In vitro aerodynamic characteristics of aerosol delivered from different inhalation methods in mechanical ventilation

References

• Abdelaziz K, Abdelrahim ME. Identification and categorisation of drug-related problems on admission to an adult intensive care unit. Eur J Hosp Pharm 2015;22:138–141.
   Google Scholar
• Rau JL. The inhalation of drugs: advantages and problems. Respir Care 2005;50:367–382.
   PubMedGoogle Scholar
• Hanhan U, Kissoon N, Payne M, et al. Effects of in-line nebulization on preset ventilatory variables. Respir Care 1993;38:474–478.
   Google Scholar
• Boukhettala N, Porée T, Diot P, Vecellio L. In vitro performance of spacers for aerosol delivery during adult mechanical ventilation. J Aerosol Med Pulm Drug Deliv 2015;28:130–136.
   PubMed Web of Science ®Google Scholar
• Sidler-Moix AL, Dolci U, Berger-Gryllaki M, et al. Albuterol delivery in an in vitro pediatric ventilator lung model: comparison of jet, ultrasonic, and mesh nebulizers. Pediatr Crit Care Med 2013;14:e98–e102.
   PubMed Web of Science ®Google Scholar
• Hassan A, Rabea H, Hussein RRS, et al. In-vitro characterization of the aerosolized dose during non-invasive automatic continuous positive airway pressure ventilation. Pulm Ther 2015;2:115–126.
   Google Scholar
• Abdelrahim M, Plant P, Chrystyn H. The relative lung and systemic bioavailability of terbutaline following nebulisation in non-invasively ventilated patients. Int J Pharm 2011;420:313–318.
   PubMed Web of Science ®Google Scholar
• O’Riordan TG, Greco MJ, Perry RJ, Smaldone GC. Nebulizer function during mechanical ventilation. Am Rev Respir Dis 1992;145:1117–1122.
   PubMed Web of Science ®Google Scholar
• Abdelrahim ME, Plant P, Chrystyn H. In-vitro characterisation of the nebulised dose during non-invasive ventilation. J Pharm Pharmacol 2010;62:966–972.
   PubMed Web of Science ®Google Scholar
• Calvert L, Jackson J, White J, et al. Enhanced delivery of nebulised salbutamol during non-invasive ventilation. J Pharm Pharmacol 2006;58:1553–1557.
   PubMed Web of Science ®Google Scholar
• Chatmongkolchart S, Schettino GP, Dillman C, et al. In vitro evaluation of aerosol bronchodilator delivery during noninvasive positive pressure ventilation: effect of ventilator settings and nebulizer position. Crit Care Med 2002;30:2515–2519.
   PubMed Web of Science ®Google Scholar
• Boe J, Dennis J, O’Driscoll B, Members of Task Force. European Respiratory Society Guidelines on the use of nebulizers: guidelines prepared by a European Respiratory Society Task Force on the use of nebulizers. Eur Respir J 2001;18:228–242.
   PubMed Web of Science ®Google Scholar
• Berg E, Svensson JO, Asking L. Determination of nebulizer droplet size distribution: a method based on impactor refrigeration. J Aerosol Med 2007;20:97–104.
   PubMedGoogle Scholar
• Abdelrahim ME, Chrystyn H. Aerodynamic characteristics of nebulized terbutaline sulphate using the next generation impactor (NGI) and CEN method. J Aerosol Med Pulm Drug Deliv 2009;22:19–28.
   PubMed Web of Science ®Google Scholar
• Abdelrahim ME. Aerodynamic characteristics of nebulized terbutaline sulphate using the Andersen Cascade Impactor compared to the Next Generation Impactor. Pharm Dev Technol 2011;16:137–145.
   PubMed Web of Science ®Google Scholar
• Carvalho TC, McCook JP, Narain NR, McConville JT. Development and characterization of phospholipid-stabilized submicron aqueous dispersions of coenzyme Q10 presenting continuous vibrating-mesh nebulization performance. J Lipos Res 2013;23:276–290.
   PubMed Web of Science ®Google Scholar
• Dai B, Kang J, Sun Lf, et al. Influence of exhalation valve and nebulizer position on albuterol delivery during noninvasive positive pressure ventilation. J Aerosol Med Pulm Drug Deliv 2014;27:125–132.
   PubMed Web of Science ®Google Scholar
• Garner SS, Wiest DB, Stevens CE, Habib DM. Effect of heliox on albuterol delivery by metered dose inhaler in pediatric in vitro models of mechanical ventilation. Pharmacotherapy 2006;26:1396–1402.
