112
Views
2
CrossRef citations to date
0
Altmetric
Articles

Monitoring the ingredient change during the production of Tan Re Qing capsules from Scutellariae Radix by HPLC-MS/MS

, , &

References

  • Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing, China: China Medical Science Press Volume I: 301, 2015.
  • Shang, X.; He, X.; He, X.; Li, M.; Zhang, R.; Fan, P.; Zhang, Q.; Jia, Z. The Genus Scutellaria an Ethnopharmacological and Phytochemical Review. J. Ethnopharmacol 2010, 128, 279–313. DOI: 10.1016/j.jep.2010.01.006.
  • Tang, W.; Fang, M.; Liu, X.; Yue, M. Simultaneous Quantitative and Qualitative Analysis of Flavonoids from Ultraviolet-B Radiation in Leaves and Roots of Scutellaria baicalensis Georgi Using LC-UV-ESI-Q/TOF/MS. J. Anal. Methods. Chem. 2014, 643879. DOI: 10.1155/2014/643879.
  • Li, C.; Lin, G.; Zuo, Z. Pharmacological Effects and Pharmacokinetics Properties of Radix Scutellariae and Its Bioactive Flavones. Biopharm. Drug Dispos. 2011, 32, 427–445. DOI: 10.1002/bdd.771.
  • Zhou, X.; Choi, P.-S.; Yang, J.; Or, P.; Hoi, P.-M.; Lee, S.-M.-Y. Chemical and Pharmacological Evaluations on the Extract of Scutellaria baicalensis Georgi (Huang-Qin) Prepared by Various Extraction Methods. Springerplus 2016, 5, 1438.
  • Chirikova, N.-K.; Olennikov, D.-N.; Rokhin, A.-V. Organic Acids from Medicinal Plants. 4. Scutellaria baicalensis. Chem. Nat. Compd. 2008, 44, 84–86. DOI: 10.1007/s10600-008-0023-y.
  • Chirikova, N. K.; Olennikov, D.-N. Composition of the Aerial Part of Scutellaria baicalensis. Chem. Nat. Compd. 2008, 44, 361–362. DOI: 10.1007/s10600-008-9062-7.
  • Son, E.; Kim, H.-K.; Kim, H.-S.; Kim, M.-R.; Kim, D.-S. Quantification of Propionic Acid from Scutellaria baicalensis Roots. Integr. Med. Res. 2017, 6, 93–96.
  • Nurul, I. M.; Downey, F.; Ng, C. Comparative Analysis of Bioactive Phytochemicals from Scutellaria baicalensis, Scutellaria lateriflora, Scutellaria racemosa, Scutellaria tomentosa and Scutellaria wrightii by LC-DAD-MS. Metabolomics 2010, 7, 446–453. DOI: 10.1007/s11306-010-0269-9.
  • Shi, G.; Yao, R.; Wang, G.; Wang, Z.; Chen, F. Liquid Chromatography-Tandem Mass Spectrometry Screening Method for the Detection of Radical-Scavenging Natural Antioxidants from the Whole Scutellariae (Radix, Stem and Leaf). J. Chromatogr. Sci. 2015, 53, 1140–1146. DOI: 10.1093/chromsci/bmu176.
  • Liu, W.; Jiang, H.; Cai, L.; Yan, M.; Dong, S.; Mao, B. Tanreqing Injection Attenuates Lipopolysaccharide-Induced Airway Inflammation through MAPK/NF-kappaB Signaling Pathways in Rats Model. Evid. Based. Complement. Alternat. Med 2016, 5292346. DOI: 10.1155/2016/5292346.
  • Zhang, F.; Sun, L.; Gao, S.; Chen, W.; Chai, Y. LC-MS/MS Analysis and Pharmacokinetic Study on Five Bioactive Constituents of Tanreqing Injection in Rats. Chin. J Nat. Med. 2016, 14, 769–775. DOI: 10.1016/S1875-5364(16)30091-7.
  • Zhang, Z.; Zhong, P.; Xu, Y. Comparison of Chemical Compositions between Tanreqing Capsule and Tanreqing Injection by HPLC-MS/MS. Chin. J. Exp. Tradit. Med. Form. 2017, 23, 44–51.
  • Geng, P.; Sun, J.; Zhang, M.; Li, X.; Harnly, J.-M.; Chen, P. Comprehensive Characterization of C-Glycosyl Flavones in Wheat (Triticum aestivum L.) Germ Using UPLC-PDA-ESI/HRMSn and Mass Defect Filtering. J. Mass Spectrom. 2016, 51, 914–930. DOI: 10.1002/jms.3803.
  • Han, J.; Ye, M.; Xu, M.; Sun, J.; Wang, B.; Guo, D. Characterization of Flavonoids in the Traditional Chinese Herbal Medicine-Huangqin by Liquid Chromatography Coupled with Electrospray Ionization Mass Spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci 2007, 848, 355–362. DOI: 10.1016/j.jchromb.2006.10.061.
