Dexamethasone loaded PLGA nanoparticles for potential local treatment of oral precancerous lesions

References

• Awadallah M, Idle M, Patel K, Kademani D. 2018. Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 125(6):628–636.
   PubMed Web of Science ®Google Scholar
• Ayroldi E, Cannarile L, Delfino DV, Riccardi C. 2018. A dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? Cell Death Dis. 9:463.
   PubMed Web of Science ®Google Scholar
• Bala I, Hariharan S, Ravi Kumar MNV. 2004. PLGA nanoparticles in drug delivery: the state of the art. Crit Rev Ther Drug Carrier Syst. 21(5):387–422.
   PubMed Web of Science ®Google Scholar
• Bennewitz MF, Saltzman WM. 2009. Nanotechnology for delivery of drugs to the brain for epilepsy. Neurotherapeutics. 6(2):323–336.
   PubMed Web of Science ®Google Scholar
• Bhardwaj V, Ankola DD, Gupta SC, Schneider M, Lehr CM, Ravi Kumar M. 2009. PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm Res. 26(11):2495–2503.
   PubMed Web of Science ®Google Scholar
• Bohrey S, Chourasiya V, Pandey A. 2016. Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study. Nano Converg. 3(1):3.
   PubMedGoogle Scholar
• Bourcier T, Forgez P, Borderie V, Scheer S, Rostene W, Laroche L. 2000. Regulation of human corneal epithelial cell proliferation and apoptosis by dexamethasone. Invest Ophthalmol Vis Sci. 41(13):4133–4141.
   PubMed Web of Science ®Google Scholar
• Budhian A, Siegel SJ, Winey KI. 2007. Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content. Int J Pharm. 336(2):367–375.
   PubMed Web of Science ®Google Scholar
• Calixto G, Bernegossi J, Fonseca-Santos B, Chorilli M. 2014. Nanotechnology-based drug delivery systems for treatment of oral cancer: A review. Int J Nanomed. 9:3719–3735.
   PubMed Web of Science ®Google Scholar
• Campolongo MJ, Luo D. 2009. Drug delivery old polymer learns new tracts. Nat Mater. 8(6):447–448.
   PubMed Web of Science ®Google Scholar
• Chaturvedi SP, Kumar V. 2012. Production techniques of lipid nanoparticles: a review. Res J Pharm Biol Chem Sci. 3(3):525–541.
   Google Scholar
• Chen F, Lin L, Liu F, Yan L, Qiu Y, Wang J, Hu Z, Wu J, Bao X, Lin L, et al. 2019. Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: a large-scale prospective study. Head Neck. 41:301–308.
   PubMed Web of Science ®Google Scholar
• Chronopoulou L, Amalfitano A, Palocci C, Nocca G, Alessandro CC. 2015. Dexamethasone-loaded biopolymeric nanoparticles promote gingival fibroblasts differentiation. Biotechnol Prog. 31(5):1981–1987.
   Web of Science ®Google Scholar
• Cui YN, Xu QX, Davoodi P, Wang DP, Wang CH. 2017. Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin. Acta Pharmacol Sin. 38(6):943–953.
   PubMed Web of Science ®Google Scholar
• Dawes GJS, Fratila-Apachitei LE, Necula BS, Apachitei I, Van Leeuwen J, Duszczyk J, Eijken M. 2012. Effects of dexamethasone-loaded PLGA microspheres on human fetal osteoblasts. J Biomater Appl. 27(4):477–483.
   PubMed Web of Science ®Google Scholar
• Desai UH, Patwari AH, Maradiya JK, Sathawara MK, Suhagia BN, Rathod IS. 2013. RP-HPLC method for simultaneous estimation of ciprofloxacin and dexamethasone in eye/ear drops. Int J Pharm Sci Res. 5(2):62–66.
   Google Scholar
• Desgouilles S, Vauthier C, Bazile D, Vacus J, Grossiord JL, Veillard M, Couvreur P. 2003. The design of nanoparticles obtained by solvent evaporation: a comprehensive study. Langmuir. 19(22):9504–9510.
   Web of Science ®Google Scholar
• Ferlay J, Bray F, Pisani P, Parkin DM, GLOBOCAN 2004. Cancer incidence. Mortality and prevalence worldwide. IARC Cancer Base No.5, version 2.0. Lyon (France): IARC Press.
