Development and Validation of a Reversed Phase HPLC Method for Simultaneous Determination of Curcumin and Piperine in Human Plasma for Application in Clinical Pharmacological Studies

REFERENCES

• Ireson , C.R. ; Jones , D.J.L. ; Orr , S. ; Coughtrie , M.W.H. ; Boocock , D.J. ; Williams , M.L. ; Farmer , P.B. ; Steward , W.P. ; Gescher , A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine . Cancer Epidemiol. Biomarkers Prev. 2002 , 11 ( 1 ), 105 – 111 .
   PubMed Web of Science ®Google Scholar
• Reddy , R.C. ; Vatsala , P.G. ; Keshamouni , V.G. ; Padmanaban , G. ; Rangarajan , P.N. Curcumin for malaria therapy . Biochem. Biophy. Res. Comm. 2005 , 326 , 472 – 474 .
   PubMed Web of Science ®Google Scholar
• Nandakumar , D.N. ; Nagaraj , V.A. ; Vathsala , P.G. ; Rangarajan , P. ; Padmanaban , G. Curcumin-artemisinin combination therapy for malaria . Antimicrob. Agents Chemother. 2006 , 50 ( 5 ), 1859 – 1860 .
   PubMed Web of Science ®Google Scholar
• Sharma , R.A. ; McLelland , H.R. ; Hill , K.A. ; Ireson , C.R. ; Euden , S.A. ; Manson , M.M. ; Pirmohamed , M. ; Marnett , L.J. ; Gescher , A.J. ; Steward , W.P. Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer . Clin. Cancer Res. 2001 , 7 , 1894 – 1900 .
   PubMed Web of Science ®Google Scholar
• Sharma , R.A. ; Euden , S.A. ; Platton , S.L. ; Cooke , D.N. ; Shafayat , A. ; Hewitt , H.R. ; Marczylo , T.H. ; Morgan , B. ; Hemingway , D. ; Plummer , S.M. ; Pirmohamed , M. ; Gescher , A.J. ; Steward , W.P. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance . Clin. Cancer Res. 2004 , 10 , 6847 – 6854 .
   PubMed Web of Science ®Google Scholar
• Ravindranath , V. ; Chandrasekhara , N. In vitro studies on the intestinal absorption of curcumin in rats . Toxicology 1981 , 20 , 251 – 257 .
   PubMed Web of Science ®Google Scholar
• Shoba , G. ; Joy , D. ; Joseph , T. ; Majeed , M. ; Rajendran , R. ; Srinivas , P.S.S.R. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers . Planta Medica 1998 , 64 , 353 – 356 .
   PubMed Web of Science ®Google Scholar
• Pak , Y. ; Patek , R. ; Mayersohn , M. Sensitive and rapid isocratic liquid chromatography method for the quantitation of curcumin in plasma . J. Chromatogr. B 2003 , 796 , 339 – 346 .
   PubMed Web of Science ®Google Scholar
• Liu , A. ; Lou , H. ; Zhao , L. ; Fan , P. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin . J. Pharm. Biomed. Anal. 2006 , 40 , 720 – 727 .
   PubMed Web of Science ®Google Scholar
• Ireson , C. ; Orr , S. ; Jones , D.J.L. ; Verschoyle , R. ; Lim , C.K. ; Luo , J.L. ; Howells , L. ; Plummer , S. ; Jukes , R. ; Williams , M. ; Steward , W.P. ; Gescher , A. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production . Cancer Res. 2001 , 61 , 1058 – 1064 .
   PubMed Web of Science ®Google Scholar
• Garcea , G. ; Jones , D.J.L. ; Singh , R. ; Dennison , A.R. ; Farmer , P.B. ; Sharma , R.A. ; Steward , W.P. ; Gescher , A.J. ; Berry , D.P. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration . Br. J. Cancer 2004 , 90 , 1011 – 1015 .
   PubMed Web of Science ®Google Scholar
• Bano , G. ; Raina , R.K. ; Zutshi , U. ; Bedi , K.L. ; Johri , R.K. ; Sharma , S.C. Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers . Eur. J. Clin. Pharmacol. 1991 , 41 , 615 – 617 .
   PubMed Web of Science ®Google Scholar
• Atal , C.K. ; Dubey , R.K. ; Singh , J. Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism. J. Pharmacol. Exp. Ther. 1985, 232, 258–262.
   PubMed Web of Science ®Google Scholar
• Heath , D.D. ; Pruitt , M.A. ; Brenner , D.E. ; Rock , C.L. Curcumin in plasma and urine: quantitation by high-performance liquid chromatography . J. Chromatogr. B 2003 , 783 , 287 – 295 .
   PubMed Web of Science ®Google Scholar
• Ma , Z. ; Shayeganpour , A. ; Brocks , D.R. ; Lavasanifar , A. ; Samuel , J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin . Biomed. Chromatogr. 2007 , 21 ( 5 ), 546 – 552 .
   PubMed Web of Science ®Google Scholar
• Bajad , S. ; Singla , A.K. ; Bedi , K.L. Liquid chromatographic method for determination of piperine in rat plasma: application to pharmacokinetics . J. Chromatogr. B 2002 , 776 , 245 – 249 .
   PubMed Web of Science ®Google Scholar
• Verma , J.K. ; Joshi , A.V. Rapid HPTLC method for identification and quantification of curcumin, piperine and thymol in an ayurvedic formulation . J. Planar Chromatogr. 2006 , 19 , 398 – 400 .
   Google Scholar
• Wang , Y.J. ; Pan , M.H. ; Cheng , A.L. ; Lin , L.I. ; Ho , Y.S. ; Hsieh , C.Y. ; Lin , J.K. Stability of curcumin in buffer solutions and characterization of its degradation products . J. Pharm. Biomed. Anal. 1997 , 15 , 1867 – 1876 .
   PubMed Web of Science ®Google Scholar
• Bressolle , F. ; Bromet-Petit , M. ; Audran , M. Validation of liquid chromatographic and gas chromatographic methods: application to pharmacokinetics . J. Chromatogr. B 1996 , 686 , 3 – 10 .
   PubMed Web of Science ®Google Scholar
• Guidance for Industry Bioanalytical Method Validation, Department of Health and Human Services, Food and Drug Administration, Rockville, US, 2001 .
   Google Scholar
• Snyder , L.R. ; Kirkland , J.J. ; Glajch , J.L. Practical HPLC Method Development, , 2nd Ed. ; Wiley Interscience : New York , 1997 ; Ch. 14 , 657 .
   Google Scholar