In situ composite ion-triggered gellan gum gel incorporating amino methacrylate copolymer microparticles: a therapeutic modality for buccal applicability

References

• Animesh K, Afrasim M, Bommareddy RR, Ayaz A, Shruthi R, Shivakumar HG. 2012. Applicability and approaches of (Meth) acrylate copolymers (Eudragits) in novel drug delivery systems. Curr Drug Ther. 7(4):219–234.
   Google Scholar
• Biswal I, Dinda A, Mohanty S, Dhara M, Das D, Chowdary K, Si S. 2011. Influence of drug/polymer ratio on the encapsulation efficiency of highly hydrophilic drug. Asian J Chem. 23(5):1973.
   Google Scholar
• Blanco M, Alonso M. 1997. Development and characterization of protein-loaded poly (lactide-co-glycolide) nanospheres. Eur J Pharm Biopharm. 43(3):287–294.
   Web of Science ®Google Scholar
• Boni FI, Prezotti FG, Cury B. 2016. Gellan gum microspheres crosslinked with trivalent ion: effect of polymer and crosslinker concentrations on drug release and mucoadhesive properties. Drug Dev Ind Pharm. 42(8):1283–1290.
   PubMed Web of Science ®Google Scholar
• Bruschi ML. 2015. Strategies to modify the drug release from pharmaceutical systems. Cambridge (UK): Woodhead Publishing.
   Google Scholar
• Chan SY, Goh CF, Lau JY, Tiew YC, Balakrishnan T. 2019. Rice starch thin films as a potential buccal delivery system: effect of plasticiser and drug loading on drug release profile. Int J Pharm. 562:203–211.
   PubMedGoogle Scholar
• Cid YP, Pedrazzi V, de Sousa VP, Pierre M. 2012. In vitro characterization of chitosan gels for buccal delivery of celecoxib: influence of a penetration enhancer. AAPS PharmSciTech. 13(1):101–111.
   PubMed Web of Science ®Google Scholar
• Cui F, Qian F, Zhao Z, Yin L, Tang C, Yin C. 2009. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles. Biomacromolecules. 10(5):1253–1258.
   PubMed Web of Science ®Google Scholar
• Dasgupta S, Dey S, Choudhury S, Mazumder B. 2013. Topical delivery of aceclofenac as nanoemulsion comprising excipients having optimum emulsification capabilities: preparation, characterization and in vivo evaluation. Expert Opin Drug Deliv. 10(4):411–420.
   PubMed Web of Science ®Google Scholar
• Dewan M, Sarkar G, Bhowmik M, Das B, Chattoapadhyay AK, Rana D, Chattopadhyay D. 2017. Effect of gellan gum on the thermogelation property and drug release profile of Poloxamer 407 based ophthalmic formulation. Int J Biol Macromol. 102:258–265.
   PubMed Web of Science ®Google Scholar
• Dhiman M, Yedurkar P, Sawant KK. 2008. Formulation, characterization, and in vitro evaluation of bioadhesive gels containing 5-fluorouracil. Pharm Dev Technol. 13(1):15–25.
   PubMed Web of Science ®Google Scholar
• El Maghraby GM, Elzayat EM, Alanazi FK. 2012. Development of modified in situ gelling oral liquid sustained release formulation of dextromethorphan. Drug Dev Ind Pharm. 38(8):971–978.
   PubMed Web of Science ®Google Scholar
• Elisha IL, Dzoyem J-P, McGaw LJ, Botha FS, Eloff JN. 2016. The anti-arthritic, anti-inflammatory, antioxidant activity and relationships with total phenolics and total flavonoids of nine South African plants used traditionally to treat arthritis. BMC Complement Altern Med. 16(1):307
   PubMedGoogle Scholar
• Elkomy MH, El Menshawe SF, Abou-Taleb HA, Elkarmalawy MH. 2017. Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers. Drug Deliv. 24(1):781–791.
   PubMed Web of Science ®Google Scholar
• Elmowafy E, Abdal-Hay A, Skouras A, Tiboni M, Casettari L, Guarino V. 2019. Polyhydroxyalkanoate (PHA): applications in drug delivery and tissue engineering. Exp Rev Med Devices. 16(6):467.
   PubMed Web of Science ®Google Scholar
• Elmowafy E, Gad H, Biondo F, Casettari L, Soliman ME. 2019. Exploring optimized methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) crystalline cored micelles in anti-glaucoma pharmacotherapy. Int J Pharm. 566:573.
