The estrogen-related receptors in metabolism and cancer: newer insights

References

• Bookout AL, Jeong Y, Downes M, et al. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell. 2006;126:789–799.
   PubMed Web of Science ®Google Scholar
• Benoit G, Cooney A, Giguere V, et al. International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev. 2006;58:798–836.
   PubMed Web of Science ®Google Scholar
• Giguère V. Orphan nuclear receptors: from gene to function. Endocr Rev. 1999;20:689–725.
   PubMed Web of Science ®Google Scholar
• Giguère V. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev. 2008;29:677–696.
   PubMed Web of Science ®Google Scholar
• Tremblay AM, Giguère V. The NR3B subgroup: an overview. Nucl Recept Signal. 2007;5:e009.
   PubMedGoogle Scholar
• Giguère V. To ERR in the estrogen pathway. Trends Endocrinol Metab. 2002;13:220–225.
   PubMed Web of Science ®Google Scholar
• Levine AJ, Puzio-Kuter AM. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science. 2010;330:1340–1344.
   PubMed Web of Science ®Google Scholar
• Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol. 2009;19:12–16.
   PubMed Web of Science ®Google Scholar
• Ao A, Wang H, Kamarajugadda S, et al. Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors. Proc Natl Acad Sci USA. 2008;105:7821–7826.
   PubMed Web of Science ®Google Scholar
• Deblois JA, Hall MC, Perry J, et al. Genome-wide identification of direct target genes implicates estrogen-related receptor α as a determinant of breast cancer heterogeneity. Cancer Res. 2009;69:6149–6157.
   PubMed Web of Science ®Google Scholar
• Tennessen JM, Baker KD, Lam G, et al. The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Cell Metab. 2011;13:139–148.
   PubMed Web of Science ®Google Scholar
• Cai Q, Lin T, Kamarajugadda S, et al. Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Oncogene. 2013;32:2079–2086.
   PubMed Web of Science ®Google Scholar
• Wang T, McDonald C, Petrenko NB, et al. Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Mol Cell Biol. 2015;35:1281–1298.
   PubMed Web of Science ®Google Scholar
• Poidatz D, Dos Santos E, Gronier H, et al. Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-γ activation. Mol Hum Reprod. 2015;21:206–216.
   PubMed Web of Science ®Google Scholar
• Cunningham KF, Beeson GC, Beeson CC, et al. Estrogen-Related Receptor α (ERRα) is required for adaptive increases in PGC-1 isoform expression during electrically stimulated contraction of adult cardiomyocytes in sustained hypoxic conditions. Int J Cardiol. 2015;187:393–400.
   PubMed Web of Science ®Google Scholar
• Cannon B, Nedergaard J. What Ignites UCP1? Cell Metab. 2017;26:697–698.
   PubMed Web of Science ®Google Scholar
• Ranhotra HS. Estrogen-related receptor alpha and mitochondria: tale of the titans. J Recept Signal Transduct Res. 2015;35:386–390.
   PubMed Web of Science ®Google Scholar
• Gantner ML, Hazen BC, Eury E, et al. Complementary roles of estrogen-related receptors in brown adipocyte thermogenic function. Endocrinology. 2016;157:4770–4781.
   PubMed Web of Science ®Google Scholar
• Gantner ML, Hazen BC, Conkright J, et al. GADD45γ regulates the thermogenic capacity of brown adipose tissue. Proc Natl Acad Sci USA. 2014;111:11870–11875.
   PubMed Web of Science ®Google Scholar
• Ariazi EA, Clark GM, Mertz JE. Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res. 2002;62:6510–6518.
   PubMed Web of Science ®Google Scholar
• Heck S, Rom J, Thewes V, et al. Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma. Cancer Res. 2009;69:5186–5193.
   PubMed Web of Science ®Google Scholar
• Han L, Liu B, Jiang L, et al. MicroRNA-497 downregulation contributes to cell proliferation, migration, and invasion of estrogen receptor alpha negative breast cancer by targeting estrogen-related receptor alpha. Tumor Biol. 2016;37:13205–13214.
   PubMedGoogle Scholar
• Tribollet V, Barenton B, Kroiss A, et al. miR-135a inhibits the invasion of cancer cells via suppression of ERRα. PLoS One. 2016;11:e0156445.
   PubMed Web of Science ®Google Scholar
• Ho PC, Bihuniak JD, Macintyre AN, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell. 2015;162:1217–1228.
   PubMed Web of Science ®Google Scholar
• Park S, Chang CY, Safi R, et al. ERRα-Regulated lactate metabolism contributes to resistance to targeted therapies in breast cancer. Cell Rep. 2016;15:323–335.
   PubMed Web of Science ®Google Scholar
• Deblois G, Giguère V. Oestrogen-related receptors in breast cancer: control of cellular metabolism and beyond. Nat Rev Cancer. 2013;13:27–36.
   PubMed Web of Science ®Google Scholar
• Audet-Walsh É, Papadopoli DJ, Gravel SP, et al. The PGC-1α/ERRα axis represses one-carbon metabolism and promotes sensitivity to anti-folate therapy in breast cancer. Cell Rep. 2016;14:920–931.
   PubMed Web of Science ®Google Scholar
• Holzbeierlein J, Lal P, La Tulippe E, et al. Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol. 2004;164:217–227.
   PubMed Web of Science ®Google Scholar
• Audet-Walsh É, Yee T, McGuirk S, et al. Androgen-dependent repression of ERRγ reprograms metabolism in prostate cancer. Cancer Res. 2017;77:378–389.
   PubMed Web of Science ®Google Scholar
• Torrano V, Valcarcel-Jimenez L, Cortazar AR, et al. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nat Cell Biol. 2016;18:645–656.
   PubMed Web of Science ®Google Scholar
• Masson N, Ratcliffe PJ. Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab. 2014;2:1–3.
   Google Scholar
• Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest. 2013;123:3664–3671.
   PubMed Web of Science ®Google Scholar
• Zou C, Yu S, Xu Z, et al. ERRα augments HIF-1 signalling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells. J Pathol. 2014;233:61–73.
   PubMed Web of Science ®Google Scholar
• Agrawal D, Chen T, Irby R, et al. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst. 2002;94:513–521.
   PubMed Web of Science ®Google Scholar
• Lund SA, Giachelli CM, Scatena M. The role of osteopontin in inflammatory processes. J Cell Commun Signal. 2009;3:311–322.
   PubMed Web of Science ®Google Scholar
• McKee MD, Pedraza CE, Kaartinen MT. Osteopontin and wound healing in bone. Cells Tissues Organs. 2011;194:313–319.
   PubMed Web of Science ®Google Scholar
• Boudjadi S, Bernatchez G, Beaulieu JF, et al. Control of the human osteopontin promoter by ERRα in colorectal cancer. Am J Pathol. 2013;183:266–276.
   PubMed Web of Science ®Google Scholar
• Bernatchez G, Giroux V, Lassalle T, et al. ERRα metabolic nuclear receptor controls growth of colon cancer cells. Carcinogenesis. 2013;34:2253–2261.
   PubMed Web of Science ®Google Scholar
• Chuffa LG, Lupi-Júnior LA, Costa AB, et al. The role of sex hormones and steroid receptors on female reproductive cancers. Steroids. 2017;118:93–108.
   PubMed Web of Science ®Google Scholar
• Sun Y, Wang C, Yang H, et al. The effect of estrogen on the proliferation of endometrial cancer cells is mediated by ERRγ through AKT and ERK1/2. Eur J Cancer Prev. 2014;23:418–424.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Mori T, Sawada M, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22:1509–1516.
   PubMed Web of Science ®Google Scholar