Metabonomics Study of the Anti-Osteoporosis Effect of Velvet Collagen Hydrolysate Using Rapid Resolution Liquid Chromatography Combined with Quadrupole Time-of-Flight Tandem Mass Spectrometry

References

• Kanis , J. A. ; Melton , L. J. ; Christiansen , C. ; Johnston , C. C. ; Khaltaev , N. The Diagnosis of Osteoporosis . J. Bone Miner. Res. 1994 , 9 ( 8 ), 1137 – 1141 .
   PubMed Web of Science ®Google Scholar
• Reid , I. R. Therapy of Osteoporosis: Calcium, Vitamin D, and Exercise . Am. J. Med. Sci. 1996 , 312 ( 6 ), 278 – 286 .
   PubMed Web of Science ®Google Scholar
• Riggs , B. L. ; Khosla , S. ; Melton , L. J. A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men . J. Bone Miner. Res. 1998 , 13 ( 5 ), 763 – 773 .
   PubMed Web of Science ®Google Scholar
• Lips , P. ; Duong , T. U. ; Oleksik , A. ; Black , D. ; Cummings , S. ; Cox , D. ; Nickelsen , T. A Global Study of Vitamin D Status and Parathyroid Function in Postmenopausal Women with Osteoporosis: Baseline Data from the Multiple Outcomes of Raloxifene Evaluation Clinical Trial . J. Clin. Endocr. Metab. 2001 , 86 ( 3 ), 1212 – 1221 .
   PubMed Web of Science ®Google Scholar
• Riggs , B. L. ; Hodgson , S. F. ; O'Fallon , W. M. ; Chao , E. Y. S. ; Wahner , H. W. ; Muhs , J. M. ; Cedel , S. L. ; Melon III , L. J. Effect of Fluoride Treatment on the Fracture Rate in Postmenopausal Women with Osteoporosis . New Engl. J. Med. 1990 , 322 ( 12 ), 802 – 809 .
   PubMed Web of Science ®Google Scholar
• Jeon , B. ; Kim , S. ; Lee , S. ; Park , P. ; Sung , S. ; Kim , J. ; Moon , S. Effect of Antler Growth Period on the Chemical Composition of Velvet Antler in Sika Deer (Cervus nippon) . Mamm. Biol. 2009 , 74 ( 5 ), 374 – 380 .
   Web of Science ®Google Scholar
• Ohtaishi , N. ; Gao , Y. A Review of the Distribution of All Species of Deer (Tragulidae, Moschidae and Cervidae) in China . Mammal Rev. 1990 , 20 ( 2–3 ), 125 – 144 .
   Web of Science ®Google Scholar
• Niu , F. ; Zhao , Y. ; Xu , Y. ; Zhang , H. ; Lin , Y. Therapeutic Effects of Collagen of Antler Plate on Osteoporosis in Ovariectomized Rats . Chin. J. Modern Appl. Pharm. 2012 , 29 ( 2 ), 93 – 97 .
   Google Scholar
• Li , H.-Q. ; Jin , L.-J. ; Wu , F.-F. ; Li , X.-Y. ; You , J.-S. ; Cao , Z.-H. ; Li , D. ; Xu , Y. P. Effect of Curcumin on Proliferation, Cell Cycle, and Caspases and MCF-7 Cells . Afr. J. Pharm. Pharmaco. 2012 , 6 ( 12 ), 864 – 870 .
   Web of Science ®Google Scholar
• Ying , Y. ; Gao , Y. ; Ma , Y.-H. ; Liu , W.-L. ; Zhao , M. ; Gao , Z. M. Clinical Study of Gushen Tablet in Reducing Children's Nephrotic Syndrome Relapse . Chin. J. Integra. Med. 2003 , 9 ( 3 ), 185 – 190 .
   Google Scholar
• Wu , F. F. ; Li , H. Q. ; Jin , L. ; Li , X. Y. ; Ma , Y. S. ; You , J. S. ; Li , S. ; Xu , Y. P. Deer Antler Base as a Traditional Chinese Medicine: A Review of Its Traditional Uses, Chemistry and Pharmacology . J. Ethnopharmacol. 2012 , 145 ( 2 ), 403 – 415 .
   PubMed Web of Science ®Google Scholar
• Kim , K.-S. ; Choi , Y.-H. ; Kim , K.-H. ; Lee , Y.-C. ; Kim , C.-H. ; Moon , S.-H. ; Kang , S.-G. ; Park , Y.-G. Protective and Anti-Arthritic Effects of Deer Antler Aqua-Acupuncture (DAA), Inhibiting Dihydroorotate Dehydrogenase, on Phosphate Ions-Mediated Chondrocyte Apoptosis and Rat Collagen-Induced Arthritis . Int. Immunopharmacol. 2004 , 4 ( 7 ), 963 – 973 .
   PubMed Web of Science ®Google Scholar
• Kang , S.-K. ; Kim , K.-S. ; Kim , S.-I. ; Chung , K.-H. ; Lee , I.-S. ; Kim , C.-H. Immunosuppressive Activity of Deer Antler Extracts of Cervus Korean TEMMINCK var. mantchuricus Swinhoe, on Type II Collagen-Induced Arthritis . In Vitro Cell. Dev-An. 2006 , 42 ( 3–4 ), 100 – 107 .
   PubMed Web of Science ®Google Scholar
• Gray , C. ; Hukkanen , M. ; Konttinen , Y. T. ; Terenghi , G. ; Arnett , T. R. ; Jones , S. J. ; Burnstock , G. ; Polak , J. M. Rapid Neural Growth: Calcitonin Gene-Related Peptide and Substance P-Containing Nerves Attain Exceptional Growth Rates in Regenerating Deer Antler . Neuroscience 1992 , 50 ( 4 ), 953 – 963 .