   Google Scholar
• Ferrua CP, Leal FB, Oliveira Gazal M, Ghisleni GC, Carvalho RV, Demarco FF, Ogliari FA, Nedel F. 2019. Iodonium salt incorporation in dental adhesives and its relation with degree of conversion, ultimate tensile strength, cell viability, and oxidative stress. Clin Oral Invest. 23(3): 1143–1151.
   PubMed Web of Science ®Google Scholar
• Flores IL, Gamba TO, Carvalho RV, Lund RG, Etges A. 2016. In vitro cytotoxicity of plantago australis ethanol extract used as an anti-inflammatory for the treatment of oral pathologies. Jentashapir J Health Res. 7(1):e28515.
   Google Scholar
• Fredenberg S, Wahlgren M, Reslow M, Axelsson A. 2011. The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review. Int J Pharm. 415(1–2):34–52.
   PubMed Web of Science ®Google Scholar
• Garcia CV, Breier AR, Steppe M, Schapoval EE, Oppe TP. 2003. Determination of dexamethasone acetate in cream by HPLC. J Pharm Biomed Anal. 31(3):597–600.
   PubMed Web of Science ®Google Scholar
• Gasper MM, Blanco D, Cruz ME, Alonso MJ. 1998. Formulation of Lasparaginase-loaded poly(lactide-co-glycolide) nanoparticles: Influence of polymer properties on enzyme loading, activity and in vitro release. J Control Release. 52(1–2):53–62.
   PubMed Web of Science ®Google Scholar
• Geurtsen W, Leinenbach F, Krage T, Leyhausen G. 1998. Cytotoxicity of four root canal sealers in permanent 3T3 cells and primary human periodontal ligament fibroblast cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85(5):592–597.
   PubMed Web of Science ®Google Scholar
• Giovino C, Ayensu I, Tetteh J, Boateng JS. 2012. Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles (NPs): a potential approach for buccal delivery of macromolecules. Int J Pharm. 428(1–2):143–151.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Moles MA, Ruiz-Avila I, Rodriguez-Archilla A, Morales-Garcia P, Mesa-Aguado F, Bascones-Martinez A, Bravo M. 2003. Treatment of severe erosive gingival lesions by topical application of clobetasol propionate in custom trays. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 95(6):688–692.
   PubMed Web of Science ®Google Scholar
• Gossmann R, Langer K, Mulac D. 2015. New perspective in the formulation and characterization of didodecyldimethylammonium bromide (DMAB) stabilized poly(lactic-co-glycolic acid) (PLGA) nanoparticles. PLoS One. 10(7):e0127532.
   PubMed Web of Science ®Google Scholar
• Goyal RN, Gupta VK, Chatterjee S. 2009. Fullerene-C60-modified edge plane pyrolytic graphite electrode for the determination of dexamethasone in pharmaceutical formulations and human biological fluids. Biosens Bioelectron. 24(6):1649–1654.
   PubMed Web of Science ®Google Scholar
• Hambly JL, Haywood A, Hattingh L, Nair RG. 2017. Comparison between self-formulation and compounded formulation dexamethasone mouth rinse for oral lichen planus: a pilot randomized cross-over trial. J Investig Clin Dent. 8:e12225.
   PubMed Web of Science ®Google Scholar
• De Hahi D. 2002. Production of inflammatory mediators by renal epithelial cells is insensitive to glucocorticoids. Br J Pharmacol. 137(2):197–204.
   PubMed Web of Science ®Google Scholar
• De Haji S, Adcock IM, Bakker AC, Gobin SJ, Daha MR, Van Kooten C. 2003. Steroid responsiveness of renal epithelial cell- dissociation of transrepression and transactivation. J Biol Chem. 278(7):5091–5098.
   PubMed Web of Science ®Google Scholar
• Hans ML, Lowman AM. 2002. Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci. 6(4):319–327.
   Web of Science ®Google Scholar
• Hansson A, Hehenberger K, Thoren M. 1996. Long-term treatment of Swiss 3T3 fibroblasts with dexamethasone attenuates MAP kinase activation induced by insulin-like growth factor-I (IGF-I) ). Cell Biochem Funct. 14(2):121–129.
   PubMed Web of Science ®Google Scholar
• He S, Wang HM, Ye J, Ogden TE, Ryan SJ, Hinton DR. 1994. Dexamethasone induced proliferation of cultured retinal pigment epithelial cells. Curr Eye Res. 13(4):257–261.
   PubMed Web of Science ®Google Scholar
• Holgado MA, Arias JL, Cózar MJ, Alvarez-Fuentes J, Gañán-Calvo AM, Fernández-Arévalo M. 2008. Synthesis of lidocaine-loaded PLGA microparticles by flow focusing. Effects on drug loading and release properties. Int J Pharm. 358(1–2):27–35.
