Determination of Flunitrazepam in Human Plasma and Urine by HPLC with Mass Spectrometry Detection

REFERENCES

• Compton , E.M. ; Volkow , N.D. Abuse of prescription drugs and the risk of addiction . Drug Alcohol Depend. 2006 , 83S , S4 – S7 .
   Web of Science ®Google Scholar
• McCabe , S.E. Correlates of nonmedical use of prescription benzodiazepine anxiolytics: results from a national survey of US . Drug Alcohol Depend. 2005 , 79 , 53 – 62 .
   PubMed Web of Science ®Google Scholar
• Druid , H. ; Holmgren , P. ; Ahlner , J. Flunitrazepam: an evaluation of use, abuse and toxicity . Foren. Sci. Int. 2001 , 122 , 136 – 141 .
   PubMed Web of Science ®Google Scholar
• Ohshima , T. A case of drug-facilitated sexual assault by the use of flunitrazepam . J. Clin. Foren. Med. 2006 , 13 , 44 – 45 .
   PubMedGoogle Scholar
• Hackett , J. ; Elian , A.A. Extraction and analysis of flunitrazepam/7-aminoflunitrazepam in blood and urine by LC-PDA and GC-MS using butyl SPE columns . Foren. Sci. Int. 2006 , 157 , 156 – 162 .
   PubMed Web of Science ®Google Scholar
• El Mahjoub , A. ; Staub , C. Simultaneous determination of benzodiazepines in whole blood or serum by HPLC/DAD with a semi-micro column. J. Pharm. Biomed. Anal. 2000, 23, 447–458.
   PubMed Web of Science ®Google Scholar
• El Mahjoub , A. ; Staub , C. High-performance liquid chromatographic method for the determination of benzodiazepines in plasma or serum using the column-switching technique . J. Chromatogr. B Biomed. Sci. Appl. 2000 , 742 ( 2 ), 381 – 390 .
   PubMedGoogle Scholar
• Berthault , F. ; Kintz , P. ; Mangin , P. Simultaneous high-performance liquid chromatographic analysis of flunitrazepam and four metabolites in serum . J. Chromatogr. B Biomed. Appl. 1996 , 685 ( 2 ), 383 – 387 .
   PubMed Web of Science ®Google Scholar
• Benhamou-Batut , F. ; Demotes-Mainard , F. ; Labat , L. ; Vincon , G. ; Bannwarth , B. Determination of flunitrazepam in plasma by liquid chromatography . J. Pharm. Biomed. Anal. 1994 , 12 ( 7 ), 931 – 936 .
   PubMed Web of Science ®Google Scholar
• Smink , B.E. ; Brandsma , J.E. ; Dijkhuizen , A. ; Lusthof , K.J. ; de Gier , J.J. ; Egberts , A.C.G. ; Uges , D.R.A. Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine-like substances in whole blood by liquid chromatography-(tandem) mass spectrometry . J. Chromatogr. B 2004 , 811 , 13 – 20 .
   PubMed Web of Science ®Google Scholar
• Bugey , A. ; Rudaz , S. ; Staub , C. A fast LC-APCI/MS method for analysing benzodiazepines in whole blood using monolithic support . J. Chromatogr. B 2006 , 832 , 249 – 255 .
   PubMed Web of Science ®Google Scholar
• Quintela , O. ; Cruz , A. ; de Castro , A. ; Concheiro , M. ; Lopez-Rivadulla , M. Liquid chromatography-electrospray ionization mass-spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid . J. Chromatogr. B 2005 , 825 , 63 – 71 .
   PubMedGoogle Scholar
• Fuh , M.-R. ; Lin , S.-W. ; Chen , L.-L. ; Lin , T.-Y. Determination of flunitrazepam and 7-aminoflunitrazepam in human urine by on-line solid phase extraction liquid chromatography-electrospray-tandem mass-spectrometry . Talanta 2007 , 72 , 1329 – 1335 .
   PubMedGoogle Scholar
• Macek , J. ; Klíma , J. ; Ptáček , P. Rapid determination of omeprazole in human plasma by protein precipitation and liquid chromatography-tandem mass spectrometry . J. Chromatogr. B 2007 , 852 , 282 – 287 .
   PubMed Web of Science ®Google Scholar
• Pirnay , S. ; Bouchonnet , S. ; Herve , F. ; Libong , D. ; Milan , N. ; d'Athis , P. ; Baud , F. ; Ricordel , I. Development and validation of a gas chromatography-mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study . J. Chromatogr. B 2004 , 807 , 335 – 342 .
   PubMedGoogle Scholar
• The European Agency for the Evaluation of Medicinal Products. Note for Guidance on the Investigation of Bioavailability and Bioequivalence, London, UK, July 2001 (CPMP/EWP/QWP/1401/98) .
   Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry. Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations, Rockville, USA, March 2003, http://www.fda.gov/cder/guidance/index.htm .
   Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for Industry-Bioanalytical Method Validation, May 2001 .
   Google Scholar
• Souverain , S. ; Rudaz , S. ; Veuthey , J.-L. Matrix effect in LC-ESI-MS and LC-APCI-MS with off-line and on-line extraction procedures. J. Chromatogr. A 2004, 1058, 61–66.
   PubMed Web of Science ®Google Scholar
• Stüber , M. ; Reemtsma , T. Evaluation of three calibration methods to compensate matrix effects in environmental analysis with LC-ESI-MS . Anal. Bioanal. Chem. 2004 , 378 , 910 – 916 .
   PubMed Web of Science ®Google Scholar