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Original Articles

Simultaneous Optimization of Product Purity and Yield in a Simulated Moving Bed Chromatography for Nystatin Purification

Pages 1-27 | Received 04 May 2008, Accepted 30 Jun 2008, Published online: 17 Nov 2008

REFERENCES

  • Jensen , T.B. ; Reijns , T.G.P. ; Billiet , H.A.H. ; van der Wielen , L.A.M. Novel simulated moving-bed for reduced solvent consumption . J. Chromatogr. A. 2000 , 873 , 149 – 162 .
  • Michel , G.W. In Analytical Profiles of Drug Substances ; Florey , K. , Ed.; Academic Press : New York , 1977 , 341 .
  • Mazzotti , M. ; Storti , G. ; Morbidelli , M. Optimal operation of simulated moving bed units for nonlinear chromatographic separations. J. Chromatogr. A. 1997, 769, 3–24.
  • Pais , L.S. ; Loureiro , J.M. ; Rodrigues , A.E. Modeling strategies for enantiomers separation by SMB chromatography . AIChE J. 1998 , 44 , 561 – 569 .
  • Ruthven , D.M. ; Ching , C.B. Counter-current and simulated counter-current adsorption separation processes . Chem. Eng. Sci. 1989 , 44 , 1011 – 1038 .
  • Juza , M. ; Mazzotti , M. ; Morbidelli , M. Simulated moving bed chromatography and its application to chirotechnology . Trends Biotechnol. 2000 , 18 , 108 – 118 .
  • Goldberg , D.E. Genetic algorithms in search, optimization, and machine learning ; Addison-Wesley Longman, Inc. : Reading , MA , 1989 .
  • Zhang , Z. ; Hidajat , K. ; Ray , A.K. ; Morbidelli , M. Multiobjective optimization of SMB and varicol process for chiral separation . AIChE J. 2002 , 48 , 2800 – 2816 .
  • Kasat , R.B. ; Gupta , S.K. Multi-objective optimization of an industrial fluidized-bed catalytic cracking unit (FCCU) using genetic algorithm (GA) with the jumping genes operator . Comput. Chem. Eng. 2003 , 27 , 1785 – 1800 .
  • Zhang , Z. ; Mazzotti , M. ; Morbidelli , M. Multiobjective optimization of simulated moving bed and varicol processes using a genetic algorithm . J. Chromatogr. A 2003 , 989 , 95 – 108 .
  • Ma , Z. ; Wang , N.H.L. Standing wave analysis of SMB chromatography: Linear systems . AIChE J. 1997 , 43 , 2488 – 2508 .
  • Wu , D.J. ; Xie , Y. ; Ma , Z. ; Wang , N.H.L. Design of simulated moving bed chromatography for amino acid separations . Ind. Eng. Chem. Res. 1998 , 37 , 4023 – 4035 .
  • Wankat , P.C. Rate-controlled separations ; Blackie Academic & Professional : Glasgow , UK , 1990 .
  • Hritzko , B.J. ; Xie , Y. ; Wooley , R. ; Wang , N.H.L. Standing wave design of tandem SMB for linear multicomponent systems . AIChE J. 2002 , 48 , 2769 – 2787 .
  • Ergun , S. Flow through packed columns . Chem. Eng. Prog. 1952 , 48 , 89 – 94 .
  • Xie , Y. ; Farrenburg , C.A. ; Chin , C.Y. ; Mun , S. ; Wang , N.H.L. Design of SMB for a nonlinear amino acid system with mass transfer effects . AIChE J. 2003 , 49 , 2850 – 2863 .
  • Zhang , Y. ; Hidajat , K. ; Ray , A.K. Determination of competitive adsorption isotherm parameters of pindolol enantiomers on α1-aicd glycoprotein chiral stationary phase . J. Chromatogr. A. 2006 , 1131 , 176 – 184 .
  • Kurup , A.S. ; Hidajat , K. ; Ray , A.K. Comparative study of modified simulated moving systems at optimal conditions for the separation of ternary mixtures under nonideal conditions . Ind. Eng. Chem. Res. 2006 , 45 , 3902 – 3915 .
  • Storti , G. ; Masi , M. ; Carra , S. ; Morbidelli , M. Optimal design of multicomponent countercurrent adsorption separation processes involving nonlinear equilibria . Chem. Eng. Sci. 1989 , 44 , 1329 – 1345 .
  • Mun , S. ; Wang , N.H.L. ; Koo , Y.M. ; Yi , S.C. Pinched wave design of a four-zone SMB for linear adsorption systems with significant mass-transfer effects . Ind. Eng. Chem. Res. 2006 , 45 , 7241 – 7250 .
  • Mun , S. Effect of subdividing the adsorbent bed in a five-zone simulated moving bed chromatography for ternary separation. J. Liq. Chromatogr. & Rel. Technol. 2008, 31, 1231–1257.
  • Wilson , E.J. ; Geankoplis , C.J. Liquid mass transfer at very low Reynolds numbers in packed beds . Ind. Eng. Chem. Fundam. 1966 , 5 , 9 – 14 .
  • Chung , S.F. ; Wen , C.Y. Longitudinal dispersion of liquid flowing through fixed and fluidized beds . AIChE J. 1968 , 14 , 857 – 866 .

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