188
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo

, , ORCID Icon, , , , & show all
Pages 504-510 | Received 28 Aug 2020, Accepted 23 Sep 2020, Published online: 01 Oct 2020

References

  • Haga RB, Ridley AJ. Rho GTPases: regulation and roles in cancer cell biology. Small GTPases. 2016;7(4):207–221.
  • Maldonado MDM, Dharmawardhane S. Targeting Rac and Cdc42 GTPases in cancer. Cancer Res. 2018;78(12):3101–3111.
  • Gómez Del Pulgar T, Valdés-Mora F, Bandrés E, et al. Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int J Oncol. 2008;33(1):185–193.
  • Valdés-Mora F, Locke WJ, Bandrés E, et al. Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer. Oncotarget. 2017;8(16):26755–26770.
  • Gao L, Bai L, Nan Q. Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells. Med Sci Monit Basic Res. 2013;19:201–207.
  • Liu M, Lang N, Chen X, et al. miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells. Cancer Lett. 2011;301(2):151–160.
  • Li Y, Zhu X, Xu W, et al. miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. Biochem Biophys Res Commun. 2013;431(3):560–565.
  • Humphreys KJ, McKinnon RA, Michael MZ. miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells. PLoS One. 2014;9(11):e112288.
  • Chen QY, Jiao DM, Yao QH, et al. Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell cancer cell lines. Int J Oncol. 2012;40(5):1561–1568.
  • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141(1):39–51.
  • Nielsen SR, Schmid MC. Macrophages as key drivers of cancer progression and metastasis. Mediators Inflamm. 2017;2017:9624760.
  • Underhill DM, Bassetti M, Rudensky A, et al. Dynamic interactions of macrophages with T cells during antigen presentation. J Exp Med. 1999;190(12):1909–1914.
  • Noy R, Pollard JW. Tumor-associated macrophages: from mechanisms to therapy. Immunity. 2014;41(1):49–61.
  • Coussens LM, Zitvogel L, Palucka AK. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science. 2013;339(6117):286–291.
  • Lin J, Zhou Z, Huo R, et al. Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis. J Immunol. 2012;188(11):5776–5784.
  • Wang L, Zhang ZG, Zhang RL, et al. Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci. 2006;26(22):5996–6003.
  • Chen J, Chen P, Backman LJ, et al. Ciliary neurotrophic factor promotes the migration of corneal epithelial stem/progenitor cells by up-regulation of MMPs through the phosphorylation of Akt. Sci Rep. 2016;6:25870.
  • Leelatian N, Doxie DB, Greenplate AR, et al. Single cell analysis of human tissues and solid tumors with mass cytometry. Cytometry B Clin Cytom. 2017;92(1):68–78.
  • Liu R, Zhao E, Wang F, et al. CCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road. Signal Transduct Target Ther. 2020;5(1):162.
  • Singh RK, Haka AS, Bhardwaj P, et al. Dynamic actin reorganization and Vav/Cdc42-dependent actin polymerization promote macrophage aggregated LDL (low-density lipoprotein) uptake and catabolism. Arterioscler Thromb Vasc Biol. 2019;39(2):137–149.
  • Reymond N, Im JH, Garg R, et al. Cdc42 promotes transendothelial migration of cancer cells through β1 integrin. J Cell Biol. 2012;199(4):653–668.
  • Almalki SG, Agrawal DK. Effects of matrix metalloproteinases on the fate of mesenchymal stem cells. Stem Cell Res Ther. 2016;7(1):129.
  • Das A, Monteiro M, Barai A, et al. MMP proteolytic activity regulates cancer invasiveness by modulating integrins. Sci Rep. 2017;7(1):14219.
  • Allen WE, Zicha D, Ridley AJ, et al. A role for Cdc42 in macrophage chemotaxis. J Cell Biol. 1998;141(5):1147–1157.
  • Wang X, Gray Z, Willette-Brown J, et al. Macrophage inducible nitric oxide synthase circulates inflammation and promotes lung carcinogenesis. Cell Death Discov. 2018;4:46.
  • Qian B, Deng Y, Im JH, et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One. 2009;4(8):e6562.
  • Qian BZ, Li J, Zhang H, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475(7355):222–225.
  • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–1022.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.