   PubMedGoogle Scholar
• Elmowafy E, Osman R, Ah Ishak R. 2017. Polymer-based novel lung targeted delivery systems. CPD. 23(3):373–392.
   Google Scholar
• Elmowafy E, Osman R, El-Shamy A-HA, Awad GA. 2014. Nasal polysaccharides-glucose regulator microparticles: optimization, tolerability and antidiabetic activity in rats. Carbohydr Polym. 108:257–265.
   PubMed Web of Science ®Google Scholar
• Elmowafy E, Soliman ME. 2019. Losartan-chitosan/dextran sulfate microplex as a carrier to lung therapeutics: dry powder inhalation, aerodynamic profile and pulmonary tolerability. Int J Biol Macromol. 136:220.
   PubMed Web of Science ®Google Scholar
• Elmowafy EM, Awad GA, Mansour S, El-Shamy A-HA. 2008. Release mechanisms behind polysaccharides-based famotidine controlled release matrix tablets. AAPS PharmSciTech. 9(4):1230–1239.
   PubMed Web of Science ®Google Scholar
• Elmowafy EM, Tiboni M, Soliman ME. 2019. Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles. J Pharm Investig. 49(4):347–380.
   Google Scholar
• Fathalla D, Abdel-Mageed A, Abdel-Hamid F, Ahmed M. 2014. In-vitro and in-vivo evaluation of niosomal gel containing aceclofenac for sustained drug delivery. Int J Pharm Sci Res. 1(105):1–11.
   Google Scholar
• Fedorchak MV, Conner IP, Schuman JS, Cugini A, Little SR. 2017. Long term glaucoma drug delivery using a topically retained gel/microsphere eye drop. Sci Rep. 7(1):8639.
   PubMedGoogle Scholar
• Ferreira IS, Bettencourt A, Bétrisey B, Gonçalves LM, Trampuz A, Almeida AJ. 2015. Improvement of the antibacterial activity of daptomycin-loaded polymeric microparticles by Eudragit RL 100: an assessment by isothermal microcalorimetry. Int J Pharm. 485(1–2):171–182.
   PubMed Web of Science ®Google Scholar
• Ferreira IS, Kikhney J, Kursawe L, Kasper S, Gonçalves LM, Trampuz A, Moter A, Bettencourt AF, Almeida AJ. 2018. Encapsulation in polymeric microparticles improves daptomycin activity against mature staphylococci biofilms—a thermal and imaging study. AAPS PharmSciTech. 19(4):1625–1636.
   PubMed Web of Science ®Google Scholar
• Fini A, Bergamante V, Ceschel GC. 2011. Mucoadhesive gels designed for the controlled release of chlorhexidine in the oral cavity. Pharmaceutics. 3(4):665–679.
   PubMedGoogle Scholar
• Galey WR, Lonsdale H, Nacht S. 1976. The in vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. J Invest Dermatol. 67(6):713–717.
   PubMed Web of Science ®Google Scholar
• Garipova V, Gennari C, Selmin F, Cilurzo F, Moustafine R. 2018. Mucoadhesive interpolyelectrolyte complexes for the buccal delivery of clobetasol. Polymers. 10(1):85.
   Web of Science ®Google Scholar
• Goodhart FW, Martin AN. 1962. Solubilization of benzoic acid derivatives by polyoxyethylene stearates. J Pharm Sci. 51(1):50–54.
   PubMed Web of Science ®Google Scholar
• Graciano TB, Coutinho TS, Cressoni CB, de Paula Freitas C, Pierre MBR, de Lima Pereira SA, Shimano MM, da Cunha Frange RC, Garcia M. 2015. Using chitosan gels as a toluidine blue O delivery system for photodynamic therapy of buccal cancer: in vitro and in vivo studies. Photodiagn Photodyn Ther. 12(1):98–107.
   PubMed Web of Science ®Google Scholar
• Harish N, Prabhu P, Charyulu R, Gulzar M, Subrahmanyam E. 2009. Formulation and evaluation of in situ gels containing clotrimazole for oral candidiasis. Indian J Pharm Sci. 71(4):421.
   PubMed Web of Science ®Google Scholar
• Harsh S, Patel K, Padhyay U. 2014. Formulation and evaluation of controlled release colon targeted micro sponge of Aceclofenac. Pharm Innov J. 3(10):81–87.
