Metoclopramide nasal spray in vitro evaluation and in vivo pharmacokinetic studies in dogs

References

• Boek WM, Romeijn SG, Graamans K, Verhoef JC, Merkus FW, Huizing EH. 1999. Validation of animal experiments on ciliary function in vitro. II. The influence of absorption enhancers, preservatives and physiologic saline. Acta Otolaryngol. 119:98–101.
   PubMed Web of Science ®Google Scholar
• Cho JH, Kwun YS, Jang HS, Kang JM, Won YS, Yoon HR. 2000. Long-term use of preservatives on rat nasal respiratory mucosa: effects of benzalkonium chloride and potassium sorbate. Laryngoscope. 110:312–317.
   PubMed Web of Science ®Google Scholar
• Chudiwal SS, Dehghan MH. 2016. Quality by design (QbD) approach for design and development of drug-device combination products: a case study on flunisolide nasal spray. Pharm Dev Technol. [Epub ahead of print]. doi: 10.1080/10837450.2016.1236130.
   PubMed Web of Science ®Google Scholar
• Colombo G, Lorenzini L, Zironi E, Galligioni V, Sonvico F, Balducci AG, Pagliuca G, Giuliani A, Calzà L, Scagliarini A. 2011. Brain distribution of ribavirin after intranasal administration. Antiviral Res. 92:408–414.
   PubMed Web of Science ®Google Scholar
• Cremaschi D, Ghirardelli R, Porta C. 1998. Relationship between polypeptide transcytosis and lymphoid tissue in the rabbit nasal mucosa. Biochim Biophys Acta. 1369:287–294.
   PubMed Web of Science ®Google Scholar
• Dollery CS. 1999. Therapeutic drugs. 2nd ed. Toronto: Churchill Livingstone. M132–M136.
   Google Scholar
• Ekelund K, Osth K, Påhlstorp C, Björk E, Ulvenlund S, Johansson F. 2005. Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on caco-2 cell monolayers and pig nasal mucosa. J Pharm Sci. 94:730–744.
   PubMed Web of Science ®Google Scholar
• Fugen G, Duo H, Gendalai M, Chunzhi W, Yi W. 2015. Preparation of bisoprolol fumarate nasal spray and its nasal delivery in rats. Pak J Pharm Sci. 28:2173–2178.
   PubMed Web of Science ®Google Scholar
• Graf P. 2001. Benzalkonium chloride as a preservative in nasal solutions: re-examining the data. Respir Med. 95:728–733.
   PubMed Web of Science ®Google Scholar
• Gu F, Ma W, Meng G, Wu C, Wang Y. 2016. Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone. Acta Pharm. 66:555–562.
   PubMed Web of Science ®Google Scholar
• Huang CH, Kimura R, Nassar RB, Hussain A. 1985. Mechanism of nasal absorption of drugs I: Physicochemical parameters influencing the rate of in situ nasal absorption of drugs in rats. J Pharm Sci. 74:608–611.
   PubMed Web of Science ®Google Scholar
• Hamamoto K, Mizuno Y, Kato M, Yamagishi N, Furuhama K. 2013. Simple and sensitive method for measurement of metoclopramide in cattle plasma by LC-MS/MS using a multimode chromatography. J Vet Med Sci. 75:509–513.
   PubMed Web of Science ®Google Scholar
• Lebe E, Baka M, Yavaşoğlu A, Aktuğ H, Ateş U, Uyanikgil Y. 2004. Effects of preservatives in nasal formulations on the mucosal integrity: an electron microscopic study. Pharmacology. 72:113–120.
   PubMed Web of Science ®Google Scholar
• Li Y, Li J, Zhang X, Ding J, Mao S. 2016. Non-ionic surfactants as novel intranasal absorption enhancers: in vitro and in vivo characterization. Drug Deliv. 23:2272–2279.
   PubMed Web of Science ®Google Scholar
• Mahajan HS, Gattani SG. 2010. Nasal administration of ondansetron using a novel microspheres delivery system part II: ex vivo and in vivo studies. Pharm Dev Technol. 15:653–657.
