ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY ANALYSIS OF FLUNITRAZEPAM AND 7-AMINOFLUNITRAZEPAM IN HUMAN PLASMA

REFERENCES

• Druid , H. ; Holmgren , P. ; Ahlner , J. Flunitrazepam: An Evaluation of Use, Abuse and Toxicity . Forensic Sci. Int. 2001 , 122 , 136 – 141 .
   PubMed Web of Science ®Google Scholar
• Ohshima , T. A Case of Drug-Facilitated Sexual Assault by the Use of Flunitrazepam . J. Clin. Forensic Med. 2006 , 13 , 44 – 45 .
   PubMedGoogle Scholar
• Hackett , J. ; Elian , A. A. Extraction and Analysis of Flunitrazepam/7-aminoflunitrazepam in Blood and Urine by LC-PDA and GC-MS Using Butyl SPE Columns . Forensic Sci. Int. 2006 , 157 , 156 – 162 .
   PubMed Web of Science ®Google Scholar
• McCabe , S. E. Correlates of Nonmedical Use of Prescription Benzodiazepine Anxiolytics: Results from a National Survey of US . Drug Alcohol Depend. 2005 , 79 , 53 – 62 .
   PubMed Web of Science ®Google Scholar
• San , L. ; Tato , J. ; Torrens , M. ; Castillo , C. ; Farre , M. ; Cami , J. Flunitrazepam Consumption Among Heroin Addicts Admitted for In-Patient Detoxification . Drug Alcohol Depend. 1993 , 32 , 281 – 286 .
   PubMedGoogle Scholar
• Gelkopf , M. ; Bleich , A. ; Hayward , R. ; Bodner , G. ; Adelson , M. Characteristics of Benzodiazepine Abuse in Methadone Maintenance Treatment Patients: A 1 Year Prospective Study in an Israeli Clinic . Drug Alcohol Depend. 1999 , 55 , 63 – 68 .
   PubMed Web of Science ®Google Scholar
• De Wet , C. ; Reed , L. ; Glasper , A. ; Moran , M. ; Bearn , J. ; Gossop , M. Benzodiazepine Co-Dependence Exacerbates the Opiate Withdrawal Syndrome . Drug Alcohol Depend. 2004 , 76 , 31 – 35 .
   PubMed Web of Science ®Google Scholar
• Rickert , V. I. ; Wiemann , C. M. ; Berenson , A. B. Prevalence, Patterns, and Correlates of Voluntary Flunitrazepam Use . Pediatrics. 1999 , 103 ( 1 ), E6 .
   PubMed Web of Science ®Google Scholar
• Scott-Ham , M. ; Burton , F. C. Toxicological Findings of Alleged Drug-Facilitated Sexual Assault in the United Kingdom Over a 3-year Period . J. Clin. Forensic Med. 2005 , 12 , 175 – 186 .
   PubMedGoogle Scholar
• Elian , A. A. Detection of Low Levels of Flunitrazepam and Its Metabolites in Blood and Bloodstains . Forensic Sci. Int. 1999 , 101 , 107 – 111 .
   Google Scholar
• Terada , M. ; Masui , S. ; Hayashi , T. ; Watanabe , R. ; Inoue , H. ; Iino , M. ; Nakatome , M. ; Matoba , R. ; Shinozuka , T. ; Murai , T. ; Tanak , E. ; Honda , K. Simultaneous Determination of Flunitrazepam and 7-aminoflunitrazepam in Human Serum by Ion Trap Gas Chromatography-Tandem Mass Spectrometry . Leg. Med. 2003 , 5 , S96 – S100 .
   Google Scholar
• Cui , S. ; Tan , S. ; Ouyang , G. ; Pawliszyn , J. Automated Polyvinylidene Difluoride Hollow Fiber Liquid-Phase Microextraction of Flunitrazepam in Plasma and Urine Samples for Gas Chromatography/Tandem Mass Spectrometry . J. Chromatogr. A 2009 , 1216 , 2241 – 2247 .
   PubMed Web of Science ®Google Scholar
• Smink , B. E. ; Brandsma , J. E. ; Dijkhuizen , A. ; Lusthof , K. J. ; de Gier , J. J. ; Egberts , A. C. G. ; Uges , D. R. A. Quantitative Analysis of 33 Benzodiazepines, Metabolites and Benzodiazepine-Like Substances in Whole Blood by Liquid Chromatography-(Tandem) Mass Spectrometry . J. Chromatogr. B 2004 , 811 , 13 – 20 .
