Simultaneous quantification of multiple active components of the ginkgo ketoester tablet when combined with donepezil in four biological matrices from an Alzheimer’s animal model: Evaluation of drug distribution patterns in vivo

References

• Zhang, J.; Wang, J.; Zhou, G.; Tan, Y.; Tao, H.; Chen, J.; Pu, Z.; Ma, J.; She, W.; Kang, A.; et al. Studies of the Anti-Amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice, Oxid. Med. Cell. Longev. 2019, 2019, 1–16.
   Web of Science ®Google Scholar
• Joseph Gaugler, J.; James, B.; Johnson, T.; Reimer, J.; Weuve, J. Alzheimer’s Disease Facts and Figures. Alzheimers Dement. 2021, 17, 327–406.
   PubMed Web of Science ®Google Scholar
• Zhu, Y.; Ouyang, Z.; Du, H.; Wang, M.; Wang, J.; Sun, H.; Kong, L.; Xu, Q.; Ma, H.; Sun, Y. New Opportunities and Challenges of Natural Products Research: When Target Identification Meets Single-Cell Multiomics. Acta Pharm. Sin. B. 2022, 12, 4011–4039. DOI: 10.1016/j.apsb.2022.08.022.
   PubMed Web of Science ®Google Scholar
• Canevelli, M.; Adali, N.; Kelaiditi, E.; Cantet, C.; Ousset, P. J.; Cesari, M. Effects of Gingko biloba Supplementation in Alzheimer’s Disease Patients Receiving Cholinesterase Inhibitors: Data from the ICTUS Study. Phytomedicine. 2014, 21, 888–892. DOI: 10.1016/j.phymed.2014.01.003.
   PubMed Web of Science ®Google Scholar
• Yue, S.-J.; Qin, Y.-F.; Kang, A.; Tao, H.-J.; Zhou, G.-S.; Chen, Y.-Y.; Jiang, J.-Q.; Tang, Y.-P.; Duan, J.-A. Total Flavonoids of Glycyrrhiza uralensis Alleviates Irinotecan-Induced Colitis via Modification of Gut Microbiota and Fecal Metabolism. Front. Immunol. 2021, 12, 628358. DOI: 10.3389/fimmu.2021.628358.
   PubMed Web of Science ®Google Scholar
• Zhou, G.; Zhang, J.; Yin, Y.; Tan, Y.; Tao, H.; Chen, J.; Pu, Z.; Zhu, Z.; Shi, X.; Tang, Y.; Duan, J.-A. HILIC-UHPLC-QTRAP/MS2 Quantification of 15 Neurotransmitters of the Combination of Donepezil and Ginkgo Ketoester Tablet in Different Biological Matrices from Dementia Mice: Application to Study the Synergistic Effect of the Two Drugs. Microchem. J. 2021, 161, 105791. DOI: 10.1016/j.microc.2020.105791.
   Web of Science ®Google Scholar
• Stein, C.; Hopfeld, J.; Lau, H.; Klein, J. Effects of Ginkgo biloba Extract EGb 761, Donepezil and Their Combination on Central Cholinergic Function in Aged Rats. J. Pharm. Pharm. Sci. 2015, 18, 634–646. DOI: 10.18433/J3WC8V.
   PubMed Web of Science ®Google Scholar
• Zhang, J.; Shi, X.; Zhou, G.; Tan, Y.; Chen, J.; Tao, H.; Pu, Z.; Liu, P.; Zhu, Y.; Qian, D.; et al. Comparative Study on the Effects of Different Proportions of Ginkgo Ketone Ester and Donepezil on Antidementia Based on Principal Component Analysis and Multi-Attribute Comprehensive Index Methods. Acta Pharm. Sin. 2019, 54, 660–669.
   Google Scholar
• Sadeghinejad, M.; Soltani, Z.; Afzalpour, M. E.; Khaksari, M.; Pourranjbar, M. What is the Combined Effect of Intense Intermittent Exercise and Ginkgo biloba Plant on the Brain Neurotrophic Factors Levels, and Learning and Memory in Young Rats? Pharmacol. Rep. 2019, 71, 503–508. DOI: 10.1016/j.pharep.2019.02.006.