   PubMed Web of Science ®Google Scholar
• Garner SS, Wiest DB, Bradley JW. Albuterol delivery by metered-dose inhaler in a pediatric high-frequency oscillatory ventilation model. Crit Care Med 2000;28:2086–2089.
   PubMed Web of Science ®Google Scholar
• Wildhaber JH, Dore ND, Devadason SG, et al. Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilator circuits – an in vitro Study. CHEST J 1998;113:186–191.
   PubMed Web of Science ®Google Scholar
• Hussein RRS, Ali AMA, Salem HF, et al. In vitro/in vivo correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients. Pharm Dev Technol 2015. [Epub ahead of print]. doi: 10.3109/10837450.2015.1116567.
   PubMedGoogle Scholar
• Miller DD, Amin MM, Palmer LB, et al. Aerosol delivery and modern mechanical ventilation: in vitro/in vivo evaluation. Am J Respir Crit Care Med 2003;168:1205–1209.
   PubMed Web of Science ®Google Scholar
• Pitance L, Vecellio L, Delval G, et al. Aerosol delivery through tracheostomy tubes: an in vitro study. J Aerosol Med Pulm Drug Deliv 2013;26:76–83.
   PubMed Web of Science ®Google Scholar
• Berlinski A, Willis JR. Albuterol delivery by 4 different nebulizers placed in 4 different positions in a pediatric ventilator in vitro model. Respir Care 2013;58:1124–1133.
   PubMed Web of Science ®Google Scholar
• Dhand R, Tobin MJ. Inhaled bronchodilator therapy in mechanically ventilated patients. Am J Respir Crit Care Med 1997;156:3–10.
   PubMed Web of Science ®Google Scholar
• Dugernier J, Wittebole X, Roeseler J, et al. Influence of inspiratory flow pattern and nebulizer position on aerosol delivery with a vibrating-mesh nebulizer during invasive mechanical ventilation: an in vitro analysis. J Aerosol Med Pulm Drug Deliv 2015;28:229–236.
   PubMed Web of Science ®Google Scholar
• Leung SSY, Parumasivam T, Tang P, Chan HK. A proof-of-principle setup for delivery of Relenza® (Zanamivir) inhalation powder to intubated patients. J Aerosol Med Pulm Drug Deliv 2015. [Epub ahead of print]. doi: 10.1089/jamp.2014.1179.
   Web of Science ®Google Scholar
• Chrystyn H, Safioti G, Keegstra JR, Gopalan G. Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: an in-vitro comparison of Spiromax with Turbuhaler. Int J Pharm 2015;491:268–276.
   PubMed Web of Science ®Google Scholar
• Pallin M, Naughton MT. Noninvasive ventilation in acute asthma. J Crit Care 2014;29:586–593.
   PubMed Web of Science ®Google Scholar
• DiBlasi RM, Coppolo DP, Nagel MW, et al. A novel, versatile valved holding chamber for delivering inhaled medications to neonates and small children: laboratory simulation of delivery options. Respir Care 2010;55:419–426.
   PubMed Web of Science ®Google Scholar
• Wright PE, Marini JJ, Bernard GR. In vitro versus in vivo comparison of endotracheal tube airflow resistance. Am Rev Respir Dis 1989;140:10–16.
   PubMed Web of Science ®Google Scholar
• Lu Q, Yang J, Liu Z, et al. Nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Am J Respir Crit Care Med 2011;184:106–115.
   PubMed Web of Science ®Google Scholar
• Darquenne C. Aerosol deposition in health and disease. J Aerosol Med Pulm Drug Deliv 2012;25:140–147.
   PubMed Web of Science ®Google Scholar
• Dunbar C, Mitchell J. Analysis of cascade impactor mass distributions. J Aerosol Med 2005;18:439–451.
   PubMedGoogle Scholar
• Rouby JJ, Bouhemad B, Monsel A, et al. Aerosolized antibiotics for ventilator-associated Pneumonia: lessons from experimental studies. J Am Soc Anesthesiol 2012;117:1364–1380.
   PubMed Web of Science ®Google Scholar
• Dolovich MB, Dhand R. Aerosol drug delivery: developments in device design and clinical use. Lancet 2011;377:1032–1045.
   PubMed Web of Science ®Google Scholar
• Waldrep J, Dhand R. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation. Curr Drug Deliv 2008;5:114–119.
   PubMedGoogle Scholar
• Carvalho TC, Peters JI, Williams RO. Influence of particle size on regional lung deposition – what evidence is there? Int J Pharm 2011;406:1–10.
   PubMed Web of Science ®Google Scholar