147
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

DETECTION AND QUANTIFICATION OF METHADONE AND ITS METABOLITE 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE (EDDP) IN URINE PAIN MANAGEMENT COMPLIANCE TESTING BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY

, &

REFERENCES

  • Ferrari , A. ; Coccia , C. P. ; Bertolini , A. ; Sternieri , E. Methadone – Metabolism, Pharmacokinetics and Interactions . Pharmacol. Res. 2004 , 50 , 551 – 559 .
  • Eap , C. E. ; Buclin , T. ; Baumann , P. Interindividual Variability of the Clinical Pharmacokinetics of Methadone Implications for the Treatment of Opioid Dependence . Clin. Pharmacokinet. 2002 , 41 , 1153 – 1193 .
  • Feldman , M. ; Kuntz , D. ; Botelho , K. ; Ananias , D. C. ; Gnezda , M. ; Hoch , D. K. ; Jordan , S. L. ; Rashid , S. ; Zhao , Y. Evaluation of Roche Diagnostics ONLINE DAT II, a New Generation of Assays for the Detection of Drugs of Abuse . J. Anal. Toxicol. 2004 , 28 , 593 – 598 .
  • Pesce , A. ; West , C. ; West , R. ; Crews , B. ; Mikel , C. ; Rosenthal , M. ; Almazon , P. ; Latyshev , S. Determination of Medication Cutoff Values in a Pain Patient Population . J. Opioid Manage. 2011 , 7 , 117 – 122 .
  • Basilicata , P. ; Pieri , M. ; Settembre , V. ; Galdiero , A. ; Della Casa , E. ; Acampora , A. ; Miraglia , N. Screening of Several Drugs of Abuse in Italian Workplace Drug Testing: Performance Comparisons of On-site Screening Tests and a Fluorescence Polarization Immunoassay-based Device . Anal. Chem. 2011 , 8 , 8566 – 8574 .
  • Widschwendter , C. G. ; Zernig , G. ; Hofer , A. Quetiapine Cross Reactivity with Urine Methadone Immunoassays . Am. J. Psychiatry. 2007 , 164 , 172 .
  • Inturrisi , C. E. ; Verebely , K. The Levels of Methadone in the Plasma in Methadone maintenance . Clin. Pharmacol. Ther. 1972 , 13 , 633 – 637 .
  • Inturrisi , C. E. ; Verebely , K. Disposition of Methadone in Man After a Single Oral Dose . Clin. Pharmacol. Ther. 1972 , 13 , 923 – 930 .
  • Bellward , G. D. ; Warren , P. M. ; Howald , W. ; Axelson , J. E. ; Abbott , F. S. Methadone Maintenance: Effect of Urinary pH on Renal Clearance in Chronic High and Low Doses . Clin. Pharmacol. Ther. 1977 , 22 , 92 – 99 .
  • Nilsson , M.-I. ; Widerlöv , E. ; Meresaar , U. ; Änggård , E. Effect of Urinary pH on the Disposition of Methadone in Man . Eur. J. Clin. Pharmacol. 1982 , 22 , 337 – 342 .
  • Sullivan , H. R. ; Due , S. L. Urinary Metabolites of Dl-methadone in Maintenance Subjects . J. Med. Chem. 1973 , 16 , 909 – 913 .
  • Änggàrd , E. ; Gunne , L. M. ; Homstrand , J. ; McMahon , R. E. ; Sandberg , C. G. ; Sullivan , H. R. Disposition of Methadone in Methadone Maintenance . Clin. Pharmacol. Ther. 1975 , 17 , 258 – 266 .
  • Choo , R. E. ; Jansson , L. M. ; Scheidweiler , K. Huestis , M. A. Validated Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometric Method for the Quantification of Methadone, 2-ethlidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in Human Breast Milk . J. Anal. Toxicol. 2007 , 31 , 265 – 269 .
  • Oiestad , E. L. ; Johansen , U. Christophersen. Drug Screening of Preserved Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry . Clin. Chem. 2007 , 53 , 300 – 309 .
  • de Castro , A. ; Concheiro , M. ; Shakleya , D. M. Huestis , M. A. Simultaneous Quantification of Methadone, Cocaine, Opiates and Metabolites in Human Placenta by Liquid Chromatography-Mass Spectrometry. J. Anal. Toxicol. 2009, 33, 243–252.
  • Moody , D. E. ; Lin , S. L. ; Chang , V. ; Lamm , L. ; Greenwald , M. K. Ahmed , M. S. An Enantiomer-Selective Liquid Chromatography-Tandem Mass Spectrometry Method for Methadone and EDDP Validated for Use in Human Plasma, Urine, and Liver Microsomes . J. Anal. Toxicol. 2008 , 32 , 208 – 219 .
  • Shakleya , D. M. ; Dams , R. ; Choo , R. E. ; Jones , H. Huestis , M. A. Simultaneous Liquid Chromatography-Mass Spectrometry Quantification of Urinary Opiates, Cocaine and Metabolites Opiate Dependent Pregnant Women in Methadone-Maintenance Treatment . J. Anal. Toxicol. 2010 , 34 , 17 – 25 .
  • Duxbury , K. ; Romagnoli , C. ; Anderson , M. ; Watts , R. Waite , G. Development of a Clinically Relevant Liquid Chromatographiy Tandem Mass Spectrometry Assay for 13 Drugs of Abuse in Urine, Designed to Meet the Needs of the Service Users . Ann. Clin. Biochem. 2010 , 47 , 415 – 422 .
  • de Jager , A. D. Bailey , N. L. Online Extraction LC-MS/MS Method for the Simultaneous Quantitative Confirmation of Urine Drugs of Abuse and Metabolites: Amphetamine, Opiates, Cocaine, Cannabis, Benzodiazepines and Methadone . J. Chromatogr. B Analyt. Technol. Biomed Life Sci. 2011 , 879 , 2642 – 2652 .
  • U.S. Department of Health and Human Services. Bioanalytical Method Validation: A Guidance for Industry. U.S. Department of Health and Human Services: Washington, DC, May, 2001.
  • Shah , V. P. ; Midha , K. K. ; Findlay , W. A. ; Hill , H. M. ; Hulse , J. D. ; McGilveray , I. J. ; McKay , G. ; Miller , K. J. ; Patnaik , R. N. ; Powell , M. L. ; Tonelli , A. ; Viswanathan , C. T. ; Yacobi , A. Bioanalytical Method Validation – A Revisit with a Decade of Progress . Pharmaceutical. Res. 2000 , 17 , 1551 – 1557 .
  • Shah , V. P. ; Midha , K. K. ; Findlay , W. A. ; Hill , H. M. ; Hulse , J. D. ; McGilveray , I. J. ; McKay , G. ; Miller , K. J. ; Patnaik , R. N. ; Powell , M. L. ; Tonelli , A. ; Viswanathan , C. T. ; Yacobi , A. Bioanalytical Method Validation – A Revisit with a Decade of Progress . Pharmaceutical. Res. 2000 , 17 , 1551 – 1557 .
  • Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ljlc.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.