   PubMed Web of Science ®Google Scholar
• Colovic, M. B.; Krstic, D. Z.; Lazarevic-Pasti, T. D.; Bondzic, A. M.; Vasic, V. M. Acetylcholinesterase Inhibitors: Pharmacology and Toxicology. Curr. Neuropharmacol. 2013, 11, 315–335. DOI: 10.2174/1570159X11311030006.
   PubMed Web of Science ®Google Scholar
• Farlow, M.; Veloso, F.; Moline, M.; Yardley, J.; Brand-Schieber, E.; Bibbiani, F.; Zou, H.; Hsu, T.; Satlin, A. Safety and Tolerability of Donepezil 23 mg in Moderate to Severe Alzheimer’s Disease. BMC Neurol. 2011, 11, 57. DOI: 10.1186/1471-2377-11-57.
   PubMed Web of Science ®Google Scholar
• Kuppusamy, A.; Arumugam, M.; George, S. Combining In Silico and In Vitro Approaches to Evaluate the Acetylcholinesterase Inhibitory Profile of Some Commercially Available Flavonoids in the Management of Alzheimer’s Disease. Int. J. Biol. Macromol. 2017, 95, 199–203.
   PubMed Web of Science ®Google Scholar
• Kesika, P.; Suganthy, N.; Sivamaruthi, B. S.; Chaiyasut, C. Role of Gut-Brain Axis, Gut Microbial Composition, and Probiotic Intervention in Alzheimer’s Disease. Life Sci. 2021, 264, 118627. DOI: 10.1016/j.lfs.2020.118627.
   PubMed Web of Science ®Google Scholar
• Hu, S.; Li, A.; Huang, T.; Lai, J.; Li, J.; Elizabeth Sublette, M.; Lu, H.; Lu, Q.; Du, Y.; Hu, Z.; et al. Gut Microbiota Changes in Patients with Bipolar Depression. Adv. Science. 2019, 17, 1900752.
   Google Scholar
• Megur, A.; Baltriukienė, D.; Bukelskienė, V.; Burokas, A. The Microbiota-Gut-Brain Axis and Alzheimer’s Disease: neuroinflammation is to Blame? Nutrients. 2020, 13, 37. DOI: 10.3390/nu13010037.
   PubMed Web of Science ®Google Scholar
• Tang, Y.; Lou, F.; Wang, J.; Li, Y.; Zhuang, S. Coumaroyl Flavonol Glycosides from the Leaves of Ginkgo biloba. Phytochemistry. 2001, 58, 1251–1256.
   PubMed Web of Science ®Google Scholar
• Zhou, G.; Yao, X.; Tang, Y.; Yang, N.; Pang, H.; Mo, X.; Zhu, S.; Su, S.; Qian, D.; Jin, C.; et al. Two New Nonacosanetriols from Ginkgo biloba Sarcotesta. Chem. Phys. Lipids 2012, 165, 731–736. DOI: 10.1016/j.chemphyslip.2012.08.003.
   PubMed Web of Science ®Google Scholar
• Chen, X.; Zhu, P.; Liu, B.; Wei, L.; Xu, Y. Simultaneous Determination of Fourteen Compounds of Hedyotis diffusa Willd Extract in Rats by UHPLC–MS/MS Method: Application to Pharmacokinetics and Tissue Distribution Study. J. Pharm. Biomed. Anal. 2018, 159, 490–512. DOI: 10.1016/j.jpba.2018.07.023.
   PubMed Web of Science ®Google Scholar
• Food Drug Administration. Bioanalytical Method Validation Guidance for Industry; U.S. Department of Health and Human Services: Silver Spring, 2018.
   Google Scholar
• Zhou, G.; Yao, X.; Tang, Y.; Qian, D.; Su, S.; Zhang, L.; Jin, C.; Qin, Y.; Duan, J.-A. An Optimized Ultrasound-Assisted Extraction and Simultaneous Quantification of 26 Characteristic Components with Four Structure Types in Functional Foods from Ginkgo Seeds. Food Chem. 2014, 158, 177–185. DOI: 10.1016/j.foodchem.2014.02.116.
