. ln press.
  • Craner MJ. Newcombe J, Black JA, Hartle C, Cuzner ML, Waxman S. Molecular changes in neurons in MS: altered axonal expression of Nav 1.2 and Nav 1.6 sodium channels and Na+ /Ca2+ exchanger. Proe Natl Acad Sei USA. 2004;101 :8168–8173.
  • Caldwell JH, Schaller KL, Lasher RS, Peies E, Levinson SR. Sodium channel Nav 1.6 is localized at nodes of Ranvier, dendrites, and synapses. Proe Natl Aead Sei USA. 2000;9 7:5616–5620.
  • Steffensen I, Waxman SG, Mills L, Stys PK. lmmunolocalization of the Na+Ca2+ exchanger in mammalian myelinated axons. Brain Res. 1997;776:1–9.
  • Blight A. Delayed myelination and macrophage invasion: a candidate for secondary darnage in spinal cord injury. Centrat Nervaus System Trauma. 1985;2:299–315.
  • Byrne TN, Waxman SG. Spinal Cord Compression. Philadelphia, Pa: FADavis Co.; 1990.
  • Windle WF, Smart JO, Beers JJ. Residual function after subtotal spinal cord resection in adult cats. Neurology. 1958;8:518–522.
  • Blight A. Morphametrieanalysis of experimental spinal cord injury in the cat: relation of injury intensity to survival of myelinated axons. Neuroseienee. 1986;19:321–341.
  • Young W. Recovery mechanisms in spinal cord injury: implications for regenerative therapy. ln: Seil FJ, ed. Neural Regeneration and Transplantation, New York: AR Liss; 1998:157–169.
  • Bostock H, Sears TA. The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination. J Physiol (Land.). 1978;280:273–301.
  • Foster RE, Whalen CC, Waxman SG. Reorga nization of the axonal membrane of demyelinated nerve fibers: morphological evidence. Seienee. 1980;210:661–663.
  • Craner MJ, Lo AC, BlackJA, Waxman SG. Abnormal sodium channel distribut ion in optic ne rve axons in a model of inflammatory demyelination. Brain. 2003;126:1552–1561.
  • Utzschneider DA, Areher D, Kocsis JD, Waxman SG, Duncan ID. Transplantation of glial cells enhances actionpotential conduction of amyelinated spinal cord axons in the myelin-deficient rat. Proe Natl Aead Sei USA. 1994;91 :53–57.
  • Honmou 0, Felts PA, Waxman SG, Kocsis JD. Restoration of normal conduction properties in demyelinated spinal cord axons in the adult rat by transplantation of exogenaus Schwann cells. J Neurosei. 1996;16:3199–3208.
  • lmaizu mi T, Lankford KL, Waxman SG, Greer CA, Kocs is JD. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J Neurosei. 1998;18:6176–6185.
  • Akiyama Y, Radtke C, Honmou O, Kocsis JD. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia. 2002;39:22 7–234.
  • Akiyama Y, Radtke C, Kocsis JD. Remyelination of the rat spinal cord by t ransplantation of identified bone marrow stromal cells. J Neurosei. 2002;22:6623–6630.
  • lnoue M, Honmou O , Oka S, Haukin K, Hashi K, Kocsis JD. Comparative analys is of remyelinating potential of focal and intravenous administration of autologaus bone marrow cells into the rat demyelinated spinal cord. Glia. 2003 ;44: 111–118.
  • lihoshi S, Honmou 0, Haukin K, Kazuo H, Kocsis JD. A therapeutic window for an intravenous administration of autologaus bone marrow after cerebral ischemia in adult rats. Brain Res. 2004; 1007:1–9.
  • Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG. Upregul ation of sodium channel Nav 1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosei. 2003 ;23 : 8881–8892.
  • Cummins TR, Waxman SG. Down-regulation of tetrodotoxin-resistant sodium currents and up-regu lation of a rapidly re priming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury. J Neurosei. 1997;17:3503–3514.
  • Cummins TR, Aglieco F, Renganathan M, Herzog Rl, Dib-Hajj SD, Waxman SG. Nav 1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences following expression in a mammalian cellline and in spinal sensory neurons. J Neurosei. 2001 ;21 5 952–5961.
  • Waxman SG, Kocsis JD, Stys PK. The Axon. New York: Oxford University Press; 1995.
  • Kocsis JD, Waxman SG. La ng-term regenerated nerve fib res retain sensitivity to potassium channel blocking agents. Nature. 1983; 304:640–642.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.