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Original Articles

THE USE OF A MONOLITHIC COLUMN TO IMPROVE THE SIMULTANEOUS DETERMINATION OF CAFFEINE, PARACETAMOL, PSEUDOEPHEDRINE, ASPIRIN, DEXTROMETHORPHAN, CHLORPHENIRAMINE IN PHARMACEUTICAL FORMULATIONS BY HPLC–A COMPARISON WITH A CONVENTIONAL REVERSED-PHASE SILICA-BASED COLUMN

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Pages 2516-2532 | Published online: 01 Dec 2011

REFERENCES

  • Sweetman , S. C. ; Ed. Martindale: The Complete Drug Reference, , 33rd ed. , Pharmaceutical Press : London , 2002 .
  • Heydari , R. A New HPLC Method for the Simultaneous Determination of Acetaminophen, Phenylephrine, Dextromethorphan and Chlorpheniramine in Pharmaceutical Formulations . Anal. Lett. 2008 , 41 ( 6 ), 965 – 976 .
  • Palabiyik , I. M. ; Onur , F. The Simultaneous Determination of Phenylephrine Hydrochloride, Paracetamol, Chlorpheniramine Maleate and Dextromethorphan Hydrobromide in Pharmaceutical Preparations, (2007) . Chromatographia 2007 , 66 ( Supplement ), S93 – S96 .
  • Golubitskii , G. B. ; Budko , E. V. ; Basova , E. M. ; Ivanov , V. M. ; Kostarnoi , A. V. Chromatographic Separation of Paracetamol, Caffeine, and Aspirin on an Adsorbent with Immobilized Nitrile Groups and the Analysis of Askofen P Tablets . J. Anal. Chem. 2007 , 62 ( 6 ), 571 – 574 .
  • El-Gindy , A. ; Emara , S. ; Mesbah , M. K. ; Hadad , G. M. New Validated Methods for the Simultaneous Determination of Two Multicomponent Mixtures Containing Guaiphenesin in syrup by HPLC and Chemometrics-Assisted UV-Spectroscopy . Anal. Lett. 2006 , 39 ( 13–15 ), 2699 – 2723 .
  • Sun , S. F. ; Lui , G. R. ; Wang , Y. H. Simultaneous Determination of Acetaminophen, Caffeine, and Chlorphenamine Maleate in Paracetamol and Chlorphenamine Maleate Granules . Chromatographia 2006 , 64 ( 11–12 ), 719 – 724 .
  • Martinez-Algaba , C. ; Bermudez-Saldana , J. M. ; Villanueva-Camanas , R. M. ; Sagrado , S. ; Medina-Hernandez , M. J. Analysis of Pharmaceutical Preparations Containing Antihistamine Drugs by Micellar Liquid Chromatography . J. Pharm. Biomed. Anal. 2006 , 40 ( 2 ), 312 – 321 .
  • El-Gindy , A. ; Emara , S. ; Mesbah , M. K. ; Hadad , G. M. Liquid Chromatography and Chemometric-Assisted Spectrophotometric Methods for the Analysis of Two Multicomponent Mixtures Containing Cough Suppressant Drugs . J. AOAC Int. 2005 , 88 ( 4 ), 1069 – 1080 .
  • Qi , M. L. ; Wang , P. ; Chen , J. LC Method for the Determination of Multiple Components in a Compound Cold Formulation . Chromatographia 2004 , 60 ( 1–2 ), 105 – 108 .
  • Qi , M. L. ; Wang , P. ; Zhou , L. ; Sun , Y. Simultaneous Determination of Four Active Components in a Compound Formulation by Liquid Chromatography . Chromatographia 2003 , 58 ( 3–4 ), 183 – 186 .
  • Sawyer , M. ; Kumar , V. A Rapid High-Performance Liquid Chromatographic Method for the Simultaneous Quantitation of Aspirin, Salicylic Acid, and Caffeine in Effervescent Tablets . J. Chromatograph. Sci. 2003 , 41 ( 8 ), 393 – 397 .
  • Burge , L. J. ; Raches , D. W. A Rapid HPLC Assay for the Determination of Dextro-Propoxyphene Related Substance in Combination with Aspirin, Acetaminophen, and Caffeine in Tablet and Capsule Formulations . J. Liq. Chromatograph. R. T. 2003 , 26 ( 12 ), 1977 – 1990 .