   PubMed Web of Science ®Google Scholar
• Karavana SY, Gökçe EH, Rençber S, Özbal S, Pekçetin Ç, Güneri P, Ertan G. 2012. A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine a solid lipid nanoparticles: in vivo/in vitro examinations. Int J Nanomed. 7:5693–5704.
   PubMed Web of Science ®Google Scholar
• Khan S, Lee M, Kang M, Noh M, Jeon J, Lee Y, Seo JH. 2016. Development of anti-biofouling interface on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties to prevent oral bacterial adhesion. Acta Biomater. 40:70–77.
   PubMed Web of Science ®Google Scholar
• Kim SH, Moon JH, Jeong SU, Jung HH, Park CS, Hwang BY, Lee CK. 2019. Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone. Int J Nanomed. 14:5229–5242.
   PubMed Web of Science ®Google Scholar
• Kim D-H, Martin DC. 2006. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials. 27(15):3031–3037.
   PubMed Web of Science ®Google Scholar
• Krakauer T, Buckley M. 2013. Efficacy of two FDA-approved drug combination in a mouse model of staphylococcal enterotoxin b-induced shock. Military Med. 178(9):1024.
   PubMed Web of Science ®Google Scholar
• Kreuter J. 1994. Drug targeting with nanoparticles. Eur J Drug Metab Pharmacokinet. 19(3):253–256.
   PubMed Web of Science ®Google Scholar
• Kulkarni SA, Feng SS. 2013. Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm Res. 30(10):2512–2522.
   PubMed Web of Science ®Google Scholar
• Kylmaniemi M, Oikarinen A, Oikarinen K, Salo T. 1996. Effects of dexamethasone and cell proliferation on the expression of matrix metalloproteinases in human mucosal normal and malignant cells. J Dent Res. 75(3):919–926.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang SM, Chen PP, Cheng L, Zhou W, Tang WX, Chen ZW, Ke CM. 2007. Controlled release of insulin from PLGA nanoparticles embedded within PVA hydrogels. J Mater Sci Mater Med. 18:2205–2210.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu X, Mi Y, Zhang B, Gu S, Liu G, Li X. 2017. PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies. Drug Deliv. 24(1):443–451.
   PubMed Web of Science ®Google Scholar
• Lü JM, Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C. 2009. Current advances in research and clinical applications of PLGA based nanotechnology. Expert Rev Mol Diagn. 9(4):325–341.
   PubMed Web of Science ®Google Scholar
• Martin-Banderas L, Alvarez-Fuentes J, Duran-Lobato M, Prados J, Melguizo C, FernandezArevalo M, Holgado A. 2012. Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies. Int J Nanomed. 7:5793–5806.
   PubMed Web of Science ®Google Scholar
• Mehdipour M, Zenouz AT. 2012. Role of corticosteroids in oral lesions. In: Sameh Magdeldin, editor. State of the art of therapeutic endocrinology. Chapter 5, IntechOpen; p. 87–120.
   Google Scholar
• Menon JU, Kona S, Wadajkar AS, Desai F, Vadla A, Nguyen KT. 2012. Effects of surfactants on the properties of PLGA nanoparticles. J Biomed Mater Res. 100A(8):1998–2005.
   Web of Science ®Google Scholar
• Mohanraj VJ, Chen Y. 2006. Nanoparticles-a review. Trop J Pharm Res. 5(1):561–573.
   Google Scholar
• Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth. 65(1–2):55–63.
   PubMed Web of Science ®Google Scholar
• Muthu MS, Rawat MK, Mishra A, Singh S. 2009. PLGA nanoparticle formulations of risperidone: preparation and neuropharmacological evaluation. Nanomed: Nanotechnol Biol Med. 5(3):323–333.
   PubMed Web of Science ®Google Scholar
• Narihira K, Watanabe A, Sheng H, Endo H, Feril LB, Irie Y, Ogawa K, Moosavi-Nejad S, Kondo S, Kikuta T, Tachibana K. 2018. Enhanced cell killing and apoptosis of oral squamous cell carcinoma cells with ultrasound in combination with cetuximab coated albumin microbubbles. J Drug Target. 26(3):278–288.
   PubMed Web of Science ®Google Scholar
• Nasef A, Gardouh AR, Ghorab MM. 2015. Polymeric nanoparticles: Influence of polymer, surfactant and composition of manufacturing vehicle on particle size. World J Pharm Sci. 3(12):2308–2322.