   PubMed Web of Science ®Google Scholar
• Merkus P, Romeijn SG, Verhoef JC, Merkus FW, Schouwenburg PF. 2001. Classification of cilio-inhibiting effects of nasal drugs. Laryngoscope. 111:595–602.
   PubMed Web of Science ®Google Scholar
• Mustafa G, Alrohaimi AH, Bhatnagar A, Baboota S, Ali J, Ahuja A. 2016. Brain targeting by intranasal drug delivery (INDD): a combined effect of trans-neural and para-neuronal pathway. Drug Deliv. 23:933–939.
   PubMed Web of Science ®Google Scholar
• Na L, Wang J, Wang L, Mao S. 2013. A novel permeation enhancer: N-succinyl chitosan on the intranasal absorption of isosorbide dinitrate in rats. Eur J Pharm Sci. 48:301–306.
   PubMed Web of Science ®Google Scholar
• Priyanka A, Shringi S, Sanjay G. 2002. Permeability issues in nasal drug delivery. Drug Discov Today. 18:967–975.
   Google Scholar
• Parkman HP, Carlson MR, Gonyer D. 2014. Metoclopramide nasal spray is effective in symptoms of gastroparesis in diabetics compared to conventional oral tablet. Neurogastroenterol Motil. 26:521–528.
   PubMed Web of Science ®Google Scholar
• Parkman HP, Carlson MR, Gonyer D. 2015. Metoclopramide nasal spray reduces symptoms of gastroparesis in women, but not men, with diabetes: results of a phase 2B randomized study. Clin Gastroenterol Hepatol. 13:1256–1263.
   PubMed Web of Science ®Google Scholar
• Scaglione F, Scanni A, Tomirotti M, Dimaiuta M, Ferrari P, Fraschini F. 1993. Pharmacokinetics and bioavailability of metoclopramide nasal spray versus metoclopramide intravenous in healthy volunteers and cancer patients. Arzneimittel-Forschung. 43:986–988.
   PubMed Web of Science ®Google Scholar
• Soliman II, Soliman NA, Abdou EM. 2010. Formulation and stability study of chlorpheniramine maleate nasal gel. Pharm Dev Technol. 15:484–491.
   PubMed Web of Science ®Google Scholar
• Tomirotti M, Dimaiuta M, Confalonieri M, Scanni A. 1994. Efficacy and tolerability of nasally administered compared to parenterally administered metoclopramide in the symptomatic treatment of chemotherapy-induced emesis in cancer outpatients. A controlled clinical study. Support Care Cancer. 2:389–392.
   PubMed Web of Science ®Google Scholar
• van de Donk HJ, van den Heuvel AG, Zuidema J, Merkus FW. 1982. The effects of nasal drops and their additives on humannasal mucociliary clearance. Rhinology. 20:127–137.
   PubMedGoogle Scholar
• Varshosaz J, Eskandari S, Tabakhian M. 2010. Production and optimization of valproic acid nanostructured lipid carriers by the Taguchi design. Pharm Dev Technol. 15:89–96.
   PubMed Web of Science ®Google Scholar
• Ventura CA, Giannone I, Musumeci T, Pignatello R, Ragni L, Landolfi C, Milanese C, Paolino D, Puglisi G. 2006. Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. Eur J Med Chem. 41:233–240.
   PubMed Web of Science ®Google Scholar
• Verse T, Sikora C, Rudolph P, Klöcker N. 2003. The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters. Laryngorhinootologie. 82:782–789.
   PubMed Web of Science ®Google Scholar
• Yu C, Gu P, Zhang W, Qi N, Cai C, He H, Tang X. 2011. Preparation and evaluation of zolmitriptan submicron emulsion for rapid and effective nasal absorption in beagle dogs. Drug Dev Ind Pharm. 37:1509–1516.
   PubMed Web of Science ®Google Scholar
• Zaki NM, Mortada ND, Awad GA, Abd ElHady SS. 2006. Rapid-onset intranasal delivery of metoclopramide hydrochloride part II: safety of various absorption enhancers and pharmacokinetic evaluation. Int J Pharm. 327:97–103.
   PubMed Web of Science ®Google Scholar