Screening and Validation of Dinucleotide Repeats in Intron 1 of the Human EGFR Gene and its Paralog in the HER2 Gene

REFERENCES

• R Todd, and D T Wong. 1999. Epidermal growth factor receptor (EGFR) biology and human oral cancer. Histol Histopathol 14:491–500.
   Google Scholar
• F Gebhardt, H Burger, and B Brandt. 2000. Modulation of EGFR gene transcription by a polymorphic repetitive sequence a link between genetics and epigenetics. Int J Biol Markers 15:105–110.
   Google Scholar
• J R Woodburn. 1999. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 82:241–250.
   PubMed Web of Science ®Google Scholar
• T Schlomm, P Kirstein, L Iwers, B Daniel, T Steuber, J Walz, F H Chun, A Haese, J Kollermann, M Graefen, H Huland, G Sauter, R Simon, and A Erbersdobler. 2007. Clinical significance of epidermal growth factor receptor protein overexpression and gene copy number gains in prostate cancer. Clin Cancer Res 13:6579–6584.
   PubMed Web of Science ®Google Scholar
• R Giuliani, V Durbecq, A Di Leo, M Paesmans, D Larsimont, J Y Leroy, M Borms, A Vindevoghel, G Jerusalem, V D'Hondt, L Dirix, J L Canon, V Richard, V Cocquyt, F Majois, M Reginster, J Demol, J P Kains, P Delree, C Keppens, C Sotiriou, M J Piccart, and F Cardoso. 2007. Phosphorylated HER-2 tyrosine kinase and Her-2/neu gene amplification as predictive factors of response to trastuzumab in patients with HER-2 overexpressing metastatic breast cancer (MBC). Eur J Cancer 43:725–735.
   Web of Science ®Google Scholar
• L Y Choong, S Lim, M C Loh, X Man, Y Chen, W Toy, M Pan, C S Chen, A Poonepalli, M P Hande, P H Tan, M Salto-Tellez, C Y Wong, N Shah, B J Druker, and Y P Lim. 2007. Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: Implications in target-directed therapeutics. Mol Cancer Ther 6:2828–2842.
   Google Scholar
• C J Witton, J R Reeves, J J Going, T G Cooke, and J M Bartlett. 2003. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 200:290–297.
   PubMed Web of Science ®Google Scholar
• M D Marmor, K B Skaria, and Y Yarden. 2004. Signal transduction and oncogenesis by ErbB/HER receptors. Int J Radiat Oncol Biol Phys 58:903–913.
   PubMed Web of Science ®Google Scholar
• F Gebhardt, K S Zanker, and B Brandt. 1999. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 274:13176–13180.
   PubMed Web of Science ®Google Scholar
• H Buerger, F Gebhardt, H Schmidt, A Beckmann, K Hutmacher, R Simon, R Lelle, W Boecker, and B Brandt. 2000. Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and EGFR-expression. Cancer Res 60:854–857.
   PubMed Web of Science ®Google Scholar
• H Buerger, J Packeisen, A Boecker, N Tidow, C Kersting, K Bielawski, J Isola, Y Yatabe, K Nakachi, W Boecker, and B Brandt. 2004. Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence—first results of an inter-ethnic breast cancer study. J Pathol 203:545–550.
   PubMed Web of Science ®Google Scholar
• M C Etienne-Grimaldi, S Pereira, N Magne, J L Formento, M Francoual, X Fontana, F Demard, O Dassonville, G Poissonnet, J Santini, R J Bensadoun, P Szepetowski, and G Milano. 2005. Analysis of the dinucleotide repeat polymorphism in the epidermal growth factor receptor (EGFR) gene in head and neck cancer patients. Ann Oncol 16:934–941.
   PubMed Web of Science ®Google Scholar
• N Kharrat, S Al'Fadhli, M Rebai, M S Aifa, I Kallel, A Khabir, T Sellami-Boudawara, M Frikha, and A Rebai. 2007. (AC) dinucleotide repeat polymorphism in intron 1 of human EGFR shows ethnic specificities and high evidence for association with breast cancer. Int J Biol Markers 22:258–264.
   PubMedGoogle Scholar
• V K Sharma, N Kumar, S K Brahmachari, and S Ramachandran. 2007. Abundance of dinucleotide repeats and gene expression are inversely correlated: A role for gene function in addition to intron length. Physiol Genomics 31:96–103.
   Google Scholar
• T Wu, T Ikezono, C W Angus, and J H Shelhamer. 1994. Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene. Nucleic Acids Res 22:5093–5108.
   PubMedGoogle Scholar
• J Akai, A Kimura, and R I Hata. 1999. Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats. Gene 239:65–73.
   PubMed Web of Science ®Google Scholar
• J Sambrook, and I Russell. 2001. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
   Google Scholar
• D Sokol, G Benson, and J Tojeira. 2007. Tandem repeats over the edit distance. Bioinformatics 23:e30–55.
   Google Scholar
• Y Akiyama. TFSEARCH: Searching Transcription Factor Binding Sites, 1995. www.cbrc.jp/research/db/TFSEARCH.html.
   Google Scholar
• BS Weir. Genetic Data Analysis. Sunderland, MA, Sinauer Associates Inc., 1996.
   Google Scholar
• R Kageyama, G T Merlino, and I Pastan. 1988. Epidermal growth factor (EGF) receptor gene transcription. Requirement for Sp1 and an EGF receptor-specific factor. J Biol Chem 263:6329–6336.
   PubMedGoogle Scholar
• Y Kitadai, W Yasui, H Yokozaki, H Kuniyasu, K Haruma, G Kajiyama, and E Tahara. 1992. The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas. Biochem Biophys Res Commun 189:1342–1348.
   PubMed Web of Science ®Google Scholar
• MG Reese, and FH Eeckman. Novel neural network algorithms for improved eukaryotic promotor site recognition. Lecture at the 7th International Genome Sequencing and Analysis ConferenceHead Island, South Carolina1995.
   Google Scholar
• P Bornstein, J McKay, D J Liska, S Apone, and S Devarayalu. 1988. Interactions between the promoter and first intron are involved in transcriptional control of α1 (I) collagen gene expression. Mol Cell Biol 8:4851–4857.
   PubMedGoogle Scholar
• A Sica, T H Tan, N Rice, M Kretzschmar, P Ghosh, and H A Young. 1992. The c-rel protooncogene product c-Rel but not NFκ B binds to the intronic region of the human interferon-γ gene at a site related to an interferon-stimulable response element. Proc Natl Acad Sci USA 89:1740–1744.
   PubMed Web of Science ®Google Scholar
• T Maekawa, F Imamoto, G T Merlino, I Pastan, and S Ishii. 1989. Cooperative function of two separate enhancers of the human epidermal growth factor receptor proto-oncogene. J Biol Chem 264:5488–5494.
   PubMedGoogle Scholar
• Y Kashi, D King, and M Soller. 1997. Simple sequence repeats as a source of quantitative genetic variation. Trends Genet 13:74–78.
   PubMed Web of Science ®Google Scholar
• Y H Xu, N Richert, S Ito, G T Merlino, and I Pastan. 1984. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proc Natl Acad Sci USA 81:7308–7312.
   PubMed Web of Science ®Google Scholar
• L G Hudson, K L Thompson, J Xu, and G N Gill. 1990. Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene. Proc Natl Acad Sci USA 87:7536–7540.
   PubMedGoogle Scholar