   Google Scholar
• Nieto K, Pei P, Wang D, Mallery SR, Schwendeman SP. 2018. In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence. Int J Pharm. 538(1–2):48–56.
   PubMedGoogle Scholar
• Ogawa Y, Okada H, Heya T, Shimamoto T. 1989. Controlled release of LHRH agonist, leuprolide acetate, from microcapsules: serum drug level profiles and pharmacological effects in animals. J Pharm Pharmacol. 41(7):439–444.
   PubMed Web of Science ®Google Scholar
• Okada H. 1997. One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate. Adv Drug Deliv Rev. 28(1):43–70.
   PubMed Web of Science ®Google Scholar
• Palacio J, Orozco VH, López BL. 2011. Effect of the molecular weight on the physicochemical properties of poly(lactic acid) nanoparticles and on the amount of ovalbumin adsorption. J Braz Chem Soc. 22(12):2304–2311.
   Web of Science ®Google Scholar
• Parkin D, Pisani P, Ferlay J. 1993. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 54(4):594–606.
   PubMed Web of Science ®Google Scholar
• Patel DM, Shah PM, Patel CN. 2012. Formulation and evaluation of bioadhesive buccal drug delivery of repaglinide tablets. Asian J Pharm. 6(3):171–179.
   Google Scholar
• Patel J, Amrutiya J, Bhatt P, Javia A, Jain M, Misra A. 2018. Targeted delivery of monoclonal antibody conjugated docetaxel loaded PLGA nanoparticles into EGFR overexpressed lung tumour cells. J Microencapsulation. 35(2):204–217.
   PubMed Web of Science ®Google Scholar
• Perez-Lozano P, Garcia-Montoya E, Minarro M, Tico JR, Sune-Negre JM. 2004. Development and validation of a new HPLC analytical method for the determination of alprazolam in tablets. J Pharm Biomed Anal. 34(11):979–987.
   PubMedGoogle Scholar
• Prakapenka AV, Bimonte-Nelson HA, Sirianni RW. 2017. Engineering poly(lactic co-glycolic) acid particles for controlled delivery of 17β-estradiol. Ann Biomed Eng. 45(7):1697–1709.
   PubMed Web of Science ®Google Scholar
• Rahikkala A, Aseyev V, Tenhu H, Kauppinen EI, Raula J. 2015. Thermoresponsive nanoparticles of self-assembled block copolymers as potential carriers for drug delivery and diagnostics. Biomacromolecules. 16(9):2750–2756.
   PubMed Web of Science ®Google Scholar
• Rençber S, Yaprak Karavana S, Yılmaz FF, Eraç B, Nenni M, Özbal S, Pekçetin Ç, Gurer-Orhan H, Hoşgör Limoncu M, Güneri P, Ertan G. 2016. Development, characterization and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis. Int J Nanomed. 11:2641–2653.
   PubMed Web of Science ®Google Scholar
• Rezvantalab S, Ingrid Drude N, Keshavarz Moraveji M, Güvener N, Koons EK, Shi Y, Lammers T, Kiessling F. 2018. PLGA-based nanoparticles in cancer treatment. Front Pharmacol. 9:Article 1260.
   PubMed Web of Science ®Google Scholar
• Ritger PL, Peppas NA. 1987. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release. 5(1):37–42.
   Google Scholar
• Sahoo SK, Panyam J, Prabha S, Labhasetwar V. 2002. Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Control Release. 82(1):105–114.
   PubMed Web of Science ®Google Scholar
• Sakai H, Toyota N, Ito F, Takahashi H, Hashimoto Y, Iizuka H. 1999. Glucocorticoids inhibit proliferation and adhesion of the IL-3-dependent mast cell line, MC/9, to NIH/3T3 fibroblasts, with an accompanying decrease in IL-3 receptor expression. Arch Dermatol Res. 291(4):224–231.
   PubMed Web of Science ®Google Scholar
• Sanchez-Lopez E, Ettcheto M, Egea MA, Espina M, Cano A, Calpena AC, Camins A, Carmona N, Silva AM, Souto EB, García ML. 2018. Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization. J Nanobiotechnol. 16(1):32.
   PubMedGoogle Scholar
• Sapre AS, Parikh RK. 2012. Design of a buccal mucoadhesive, nanoparticles based delivery system of fluoxetine. J Pharm Sci Biosci Res. 2(3):148–161.
   Google Scholar
• Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, Verma IM, Evans RM. 1990. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 62(6):1217–1226.
