Advanced search
Publication Cover
Journal of Receptors and Signal Transduction Volume 42, 2022 - Issue 5
Submit an article Journal homepage
199
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway

Jingti JingDepartment of Orthopedics, The Third Affiliated Hospital of Shenzhen University, Shenzhen, ChinaView further author information
,
Haoming JiangDepartment of Orthopedics, The Third Affiliated Hospital of Shenzhen University, Shenzhen, ChinaView further author information
&
Lin ZhangDepartment of Orthopedics, The Third Affiliated Hospital of Shenzhen University, Shenzhen, ChinaCorrespondence[email protected]
View further author information
Pages 479-485 | Received 11 Nov 2021, Accepted 09 Dec 2021, Published online: 18 Jan 2022

References

  • Gong Z, Xia K, Xu A, et al. Stem cell transplantation: a promising therapy for spinal cord injury. Curr Stem Cell Res Ther. 2020;15(4):321–331.
  • Lan H, Wang Y, Yin T, et al. Progress and prospects of endothelial progenitor cell therapy in coronary stent implantation. J Biomed Mater Res B Appl Biomater. 2016;104(6):1237–1247.
  • Chong MS, Ng WK, Chan JK. Concise review: endothelial progenitor cells in regenerative medicine: applications and challenges. Stem Cells Transl Med. 2016;5(4):530–538.
  • Winkelman MA, Koppes AN, Koppes RA, et al. Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells. APL Bioeng. 2021;5(1):011507.
  • Dumont CM, Piselli JM, Kazi N, et al. Factors released from endothelial cells exposed to flow impact adhesion, proliferation, and fate choice in the adult neural stem cell lineage. Stem Cells Dev. 2017;26(16):1199–1213.
  • Liu ZY, Yang QX, Cao Y, et al. CXCR4 protects bone marrow-derived endothelial progenitor cells against hypoxia through the PI3K/AKT signaling pathway. Exp Ther Med. 2021;22(5):1200.
  • Clarke DL. Neural stem cells. Bone Marrow Transpl. 2003;32(Suppl 1):S13–S17.
  • Yuan D, Xia M, Meng G, et al. Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs. Oncotarget. 2015;6(30):29664–29674.
  • Wang L, Shi Q, Dai J, et al. Increased vascularization promotes functional recovery in the transected spinal cord rats by implanted vascular endothelial growth factor-targeting collagen scaffold. J Orthop Res: Off Pub Orthop Res Soc. 2018;36(3):1024–1034.
  • Pawar UM, Sengupta DK. Pathophysiology of spinal cord injury. Spinal Infect & Trauma. 2014;11(4):389. [10.1016/s1096-2867(96)80013-2]
  • Ruthenborg RJ, Ban JJ, Wazir A, et al. Regulation of wound healing and fibrosis by hypoxia and hypoxia-inducible factor-1. Mol Cells. 2014;37(9):637–643.
  • Liu D, Ye Y, Xu L, et al. Icariin and mesenchymal stem cells synergistically promote angiogenesis and neurogenesis after cerebral ischemia via PI3K and ERK1/2 pathways. Biomed Pharmacother. 2018;108:663–669.
  • Jin K, Zhu Y, Sun Y, et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A. 2002;99(18):11946–11950.
  • Ara J, Fekete S, Zhu A, et al. Characterization of neural stem/progenitor cells expressing VEGF and its receptors in the subventricular zone of newborn piglet brain. Neurochem Res. 2010;35(9):1455–1470.
  • Xiao Z, Kong Y, Yang S, et al. Upregulation of flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation. Cell Res. 2007;17(1):73–79.
  • Koh SH, Lo EH. The role of the PI3K pathway in the regeneration of the damaged brain by neural stem cells after cerebral infarction. J Clin Neurol. 2015;11(4):297–304.
  • Faigle R, Song H. Signaling mechanisms regulating adult neural stem cells and neurogenesis. Biochim Biophys Acta. 2013;1830(2):2435–2448.
  • Anjum A, Yazid MD, Fauzi Daud M, et al. Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. IJMS. 2020;21(20):7533.
  • Zhang J, Chen H, Duan Z, et al. The effects of Co-transplantation of olfactory ensheathing cells and Schwann cells on local inflammation environment in the contused spinal cord of rats. Mol Neurobiol. 2017;54(2):943–953.
  • Gazdic M, Volarevic V, Harrell CR, et al. Stem cells therapy for spinal cord injury. IJMS. 2018;19(4):1039.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.