   Google Scholar
• Hassan EE, Gallo JM. 1990. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm Res. 7(5):491–495.
   PubMed Web of Science ®Google Scholar
• Hassan M, Barakat N, El-Badry M, Shehata S. 2011. Formulation and in vitro/in vivo evaluation of naproxen mucoadhesive buccal patches for local effect. J Drug Deliv Sci Technol. 21(5):423.
   Web of Science ®Google Scholar
• Hoare TR, Kohane DS. 2008. Hydrogels in drug delivery: progress and challenges. Polymer. 49(8):1993–2007.
   Web of Science ®Google Scholar
• Ibrahim E-S, Ismail S, Fetih G, Shaaban O, Hassanein K, Abdellah N. 2012. Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application. Acta Pharma. 62(1):59–70.
   PubMed Web of Science ®Google Scholar
• Ilić T, Savić S, Batinić B, Marković B, Schmidberger M, Lunter D, Savić M, Savić S. 2018. Combined use of biocompatible nanoemulsions and solid microneedles to improve transport of a model NSAID across the skin: in vitro and in vivo studies. Eur J Pharm Sci. 125:110–119.
   PubMed Web of Science ®Google Scholar
• Irimia T, Dinu-Pîrvu C-E, Ghica M, Lupuleasa D, Muntean D-L, Udeanu D, Popa L. 2018. Chitosan-based in situ gels for ocular delivery of therapeutics: a state-of-the-art review. Mar Drugs. 16(10):373.
   Web of Science ®Google Scholar
• Jana S, Das A, Nayak AK, Sen KK, Basu SK. 2013. Aceclofenac-loaded unsaturated esterified alginate/gellan gum microspheres: in vitro and in vivo assessment. Int J Biol Macromol. 57:129–137.
   PubMed Web of Science ®Google Scholar
• Jana S, Manna S, Nayak AK, Sen KK, Basu SK. 2014. Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery. Colloids Surf B Biointerfaces. 114:36–44.
   PubMed Web of Science ®Google Scholar
• Jana S, Saha A, Nayak AK, Sen KK, Basu SK. 2013. Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles. Colloids Surf B Biointerfaces. 105:303–309.
   PubMed Web of Science ®Google Scholar
• Karthikeyan K, Durgadevi R, Saravanan K, Shivsankar K, Usha S, Saravanan M. 2012. Formulation of bioadhesive carbomer gel incorporating drug-loaded gelatin microspheres for periodontal therapy. Trop J Pharm Res. 11(3):335–343.
   Web of Science ®Google Scholar
• Kesavan K, Nath G, Pandit J. 2010. Preparation and in vitro antibacterial evaluation of gatifloxacin mucoadhesive gellan system. Daru. 18(4):237
   PubMed Web of Science ®Google Scholar
• Khames A. 2019. Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability. Drug Des Devel Ther. 13:925–940.
   PubMed Web of Science ®Google Scholar
• Khutoryanskiy VV. 2011. Advances in mucoadhesion and mucoadhesive polymers. Macromol Biosci. 11(6):748–764.
   PubMed Web of Science ®Google Scholar
• Krokida M, Pappa A, Agalioti M. 2011. Effect of drying on Aloe’s functional components. Proc Food Sci. 1:1523–1527.
   Google Scholar
• Lopez FL, Bowles A, Gul MO, Clapham D, Ernest TB, Tuleu C. 2016. Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers. Eur J Pharm Sci. 92:156–162.
   PubMed Web of Science ®Google Scholar
• Madhusudhan S, Panda AK, Parimalakrishnan S, Manavalan R, Manna P. 2010. Design, in vitro and in vivo evaluation of glipizide Eudragit microparticles. J Microencapsul. 27(4):281–291.
   PubMed Web of Science ®Google Scholar
• Mahdi MH, Conway BR, Mills T, Smith AM. 2016. Gellan gum fluid gels for topical administration of diclofenac. Int J Pharm. 515(1-2):535–542.
   PubMedGoogle Scholar
• Mahdi MH, Conway BR, Smith AM. 2014. Evaluation of gellan gum fluid gels as modified release oral liquids. Int J Pharm. 475(1-2):335–343.
   PubMedGoogle Scholar
• Meneguin AB, Beyssac E, Garrait G, Hsein H, Cury BS. 2018. Retrograded starch/pectin coated gellan gum-microparticles for oral administration of insulin: a technological platform for protection against enzymatic degradation and improvement of intestinal permeability. Eur J Pharm Biopharm. 123:84–94.