   PubMed Web of Science ®Google Scholar
• Yao, X.; Zhou, G.; Tang, Y.; Guo, S.; Qian, Y.; Jin, C.; Qin, Y.; Qian, D.; Duan, J.-A. UPLC-PDA-TOF/MS Coupled with Multivariate Statistical Analysis to Rapidly Analyze and Evaluate Ginkgo biloba Leaves from Different Origin. Drug Test. Anal. 2014, 6, 288–294. DOI: 10.1002/dta.1477.
   PubMed Web of Science ®Google Scholar
• Ishida, K.; Yamamoto, M.; Misawa, K.; Nishimura, H.; Misawa, K.; Ota, N.; Shimotoyodome, A. Coffee Polyphenols Prevent Cognitive Dysfunction and Suppress Amyloid Beta Plaques in APP/PS2 Transgenic Mouse. Neurosci. Res 2020, 154, 35–44.
   PubMed Web of Science ®Google Scholar
• Deshmukh, R.; Kaundal, M.; Bansal, V.; Samardeep . Samardeep, Caffeic Acid Attenuates Oxidative Stress, Learning and Memory Deficit in Intra-Cerebroventricular Streptozotocin Induced Experimental Dementia in Rats. Biomed. Pharmacother. 2016, 81, 56–62. DOI: 10.1016/j.biopha.2016.03.017.
   PubMed Web of Science ®Google Scholar
• Kang, S.; Lee, J. Y.; Choi, Y. K.; Song, S.; Kim, J. S.; Jeon, S. J.; Han, Y. N.; Son, K. H.; Han, B. H. Neuroprotective Effects of Naturally Occurring Biflavonoids. Bioorg. Med. Chem. Lett. 2005, 15, 3588–3591. DOI: 10.1016/j.bmcl.2005.05.078.
   PubMed Web of Science ®Google Scholar
• Gu, Q.; Li, Y.; Chen, Y.; Yao, P.; Ou, T. Sciadopitysin: Active Component from Taxus chinensis for Anti-Alzheimer’s Disease. Nat. Prod. Res. 2013, 27, 2157–2160. DOI: 10.1080/14786419.2013.790031.
   PubMed Web of Science ®Google Scholar
• Berg, K.; Braun, C.; Krug, I.; Schrenk, D. Evaluation of the Cytotoxic and Mutagenic Potential of Three Ginkgolic Acids. Toxicology. 2015, 327, 47–52. DOI: 10.1016/j.tox.2014.10.001.
   PubMed Web of Science ®Google Scholar
• Khodabakhsh, P.; Bazrgar, M.; Dargahi, L.; Mohagheghi, F.; Asgari Taei, A.; Parvardeh, S.; Ahmadiani, A. Does Alzheimer’s Disease Stem in the Gastrointestinal System? Life Sci. 2021, 287, 120088. DOI: 10.1016/j.lfs.2021.120088.
   PubMed Web of Science ®Google Scholar
• Chen, F.; Li, L.; Xu, F.; Sun, Y.; Du, F.; Ma, X.; Zhong, C.; Li, X.; Wang, F.; Zhang, N.; Li, C. Systemic and Cerebral Exposure to and Pharmacokinetics of Flavonols and Terpene Lactones after Dosing Standardized Ginkgo biloba Leaf Extracts to Rats via Different Routes of Administration. Br. J. Pharmacol. 2013, 170, 440–457. DOI: 10.1111/bph.12285.
   PubMed Web of Science ®Google Scholar
• Zhou, G.; Yuan, Y.; Yin, Y.; Tang, Y.; Xu, R.; Liu, Y.; Chen, P.; Yin, L.; Duan, J.-A. Hydrophilic Interaction Chromatography Combined with Ultrasound-Assisted Ionic Liquid Dispersive Liquid-Liquid Microextraction for Determination of Underivatized Neurotransmitters in Dementia Patients’ Urine Samples. Anal. Chim. Acta. 2020, 1107, 74–84. DOI: 10.1016/j.aca.2020.02.027.
   PubMed Web of Science ®Google Scholar
• Alkasir, R.; Li, J.; Li, X.; Jin, M.; Zhu, B. Human Gut Microbiota: The Links with Dementia Development. Protein Cell. 2017, 8, 90–102. DOI: 10.1007/s13238-016-0338-6.
   PubMed Web of Science ®Google Scholar