   PubMed Web of Science ®Google Scholar
• Sengel Türk CT, Sezgin Bayindir Z, Badilli U. 2009. Preparation of polymeric nanoparticles using different stabilizing agents. J Fac Pharm. 38(4):257–268.
   Google Scholar
• Şenyiğit T, Sonvico F, Barbieri S, Ozer O, Santi P, Colombo P. 2010. Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin. J Control Release. 142(3):368–373.
   PubMed Web of Science ®Google Scholar
• Severino P, Chaud MV, Shimojo A, Antonini D, Lancelloti M, Santana MHA, Souto EB. 2015. Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies. Colloids Surf B Biointerfaces. 129:191–197.
   PubMed Web of Science ®Google Scholar
• Shojaei AH. 1998. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci. 1(1):15–30.
   PubMedGoogle Scholar
• Singh R, Lillard JW. 2009. Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 86(3):215–223.
   PubMed Web of Science ®Google Scholar
• Siu FYK, Ye S, Lin H, Li S. 2018. Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity. Int J Nanomed. 13:4133–4144.
   PubMed Web of Science ®Google Scholar
• Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. 2001. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 70(1–2):1–20.
   PubMed Web of Science ®Google Scholar
• Suh JW, Lee JS, Ko SG, Lee H. 2016. Preparation and characterization of mucoadhesive buccal nanoparticles using chitosan and dextran sulfate. J Agric Food Chem. 64(26):5384–5388.
   PubMed Web of Science ®Google Scholar
• Sun C, Wang X, Zheng Z, Chen D, Wang X, Shi F, Yu D, Wu H. 2015. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration. Int J Nanomed. 10:3567–3579.
   PubMed Web of Science ®Google Scholar
• Sun D, Xue A, Zhang B, Xue X, Zhang J, Liu W. 2016. Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology. Drug Des Dev Ther. 10:2029–2039.
   PubMed Web of Science ®Google Scholar
• Sun SB, Liu P, Shao FM, Miao QL. 2015. Formulation and evaluation of PLGA nanoparticles loaded capecitabine for prostate cancer. Int J Clin Exp Med. 8(10):19670–19681.
   PubMed Web of Science ®Google Scholar
• Tabatabaei Mirakabad FS, Nejati-Koshki K, Akbarzadeh A, Rahmati Yamchi M, Milani M, Zarghami N, Zeighamian V, Rahimzadeh A, Alimohammadi S, Hanifehpour Y, Woo Joo S. 2014. PLGA-based nanoparticles as cancer drug delivery systems. Asian Pac J Cancer Prev. 15(2):517–535.
   PubMedGoogle Scholar
• Topcuoglu N, Lacin CC, Erguven M, Bilir A, Sutlupinar N, Kulekci G. 2015. Antibacterial effect of kenger gum on mutans streptococci and its cytotoxic effect on the 3T3 fibroblast cell line. Oral Health Prev Dent. 13(2):157–162.
   PubMed Web of Science ®Google Scholar
• Vauthier CV, Bouchemal K. 2009. Methods for the preparation and manufacture of polymeric nanoparticles. Pharm Res. 26(5):1025–1058.
   PubMed Web of Science ®Google Scholar
• Wan S, Zhang L, Quan Y, Wei K. 2018. Resveratrol-loaded PLGA nanoparticles: enhanced stability, solubility and bioactivity of resveratrol for non-alcoholic fatty liver disease therapy. R Soc Open Sci. 5(11):181457.
   PubMed Web of Science ®Google Scholar
• Warnakulasuriya S. 2009. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 45(4–5):309–316.
   PubMed Web of Science ®Google Scholar
• Westedt U, Kalinowski M, Wittmar M, Merdan T, Unger F, Fuchs J, Schäller S, Bakowsky U, Kissel T. 2007. Poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment. J Control Release. 119(1):41–51.
   PubMed Web of Science ®Google Scholar
• Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BY, Yeo GSH, Coll AP, Harno E, White A. 2019. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 26:5–17.
   PubMed Web of Science ®Google Scholar
• Yardimci G, Kutlubay Z, Engin B, Tuzun Y. 2014. Precancerous lesions of oral mucosa. World J Clin Cases. 2(12):866–872.
   PubMed Web of Science ®Google Scholar
• Yoo JW, Giri N, Lee CH. 2011. pH-sensitive Eudragit nanoparticles for mucosal drug delivery. Int J Pharm. 403(1–2):262–267.
   PubMedGoogle Scholar