224
Views
18
CrossRef citations to date
0
Altmetric
Research Articles

Composite chitosan hydrogels as advanced wound dressings with sustained ibuprofen release and suitable application characteristics

, , &
Pages 332-339 | Received 05 Aug 2019, Accepted 03 Dec 2019, Published online: 12 Dec 2019

References

  • Alsarra IA. 2009. Chitosan topical gel formulation in the management of burn wounds. Int J Biol Macromol. 45:16–21.
  • Arapoglou V, Katsenis K, Syrigos KN, Dimakakos EP, Zakopoulou N, Tsoutsos D, Gjødsbøl K, Glynn C, Schäfer E, Petersen B. 2011. Analgesic efficacy of an ibuprofen-releasing foam dressing compared with local best practice for painful exuding wounds. Wound Care. 20:319–320, 322–325.
  • Bhattarai N, Gunn J, Zhang M. 2010. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev. 62:83–99.
  • Boateng J, Catanzano O. 2015. Advanced therapeutic dressings for effective wound healing-a review. J Pharm Sci. 104:3653–3680.
  • Boucard N, Viton C, Agay D, Mari E, Roger T, Chancerelle Y, Domard A. 2007. The use of physical hydrogels of chitosan for skin regeneration following third-degree burns. Biomaterials. 28:3478–3488.
  • Briggs M, Nelson EA. 2010. Topical agents or dressings for pain in venous leg ulcers. Cochrane Database Syst Rev. 11:CD001177. [accessed 2019 Jul 29]. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD001177.pub3/full.
  • Bshara H, Osman R, Mansour S, El-Shamy AH. 2014. Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Carbohydr Polym. 99:297–305.
  • Coats TJ, Edwards C, Newton R, Staun E. 2002. The effect of gel burns dressings on skin temperature. Emerg Med J. 19:224–225.
  • Delmar K, Bianco-Peled H. 2016. Composite chitosan hydrogels for extended release of hydrophobic drugs. Carbohydr Polym. 136:570–580.
  • Demling RH, Lalonde C. 1987. Topical ibuprofen decreases early postburn edema. Surgery. 102:857–861.
  • Dissemond J, Witthoff M, Brauns TC, Haberer D, Goos M. 2003. pH values in chronic wounds. Evaluation during modern wound therapy]. Hautarzt. 54:959–965. [ German.
  • Djekic L, Martinovic M, Stepanovic-Petrovic R, Tomic M, Micov A, Primorac M. 2015. Design of block copolymer costabilized nonionic microemulsions and their in vitro and in vivo assessment as carriers for sustained regional delivery of ibuprofen via topical administration. J Pharm Sci. 104:2501–2512.
  • Djekic L, Martinovic M, Stepanović-Petrović R, Micov A, Tomić M, Primorac M. 2016. Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats. Eur J Pharm Sci. 92:255–265.
  • Djekic L, Primorac M. 2008. The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides. Int J Pharm. 352:231–239.
  • Djekic L, Primorac M, Filipic S, Agbaba D. 2012. Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions. Int J Pharm. 433:25–33.
  • Dutta PK, Dutta J, Tripathi VS. 2004. Chitin and chitosan: chemistry, properties and applications. J Sci Ind Res. 63:20–31.
  • El-Hefian EA, Yahaya AH. 2010. Rheological study of chitosan and its blends: an overview. Maejo Int J Sci Tech. 4:210–220.
  • Elias PM. 2007. The skin barrier as an innate immune element. Semin Immunopathol. 29:3–14.
  • Erfurt-Berge C, Renner R. 2014. Recent developments in topical wound therapy: impact of antimicrobiological changes and rebalancing the wound milieu. BioMed Res Int. 2014:1. Article ID 819525. [accessed 2019 July 29]. http://dx.doi.org/10.1155/2014/819525.
  • Falanga V. 2000. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen. 8:347–352.
  • Gottrup F, Jørgensen B, Karlsmark T, Sibbald RG, Rimdeika R, Harding K, Price P, Venning V, Vowden P, Jünger M, et al. 2007. Less pain with Biatain-Ibu: initial findings from a randomised, controlled, double-blind clinical investigation on painful venous leg ulcers. Int Wound J. 4:24–34.
  • Grice EA, Segre JA. 2011. The skin microbiome. Nat Rev Microbiol. 9:244–253.
  • Guo S, DiPietro LA. 2010. Factors affecting wound healing. J Dent Res. 89:219–229.
  • Harper D, Young A, McNaught CE. 2014. The physiology of wound healing. Surgery. 32:445–450.
  • Hurler J, Engesland A, Kermany BP, Škalko-Basnet N. 2012. Improved texture analysis for hydrogel characterization: gel cohesiveness, adhesiveness, and hardness. J Appl Polym Sci. 125:180–188.