  • Qi , M. L. ; Wang , P. ; Leng , Y. X. ; Gu , J. L. ; Fu , R. N. Simple HPLC Method for Simultaneous Determination of Acetaminophen, Caffeine and Chlorpheniramine Maleate in Tablet Formulations . Chromatographia 2002 , 56 ( 5–6 ), 295 – 298 .
  • Paciolla , M. D. ; Jansen , S. A. ; Martellucci , S. A. ; Osei , A. A. A Fast and Efficient Determination of Amines and Preservatives in Cough and Cold Liquid and Suspension Formulations Using a Single Isocratic Ion-Pairing High Power Liquid Chromatography Method. J. Pharm. Biomed. Anal. 2001, 26 (1), 143–149.
  • Ramos-Martos , N. ; Aguirre-Gomez , F. ; Molina-Diaz , A. ; Capitan-Vallvey , L. F. Application of Liquid Chromatography to the Simultaneous Determination of Acetylsalicylic Acid, Caffeine, Codeine, Paracetamol, Pyridoxine, and Thiamine in Pharmaceutical Preparations . J. AOAC. Int. 2001 , 84 ( 3 ), 676 – 683 .
  • Altun , M. L. ; Ceyhan , T. ; Kartal , M. ; Atay , T. ; Ozdemir , N. ; Cevheroglu , S. LC Method for the Analysis of Acetylsalicylic Acid, Caffeine and Codeine Phosphate in Pharmaceutical Preparations . J. Pharm. Biomed. Anal. 2001 , 25 ( 1 ), 93 – 101 .
  • Liu , S. Y. ; Woo , S. O. ; Koh , H. L. HPLC and GC-MS Screening of Chinese Proprietary Medicine for Undeclared Therapeutic Substances . J. Pharm. Biomed. Anal. 2001 , 24 ( 5–6 ), 983 – 992 .
  • Xu , X. ; Stewart , J. T. HPLC Methods for Aspirin-Caffeine-Butalbital and Acetaminophen-Caffeine-Butalbital Mixtures in Tablet Dosage Forms Using Non-Porous Octadecylsilane Columns . J. Liq. Chromatograph. R. T. 2000 , 23 ( 5 ), 769 – 779 .
  • Harsono , T. ; Yuwono , M. ; Indrayanto , G. Simultaneous Determination of Some Active Ingredients in Cough and Cold Preparations by Gas Chromatography and Method Validation . J. AOAC. Int. 2005 , 88 ( 4 ), 1093 – 1098 .
  • Moreira , A. B. ; Dias , I. L. T. ; Neto , G. O. ; Zagatto , E. A. G. ; Ferreira , M. M. C. ; Kubota , L. T. Solid-Phase Spectrofluorimetric Determination of Acetylsalicylic Acid and Caffeine in Pharmaceutical Preparations Using Partial Least-Squares Multivariate Calibration . Talanta 2005 , 67 ( 1 ), 65 – 69 .
  • Dinc , E. ; Ozdemir , A. ; Baleanu , D. An Application of Derivative and Continuous Wavelet Transforms to the Overlapping Ratio Spectra for the Quantitative Multiresolution of a Ternary Mixture of Paracetamol, Acetylsalicylic Acid and Caffeine in Tablets . Talanta 2005 , 65 ( 1 ), 36 – 47 .
  • Kompany-Zareh , M. ; Mirzaei , S. Spectrophotometric Resolution of Ternary Mixtures of Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide, and Sodium Benzoate in Syrups Using Wavelength Selection by Net Analyte Signals Calculated with Hybrid Linear Analysis . Anal. Chim. Acta 2004 , 526 ( 1 ), 83 – 94 .
  • Sena , M. M. ; Poppi , R. J. N-way PLS Applied to Simultaneous Spectrophotometric Determination of Acetylsalicylic Acid, Paracetamol and Caffeine . J. Pharm. Biomed. Anal. 2004 , 34 ( 1 ), 27 – 34 .
  • Dinc , E. ; Baleanu , D. ; Onur , F. Simultaneous Spectrophotometric Analysis of Codeine Phosphate, Acetylsalicylic Acid and Caffeine in Tablets by Inverse Least-Squares and Principal Component Regression Techniques . Anal. Lett. 2002 , 35 ( 3 ), 545 – 558 .
  • Lopez-Martinez , L. ; Lopez-de-Alba , P. L. ; Cerda-Martin , V. Bivariate Calibration as an Alternative for Zero-Crossing Technique in the Resolution of Binary Mixtures by Derivative Spectrophotometry . Anal. Lett. 2001 , 34 ( 4 ), 2563 – 2583 .