  • Qiao, X.; Li, R.; Song, W.; Miao, W-j.; Liu, J.; Chen, H-b.; Guo, D-a.; Ye, M. A Targeted Strategy to Analyze Untargeted Mass Spectral Data: Rapid Chemical Profiling of Scutellaria Baicalensis Using Ultra-high Performance Liquid Chromatography Coupled with Hybrid Quadrupole Orbitrap Mass Spectrometry and Key Ion Filtering. J. Chromatogr. A 2016, 1441, 83–95. DOI: 10.1016/j.chroma.2016.02.079.
  • Liu, G.; Ma, J.; Chen, Y.; Tian, Q.; Shen, Y.; Wang, X.; Chen, B.; Yao, S. Investigation of Flavonoid Profile of Scutellaria bacalensis Georgi by High Performance Liquid Chromatography with Diode Array Detection and Electrospray Ion Trap Mass Spectrometry. J. Chromatogr. A 2009, 1216, 4809–4814. DOI: 10.1016/j.chroma.2009.04.021.
  • Wu, W.; Yan, C.; Li, L.; Liu, Z.; Liu, S. Studies on the Flavones Using Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry. J. Chromatogr. A 2004, 1047, 213–220. DOI: 10.1016/j.chroma.2004.06.128.
  • Cao, J.; Yin, C.; Qin, Y.; Cheng, Z.; Chen, D. Approach to the Study of Flavone di-C-glycosides by High Performance Liquid Chromatography-Tandem Ion Trap Mass Spectrometry and Its Application to Characterization of Flavonoid Composition in Viola yedoensis. J. Mass Spectrom. 2014, 49, 1010–1024. DOI: 10.1002/jms.3413.
  • Ye, M.; Liu, S.; Jiang, Z.; Lee, Y.; Tilton, R.; Cheng, Y. Liquid Chromatography/mass Spectrometry Analysis of PHY906, a Chinese Medicine Formulation for Cancer Therapy. Rapid Commun. Mass Spectrom. 2007, 21, 3593–3607. DOI: 10.1002/rcm.2832.
  • Abad-Garcia, B.; Garmon-Lobato, S.; Berrueta, L.-A.; Gallo, B.; Vicente, F. New Features on the Fragmentation and Differentiation of C-glycosidic Flavone Isomers by Positive Electrospray Ionization and Triple Quadrupole Mass Spectrometry. Rapid Commun. Mass Spectrom. 2008, 22, 1834–1842. DOI: 10.1002/rcm.3560.
  • Sun, Y.; Zhang, X.; Xue, X.; Zhang, Y.; Xiao, H.; Liang, X. Rapid Identification of Polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS. J. Chromatogr. Sci. 2009, 47, 190–196. DOI: 10.1093/chromsci/47.3.190.
  • He, L.; Zhang, Z.; Lu, L.; Liu, Y.; Li, S.; Wang, J.; Song, Z.; Yan, Z.; Miao, J. Rapid Identification and Quantitative Analysis of the Chemical Constituents in Scutellaria indica L. by UHPLC-QTOF-MS and UHPLC-MS/MS. J. Pharm. Biomed. Anal. 2016, 117, 125–139. DOI: 10.1016/j.jpba.2015.08.034.
  • Wang, H.; Cao, J.; Xu, S.; Gu, D.; Wang, Y.; Xiao, S. Depletion of High-Abundance Flavonoids by Metal Complexation and Identification of Low-Abundance Flavonoids in Scutellaria baicalensis Georgi. J. Chromatogr. A 2013, 1315, 107–117. DOI: 10.1016/j.chroma.2013.09.052.
  • Schmidt, J. Negative Ion Electrospray High-Resolution Tandem Mass Spectrometry of Polyphenols. J Mass Spectrom. 2016, 51, 33–43.
  • Yang, W.; Ye, M.; Qiao, X.; Wang, Q.; Bo, T.; Guo, D. Collision-induced Dissociation of 40 Flavonoid Aglycones and Differentiation of the Common Flavonoid Subtypes Using Electrospray Ionization Ion-trap Tandem Mass Spectrometry and Quadrupole Time-of-flight Mass Spectrometry. Eur. J. Mass Spectrom. (Chichester) 2012, 18, 493–503. DOI: 10.1255/ejms.1206.
  • Yao, C.; Yang, W.; Si, W.; Shen, Y.; Zhang, N.; Chen, H. An Enhanced Targeted Identification Strategy for the Selective Identification of Flavonoid O-glycosides from Carthamus tinctorius by Integrating Offline Two-Dimensional Liquid Chromatography/linear Ion-Trap-Orbitrap Mass Spectrometry, high-resolution Diagnostic Product Ions/neutral Loss Filtering and Liquid Chromatography-Solid Phase Extraction-nuclear Magnetic Resonance. J. Chromatogr. A 2017, 1491, 87–97. DOI: 10.1016/j.chroma.2017.02.041.
  • Zhang, L.; Zhang, R.-W.; Li, Q.; Lian, J.-W.; Liang, J.; Chen, X.-H.; Bi, K.-S. Development of the Fingerprints for the Quality Evaluation of Scutellariae Radix by HPLC-DAD and LC-MS-MS. Chroma 2007, 66, 13–20. DOI: 10.1365/s10337-007-0250-6.