  • Jayakumar R, Prabaharan M, Sudheesh Kumar PT, Nair SV, Tamura H. 2011. Biomaterials based on chitin and chitosan in wound dressing applications. Biotechnol Adv. 29:322–337.
  • Kiene K, Porta F, Topacogullari B, Detampel P, Huwyler J. 2018. Self-assembling chitosan hydrogel: a drug-delivery device enabling the sustained release of proteins. J Appl Polym Sci. 135:45638. [accessed 2019 July 29]..
  • Kumari B, Kesavan K. 2017. Effect of chitosan coating on microemulsion for effective dermal clotrimazole delivery. Pharm Dev Technol. 22:617–626.
  • Landriscina A, Rosen J, Friedman AJ. 2015. Systematic approach to wound dressings. J Drugs Dermatol. 14:740–744.
  • Lee KY, Mooney DJ. 2001. Hydrogels for tissue engineering. Chem Rev. 101:1869–1879.
  • Lucero MJ, Ferris C, Sánchez-Gutiérrez CA, Jiménez-Castellanos MR, de-Paz MV. 2016. Novel aqueous chitosan-based dispersions as efficient drug delivery systems for topical use. Rheological, textural and release studies. Carbohydr Polym. 151:692–699.
  • Lunter DJ, Rottke M, Daniels R. 2014. Oil-in-oil-emulsions with enhanced substantivity for the treatment of chronic skin diseases. J Pharm Sci. 103:1515–1519.
  • Mogoşanu GD, Grumezescu AM. 2014. Natural and synthetic polymers for wounds and burns dressing. Int J Pharm. 463:127–136.
  • Montembault A, Viton C, Domard A. 2005. Rheometric study of the gelation of chitosan in a hydroalcoholic medium. Biomaterials. 26:1633–1643.
  • Morgado PI, Miguel SP, Correia IJ, Aguiar-Ricardo A. 2017. Ibuprofen loaded PVA/chitosan memebranes: a highly efficient strategy towards an improved skin wound healing. Carbohydr Polym. 159:136–145.
  • Morton LM, Phillips TJ. 2016. Wound healing and treating wounds: differential diagnosis and evaluation of chronic wounds. J Am Acad Dermatol. 74:589–605.
  • Peppas NA, Khare AR. 1993. Preparation, structure and diffusional behavior of hydrogels in controlled release. Adv Drug Deliv Rev. 11:1–35.
  • Rockwell WB, Ehrlich HP. 1990. Ibuprofen in acute-care therapy. Ann Surg. 211:78–83.
  • Romanelli M, Dini V, Polignano R, Bonadeo P, Maggio G. 2009. Ibuprofen slow-release foam dressing reduces wound pain in painful exuding wounds: preliminary findings from an international real-life study. J Dermatol Treat. 20:19–26.
  • Rossi S, Marciello M, Sandri G, Ferrari F, Bonferoni MC, Papetti A, Caramella C, Dacarro C, Grisoli P. 2007. Wound dressings based on chitosans and hyaluronic acid for the release of chlorhexidine diacetate in skin ulcer therapy. Pharm Dev Technol. 12:415–422.
  • Schmidberger M, Daniels R, Lunter DJ. 2018. Method to determine the impact of substantivity on ex vivo skin-permeation. Eur J Pharm Biopharm. 131:1–7.
  • Starychová L, Žabka M, Špaglová M, Cuchorová M, Vitková M, Čierna M, Bartoniková K, Gardavská K. 2014. In vitro liberation of indomethacin from chitosan gels containing microemulsion in different dissolution mediums. J Pharm Sci. 103:3977–3984.
  • Tessmar JK, Göpferich AM. 2007. Matrices and scaffolds for protein delivery intissue engineering. Adv Drug Deliv Rev. 59:274–291.
  • Thomas L, Zakir F, Mirza MA, Anwer MK, Ahmad FJ, Iqbal Z. 2017. Development of curcumin loaded chitosan polymer based nanoemulsion gel: in vitro, ex vivo evaluation and in vivo wound healing studies. Int J Biol Macromol. 101:569–579.
  • Vowden K, Vowden P. 2017. Wound dressings: principles and practice. Surgery. 35:489–494.
  • Vunain E, Mishra AK, Mamba BB. 2017. Fundamentals of chitosan for biomedical applications. In: Jennings JA, Bumgardner JD, editors. Chitosan based biomaterials. Vol. 1. Amsterdam (Netherlands): Woodhead Publishing; p. 3–30.
  • Wang W, Bo SQ, Li SQ, Qin W. 1991. Determination of the Mark-Houwink equation for chitosans with different degrees of deacetylation. Int J Biol Macromol. 13:281–285.
  • Xu Y, Han J, Lin H. 2017. Fabrication and characterization of a self-crosslinking chitosan hydrogel under mild conditions without the use of strong bases. Carbohydr Polym. 156:372–379.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.