211
Views
20
CrossRef citations to date
0
Altmetric
Research Articles

Baicalein inhibits cell development, metastasis and EMT and induces apoptosis by regulating ERK signaling pathway in osteosarcoma

, , , &
Pages 49-57 | Received 31 Jul 2019, Accepted 06 Jan 2020, Published online: 17 Jan 2020

References

  • Ma O, Cai WW, Zender L, et al. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Res. 2009;69(6):2559–2567.
  • Longhi A, Errani C, De Paolis M, et al. Primary bone osteosarcoma in the pediatric age: state of the art. Cancer Treat Rev. 2006;32(6):423–436.
  • Bacci G, Fabbri N, Balladelli A, et al. Treatment and prognosis for synchronous multifocal osteosarcoma in 42 patients. J Bone Joint Surg Br. 2006;88(8):1071–1075.
  • Vijayamurugan N, Bakhshi S. Review of management issues in relapsed osteosarcoma. Expert Rev Anticancer Ther. 2014;14(2):151–161.
  • Luetke A, Meyers PA, Lewis I, et al. Osteosarcoma treatment - where do we stand? A state of the art review. Cancer Treat Rev. 2014;40(4):523–532.
  • Maran A, Dadsetan M, Buenz CM, et al. Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells. J Biomed Mater Res. 2013;101(9):2491–2499.
  • Kimura Y, Sumiyoshi M. Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis. Phytomedicine. 2013;20(3–4):328–336.
  • Zheng F, Wu J, Zhao S, et al. Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKalpha and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2015;34:41.
  • Cathcart MC, Useckaite Z, Drakeford C, et al. Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo. BMC Cancer. 2016;16(1):707.
  • Yan X, Rui X, Zhang K. Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway. Oncol Rep. 2015;33(2):737–743.
  • Tang Z, Li C, Chen Z. [Inhibitory effect of baicalein on the proliferation and invasion of osteosarcoma cells and mechanism]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31(3):342–345.
  • Dai G, Zheng D, Wang Q, et al. Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/beta-catenin signaling pathway. Oncotarget. 2017;8(49):86098–86116.
  • Saika S, Miyamoto T, Tanaka S, et al. Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition. Invest Ophthalmol Vis Sci. 2003;44(5):2094–2102.
  • Zhang X, Zhang Y, Mao Y, et al. The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma. Onco Targets Ther. 2018;11:629–638.
  • Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 2009;28(1–2):15–33.
  • Ren Y, Guo F, Chen A, et al. Involvement of MMP-2 in adriamycin resistance dependent on ERK1/2 signal pathway in human osteosarcoma MG-63 cells. J Huazhong Univ Sci Technol [Med Sci]. 2012;32(1):82–86.
  • Kaste SC, Pratt CB, Cain AM, et al. Metastases detected at the time of diagnosis of primary pediatric extremity osteosarcoma at diagnosis: imaging features. Cancer. 1999;86(8):1602–1608.
  • Song B, Wang Y, Xi Y, et al. Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene. 2009;28(46):4065–4074.
  • Wu B, Cui J, Zhang C, et al. A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells. Int J Biol Macromol. 2012;50(4):1116–1120.
  • Shang D, Li Z, Zhu Z, et al. Baicalein suppresses 17-beta-estradiol-induced migration, adhesion and invasion of breast cancer cells via the G protein-coupled receptor 30 signaling pathway. Oncol Rep. 2015;33(4):2077–2085.
  • Wang Z, Jiang C, Chen W, et al. Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells. Biomed Res Int. 2014;2014:732516.
  • Roy MK, Nakahara K, Na TV, et al. Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. Pharmazie. 2007;62(2):149–153.
  • Oredsson SM. Polyamine dependence of normal cell-cycle progression. Biochem Soc Trans. 2003;31(2):366–370.
  • Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994;266(5192):1821–1828.
  • Yin JQ, Chen HM, Luo WJ, et al. Comparison of in vitro anti-osteosarcoma effects of baicalein and baicalin (in Chinese). Huaxi Pharma J. 2011;26(2):133–135.
  • Piróg-Garcia KA, Meadows RS, Knowles L, et al. Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP. Hum Mol Genet. 2007;16(17):2072–2088.
  • Nagata S. Apoptosis by death factor. Cell. 1997;88(3):355–365.
  • Lopez-Novoa JM, Nieto MA. Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med. 2009;1(6–7):303–314.
  • Brabletz T. EMT and MET in metastasis: where are the cancer stem cells? Cancer Cell. 2012;22(6):699–701.
  • De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13(2):97–110.
  • Ishikawa T, Shimizu T, Ueki A, et al. Twist2 functions as a tumor suppressor in murine osteosarcoma cells. Cancer Sci. 2013;104(7):880–888.
  • Tan Y, Tan L, Huang S, et al. Content determination of active component in Huangqi Yinyanghuo Group and its effects on hTERT and Bcl-2 protein in osteosarcoma. J Anal Methods Chem. 2014;2014:1–6.
  • Morris EJ, Jha S, Restaino CR, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013;3(7):742–750.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.