https://orcid.org/0000-0002-2959-1735
References
- Schalkwijk CG, Stehouwer CDA. Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, ıts vascular complications, and other age-related diseases. Physiol Rev. 2020;100(1):407–461.
- Rabbani N, Thornalley PJ. The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy. Diabetes. 2014;63(1):50–52.
- Rabbani N, Xue M, Thornalley PJ. Dicarbonyl stress, protein glycation and the unfolded protein response. Glycoconj J. 2021;38(3):331–340.
- Basatemur GL, Jørgensen HF, Clarke MCH, et al. Vascular smooth muscle cells in atherosclerosis. Nat Rev Cardiol. 2019;16(12):727–744.
- Yan Y, Li T, Li Z, et al. Metformin suppresses the progress of diabetes-accelerated atherosclerosis by ınhibition of vascular smooth muscle cell migration through AMPK–PDLİM5 pathway. Front Cardiovasc Med. 2021;8(740):690627.
- Chang T, Wang R, Olson DJ, et al. Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. FASEB J. 2011;25(5):1746–1757.
- Jia X, Chang T, Wilson TW, et al. Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1. PLOS One. 2012;7(5):e36610-e36610.
- Lee JH, Parveen A, Do MH, et al. Molecular mechanisms of methylglyoxal-induced aortic endothelial dysfunction in human vascular endothelial cells. Cell Death Dis. 2020;11(5):403.
- Wang Y, Hall LM, Kujawa M, et al. Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K(ATP)/MAPK pathway. Am J Physiol Cell Physiol. 2019;317(1):C68–c81.
- Leone A, Nigro C, Nicolò A, et al. The dual-role of methylglyoxal in tumor progression – novel therapeutic approaches. Front Oncol. 2021;22(11):645686.
- Piazza M, Hanssen NMJ, Persson F, et al. Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: an IRMA2 sub-study. Diabet Med. 2021;38(9):e14405.
- Nigro C, Leone A, Longo M, et al. Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells. Biochim Biophys Acta Mol Basis Dis. 2019;1865(1):73–85.
- Kırça M, Yeşilkaya A. Methylglyoxal stimulates endoplasmic reticulum stress in vascular smooth muscle cells. J Recept Signal Transduction. 2022;42(3):279–276.
- Chang Y-C, Hsieh M-C, Wu H-J, et al. Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells. Toxicol In Vitro. 2015;29(7):1358–1368.
- Liu D, Cheng Y, Tang Z, et al. Potential mechanisms of methylglyoxal-ınduced human embryonic kidney cells damage: regulation of oxidative stress, DNA damage, and apoptosis. Chem Biodivers. 2022;19(2):e202100829.
- Liu B-F, Miyata S, Hirota Y, et al. Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells. Kidney Int. 2003;63(3):947–957.
- Chantarasinlapin P. Regulation of adipocyte differentiation and metabolism: Rab5-guanine nucleotide exchange factors and methylglyoxal. FIU Electronic Theses and Dissertations. 3227. Miami (FL): Florida International University; 2017.
- Afridi SK, Aftab MF, Murtaza M, et al. A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells. Biochem Biophys Res Commun. 2016;476(4):188–195.
- Dhar I, Dhar A, Wu L, et al. Increased methylglyoxal formation with upregulation of renin angiotensin system in fructose fed Sprague Dawley rats. PLOS One. 2013;8(9):e74212-e74212.
- Dhar I, Dhar A, Wu L, et al. Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats. Am J Hypertens. 2014;27(3):308–316.
- Izuhara Y, Sada T, Yanagisawa H, et al. A novel sartan derivative with very low angiotensin II type 1 receptor affinity protects the kidney in type 2 diabetic rats. Arterioscler Thromb Vasc Biol. 2008;28(10):1767–1773.
- Nigro C, Leone A, Raciti GA, et al. Methylglyoxal-glyoxalase 1 balance: the root of Vascular Damage. IJMS. 2017;18:18(1):188.
- Gong L, Li Y, Nedeljkovic-Kurepa A, et al. Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene. 2003;22(30):4702–4709.
- Meng F, Liu L, Chin PC, et al. Akt ıs a downstream target of NF-κB*. J Biol Chem. 2002;277(33):29674–29680.