REFERENCES
- Albert , R and Othm er HG . 2003 . The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster . J Theor Biol , 223 : 1 – 18 .
- Andersen , M E , Clewell , H J III Gargas , M L . 1987 . Physiologically based pharmacokinetics and the risk assessment process for methylene chloride . Toxicol Appl Pharmacol , 87 : 185 – 205 .
- Andersen , M E , Birnbaum , L S Barton , H A . 1997 . Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation . Toxicol Appl Pharmacol , 144 : 145 – 55 .
- Berns , K , Hijmans , E M Mullenders , J . 2004 . A large-scale RNAi screen in human cells identifies new components of the p53 pathway . Nature , 428 : 431 – 7 .
- Bhalla , U S , Ram , P T and Iyengar , R . 2002 . MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network . Science , 297 : 1018 – 23 .
- Chanda , S K , White , S Orth , A P . 2003 . Genome-scale functional profiling of the mammalian AP-1 signaling pathway . Proc Natl Acad Sci USA , 100 : 12153 – 8 .
- Clark , L H , Setzer , R W and Barton , H A . 2004 . Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment . Risk Anal , 24 : 1697 – 717 .
- Gehring , P J , Watanabe , P G and Park , C N . 1978 . Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example—Vinyl chloride . Toxicol Appl Pharmacol , 44 : 581 – 91 .
- Hoffmann , A , Levchenko , A Scott , M L . 2002 . The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation . Science , 298 : 1241 – 5 .
- Ingolia , N T and Murray , A W . 2002 . Signal transduction: History matters . Science , 297 : 948 – 949 .
- Kimbell , J S , Subramaniam , R P Gross , E A . 2001 . Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages . Toxicol Sci , 64 : 100 – 10 .
- Lum , L , Yao , S Mozer , B . 2003 . Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells . Science , 299 : 2039 – 45 .
- Michiels , F , van Es , H van Rompaey , L . 2002 . Arrayed adenoviral expression libraries for functional screening . Nat Biotechnol , 20 : 1154 – 7 .
- Moolgavkar , S H , Luebeck , E G Turim , J . 1999 . Quantitative assessment of the risk of lung cancer associated with occupational exposure to refractory ceramic fibers . Risk Anal , 19 : 599 – 611 .
- Ramsey , J R and Andersen , M E . 1984 . A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans . Toxicol Appl Pharmacol , 73 : 159 – 75 .
- Sheiner , L B and Steimer , J L . 2000 . Pharmacokinetic/pharmacodynamic modeling in drug development . Annu Rev Pharmacol Toxicol , 40 : 67 – 95 .
- Slikker , W Jr , Andersen , M E Bogdanffy , M S . 2004a . Dose-dependent transitions in mechanisms of toxicity . Toxicol Appl Pharmacol , 201 : 203 – 25 .
- Slikker , W Jr , Andersen , M E Bogdanffy , M S . 2004b . Dose-dependent transitions in mechanisms of toxicity: Case studies . Toxicol Appl Pharmacol , 201 : 226 – 94 .
- Ting , A Y and Endy , D . 2002 . Decoding NF-κ B signaling . Science , 298 : 1189 – 90 .
- Tritscher , A M , Goldstein , J A Portier , C J . 1992 . Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: Quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver . Cancer Res , 52 : 3436 – 42 .