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Original Articles

Effects of Sample Processing Techniques and Instrument Model on Matrix Effect in LC-MS/MS for a Model Drug

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References

  • Taylor, P. J. Matrix Effects: The Achilles Heel of Quantitative High-Performance Liquid Chromatography-Electrospray-Tandem Mass Spectrometry. Clin. Biochem. 2005, 38 (4), 328–334.
  • King, R.; Bonfiglio, R.; Metzlera, C. F.; Stein, C. M.; Olah, T. Mechanistic Investigation of Ionization Suppression in Electrospray Ionization. J. Am. Soc. Mass Spectrometry 2000, 11 (11), 942–950.
  • Mei, H.; Hsieh, Y.; Nardo, C.; Xu, X.; Wasng, S.; Ng, K.; Korfmacher, W. A. Investigation of Matrix Effects in Bioanalytical High-Performance Liquid Chromatography/Tandem Mass Spectrometric Assays: Application to Drug Discovery. Rapid Commun. Mass Spectrometry 2003, 17 (1), 97–103.
  • Gustavsson, S. A.; Samskog, J.; Markides, K. E.; Langstrom, B. Studies of Signal Suppression in Liquid Chromatography-Electrospray Ionization Mass Spectrometry Using Volatile Ion-Pairing Reagents. J. Chromatography A 2001, 937 (1–2), 41–47.
  • Heller, D. N. Ruggedness Testing of Quantitative Atmospheric Pressure Ionization Mass Spectrometry Methods: The Effect of Co-Injected Matrix on Matrix Effects. Rapid Commun. Mass Spectrometry 2007, 21 (5), 644–652.
  • Chambers, E.; Diehl, D. M. W.; Lu, Z.; Mazzeo, J. R. Systematic and Comprehensive Strategy for Reducing Matrix Effects in LC/MS/MS Analyses. J. Chromatography B, Anal. Technol. Biomed. Life Sci. 2007, 852 (1–2), 22–34.
  • Ghosh, C.; Shashank, G.; Shinde, C. P.; Chakraborthy, B. S. A Systematic Approach to Overcome the Matrix Effect during LC-ESI-MS/MS Analysis by Different Sample Extraction Techniques. J. Bioequivalence Bioavailability 2011, 3 (6), 122–127.
  • Dams, R.; Huestis, M. A.; Lambert, W. E.; Murphy, C. M. Matrix Effect in Bio-Analysis of Illicit Drugs with LC-MS/MS: Influence of Ionization Type, Sample Preparation, and Biofluid. J. Am. Soc. Mass Spectrometry 2003, 14 (11), 1290–1294.
  • Remane, D.; Meyer, M. R.; Wissenbach, D. K.; Maurer, H. H. Ion Suppression and Enhancement Effects of Co-Eluting Analytes in Multi Analyte Approaches: Systematic Investigation Using Ultra-High Performance Liquid Chromatography/Mass Spectrometry with Atmospheric-Pressure Chemical Ionization or Electrospray Ionization. Rapid Commun. Mass Spectrometry 2010, 24 (21), 3103–3108.
  • Lindegardh, N.; Annerberg, A.; White, N. J.; Day, N. P. J. Development and Validation of a Liquid Chromatographic-Tandem Mass Spectrometric Method for Determination of Piperaquine in Plasma Stable Isotope Labeled Internal Standard does not always Compensate for Matrix Effects. J. Chromatography B, Anal. Technol. Biomed. Life Sci. 2008, 862 (1–2), 227–236.
  • Michotte, Y.; Lanckmans, K.; Sarre, S.; Smolders, I. Use of a Structural Analogue Versus a Stable Isotope Labeled Internal Standard for the Quantification of Angiotensin IV in Rat Brain Dialysates using Nano-Liquid Chromatography/Tandem Mass Spectrometry. Rapid Commun. Mass Spectrometry 2007, 21 (7), 1187–1195.
  • Schuhmacher, J.; Zimmer, D.; Tesche, F.; Pickard, V. Matrix Effects during Analysis of Plasma Samples by Electrospray and Atmospheric Pressure Chemical Ionization Mass Spectrometry: Practical Approaches to Their Elimination. Rapid Commun. Mass Spectrometry 2003, 17 (17), 1950–1957.
  • Matuszewski, B. R. Standard Line Slopes as a Measurement of Relative Matrix Effect in Quantitative HPLC-MS Bioanalysis. J. Chromatography B 2006, 830 (2), 293–300.
  • Kauppila, T. J.; Kuuranne, T.; Meurer, E. C.; Eberlin, M. N.; Kotiaho, T.; Ostiainen, R. Atmospheric Pressure Photoionization Mass Spectrometry (APPIMS)—Ionization Mechanism and the Effect of Solvent on the Ionization of Naphthalenes. Anal. Chem. 2002, 74 (3), 5470–5479.
  • Guidance for Industry: Bioanalytical Method Validation. US Food and Drug http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM368107.pdf. (Accessed Nov 9, 2014) 2013.
  • Guideline on Bioanalytical Method Validation. European Medicines Agency: Guideline on Bioanalytical Method Validation. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf. (accessed Nov 9, 2014) 2011.

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