  • Franeta , J. T. ; Agbaba , D. D. ; Eric , S. M. ; Pavkov , S. P. ; Vladimirov , S. D. ; Aleksic , M. B. Quantitative Analysis of Analgoantipyretics in Dosage Form Using Planar Chromatography . J. Pharm. Biomed. Anal. 2001 , 24 ( 5–6 ), 1169 – 1173 .
  • Injac , R. ; Srdjenovic , B. ; Prijatelj , M. ; Boskovic , M. ; Karljikovic-Rajic , K. ; Strukelj , B. Determination of Caffeine and Associated Compounds in Food, Beverages, Natural Products, Pharmaceuticals, and Cosmetics by Micellar Electrokinetic Capillary Chromatography . J. Chromatogr. Sci. 2008 , 46 ( 2 ), 137 – 143 .
  • Dong , Y. M. ; Chen , X. F. ; Chen , Y. L. ; Chen , X. G. ; Hu , Z. D. Separation and Determination of Pseudoephedrine, Dextromethorphan, Diphenhydramine and Chlorpheniramine in Cold Medicines by Nonaqueous Capillary Electrophoresis . J. Pharm. Biomed. Anal. 2005 , 39 ( 1–2 ), 285 – 289 .
  • Okamoto , H. ; Nakajima , T. ; Ito , Y. ; Aketo , T. ; Shimada , K. ; Yamato , S. Simultaneous Determination of Ingredients in a Cold Medicine by Cyclodextrin-Modified Microemulsion Electrokinetic Chromatography . J. Pharm. Biomed. Anal. 2005 , 37 ( 3 ), 517 – 528 .
  • Wei , W. ; Yu , X. D. ; Ju , H. X. Simultaneous Determination of Several Antalgic Drugs Based on Their Interactions with β-cyclodextrin by Capillary Zone Electrophoresis . J. Chromatograph. Sci. 2004 , 42 ( 3 ), 155 – 160 .
  • Zhang , L. ; Hu , Q. ; Chen , G. N. ; Fang , Y. Z. Simultaneous Determination of the Active Ingredients in Composite Pseudoephedrine Hydrochloride Tablets by Capillary Electrophoresis . Anal. Chim. Acta 2000 , 424 ( 2 ), 257 – 262 .
  • Xu , X. H. ; Stewart , J. T. MEKC Determination of Guaifenesin, Pseudoephedrine and Dextromethorphan in a Capsule Dosage Form. J. Liq. Chromatograph. R. T. 2000, 23 (1), 1–13.
  • Liu , K. H. ; Lee , Y. K. ; Ryu , J. Y. ; Lee , D. J. ; Kang , W. ; Lee , S. S. ; Yoon , Y. R. ; Shin , J. G. Simple and Sensitive Assay of Torasemide in Human Plasma by High-Performance Liquid Chromatography Using a Monolithic Silica Column . Chromatographia 2004 , 60 ( 11–12 ), 639 – 643 .
  • Samanidou , V. F. ; Ioannou , A. S. ; Papadoyannis , I. N. The Use of a Monolithic Column to Improve the Simultaneous Determination of Four Cephalosporin Antibiotics in Pharmaceuticals and Body Fluids by HPLC After Solid Phase Extraction—A Comparison with a Conventional Reversed-Phase Silica-Based Column . J. Chromatogr. B 2004 , 809 ( 1 ), 75 – 182 .
  • Tzanavaras , P. D. ; Themelis , D. G. High-Throughput HPLC Assay of Acyclovir and Its Major Impurity Guanine Using a Monolithic Column and a Flow Gradient Approach . J. Pharm. Biomed. Anal. 2007 , 43 ( 4 ), 1526 – 1530 .
  • Juan , J. B. N. ; Carmen , G. C. ; Maria , J. V. L. ; Virginia , R. R. Enantiomeric Determination, Validation and Robustness Studies of Racemic Citalopram in Pharmaceutical Formulations by Capillary Electrophoresis . J. Chromatogr. A 2005 , 1072 ( 2 ), 249 – 257 .
  • Draper , N. R. ; Smith , H. Fitting a Straight Line by Least Squares . In Applied Regression Analysis ; Wiley : New York , 1981 , pp. 22 – 40 .
  • The European Agency for the Evaluation of Medical Products. ICH Topic Q2B Note for Guidance on Validation of Analytical Procedures: Methodology GPMP/ICH/281/95, 1996 .

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