Polygonatum sibiricum polysaccharide inhibits high glucose-induced oxidative stress, inflammatory response, and apoptosis in RPE cells

References

• Petersmann A, Muller-Wieland D, Muller UA, et al. Definition, classification and diagnosis of diabetes mellitus. Exp Clin Endocrinol Diabetes. 2019;127(S 01):S1–S7.
   PubMedGoogle Scholar
• Guthrie RA, Guthrie DW. Pathophysiology of diabetes mellitus. Crit Care Nurs Q. 2004;27(2):113–125.
   PubMedGoogle Scholar
• Sen S, Chakraborty R. Treatment and diagnosis of diabetes mellitus and its complication: advanced approaches. Mini Rev Med Chem. 2015;15(14):1132–1133.
   PubMed Web of Science ®Google Scholar
• Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136.
   PubMed Web of Science ®Google Scholar
• Lechner J, O’Leary OE, Stitt AW. The pathology associated with diabetic retinopathy. Vision Res. 2017;139:7–14.
   PubMed Web of Science ®Google Scholar
• Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93(1):137–188.
   PubMed Web of Science ®Google Scholar
• Simo R, Villarroel M, Corraliza L, et al. The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol. 2010;2010:190724.
   PubMedGoogle Scholar
• Tonade D, Kern TS. Photoreceptor cells and RPE contribute to the development of diabetic retinopathy. Prog Retin Eye Res. 2020;12:100919.
   Google Scholar
• Ponnalagu M, Subramani M, Jayadev C, et al. Retinal pigment epithelium-secretome: a diabetic retinopathy perspective. Cytokine. 2017;95:126–135.
   PubMed Web of Science ®Google Scholar
• Tenconi PE, Bermudez V, Oresti GM, et al. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: new insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019;184:243–257.
   PubMed Web of Science ®Google Scholar
• Devi TS, Yumnamcha T, Yao F, et al. TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells. Biol Open. 2019;8(4):bio038521.
   PubMed Web of Science ®Google Scholar
• Tohari AM, Almarhoun M, Alhasani RH, et al. Protection by vitamin D against high-glucose-induced damage in retinal pigment epithelial cells. Exp Cell Res. 2020;392(1):112023.
   PubMed Web of Science ®Google Scholar
• Wang J, Wong YK, Liao F. What has traditional Chinese medicine delivered for modern medicine? Expert Rev Mol Med. 2018;20:e4.
   PubMed Web of Science ®Google Scholar
• Cui X, Wang S, Cao H, et al. A review: the bioactivities and pharmacological applications of Polygonatum sibiricum polysaccharides. Molecules. 2018;23(5):1170.
   PubMed Web of Science ®Google Scholar
• Long T, Liu Z, Shang J, et al. Polygonatum sibiricum polysaccharides play anti-cancer effect through TLR4-MAPK/NF-κB signaling pathways. Int J Biol Macromol. 2018;111:813–821.
   PubMed Web of Science ®Google Scholar
• Zhang H, Cai XT, Tian QH, et al. Microwave-assisted degradation of polysaccharide from Polygonatum sibiricum and antioxidant activity. J Food Sci. 2019;84(4):754–761.
   PubMed Web of Science ®Google Scholar
• Peng X, He J, Zhao J, et al. Polygonatum sibiricum polysaccharide promotes osteoblastic differentiation through the ERK/GSK-3β/β-catenin signaling pathway in vitro. Rejuvenat Res. 2018;21(1):44–52.
   PubMed Web of Science ®Google Scholar
• Wang Y, Lan C, Liao X, et al. Polygonatum sibiricum polysaccharide potentially attenuates diabetic retinal injury in a diabetic rat model. J Diabetes Investig. 2019;10(4):915–924.
   PubMed Web of Science ®Google Scholar
• Liu N, Dong Z, Zhu X, et al. Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb/c mice. Int J Biol Macromol. 2018;107(Pt A):796–802.
   PubMedGoogle Scholar
• Zheng S. Protective effect of Polygonatum sibiricum polysaccharide on D-galactose-induced aging rats model. Sci Rep. 2020;10(1):2246.
   PubMed Web of Science ®Google Scholar
• Deliyanti D, Alrashdi SF, Tan SM, et al. Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy. Invest Ophthalmol Vis Sci. 2018;59(2):815–825.
   PubMed Web of Science ®Google Scholar
• Samuel W, Jaworski C, Postnikova OA, et al. Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells. Mol Vis. 2017;23:60–89.
   PubMed Web of Science ®Google Scholar
• Liu R, Li X, Zhang X. Dexmedetomidine protects high-glucose induced apoptosis in human retinal pigment epithelial cells through inhibition on p75(NTR). Biomed Pharmacother. 2018;106:466–471.
   PubMed Web of Science ®Google Scholar
• Ahmado A, Carr AJ, Vugler AA, et al. Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19. Invest Ophthalmol Vis Sci. 2011;52(10):7148–7159.
   PubMed Web of Science ®Google Scholar
• Zhu X, Wu W, Chen X, et al. Protective effects of Polygonatum sibiricum polysaccharide on acute heart failure in rats 1. Acta Cir Bras. 2018;33(10):868–878.
   PubMed Web of Science ®Google Scholar
• Cai J, Zhu Y, Zuo Y, et al. Polygonatum sibiricum polysaccharide alleviates inflammatory cytokines and promotes glucose uptake in high-glucose- and high-insulin-induced 3T3-L1 adipocytes by promoting Nrf2 expression. Mol Med Rep. 2019;20(4):3951–3958.
   PubMed Web of Science ®Google Scholar
• Tenconi PE, Bermúdez V, Oresti GM, et al. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: new insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019;07:184–221.
   Google Scholar
• Suzuki T, Yamamoto M. Molecular basis of the Keap1-Nrf2 system. Free Radic Biol Med. 2015;88(Pt B):93–100.
   PubMed Web of Science ®Google Scholar
• Bellezza I, Giambanco I, Minelli A, et al. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 2018;1865(5):721–733.
   PubMed Web of Science ®Google Scholar
• Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2. Antioxid Redox Signal. 2018;29(17):1727–1745.
   PubMed Web of Science ®Google Scholar
• Long M, Rojo de la Vega M, Wen Q, et al. An essential role of NRF2 in diabetic wound healing. Diabetes. 2016;65(3):780–793.
   PubMed Web of Science ®Google Scholar
• Tan SM, de Haan JB. Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much? Redox Rep. 2014;19(3):107–117.
   PubMed Web of Science ®Google Scholar
• Li B, Liu S, Miao L, et al. Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy. Exp Diabetes Res. 2012;2012:216512.
   PubMedGoogle Scholar