   PubMed Web of Science ®Google Scholar
• Bugey , A. ; Rudaz , S. ; Staub , C. A Fast LC-APCI/MS Method for Analyzing Benzodiazepines in Whole Blood Using Monolithic Support . J. Chromatogr. B 2006 , 832 , 249 – 255 .
   PubMed Web of Science ®Google Scholar
• Marchi , I. ; Schappler , J. ; Veuthey , J. L. ; Rudaz , S. Development and Validation of a Liquid Chromatography-Atmospheric Pressure Photoionization-Mass Spectrometry Method for the Quantification of Alprazolam, Flunitrazepam, and Their Main Metabolites in Haemolysed Blood . J. Chromatogr. B 2009 , 877 , 2275 – 2283 .
   PubMed Web of Science ®Google Scholar
• Berthault , F. ; Kintz , P. ; Mangin , P. Simultaneous High-Performance Liquid Chromatographic Analysis of Flunitrazepam and Four Metabolites in Serum . J. Chromatogr. B 1996 , 685 ( 2 ), 383 – 387 .
   PubMed Web of Science ®Google Scholar
• He , W. ; Parissis , N. Simultaneous Determination of Flunitrazepam and Its Metabolites in Plasma and Urine by HPLC/DAD After Solid Phase Extraction . J. Pharm. Biomed. Anal. 1997 , 16 , 707 – 715 .
   Google Scholar
• El Mahjoub , A. ; Staub , C. Simultaneous Determination of Benzodiazepines in Whole Blood or Serum by HPLC/DAD with a Semi-Micro Column. J. Pharm. Biomed. Anal. 2000, 23, 447–458.
   PubMed Web of Science ®Google Scholar
• Bugey , A. ; Staub , C. Rapid Analysis of Benzodiazepines in Whole Blood by High-Performance Liquid Chromatography: Use of a Monolithic Column . J. Pharm. Biomed. Anal. 2004 , 35 , 555 – 562 .
   PubMed Web of Science ®Google Scholar
• Bastos Borges , K. ; Freire , E. F. ; Martins , I. ; Bastos De Siqueira , M. E. P. Simultaneous Determination of Multibenzodiazepines by HPLC/UV: Investigation of Liquid-Liquid and Solid-Phase Extractions in Human Plasma . Talanta 2009 , 78 , 233 – 241 .
   Google Scholar
• Benhamou-Batut , F. ; Demotes-Mainard , F. ; Labat , L. ; Vincon , G. ; Bannwarth , B. Determination of Flunitrazepam in Plasma by Liquid Chromatography . J. Pharm. Biomed. Anal. 1994 , 12 ( 7 ), 931 – 936 .
   PubMed Web of Science ®Google Scholar
• Kiss , B. ; Popa , D. S. ; Bojita , M. ; Loghin , F. Development and Validation of a High-Performance Liquid Chromatography Method with Ultraviolet Detection for the Determination of Flunitrazepam in Human Plasma . Rev. Chim.-Bucharest 2008 , 59 ( 12 ), 1301 – 1304 .
   Web of Science ®Google Scholar
• Vlase , L. ; Kiss , B. ; Loghin , F. ; Leucuta , S. E. Determination of Flunitrazepam in Human Plasma and Urine by HPLC with Mass Spectrometry Detection . J. Liq. Chromatogr. Rel. Technol. 2008 , 31 ( 16 ), 2442 – 2454 .
   Web of Science ®Google Scholar
• Moffat , A. C. ; Osselton , M. D. ; Widdop , B. (Eds.) Clarke's Analysis of Drugs and Poisons. , 3rd ed. ; Pharmaceutical Press : London , UK , 2004 ; Vols.775–776 ; pp 1044 – 1045 .
   Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research . Guidance for Industry. Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations ; Rockville , MD , USA , March 2003 , http://www.fda.gov/cder/guidance/index.htm
   Google Scholar
• U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research . Guidance for Industry-Bioanalytical Method Validation ; Rockville , MD , USA , May 2001 .
   Google Scholar