   PubMed Web of Science ®Google Scholar
• Menjoge A, Kulkarni M. 2007. Mechanistic investigations of phase behavior in Eudragit® E blends. Int J Pharm. 343(1-2):106–121.
   PubMedGoogle Scholar
• Miyazaki S, Aoyama H, Kawasaki N, Kubo W, Attwood D. 1999. In situ-gelling gellan formulations as vehicles for oral drug delivery. J Control Rel. 60(2-3):287–295.
   PubMed Web of Science ®Google Scholar
• Momoh M, Kenechukwu F, Adedokun M, Odo C, Attama A. 2014. Pharmacodynamics of diclofenac from novel Eudragit entrapped microspheres. Drug Deliv. 21(3):193–203.
   PubMed Web of Science ®Google Scholar
• Morales JO, Su R, McConville JT. 2013. The influence of recrystallized caffeine on water-swellable polymethacrylate mucoadhesive buccal films. AAPS PharmSciTech. 14(2):475–484.
   PubMed Web of Science ®Google Scholar
• Mouftah S, Abdel-Mottaleb MM, Lamprecht A. 2016. Buccal delivery of low molecular weight heparin by cationic polymethacrylate nanoparticles. Int J Pharm. 515(1-2):565–574.
   PubMedGoogle Scholar
• Murakami H, Kawashima Y, Niwa T, Hino T, Takeuchi H, Kobayashi M. 1997. Influence of the degrees of hydrolyzation and polymerization of poly (vinylalcohol) on the preparation and properties of poly (DL-lactide-co-glycolide) nanoparticle. Int J Pharm. 149(1):43–49.
   Google Scholar
• Nagarwal RC, Pandit J. 2008. Phase transition system: novel oral in-situ gel. Curr Drug Deliv. 5(4):282–289.
   PubMedGoogle Scholar
• Nazari K, Kontogiannidou E, Ahmad RH, Gratsani A, Rasekh M, Arshad MS, Sunar BS, Armitage D, Bouropoulos N, Chang M-W, et al. 2017. Development and characterisation of cellulose based electrospun mats for buccal delivery of non-steroidal anti-inflammatory drug (NSAID). Eur J Pharm Sci. 102:147–155.,
   PubMed Web of Science ®Google Scholar
• Osmałek T, Milanowski B, Froelich A, Szybowicz M, Białowąs W, Kapela M, Gadziński P, Ancukiewicz K. 2017. Design and characteristics of gellan gum beads for modified release of meloxicam. Drug Dev Ind Pharm. 43(8):1314–1329.
   PubMed Web of Science ®Google Scholar
• Patel B, Banwait H, Parmar K, Patel M. 2011. Formulation and evaluation of topical aceclofenac gel using different gelling agent. Int J Drug Dev Res. 3(1):156–164.
   Google Scholar
• Patel V, Prajapat B, Patel J, Patel M. 2006. Physicochemical characterization and evaluation of buccal adhesive patches containing propranolol hydrochloride. CDD. 3(3):325–331.
   PubMedGoogle Scholar
• Patel VF, Liu F, Brown MB. 2011. Advances in oral transmucosal drug delivery. J Control Rel. 153(2):106–116.
   PubMed Web of Science ®Google Scholar
• Patil HG, Tiwari RV, Repka MA, Singh KK. 2016. Formulation and development of orodispersible sustained release tablet of domperidone. Drug Dev Ind Pharm. 42(6):906–915.
   PubMed Web of Science ®Google Scholar
• Patnaik S, Aditha SK, Rattan T, Kamisetti V. 2015. Aceclofenac-soluplus® nanocomposites for increased bioavailability. SNL. 05(02):13.
   Google Scholar
• Paul A. 1996. Analgesic-antipyretics and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE, editors. The pharmacological basis of therapeutics. New York (NY): McGraw Hill; p. 617–657.
   Google Scholar
• Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccella M, Rossi C. 2004. Development of mucoadhesive patches for buccal administration of ibuprofen. J Control Rel. 99(1):73–82.
   PubMed Web of Science ®Google Scholar
• Perioli L, Ambrogi V, Giovagnoli S, Ricci M, Blasi P, Rossi C. 2007. Mucoadhesive bilayered tablets for buccal sustained release of flurbiprofen. AAPS PharmSciTech. 8(3):E20–E27.
