156
Views
0
CrossRef citations to date
0
Altmetric
Perspective Article

Needed: Improved Dose Selection in Genetic Toxicology Studies

, &
Pages 4-12 | Published online: 13 Jan 2012

REFERENCES

  • Bryce , S M , Avlasevich , S L Bemis , J C . 2010 . Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships . Mutat Res , 703 : 191 – 9 .
  • Conolly , R B , Beck , B D and Goodman , J I . 1999 . Stimulating research to improve the scientific basis of risk assessment . Toxicol Sci , 49 : 1 – 4 .
  • Doak , S H , Jenkins , G J Johnson , G E . 2007 . Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens . Cancer Res , 67 : 3904 – 11 .
  • Gocke , E and Müller , L . 2009 . In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU . Mutat Res , 678 : 95 – 100 .
  • JECFA (Joint FAO/WHO Expert Committee on Food Additives) . Toxicological Evaluation of Certain Food Additives with a Review of General Principles and of Specifications . 17th report of the Joint FAO/WHO Expert Committee on Food Additives, FAO Nutrition Meetings Report Series 53, WHO Technical Report Series 539 . Rome , Italy.
  • NAS/NRC (National Academy of Sciences/National Research Council) . 2007 . Toxicity Testing in the 21st Century: A Vision and a Strategy , Washington, DC , , USA : Committee on Toxicity Testing and Assessment of Environmental Agents, National Academies Press .
  • OECD (Organization for Economic Co-operation and Development) . 1997a . “ Guidelines for Testing of Chemicals, #476: In Vitro Mammalian Gene Mutation Tests, OECD Publication Service, 2, rue Andre-Pascal, 75775 Paris Cedex 16, France ” .
  • OECD . 1997b . “ Guidelines for Testing of Chemicals, #474: Genetic Toxicology—Micronucleus Test, OECD Publication Service, 2 rue Andre-Pascal, 75775 Paris Cedex 16, France ” .
  • Pollycove , M and Feinendegren , L E . 1999 . Molecular biology, epidemiology, and the demise of the linear no-threshold (LNT) hypothesis . C. R. Acad. Sci. Paris, Sciences de la vie/Life Sciences , 322 : 197 – 204 .
  • Pottenger , L H and Gollapudi , B B . 2009 . A case for a new paradigm in genetic toxicology testing . Mutat Res , 678 : 148 – 51 .
  • Pottenger , L H and Gollapudi , B B . 2010 . Genotoxicity testing: Moving beyond qualitative ‘‘screen and bin” approach towards characterization of dose-response and thresholds . Environ Molec Mutagen , 51 : 792 – 9 .
  • Pottenger , L H , Bus , J S and Gollapudi , B B . 2007 . Genetic toxicity assessment: Employing the best science for human safety evaluation Part VI. When salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment? . Toxicol. Sci. , 98 : 327 – 31 .
  • Pottenger , L H , Schisler , M R Zhang , F . 2009 . Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU . Mutat. Res. , 678 : 138 – 147 .
  • Rappaport , S M and Smith , M T . 2010 . Epidemiology. Environment and disease risks . Science , 330 : 460 – 1 .
  • Rotroff , D M , Wetmore , B A Dix , D J . 2010 . Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening . Toxicol Sci , 117 : 348 – 58 .
  • Slikker , W Jr , Andersen , M E Bogdanffy , M S . 2004a . Dose-dependent transitions in mechanisms of toxicity . Toxicol Appl Pharmacol , 201 : 203 – 25 .
  • Slikker , W Jr , Andersen , M E Bogdanffy , M S . 2004b . Dose-dependent transitions in mechanisms of toxicity: Case studies . Toxicol Appl Pharmacol , 201 : 226 – 94 .
  • Tubiana , M. 2005 . Dose–effect relationship and estimation of the carcinogenic effects of low doses of ionizing radiation: The Joint Report of the Academie des Sciences (Paris) and of the Academie Nationale de Medecine . Int J Radiat Oncol Biol Phys , 63 : 317 – 9 .
  • Wild , CP. 2005 . Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology . Cancer Epidemiol Biomarkers Prev , 14 : 1847 – 50 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.