Rapidly identify compounds from danshen by using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer and predict its mechanisms of intervening thrombotic diseases

References

• Huang, J.; Tang, X.; Ye, F.; He, J.; Kong, X. Clinical Therapeutic Effects of Aspirin in Combination with Fufang Danshen Diwan, a Traditional Chinese Medicine Formula, on Coronary Heart Disease: A Systematic Review and Meta-Analysis. Cell. Physiol. Biochem. 2016, 39, 1955–1963. doi:10.1159/000447892.
   PubMed Web of Science ®Google Scholar
• Cheng, T. O. Danshen: A Versatile Chinese Herbal Drug for the Treatment of Coronary Heart Disease. Int. J. Cardiol. 2006, 113, 437–438. doi:10.1016/j.ijcard.2005.10.026.
   PubMed Web of Science ®Google Scholar
• Fan, H. Y.; Fu, F. H.; Yang, M. Y.; Xu, H.; Zhang, A. H.; Liu, K. Antiplatelet and Antithrombotic Activities of Salvianolic Acid A. Thromb. Res. 2010, 126, e17–e22. doi:10.1016/j.thromres.2010.04.006.
   PubMed Web of Science ®Google Scholar
• Wang, F.; Liu, Y. Y.; Liu, L. Y.; Zeng, Q. J.; Wang, C. S.; Sun, K.; Yang, J. Y.; Guo, J.; Fan, J. Y.; Han, J. Y. The Attenuation Effect of 3,4-Dihydroxy-Phenyl Lactic Acid and Salvianolic Acid B on Venular Thrombosis Induced in Rat Mesentery by Photochemical Reaction. Clin. Hemorheol. Microcirc. 2009, 42, 7–18.
   PubMed Web of Science ®Google Scholar
• Moon, C. Y.; Ku, C. R.; Cho, Y. H.; Lee, E. J. Protocatechuic Aldehyde Inhibits Migration and Proliferation of Vascular Smooth Muscle Cells and Intravascular Thrombosis. Biochem. Biophys. Res. Commun. 2012, 423, 116–121. doi:10.1016/j.bbrc.2012.05.092.
   PubMed Web of Science ®Google Scholar
• Fan, H.; Li, M.; Yu, L.; Jin, W.; Yang, J.; Zhang, Y.; Wan, H. Effects of Danhong Injection on Platelet Aggregation in Hyperlipidemia Rats. J. Ethnopharmacol. 2018, 212, 67–73. doi:10.1016/j.jep.2017.10.017.
   PubMed Web of Science ®Google Scholar
• Wang, X.; Zhang, Z. R.; Fu, H.; Liu, J.; Chen, Q.; Nie, Y.; Deng, L.; Gong, T. Simultaneous Determination and Pharmacokinetic Study of Water-Soluble and Lipid-Soluble Components of Danshen in Rat Plasma Using HPLC-UV Method. Biomed. Chromatogr. 2007, 21, 1180–1185. doi:10.1002/bmc.872.
   PubMed Web of Science ®Google Scholar
• Wang, J.; Jiang, Q.; Wan, L.; Yang, K.; Zhang, Y.; Chen, Y.; Wang, E.; Lai, N.; Zhao, L.; Jiang, H.; et al. Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats. Am. J. Respir. Cell Mol. Biol. 2013, 48, 125–134. doi:10.1165/rcmb.2012-0071OC.
   PubMed Web of Science ®Google Scholar
• Joe, Y.; Zheng, M.; Kim, H. J.; Kim, S.; Uddin, M. J.; Park, C.; Ryu, D. G.; Kang, S. S.; Ryoo, S.; Ryter, S. W.; et al. Salvianolic Acid B Exerts Vasoprotective Effects through the Modulation of Heme Oxygenase-1 and Arginase Activities. J. Pharmacol. Exp. Ther. 2012, 341, 850–858. doi:10.1124/jpet.111.190736.
   PubMed Web of Science ®Google Scholar
• Qi, Y.; Zhao, X.; Liu, H.; Wang, Y.; Zhao, C.; Zhao, T.; Zhao, B.; Wang, Y. Identification of a Quality Marker (Q-Marker) of Danhong Injection by the Zebrafish Thrombosis Model. Molecules 2017, 22, 1443. doi:10.3390/molecules22091443.
   Web of Science ®Google Scholar
• Li, D.; Xu, G.; Ren, G.; Sun, Y.; Huang, Y.; Liu, C. The Application of Ultra-High-Performance Liquid Chromatography Coupled with a LTQ-Orbitrap Mass Technique to Reveal the Dynamic Accumulation of Secondary Metabolites in Licorice under ABA Stress. Molecules 2017, 22, 1742. doi:10.3390/molecules22101742.
   Web of Science ®Google Scholar
• Li, X.; Xu, X.; Wang, J.; Yu, H.; Wang, X.; Yang, H.; Xu, H.; Tang, S.; Li, Y.; Yang, L.; et al. A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment. PLoS One. 2012, 7, e43918 doi:10.1371/journal.pone.0043918.
   PubMed Web of Science ®Google Scholar
• Hu, P.; Luo, G. A.; Zhao, Z.; Jiang, Z. H. Quality Assessment of Radix Salviae miltiorrhizae. Chem. Pharm. Bull. 2005, 53, 481–486. doi:10.1248/cpb.53.481.