  • Fabre, N.; Rustan, I.; Hoffmann, E.; Quetin-Leclercq, J. Determination of Flavone, Flavonol, and Flavanone Aglycones by Negative Ion Liquid Chromatography Electrospray Ion Trap Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2001, 12, 707–715. DOI: 10.1016/S1044-0305(01)00226-4.
  • Su, D.; Li, W.; Xu, Q.; Liu, Y.; Song, Y.; Feng, Y. New Metabolites of Acteoside Identified by Ultra-Performance Liquid Chromatography/Quadrupole-Time-of-Flight MS(E) in Rat Plasma, urine, and Feces. Fitoterapia 2016, 112, 45–55. DOI: 10.1016/j.fitote.2016.05.004.
  • Miao, W-J.; Wang, Q.; Bo, T.; Ye, M.; Qiao, X.; Yang, W-Z.; Xiang, C.; Guan, X-Y.; Guo, D-A. Rapid Characterization of Chemical Constituents and Rats Metabolites of the Traditional Chinese Patent Medicine Gegen-Qinlian-Wan by UHPLC/DAD/qTOF-MS. J. Pharm. Biomed. Anal. 2013, 72, 99–108. DOI: 10.1016/j.jpba.2012.09.015.
  • Mari, A.; Ciocarlan, A.; Aiello, N.; Scartezzini, F.; Pizza, C.; D'Ambrosio, M. Research Survey on Iridoid and Phenylethanoid Glycosides among Seven Populations of Euphrasia Rostkoviana Hayne from the Alps. Phytochemistry 2017, 137, 72–80. DOI: 10.1016/j.phytochem.2017.02.013.
  • Liu, H.; Zheng, Y.; Li, C.-Y.; Zheng, Y.; Wang, D.; Wu, Z. Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule Based on Relevance Analysis between Chemical Characters and Biological Effects. Sci. Rep. 2015, 5, 18080.
  • Piraud, M.; Vianey-Saban, C.; Petritis, K.; Elfakir, C.; Steghens, J-P.; Morla, A.; Bouchu, D. ESI-MS/MS Analysis of Underivatised Amino Acids: A New Tool for the Diagnosis of Inherited Disorders of Amino Acid Metabolism. Fragmentation Study of 79 Molecules of Biological Interest in Positive and Negative Ionisation Mode. Rapid Commun. Mass Spectrom. 2003, 17, 1297–1311. DOI: 10.1002/rcm.1054.
  • Tang, L.; Dong, L-N.; Peng, X-J.; Li, Y.; Shi, J.; Zhou, F-Y.; Liu, Z-Q. Pharmacokinetic Characterization of Oxymatrine and Matrine in Rats after Oral Administration of Radix Sophorae Tonkinensis Extract and Oxymatrine by Sensitive and Robust UPLC-MS/MS Method. J. Pharm. Biomed. Anal. 2013, 83, 179–185. DOI: 10.1016/j.jpba.2013.05.003.
  • Chen, H.; Han, F.; Du, P.; Chen, Y. Electrospray Ionization Mass Spectrometry for Analyses of Alkaloids in Sophoraflavescens ait. Chin. J. Anal. Chem. 2006, 34, 205–208.
  • Guo, H.; Yang, X.; Liu, J.; Zheng, W. Preparation of Flavonoid Reference Standards from Scutellariae Radix under the Guidance of High Performance Liquid Chromatography-Mass Spectrometry Analysis. Chin. J. Chromatogr. 2013, 30, 690–695. DOI: 10.3724/SP.J.1123.2012.02030.
  • Seo, O. N.; Kim, G.-S.; Kim, Y.-H.; Park, S.; Jeong, S. W.; Lee, S. J.; Jin, J. S.; Shin, S. C. Determination of Polyphenol Components of Korean Scutellaria Baicalensis Georgi Using Liquid Chromatography–tandem Mass Spectrometry: Contribution to Overall Antioxidant Activity. J. Funct. Foods 2013, 5, 1741–1750. DOI: 10.1016/j.jff.2013.07.020.
  • Zhang, Z.; He, L.; Lu, L.; Liu, Y.; Dong, G.; Miao, J.; Luo, P. Characterization and Quantification of the Chemical Compositions of Scutellariae Barbatae herba and differentiation from its substitute by combining UHPLC-PDA-QTOF-MS/MS with UHPLC-MS/MS. J. Pharm. Biomed. Anal. 2015, 109, 62–66.
  • Chen, H.; Chen, X.; Han, Q.; Wu, J.; Tang, D-q.; Du, Q.; Yin, X-x.; Yang, D-z. A New Strategy for Quality Control and Qualitative Analysis of Yinhuang Preparations by HPLC-DAD-MS/MS. Anal. Bioanal. Chem. 2012, 404, 1851–1865. DOI: 10.1007/s00216-012-6281-3.
  • Liu, S.; Xue, D.; Li, J.; Wang, B.; Zhang, Z.; Miao, M. Assay of Amino Acid in Cornu Caprae Hircus Extract. Centr. South. Pharm. 2015, 12, 271–274. DOI: 10.1155/2015/598386.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.