   PubMed Web of Science ®Google Scholar
• Prezotti F, Boni F, Ferreira N, Silva D, Campana-Filho S, Almeida A, Vasconcelos T, Gremião M, Cury B, Sarmento B. 2018. Gellan gum/pectin beads are safe and efficient for the targeted colonic delivery of resveratrol. Polymers. 10(1):50.
   Web of Science ®Google Scholar
• Prezotti FG, Cury BSF, Evangelista RC. 2014. Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs. Carbohydr Polym. 113:286–295.
   PubMed Web of Science ®Google Scholar
• Raj R, Mongia P, Ram A, Jain N. 2016. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Artif Cells Nanomed Biotechnol. 44(6):1434–1439.
   PubMed Web of Science ®Google Scholar
• Reddy PC, Chaitanya K, Rao YM. 2011. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU J Pharm Sci. 19(6):385.
   Web of Science ®Google Scholar
• Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F, Minghetti P, Parodi B. 2016. A focus on mucoadhesive polymers and their application in buccal dosage forms. J Drug Deliv Sci Technol. 32:113–125.
   Web of Science ®Google Scholar
• Sanghai P, Nandgude T, Poddar S. 2016. Formulation of bilayer benzydamine HCl patch targeted for gingivitis. J Drug Deliv. :1. 2016
   Google Scholar
• Sharma N, Madan P, Lin S. 2016. Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: A co-surfactant study. Asian J Pharm Sci. 11(3):404–416.
   Web of Science ®Google Scholar
• Soliman ME, Elmowafy E, Casettari L, Alexander C. 2018. Star-shaped poly (oligoethylene glycol) copolymer-based gels: thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery. Int J Pharm. 543(1–2):224–233.
   PubMedGoogle Scholar
• Soliman ME, Elmowafy EM, Almogerbi A, Mansour SA, Shamy AA. 2016. Dual buoyant/mucoadhesive macroporous polypropylene microparticles for gastric delivery of Repaglinide. Int J Drug Deliv. 7(4):197–207.
   Google Scholar
• Srinivas S, Kumar YA, Hemanth A, Anitha M. 2010. Preparation and evaluation of niosomes containing aceclofenac. Dig J Nanomater Bios. 5(1):249–254.
   Web of Science ®Google Scholar
• Sudhakar Y, Kuotsu K, Bandyopadhyay A. 2006. Buccal bioadhesive drug delivery-a promising option for orally less efficient drugs. J Control Rel. 114(1):15–40.
   PubMed Web of Science ®Google Scholar
• Suresh PK, Manhar S. 2014. Bioadhesive buccal gels impregnated with fluconazole: formulation, in vitro and ex vivo characterization. J Appl Pharm Sci. 4(3):15.
   Google Scholar
• Suvannasara P, Juntapram K, Praphairaksit N, Siralertmukul K, Muangsin N. 2013. Mucoadhesive 4-carboxybenzenesulfonamide-chitosan with antibacterial properties. Carbohydr Polym. 94(1):244–252.
   PubMed Web of Science ®Google Scholar
• Swain GP, Patel S, Gandhi J, Shah P. 2019. Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: in-vitro drug release study and antibacterial activity. J Oral Biol Craniofac Res. 9(3):190–200.
   PubMedGoogle Scholar
• Thirawong N, Kennedy RA, Sriamornsak P. 2008. Viscometric study of pectin–mucin interaction and its mucoadhesive bond strength. Carbohydr Polym. 71(2):170–179.
   Web of Science ®Google Scholar
• Usha AN, Mutalik S, Reddy MS, Ranjith AK, Kushtagi P, Udupa N. 2008. Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates. Eur J Pharm Biopharm. 70(2):674–683.
   PubMed Web of Science ®Google Scholar
• Wan LS, Lee PF. 1974. CMC of polysorbates. J Pharm Sci. 63(1):136–137.
   PubMed Web of Science ®Google Scholar
• Xie H, Li L, Sun Y, Wang Y, Gao S, Tian Y, Ma X, Guo C, Bo F, Zhang L. 2019. An available strategy for nasal brain transport of nanocomposite based on PAMAM dendrimers via in situ gel. Nanomaterials. 9(2):147.
   Web of Science ®Google Scholar
• Zhu L, Ao J, Li P. 2015. A novel in situ gel base of deacetylase gellan gum for sustained ophthalmic drug delivery of ketotifen: in vitro and in vivo evaluation. Drug Des Devel Ther. 9:3943.
   PubMed Web of Science ®Google Scholar