   PubMed Web of Science ®Google Scholar
• Chang, Y. X.; Yan, D. M.; Chen, L. L.; Ding, X. P.; Qi, J.; Kang, L. Y.; Zhang, B. L.; Yu, B. Y. Potency Fingerprint of Herbal Products Danshen Injection for Their Quality Evaluation. Chem. Pharm. Bull. 2009, 57, 586–590. doi:10.1248/cpb.57.586.
   PubMed Web of Science ®Google Scholar
• Yao, H.; Huang, X.; Li, S.; Wu, Y.; Lin, X.; Shi, P. Simultaneous Determination of Eight Phenolic Acids, Five Saponins and Four Tanshinones for Quality Control of Compound Preparations Containing Danshen-Sanqi Herb-Pair by HPLC-DAD. Pharmacogn. Mag. 2017, 13, 64–75.
   PubMed Web of Science ®Google Scholar
• Liu, A. H.; Lin, Y. H.; Yang, M.; Guo, H.; Guan, S. H.; Sun, J. H.; Guo, D. A. Development of the Fingerprints for the Quality of the Roots of Salvia Miltiorrhiza and Its Related Preparations by HPLC-DAD and LC-MS(n). J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2007, 846, 32–41. doi:10.1016/j.jchromb.2006.08.002.
   PubMed Web of Science ®Google Scholar
• Cao, J.; Qi, L. W.; Chen, J.; Yi, L.; Li, P.; Ren, M. T.; Li, Y. J. Application of Liquid Chromatography-Electrospray Ionization Time-of-Flight Mass Spectrometry for Analysis and Quality Control of Compound Danshen Preparations. Biomed. Chromatogr. 2009, 23, 397–405. doi:10.1002/bmc.1130.
   PubMed Web of Science ®Google Scholar
• Song, J. Z.; Li, S. L.; Zhou, Y.; Qiao, C. F.; Chen, S. L.; Xu, H. X. A Novel Approach to Rapidly Explore Analytical Markers for Quality Control of Radix Salviae Miltiorrhizae Extract Granules by Robust Principal Component Analysis with Ultra-High Performance Liquid Chromatography-Ultraviolet-Quadrupole Time-of-Flight Mass Spectrometry. J. Pharm. Biomed. Anal. 2010, 53, 279–286. doi:10.1016/j.jpba.2010.03.022.
   PubMed Web of Science ®Google Scholar
• Li, M. H.; Chen, J. M.; Peng, Y.; Wu, Q.; Xiao, P. G. Investigation of Danshen and Related Medicinal Plants in China. J. Ethnopharmacol. 2008, 120, 419–426. doi:10.1016/j.jep.2008.09.013.
   PubMed Web of Science ®Google Scholar
• Wang, Y.; Shen, Y.; Shen, Z.; Zhao, L.; Ning, D.; Jiang, C.; Zhao, R.; Huang, L. Comparative Proteomic Analysis of the Response to Silver Ions and Yeast Extract in Salvia Miltiorrhiza Hairy Root Cultures. Plant Physiol. Biochem. 2016, 107, 364–373. doi:10.1016/j.plaphy.2016.06.028.
   PubMed Web of Science ®Google Scholar
• Zhou, L. S.; Tang, K.; Guo, S. X. The Plant Growth-Promoting Fungus (PGPF) Alternaria Sp. A13 Markedly Enhances Salvia Miltiorrhiza Root Growth and Active Ingredient Accumulation under Greenhouse and Field Conditions. Ijms. 2018, 19, 270. doi:10.3390/ijms19010270.
   Google Scholar
• Wang, D.; Yao, W.; Song, Y.; Liu, W.; Wang, Z. Molecular Characterization and Expression of Three Galactinol Synthase Genes That Confer Stress Tolerance in Salvia Miltiorrhiza. J. Plant Physiol. 2012, 169, 1838–1848. doi:10.1016/j.jplph.2012.07.015.
   PubMed Web of Science ®Google Scholar
• Wang, H.; Wu, Y.; Yang, X.; Guo, X.; Cao, X. SmLEA2, a Gene for Late Embryogenesis Abundant Protein Isolated from Salvia Miltiorrhiza, Confers Tolerance to Drought and Salt Stress in Escherichia coli and S. miltiorrhiza. Protoplasma 2017, 254, 685–696. doi:10.1007/s00709-016-0981-z.
   PubMed Web of Science ®Google Scholar
• Fei, Y. X.; Wang, S. Q.; Yang, L. J.; Qiu, Y. Y.; Li, Y. Z.; Liu, W. Y.; Xi, T.; Fang, W. R.; Li, Y. M. Salvia Miltiorrhiza Bunge (Danshen) Extract Attenuates Permanent Cerebral Ischemia through Inhibiting Platelet Activation in Rats. J. Ethnopharmacol. 2017, 207, 57–66. doi:10.1016/j.jep.2017.06.023.
   PubMed Web of Science ®Google Scholar
• Xu, G.; Cai, W.; Gao, W.; Liu, C. A Novel Glucuronosyltransferase Has an Unprecedented Ability to Catalyse Continuous Two-Step Glucuronosylation of Glycyrrhetinic Acid to Yield Glycyrrhizin. New Phytol. 2016, 212, 123 doi:10.1111/nph.14039.
   PubMed Web of Science ®Google Scholar