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Research Article

In vivo study of mPEG–PCL as a nanocarriers for anti-inflammatory drug delivery of simvastatin

ORCID Icon, , ORCID Icon, & ORCID Icon
Pages 663-670 | Received 31 Mar 2018, Accepted 25 Oct 2018, Published online: 03 Apr 2019

References

  • Aghajanzadeh M, Zamani M, Rashidzadeh H, Rostamizadeh K, Sharafi A, Danafar H. 2018. Amphiphilic Y shaped Miktoarm Star copolymer for anti‐cancer hydrophobic and hydrophilic drugs co‐delivery: synthesis, characterization, in vitro and in vivo biocompatibility study. J Biomed Mater Res Part A. 106:2817–2826.
  • Alie N, Eldib M, Fayad ZA, Mani V. 2014. Inflammation, atherosclerosis, and coronary artery disease: PET/CT for the evaluation of atherosclerosis and inflammation. Clin Med Insights Cardiol. 8:13.
  • Bays HE, Patel MD, Mavros P, Ramey DR, Tomassini JE, Tershakovec AM, Baxter CA. 2017. Using real-world data to assess changes in low-density lipoprotein cholesterol and predicted cardiovascular risk after ezetimibe discontinuation after the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression trial. J Clin Lipidol. 11:929–937.
  • Care IoLARCo, Animals UoL, Resources NIoHDoR. 1985. Guide for the care and use of laboratory animals. Washington (DC): National Academies.
  • Collins R. 2003. Heart Protection Study Collaborative group: MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet. 361:2005–2016.
  • Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, et al. 2014. A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun. 5:3065.
  • Eckard AR, Jiang Y, Debanne SM, Funderburg NT, McComsey GA. 2014. Effect of 24 weeks of statin therapy on systemic and vascular inflammation in HIV-infected subjects receiving antiretroviral therapy. J Infect Dis. 209:1156–1164.
  • Ghanim H, Green K, Abuaysheh S, Patel R, Batra M, Chaudhuri A, Makdissi A, Kuhadiya ND, Dandona P. 2017. Ezetimibe and simvastatin combination inhibits and reverses the pro-inflammatory and pro-atherogenic effects of cream in obese patients. Atherosclerosis. 263:278–286.
  • Hansson GK. 2005. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 352:1685–1695.
  • Jamil K, Kandula V, Kandula R, Asimuddin M, Joshi S, Yerra SK. 2014. Polymorphism of CYP3A4 2 and eNOS genes in the diabetic patients with hyperlipidemia undergoing statin treatment. Mol Biol Rep. 41:6719–6727.
  • Lin S-Y, Kawashima Y. 1985. The influence of three poly(oxyethylene)poly(oxypropylene) surface-active block copolymers on the solubility behavior of indomethacin. Pharm Acta Helv. 60:339–344.
  • Lin S-Y, Kawashima Y. 1987. Pluronic surfactants affecting diazepam solubility, compatibility, and adsorption from iv admixture solutions. PDA J Pharm Sci Technol. 41:83–87.
  • Navar-Boggan AM, Peterson ED, D’Agostino RB, Neely B, Sniderman AD, Pencina MJ. 2015. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation. 131:451–458.
  • Navarese EP, Szczesniak A, Kolodziejczak M, Gorny B, Kubica J, Suryapranata H. 2014. Statins and risk of new-onset diabetes mellitus: is there a rationale for individualized statin therapy? Am J Cardiovasc Drugs. 14:79–87.
  • Pinho-Gomes AC, Reilly S, Brandes RP, Casadei B. 2014. Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins. Antioxidants Redox Signal. 20:1268–1285.
  • Schönbeck U, Libby P. 2004. Inflammation, immunity, and HMG-CoA reductase inhibitors. Circulation. 109:II-18–II-26.
  • Steinberg D. 2005. Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin. Mol Nutr Food Res. 49:995–998.
  • Stoll G, Bendszus M. 2006. Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke. 37:1923–1932.
  • Tawakol A, Fayad ZA, Mogg R, Alon A, Klimas MT, Dansky H, Subramanian SS, Abdelbaky A, Rudd JHF, Farkouh ME, et al. 2013. Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study. J Am Coll Cardiol. 62:909–917.
  • Tousoulis D, Psarros C, Demosthenous M, Patel R, Antoniades C, Stefanadis C. 2014. Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins. J Am Coll Cardiol. 63:2491–2502.
  • Ubeda M, Muñoz L, Paule L, del Campo R, Álvarez-Mon M, Albillos A, Albillos A. 2017. THU-064-simvastatin neither reduces gut bacterial translocation nor sistemic/mesenteric inflammation in cirrhotic rats with ascites. J Hepatol. 66:S147.
  • Wei X, Gong C, Gou M, Fu S, Guo Q, Shi S, Luo F, Guo G, Qiu L, Qian Z, et al. 2009. Biodegradable poly (ɛ-caprolactone)–poly (ethylene glycol) copolymers as drug delivery system. Int J Pharm. 381:1–18.
  • Zamani M, Rostamizadeh K, Kheiri Manjili H, Danafar H. 2018. In vitro and in vivo biocompatibility study of folate-lysine-PEG-PCL as nanocarrier for targeted breast cancer drug delivery. Eur Polym J. 103:260–270.

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