   PubMed Web of Science ®Google Scholar
• Zhao , Y. ; Yao , B. ; Zhang , M. ; Wang , S. ; Zhang , H. ; Xiao , W. Comparative Analysis of Differentially Expressed Genes in Sika Deer Antler at Different Stages . Mol. Biol. Rep. 2013 , 40 ( 2 ), 1665 – 1676 .
   PubMed Web of Science ®Google Scholar
• Nicholson , J. K. ; Lindon , J. C. ; Holmes , E. “Metabonomics”: Understanding the Metabolic Responses of Living Systems to Pathophysiological Stimuli Via Multivariate Statistical Analysis of Biological NMR Spectroscopic Data. Xenobiotica 1999, 29 (11), 1181–1189.
   PubMed Web of Science ®Google Scholar
• Nicholson , J. K. ; Connelly , J. ; Lindon , J. C. ; Holmes , E. Metabonomics: A Platform for Studying Drug Toxicity and Gene Function . Nat. Rev. Drug Discov. 2002 , 1 ( 2 ), 153 – 161 .
   PubMed Web of Science ®Google Scholar
• Li , F. ; Lu , X.-M. ; Liu , H.-P. ; Liu , M. ; Xiong , Z. A Pharmaco‐Metabonomic Study on the Therapeutic Basis and Metabolic Effects of Epimedium brevicornum Maxim. on Hydrocortisone‐Induced Rat Using UPLC–MS . Biomed. Chromatogr. 2007 , 21 ( 4 ), 397 – 405 .
   PubMed Web of Science ®Google Scholar
• Lao , Y.-M. ; Jiang , J. ; Yan , L. Application of Metabonomic Analytical Techniques in the Modernization and Toxicology Research of Traditional Chinese Medicine . Brit. J. Pharmacol. 2009 , 157 ( 7 ), 1128 – 1141 .
   PubMed Web of Science ®Google Scholar
• Griffin , J. L. Metabonomics: NMR Spectroscopy and Pattern Recognition Analysis of Body Fluids and Tissues for Characterization of Xenobiotic Toxicity and Disease Diagnosis . Curr. Opin. Chem. Biol. 2003 , 7 ( 5 ), 648 – 654 .
   PubMed Web of Science ®Google Scholar
• Brindle , J. T. ; Antti , H. ; Holmes , E. ; Tranter , G. ; Nicholson , J. K. ; Bethell , H. W.L. ; Clarke , S. ; Schofield , P. M. ; McKilligin , E. ; Mosedale , D. E. Rapid and Noninvasive Diagnosis of the Presence and Severity of Coronary Heart Disease Using 1H-NMR-Based Metabonomics . Nat. Med. 2002 , 8 ( 12 ), 1439 – 1445 .
   PubMed Web of Science ®Google Scholar
• Sangster , T. ; Major , H. ; Plumb , R. ; Wilson , A. J. ; Wilson , I. D. A Pragmatic and Readily Implemented Quality Control Strategy for HPLC–MS and GC–MS-Based Metabonomic Analysis . Analyst 2006 , 131 ( 10 ), 1075 – 1078 .
   PubMed Web of Science ®Google Scholar
• Wiklund , S. ; Johansson , E. ; Sjöström , L. ; Mellerowicz , E. J. ; Edlund , U. ; Shockcor , J. P. ; Gottfries , J. ; Moritz , T. ; Trygg , J. Visualization of GC/TOF-MS-Based Metabolomics Data for Identification of Biochemically Interesting Compounds Using OPLS Class Models . Anal. Chem. 2008 , 80 ( 1 ), 115 – 122 .
   PubMed Web of Science ®Google Scholar
• Niu , J. ; Pi , Z. ; Yue , H. ; Yang , H.-M. ; Wang , Y. ; Yu , Q. ; Liu , S. Effect of 20 (S)‐Ginsenoside Rg3 on Streptozotocin‐Induced Experimental Type 2 Diabetic Rats: A Urinary Metabonomics Study by Rapid‐Resolution Liquid Chromatography/Mass Spectrometry . Rapid Commun. Mass Sp. 2012 , 26 ( 23 ), 2683 – 2689 .
   PubMed Web of Science ®Google Scholar
• Yue , H. ; Wang , Y. ; Zhang , Y. n. ; Ren , H. ; Wu , J. ; Ma , L. ; Liu , S. A Metabnomics Study of Colorectal Cancer by RRLC–QTOF/MS . J. Liq. Chromatogr. R. T. 2013 , 36 ( 4 ), 428 – 438 .
   Web of Science ®Google Scholar
• Ramautar , R. ; Somsen , G. W. ; de Jong , G. J. CE–MS for Metabolomics: Developments and Applications in the Period 2010–2012 . Electrophoresis 2013 , 34 ( 1 ), 86 – 98 .
   PubMed Web of Science ®Google Scholar
• D'Eufemia , P. ; Finocchiaro , R. ; Celli , M. ; Raccio , I. ; Zambrano , A. ; Tetti , M. ; Smacchia , P. ; Iacobini , M. Taurine Deficiency in Thalassemia Major-Induced Osteoporosis Treated with Neridronate . Biomed. Pharmacother. 2010 , 64 ( 4 ), 271 – 274 .
   PubMed Web of Science ®Google Scholar
• Na Li and Lijing Zhao contributed equally to this work.
   Google Scholar